420chan now has a web-based IRC client available, right here
Leave these fields empty (spam trap):
You can leave this blank to post anonymously, or you can create a Tripcode by using the float Name#Password
A subject is required when posting a new thread
[*]Italic Text[/*]
[**]Bold Text[/**]
[~]Taimapedia Article[/~]
[%]Spoiler Text[/%]
>Highlight/Quote Text
[pre]Preformatted & Monospace text[/pre]
1. Numbered lists become ordered lists
* Bulleted lists become unordered lists


Community Updates

420chan now supports HTTPS! If you find any issues, you may report them in this thread
Alkene synthesis by Esther Snodfuck - Fri, 24 Jun 2016 13:52:08 EST ID:WznVySGw No.78005 Ignore Report Reply Quick Reply
File: 1466790728463.png -(94053B / 91.85KB, 704x830) Thumbnail displayed, click image for full size. 94053
anyone know how to solve this question with all the organic products ?
16 posts and 11 images omitted. Click Reply to view.
Bombastus !RZEwn1AX62!!xXxJO70U - Sun, 26 Jun 2016 11:49:55 EST ID:R7YMUN76 No.78025 Ignore Report Quick Reply
1466956195563.gif -(1574700B / 1.50MB, 402x226) Thumbnail displayed, click image for full size.
Oh Vehk and Press are buttbuddies. It's okay :3

Also, I looked up the reaction and possible transition states to make sure I'm not retarded. And no. I'm not retarded:
I'm sorry, OPee. But under the falsification principle, it seems that "the software is wrong" is the most likely answer.
You could try drawing the tertiary carbocation intermediate. But that would just be retarded to ask of you.

Why are you even doing Organic chemistry in July.
This problem - Sun, 26 Jun 2016 12:03:04 EST ID:YfyCDm6o No.78026 Ignore Report Quick Reply
1466956984852.jpg -(121804B / 118.95KB, 619x925) Thumbnail displayed, click image for full size.
I even tried that lol still said wrong idk I gonna attempt one more time then ill post answer they said was "correct", and I got a B+ in the lab1, B+ in orgo2 and an A- in lab2, but because I got a C- in the first semester of orgo the new school I transferred too said I have to retake in the summer or no diploma, I only have 1 week left so not that bad but 2300 rip for a class I already passed
Bombastus !RZEwn1AX62!!xXxJO70U - Sun, 26 Jun 2016 13:56:28 EST ID:V/Ex51MS No.78027 Ignore Report Quick Reply
1466963788948.png -(119507B / 116.71KB, 680x509) Thumbnail displayed, click image for full size.
Bump. It's been two hours. What now.

I also fucking hate when schools make you do that. Sorry OP.
This problem - Sun, 26 Jun 2016 15:29:16 EST ID:YfyCDm6o No.78030 Ignore Report Quick Reply
1466969356802.png -(70639B / 68.98KB, 880x922) Thumbnail displayed, click image for full size.
Wanna see some bullshit ..... stupid software I was right all along
William Clonkinman - Sun, 26 Jun 2016 15:42:25 EST ID:IK7sy6RX No.78031 Ignore Report Quick Reply
that's that pearson bullshit online hw isn't it? That's the worst shit I've ever used, the problems are all terribly made and there's typos everywhere.

Dumb scifi question by Jarvis Drerryson - Fri, 24 Jun 2016 12:37:45 EST ID:TtNn9wfR No.78004 Ignore Report Reply Quick Reply
File: 1466786265335.gif -(317533B / 310.09KB, 180x200) Thumbnail displayed, click image for full size. 317533
So I'm dicking around with a videogame, and I had the dumb idea to make a character that's essentially a biological computer, radio controlling organic drone bodies through biological radio transmitters - basically technobabble telepathy.

Would such a thing be possible, if you had countless of hours to dick around with genes and shitloads of funding?

Also, would someone be able to jam such a biological radio signal? I mean, if you can jam real radio, or take over control of a radio signal, in real life, surely you should be able to control some biological radio controlled drone...

Also, would it be possible with only radio transmitters, or could other more exotic waves be used?

Old, novel 14-hydroxylation by Bombastus !RZEwn1AX62!!xXxJO70U - Wed, 02 Mar 2016 21:02:15 EST ID:qWybWc+e No.77704 Ignore Report Reply Quick Reply
File: 1456970535551.jpg -(10007B / 9.77KB, 200x200) Thumbnail displayed, click image for full size. 10007
Acetylate codeine. Protects the group.
Peroxyacid attacks the 14th position caused by the resonance of the double bond (absent in dihydro intermediates proposed earlier). Theoretically creates 14-hydroxy-acetyl-codeine but due to the heat, codeine and 14-hydroxycodeine are also formed.
Another acetylation can be performed and peroxyacid attack to adequately react away the byproducts (worth it IMO but needs to be recalculated).
Deacetylation with a strong acid (sulphuric) upon heating can render the hydroxide workable. Dilution and Pd/C reflux should be able to both hydrogenate and oxidise the 14-hydroxycodeine to 14-hydroxy-dihydro-codeinone.

Sounds workable but the 1916 journal mentions that it is an intermediate to create 14-hydroxycodeinone, not 14-hydroxycodeine. That's not a big issue, if that is the case. A simple borohydride reduction to 14-hydroxycodeine should make the Pd/C reflux workable and remove the need for hydrogenation - which most people cannot do.

The first step should take around 15 minutes with a workup for 30. The second step is an 8 hour reflux. The third step is a 4 hour reflux. This really means that this reaction can take just one day. A column purification step is highly recommended.

It'd be interesting to see if anyone can try it to work.
2 posts and 1 images omitted. Click Reply to view.
Bombastus !RZEwn1AX62!!xXxJO70U - Fri, 25 Mar 2016 01:34:07 EST ID:iJW+fxXz No.77767 Ignore Report Quick Reply
Bombastus !RZEwn1AX62!!xXxJO70U - Sat, 02 Apr 2016 17:17:27 EST ID:7o87/hD6 No.77790 Ignore Report Quick Reply
Ru. Keep up the good work. It's like you came out of nowhere and suddenly there are 2.2 organic chemists on this board now!
(fuck you vehk. you're only 20% of one right now. go back to ledickcirclejerk)

what do you think of my idea up there ^
Vehk !7HYGxe5v5c - Sat, 02 Apr 2016 22:44:41 EST ID:aFt0bd4t No.77792 Ignore Report Quick Reply

25% of an organic chemist in a month. Also, you're the one always sending me links to circlejerk threads.
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 14 Apr 2016 21:25:21 EST ID:V1Ngvki3 No.77839 Ignore Report Quick Reply
Lydia Cruvinghet - Tue, 21 Jun 2016 16:12:35 EST ID:dORvzyL7 No.77988 Ignore Report Quick Reply

Phenylethylamine (PEA) to Amphetamine by George Pimbletodge - Fri, 27 May 2016 23:24:35 EST ID:ccTkU6G9 No.77916 Ignore Report Reply Quick Reply
File: 1464405875697.jpg -(39686B / 38.76KB, 566x567) Thumbnail displayed, click image for full size. 39686
Will this actually work?


Phenylethylamine (PEA) to Amphetamine :) PURE

  1. Add an OH group. Dissolve your PEA in warm ethanol (alcohol). Grain would work, i use hand sanitizer (after salted out of course). No boil off that ethanol on about 180F. Can go up to almost 300F if you want to speed it up.

2. Scrape the remaining white powder off the pan. Place in a mix of white vinegar and warm ethanol. Let it dissolve. Now boil this shit off on same temp. Now you have a Ketone aka ====O. Next you're going to methylate this and have Amphetamine.

3. Scrape this powder off pan, place in a VERY small mixture of methanol and acetone (1mL per gram). Shake it. It should react ithin 2 minutes. Now filter this and let it dry. You just fucking made pure Amphetamine. Go give some to your friends. Take some too. Keep a big stash. Sell a bit even.
6 posts omitted. Click Reply to view.
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 09 Jun 2016 18:11:15 EST ID:vbS8CtHn No.77951 Ignore Report Quick Reply
Uh wat. Amines are more reactive than alcohols in terms of acetylation, tosylation, t-boc-ification and whatever

nb. maybe i missed the point
Press !QUHukXEvkY - Fri, 10 Jun 2016 10:53:54 EST ID:3JmPYuOx No.77954 Ignore Report Quick Reply
Well not if you just put an amine and acetic acid in a pot and then spend an hour standing next to it.
Theyd just undergo an acid base reaction unless you were to add an activation agent like ddq or had a better leaving group.
Press !QUHukXEvkY - Fri, 10 Jun 2016 10:57:30 EST ID:3JmPYuOx No.77955 Ignore Report Quick Reply
Fuck dic or bop or whatever, not ddq
Nicholas Crarringchag - Thu, 16 Jun 2016 00:29:04 EST ID:qwgyiW+Y No.77971 Ignore Report Quick Reply
>Now you have a Ketone aka ====O
thanks OP this really breaks it down for ya

just put in my order for 5kg of PEA
Walter Binnerdodge - Mon, 20 Jun 2016 17:53:45 EST ID:A4nip1Ns No.77982 Ignore Report Quick Reply
I would take your PEA, throw in a base and some methyl chloride and pray to god things work.

Shit had me weak man by Thomas Publingstock - Thu, 03 Mar 2016 15:25:23 EST ID:NLJmhbvz No.77707 Ignore Report Reply Quick Reply
File: 1457036723155.jpg -(10453B / 10.21KB, 218x231) Thumbnail displayed, click image for full size. 10453
In an attempt to make some counterfeit codeine with prometh syrup (it was for a southern rap themed party), I dropped about 3 oz of pg/vg mix with some flavor, two or three shots of everclear and two shots of tito's vodka, 10 finely crushed alprazolam 2mg tablets, and to top it off, corn syrup for the texture.

Here's the real question though: Would heating up the alcohol and/or alprazolam mixture do anything to potentiate it?

I put an ounce in a big pineapple and drank that and caught a fantastic buzz and when I tried doing it with two ounces of the solution, I fell asleep before finishing it. They way I heated it up was I took two pyrex measuring cups, put very hot water in the first one and placed the second pyrex (containing the solution) on top and using a metal whisk, I mixed the ingredients until they were nice and even. There was still a little pill matter so I just took that off with a spoon since it rose to the top and ended up with a pint of some "lean".

Did the heat help or could it just be the alprazolam and alcohol working together? I put half an oz in my drink today in class because I took an adderall (it makes me nervous so I needed to chill) and ended up pretty buzzed for about an hour rather than just chilled out lol thank god the adderall kept me functional.

So what's the deal gais? I need a chemistry guy on this, help a brotha out
Thomas Publingstock - Thu, 03 Mar 2016 15:27:16 EST ID:NLJmhbvz No.77708 Ignore Report Quick Reply
What I'd also like to know is whether or not the xanax binded to the alcohol or any of the other ingredients, as I know it isn't water soluble. I may have put more alcohol in there than previously stated, btw, I didn't measure just dropped some in the pyrex until it looked right
Jenny Blushham - Thu, 03 Mar 2016 20:22:39 EST ID:2wC1bo8y No.77709 Ignore Report Quick Reply
1457054559289.jpg -(71340B / 69.67KB, 400x533) Thumbnail displayed, click image for full size.
No to everything. That's just a shitload of alcohol and 20mg of xanax, way too much sugar and for some retarded reason pg/vg.. I'm guessing that was the grape flavor?
Polly Mellyham - Tue, 08 Mar 2016 20:50:36 EST ID:xxs07y/f No.77734 Ignore Report Quick Reply
Your friends are gonna black out, not remember the party, and blame you.
John Brazzleshaw - Thu, 10 Mar 2016 12:44:43 EST ID:TrPWlcRq No.77737 Ignore Report Quick Reply
...Why not just get the actual syrup?
This seems unnecessary and possibly dangerous.
Ebenezer Lightville - Fri, 17 Jun 2016 18:31:54 EST ID:RMLgtyMj No.77979 Ignore Report Quick Reply
This shit sounds amazing, give in depth instructions

Phalaris Extraction Thread by Ian Ciffingbidging - Sat, 28 May 2016 12:28:20 EST ID:cOHpZlwa No.77923 Ignore Report Reply Quick Reply
File: 1464452900987.jpg -(132334B / 129.23KB, 800x999) Thumbnail displayed, click image for full size. 132334
Has anyone here done any work with extracting DMT or other trptamines from various specieis of Phalaris grass? DMT Nexus has a lot of information but a lot of it is contradictory and incomplete.
Esther Diddlemene - Sun, 29 May 2016 16:25:14 EST ID:alUhohOf No.77931 Ignore Report Quick Reply
I wouldn't bother. I'd just purchase Acacia Confuse or Mimosa Hostilis online.
Molly Honningshit - Tue, 14 Jun 2016 11:24:06 EST ID:DXmzOHk9 No.77967 Ignore Report Quick Reply
Once you have the real materials its super easy, I made some yuasca in my dorms on a freakin hot plate.
Oliver Clepperdale - Wed, 15 Jun 2016 01:23:52 EST ID:vp89ZYzI No.77968 Ignore Report Quick Reply

Stop being so afraid and jump into it. Vaporize it ideally.

liquid weed by Verotos - Mon, 13 Jun 2016 17:05:06 EST ID:DXmzOHk9 No.77966 Ignore Report Reply Quick Reply
File: 1465851906550.jpg -(21155B / 20.66KB, 225x225) Thumbnail displayed, click image for full size. 21155
So my question is, how much thc, cbd,(weed) can 1 gallon of 100% VG absorb? I'm stoned and forget the term, deal with it lol

Chlorine Biosphere? by Thomas Bollynog - Mon, 06 Jun 2016 14:04:43 EST ID:QeFTOZ30 No.77943 Ignore Report Reply Quick Reply
File: 1465236283025.jpg -(7093B / 6.93KB, 200x200) Thumbnail displayed, click image for full size. 7093
I'm an artist that depicts space scenes. Rather than focus on scifi space battles or nebula or some shit I like to focus on making realistic-looking planets (or as realistic as I can get them to look at least). I do a lot of Earth-like planets but, as a biology nerd, I wanted to try something new. I've done a few Earth-like planets with usual colors of vegetation: red, purple, black, etc. I've been reading about alternative biochemistry and wanted to try depicting a planet with a biosphere that isn't necessarily carbon-aqueous.

Anyways, I'm not here to talk about the planet in particular. This isn't /sagan/ after all. No, I want to discussion biochemistry involving chlorides. I read a study about some scientists replacing the thymine in the DNA of E. coli with 5-Chlorouracil, so there is some precedent for chlorides being incorporated into biological systems. In my research I also came across this: 2HCl + CO2 ---> CH2O +Cl2. It looks kind of like some kind of photosynthesis that uses hydrochloric acid to form organic compounds? I'm pretty sure that's formaldehyde and chlorine gas. Do you think that the chlorine gas could be utilized in a manner similar to oxygen? Could this create any kind of sustainable biosphere? I'm honestly not sure this concept is even remotely possible but it is interesting.
1 posts omitted. Click Reply to view.
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 09 Jun 2016 21:27:23 EST ID:4ppVjZXo No.77952 Ignore Report Quick Reply
Chlorine wouldn't be prevalent enough in the hydrosphere or atmosphere to be used by major biological creatures.
There are a few species of tiny algea and bacteria that CAN metabolize chlorinated and brominated substances for energy but not as their main fuel source. They also excrete simple chloro-carbon compounds like mono-chloromethane and chloroform. It gets to be an issue when they release a lot of this shit into the atmosphere.
Their chlorine source is located on vents in the Earth's crust from decay and slow reslease of built in gasses. Then they escape into the atmosphere and then into space.
You would need a planet with ridiculous gravity to keep chlorinated compounds low enough. But that would also crush a lot potential life candidates.
Ian Werrypan - Sat, 11 Jun 2016 01:44:16 EST ID:DpF94DTG No.77961 Ignore Report Quick Reply
1465623856297.jpg -(2104242B / 2.01MB, 2300x1650) Thumbnail displayed, click image for full size.
Flourine? Might be interesting.
I got the photosynthesis reaction from here:
The 5-Chlorouracil info I go from skimming through this paper:

How ridiculous are we talking? I don't think higher gravity is necessarily a big hinderance to complex life. Imagine what Martians would think about the appearnace of life on a world with Earth's amount of gravity, after all. There is a point, however, at which gravity would definitely preclude anything but microbes from evolving. Of course there's still possibilities with that. Perhaps an ecosystem of slime mold-like organisms? I'm unsure what the diversification potential of slime is but I'm sure natural selection could come up with some interesting stuff even if I can't.
Bombastus !RZEwn1AX62!!xXxJO70U - Sat, 11 Jun 2016 11:15:13 EST ID:4ppVjZXo No.77962 Ignore Report Quick Reply
Jupiter level gravity. The gravity would be so strong that life would not exist due to the activation energy to sustain wall membranes would be too high. It's just theoretically so implausible for it to work.
Methane would be the other best bet as it can be burned for fuel relatively easily and would be so abundant in the universe. Carbon fixation comes first; then nitrogen fixation.

On a low pressure system, it's hypothesized that silicon would be the binding site of choice due to its molecular weight. In this case, you might have gaseous bromine sticking around. However, it would be so implausible because the halogen % composition of the universe is so miniscule, the odds are just heavily stacked against your favor of a halogen- based organism.

Oxygen is the best candidate because it's heavy enough to stay on the atmosphere, be gaseous, and most importantly: is abundant enough in star death.
Bombastus !RZEwn1AX62!!xXxJO70U - Sat, 11 Jun 2016 11:16:15 EST ID:4ppVjZXo No.77963 Ignore Report Quick Reply
Uracil is made after multiple millions of years of carbon fixation and added nitrogen fixation. No way such a complex structure would exist otherwise, unfortunately.

Edwin Fupperstodge - Sat, 11 Jun 2016 23:34:49 EST ID:GSuYkmZT No.77964 Ignore Report Quick Reply
1465702489325.jpg -(1562155B / 1.49MB, 2600x1980) Thumbnail displayed, click image for full size.
Seems like this idea is a bust. Oh well, thanks for the input anyways. It's always nice to learn something, even if it leads to disappointment.


H2SO4 by Burney - Tue, 10 May 2016 23:12:56 EST ID:V/Jmd1aC No.77888 Ignore Report Reply Quick Reply
File: 1462936376814.jpg -(516226B / 504.13KB, 1920x1080) Thumbnail displayed, click image for full size. 516226
I acdentely 98% pure sulefuric acid. Should I have this checked out? Could be a third degree chemicle burn? Should I just ingore it and hope it goes away. Also this happened a few days ago so this isen't a fresh wound.
Jarvis Bicklestirk - Wed, 11 May 2016 10:07:58 EST ID:QpnKQ24z No.77889 Ignore Report Quick Reply
hard to tell but id guess youre right about it being thrid degree. since its that severe and a few days old, expect permanent scar tissue

dont just ignore it. how big is it? kind of hard to tell, shouldve put a lime next to it for scale.

make sure it doesnt get infected and get some burn cream. keeping it wet with that creme really speeds up the healing process and keeps scabbing or scarring to the minimum.
Nathaniel Brooklock - Fri, 20 May 2016 18:49:00 EST ID:j2okwtbe No.77899 Ignore Report Quick Reply
I hope you put that under running water
Bombastus !RZEwn1AX62!!xXxJO70U - Wed, 25 May 2016 21:14:28 EST ID:aXFxXtc6 No.77914 Ignore Report Quick Reply
>I acdentely 98% pure sulefuric acid.

You should be fine, OP. Acid burns are normally very localised and don't cause any damage on your flesh that isn't superficial. As long as you're not using it as an inhalant, huffing it, using it as eyedrops, injecting it, plugging it, or bathing in it, this burn will just be like a tattoo.
What you have to worry about is potential infection.

How'd you let that happen to you, anyway? I've accidentally poured H2SO4 on the back of my hand before and washed it off within 20 seconds while it was already burning. How'd you let it get to that extreme?
Shit Basslesadge - Fri, 10 Jun 2016 19:11:42 EST ID:zwhzKcaA No.77958 Ignore Report Quick Reply
Keeping the sunlight(UV) off of it should also help reduce scaring. Cover lightly.

I'm a dumb ass. by Shit Basslesadge - Fri, 10 Jun 2016 19:04:12 EST ID:zwhzKcaA No.77956 Ignore Report Reply Quick Reply
File: 1465599852698.jpg -(106264B / 103.77KB, 720x719) Thumbnail displayed, click image for full size. 106264
Why won't my shitty bottle crank fully dry out: It's kind of waxy. Seems acidic. Also burns toward the end of evaporation.
Shit Basslesadge - Fri, 10 Jun 2016 19:04:45 EST ID:zwhzKcaA No.77957 Ignore Report Quick Reply
Google absolutely refuses to help me.
Shit Basslesadge - Fri, 10 Jun 2016 19:27:34 EST ID:zwhzKcaA No.77959 Ignore Report Quick Reply
This is the only time this has occurred; Generally I get a nice fluffy white substance that evaporates cleanly, so I'm a bit confused as to what I changed. Under-reduced?

Future LSD Analogs? by TheDiggityDank !jmUcEJD43k!!E9WUPA0s - Fri, 29 Apr 2016 05:18:06 EST ID:7x9SM9m4 No.77870 Ignore Report Reply Quick Reply
File: 1461921486846.jpg -(871740B / 851.31KB, 3354x1758) Thumbnail displayed, click image for full size. 871740
Hey guys, I had an idea for new possible LSD analogs. All important details are in the attached image, I am curious to see what all your thoughts will be on this!
Doris Wurrytack - Fri, 29 Apr 2016 15:28:22 EST ID:TZRaxcWf No.77871 Ignore Report Quick Reply
I'm only part way through my degree, so I could be wrong, but I don't see halogenated amines very often. I have no idea how you would add a halogen to that N, but it seems like it would be difficult to make/unstable. Interesting idea though, curious to see what others have to say
TheDiggityDank !jmUcEJD43k!!E9WUPA0s - Fri, 29 Apr 2016 17:54:30 EST ID:7x9SM9m4 No.77872 Ignore Report Quick Reply
Yeah, I have no real knowledge about the synthesis of these compounds, and I lack a fair bit of chem knowledge outside of more basic things like structural formulas etc. I do however have an alright amount of knowledge when it comes to Structure Activity Relationships in psychoactive compounds. This is why I came to you guys, as I you guys might have a greater understanding on this topic.
Charlotte Shakeham - Sun, 15 May 2016 19:41:26 EST ID:+5AM2MwN No.77891 Ignore Report Quick Reply
Does anyone know how these break down in the body? Probably the one that is most risky is the bromine one. LSD is in microgram doses so this probably isn't a risk but the bromide ion does have a long half-life in the body. As a rough estimate, if someone does 800 000 100 ug blots a day for 12 days straight they might run into problems but maybe I'm missing something.
Bombastus !RZEwn1AX62!!xXxJO70U - Wed, 25 May 2016 21:10:53 EST ID:G8mu3scS No.77913 Ignore Report Quick Reply
Hey Press. Get over here and check out these N-X bonds (where X-Cl,F,Br,I).

I don't think these would be stable at all. Google the stability of chloramine and their reactions. I know mono-chloro-amine hydrolyses into ammonium and chlorine gas. I don't see how these compounds would be stable given the first chance at a proton source and create the R2N-H bond.

If you want to make it a relatively good leaving group and available for adaptation in the body, I would highly recommend an Acetyl or a Tosyl group on that nitrogen. Tosylic acid is toxic to your kidneys but maybe at light concentrations like 1mg in the blood stream, it could be fine.
I wonder if you could make di-tosylic-morphine as a better alternative to heroin................ hmmmmmmmm.............................................

Organobromides are toxic to your liver and endocrine system. However, aromatic bromides are either excreted in your urine, safely or made into HBr and then NaBr which are safe enough in low concentrations. Not of a concern.
Examples: Bromovanilin, Bromazepam
TheDiggityDank !jmUcEJD43k!!E9WUPA0s - Fri, 10 Jun 2016 00:48:00 EST ID:aNLlWMG5 No.77953 Ignore Report Quick Reply

Thank you for the thorough explanation! I suspected that might be an issue, but I was just not sure if having the nitrogen of the amine group bonded into a more complex structure, as it is in LSD, would alleviate the issue. I have been looking into other potential LSD analogs, and I have come up with a few interesting hypothetical structures. However, I really do not know enough about lysergamide structural activity relationships to know if they would be active or not.

CWE and saturation by Cyril Cremmerwat - Wed, 18 May 2016 13:54:30 EST ID:9YAuxRQ8 No.77896 Ignore Report Reply Quick Reply
File: 1463594070164.jpg -(61049B / 59.62KB, 400x400) Thumbnail displayed, click image for full size. 61049
I've been wondering about some thing regarding CWE. The main point of CWE with products containing APAP seems to be to reduce the amount of APAP in the final product since it seems to be more water soluble than I thought it was. Which means the less water you use and the colder it is, less APAP will be in the final product. Which led me to some questions:

  1. Assuming that you have a drug containing Codeine Phosphate and APAP. Could you, in theory, dissolve the pills in say 10ml of water ("One gram [of Codeine Phosphate ]dissolves in 2.3 ml water,", O'Neil M. J. (ed.), Smith A. (ed.), Heckelman P. E. (ed.)-The Merck Index_ An Encyclopedia of Chemicals, Drugs, and Biologicals (1996)) and have some kind of "super concentrated", crystal clear solute of Codeine Phosphate with a ridiculous low amount of APAP? Or would the filter clog up? Or the solution get over-saturated? Which leads me to my next question

2. Both APAP and Codeine Phosphate are soluble in water. I don't understand the mechanics of dissolution completely but would it be possible to not have any 'space' left to dissolve the Codeine Phosphate? Or does it get dissolved first because it's so much more soluble? Or does it work completely different?

Recrystallizing APAP is a bother to me so by exploiting the great solubility of Codeine Phosphate I could in theory use cold water from the fridge or something. Maybe dissolving the pills in 50ml? Even at 20C this would leave me with 639mg of APAP which is a joke. (https://en.wikipedia.org/wiki/Paracetamol)
13 posts and 4 images omitted. Click Reply to view.
Bombastus !RZEwn1AX62!!xXxJO70U - Sat, 04 Jun 2016 05:07:04 EST ID:z4/bY936 No.77941 Ignore Report Quick Reply
Awful meme magic
Vehk !7HYGxe5v5c - Mon, 06 Jun 2016 17:02:17 EST ID:AEFFwJfE No.77944 Ignore Report Quick Reply

For a beginning, Central Science is good and it's what I use for foundational chemistry revision. If you want a good general book for Organic Chemistry in specific, Central Science isn't useful. I'd recommend Claydens, it's comprehensive and structured in an accessible manner.
press !QUHukXEvkY - Wed, 08 Jun 2016 16:11:39 EST ID:fcMijPsC No.77946 Ignore Report Quick Reply
1465416699151.jpg -(38045B / 37.15KB, 500x375) Thumbnail displayed, click image for full size.
well shit. apparently my version of claydens is too big for 420chan even compressed. a tiny low res pic thats 30mb big is mighty suspicious anyways.

but it shouldnt be too hard to come by
Edward Fanningdodge - Thu, 09 Jun 2016 11:43:00 EST ID:D9t26pna No.77948 Ignore Report Quick Reply
what the fuck is wrong with you
press !QUHukXEvkY - Thu, 09 Jun 2016 13:57:30 EST ID:fcMijPsC No.77949 Ignore Report Quick Reply
why dont you try opening it in winrar?

<<Last Pages Next>>
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Report Post
Please be descriptive with report notes,
this helps staff resolve issues quicker.