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Help an unmotivated loser out by Polly Winnertid - Fri, 01 Apr 2016 15:00:53 EST ID:hqftNCGp No.77783 Ignore Report Reply Quick Reply
File: 1459537253692.gif -(11030B / 10.77KB, 197x200) Thumbnail displayed, click image for full size. 11030
I realise that this board is mostly used for instructions on how to make drugs in your fucking garage, but since this is also a science board I thought that I would ask you brilliant minds for help.
I have a upcoming project, spanning a year or so, that will entail/connect almost every course I am taking. I am supposed to pick something to create, experiment, etc. and present the result to my professor(s) and peers.
I have seen dudes investigate pharmacuticals, tried to treat salmonella by destroying its flagella with enzymes, etc.
What the hell am I supposed to do?
I might be given access to chemicals, but I do not want to make drugs, even though that would be sweet.
Alice Bicklechot - Fri, 01 Apr 2016 15:32:24 EST ID:NPdGYjgm No.77786 Ignore Report Quick Reply
Is there anything else than sweet sweet drugs that you are even slightly interested in? Preferably something to do with making the world a better place. Great grades coming easily if you do some shit to help african children or make an anti hangover pill.
Start with something not so specific that interests you, do some investigation and then get closer and closer to your ideea until you are drinking champange from a nobel prize while popping anti hangover pills that help african children.

Naltrexone -> Oxymorphone? by Hamilton Beggleshit - Thu, 17 Mar 2016 18:16:02 EST ID:GksK9UMc No.77752 Ignore Report Reply Quick Reply
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Dear /chem/,

wikipedia cites that "Naltrexone can be described as a substituted oxymorphone – here the tertiary amine methyl-substituent is replaced with methylcyclopropane. Naltrexone is the N-cyclopropylmethyl derivative of oxymorphone."

Is it possible to revert naltrexone back to oxymorphone? If so, how?

My very limited understanding of organic chemistry leads me to believe that naltrexone could, in proper solution and (probably) with the addition of heat, be broken into oxymorphone and cyclopropylmethylbromide. (pic related)

Any input regarding said (hypothetical) reaction will be greatly appreciated!
2 posts omitted. Click Reply to view.
Bombastus !RZEwn1AX62!!xXxJO70U - Sun, 27 Mar 2016 13:18:03 EST ID:4ppVjZXo No.77773 Ignore Report Quick Reply
Didn't you start your comment by saying that "you cannot remove the cyclopropylmethyl group of the amine" and then go on and say how to remove that group? Correct me if I misunderstand, please.

If I understand correctly, I don't see why it would. The less sterically-hindered ethylene-amino bridge be cleaved vs the cyclo-propyl (more hindered) group?

However, I guess using a sterically selective agent like dodecanethiol would help. You're right that the alkyl group would fall apart but which one? Isee the ethylene bridge snapping apart before the methylcyclopropyl group is even touched with an equilibrium of 1:1000 or greater
Vehk !7HYGxe5v5c - Mon, 28 Mar 2016 10:59:30 EST ID:mqpMZrCV No.77774 Ignore Report Quick Reply
1459177170548.jpg -(38976B / 38.06KB, 463x411) Thumbnail displayed, click image for full size.

OP was talking about naltrexone, which contains the methylcyclopropane substituent, the guy above you is talking about naloxone, which shares the same structure as naltrexone except with an allyl group instead of a methylcyclopropane group forming the substituent.

See picture for reference.
Fanny Munkinspear - Wed, 30 Mar 2016 11:18:57 EST ID:8U0GcjC9 No.77775 Ignore Report Quick Reply
>in real world amine chemistry:
I read this is "in real anime world chemistry"
Ru-lover - Wed, 30 Mar 2016 19:13:14 EST ID:1yz9Gpwk No.77777 Ignore Report Quick Reply
Thanks for clearing this up. Its exactly what I am talking about. Allyl group is 1000x easier to remove than cyclopropylmethyl. You can also use wilkinson catalyst, there are some papers about that.
Cornelius Bushwen - Sun, 10 Apr 2016 22:52:26 EST ID:ljoFE2/4 No.77821 Ignore Report Quick Reply
Quints don't happen here but once in a great while.

A. muscaria - complete decarboxylation of ibotenic acid to muscimol by Faggy Sorringdedge - Thu, 17 Mar 2016 12:28:40 EST ID:ge3zUrSE No.77751 Ignore Report Reply Quick Reply
File: 1458232120013.jpg -(80063B / 78.19KB, 511x487) Thumbnail displayed, click image for full size. 80063
I have a chemistry related question for you.

I've read in two separate sources that it is possible to decompose all the ibotenic acid in the muscarias to muscimol by boiling it in a very low pH solution (2.7). One source seems to have used HCl to achieve this. I was wondering if this would be possible to achieve using household vinegar or citric acid.

5% household vinegar seems to have a pH of 2.4, but acetic acid has a low vapour pressure, so boiling vinegar would vapourize acetic acid with water. apart from making your house smell, vapourising acetic acid would drive the pH of the solution higher, so you might need to add more vinegar to the pot regularly.

However, attempting the same with citric acid seems to be more straightforward since citric acid doesn't vapourise as readily. You can just add water to the boiling solution to cover for evaporation losses and be fine. Lemon juice is said to have a pH around 2, and you can calculate the pH of a solution from the amount of citric acid you add so it should work.

After 2.30 - 3 hours of boiling, you can just add some sodium carbonate to neutralize the pH in order to make it more palatable, and filter to remove leftover carbonate/mushroom pieces, and drink. I'm pretty certain this step wouldn't alter the structure of muscimol.

The conversion from ibotenic acid to muscimol seems to be dependent on pH, so I think it should be possible, but I don't have enough chemistry knowledge to say or certain. What do you think?

If this works, this could be used as a very easy homemade tek for preparing Amanitas.

Pic related, ibotenic acid converts to muscimol after boiling at low pH.
Comment too long. Click here to view the full text.

Learning chemistry online by Alice Mevingpug - Sat, 12 Mar 2016 03:40:46 EST ID:KCS86o4a No.77741 Ignore Report Reply Quick Reply
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Hey guys,

I want to get into chemistry. Can you recommend some good, free online courses or something? Or maybe some book(s) that is good for a self-learner? The site study.com offers a free 5 day trial (afterwards the cheapest thing is $50/month which isn't bad), I will give that one a go. On this other site, alison.com are some free courses of introduction to chemistry, which is exactly what I'm looking for, but it looks like these are only videos, I'd rather have something like videos and presentations/written text so I can re-read it and learn it.. you know, just like in college. Yeah I could make my own notices while watching the videos but fuck that noise, I hate making notices. Any suggestions?
Hannah Tootgold - Sat, 12 Mar 2016 17:37:00 EST ID:xxs07y/f No.77742 Ignore Report Quick Reply
Kahn Academy

General and organic chem text books. do the practice problems
Fuck Chondlegold - Mon, 14 Mar 2016 03:11:44 EST ID:hqftNCGp No.77745 Ignore Report Quick Reply
khan academy will have all the chem high school courses
only thing is you wont be able to make cool experiments and shit
schools got access to some sweet fucking chems, dude
Samuel Pibberbutch - Mon, 14 Mar 2016 13:16:59 EST ID:ybs70zkB No.77746 Ignore Report Quick Reply
thanks man, I'll check it out

yeah I know, but I already finished one college and I just started at a new job, I don't have the time right now to start another college. Besides, I don't remember shit from the high school chemistry, so this is a great start for me.

Anthropology by Eugene Meblingkut - Thu, 10 Mar 2016 23:29:56 EST ID:HSdvhBMF No.77739 Ignore Report Reply Quick Reply
File: 1457670596092.jpg -(524037B / 511.75KB, 900x1200) Thumbnail displayed, click image for full size. 524037
Please mystify me.

can you id this? by Lillian Honeywell - Thu, 12 Mar 2015 12:32:49 EST ID:wC5/3Op6 No.76238 Ignore Report Reply Quick Reply
File: 1426177969958.jpg -(198139B / 193.50KB, 808x1078) Thumbnail displayed, click image for full size. 198139
saw this written down somewhere
curious to what it is
12 posts and 3 images omitted. Click Reply to view.
Emma Worthinghood - Tue, 23 Feb 2016 23:47:16 EST ID:6FVGXA05 No.77693 Ignore Report Quick Reply
So you own /chem/ now? It's called a joke dipshit
Faggy Havingkedge - Thu, 25 Feb 2016 11:39:02 EST ID:vFjYr6dk No.77696 Ignore Report Quick Reply
Haha we're all laughing fuckface. Good joke. Spam more please.
Cornelius Grimbury - Tue, 08 Mar 2016 23:49:48 EST ID:BrbiAnNp No.77735 Ignore Report Quick Reply
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Priscilla Huttingtotch - Wed, 09 Mar 2016 08:38:54 EST ID:5P3qbCIv No.77736 Ignore Report Quick Reply
The picture is from Finland. "Tarjous pizza" means "cheap pizza" roughly translated from finnish to english.
Jenny Binnersetch - Fri, 11 Mar 2016 21:39:50 EST ID:imwkOt2v No.77740 Ignore Report Quick Reply
Maybe it's supposed to be beta-keto-dmt. Like Bk-2cb but with dmt.

Fun chemistry experiments by Lillian Henningstane - Mon, 29 Feb 2016 18:32:27 EST ID:hqftNCGp No.77699 Ignore Report Reply Quick Reply
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I remember as a kid I used to mix mr muscle containing NaOH, aluminium and water. A strong exothermic reaction occurs by mixing the NaOH and water. Adding the aluminium instantly reacts with the solution and creates hydrogen gas.
Me and my friends had a blast doing it when we compressed it in a regular old plastic PET bottle (get the pun?)

Are there any similair experiments that causes the same kind of explosive result (made from homemade stuff of course)?

I've heard something about El Dorado soap but idk

I can't really make nitro glycerin like that cool youtube chemist because I don't have access to nitric acid, etc.

And no, officer, I am not a terrorist
Thomas Cluttingforth - Wed, 02 Mar 2016 03:00:48 EST ID:f7nOMwEX No.77700 Ignore Report Quick Reply
gasoline + soft soap or styrofoam. stir in sytrofoam until gasoline will not dissolve any more. Makes napalm.
Ammonia nitrate (Slit open single use ice packs)+ Potassium something (called salt substitute in any grocery store. make sure it's 100% potassium sorbate or potassium sulfate or something). Don't remember the ratios but find that shit out yourself nigga. Crush the ammonia nitrate beads to make powder. Mix the salt substitute in water and boil it until it stops dissolving. filter out whatever remains and discard. Add the ammonia nitrate powder to the water and heat slightly because the mixture will lose temperature quickly. once it is completly dissolved, put it in a mason jar in a fridge overnight. in the morning scrape the crystals. You may get more if you put the liquid back in the fridge.
Crush the crystals into powder. This is potassium nitrate, or "saltpeter".
From a chemichal supply or science or gardening store buy pure powdered sulfur. from a gardening store buy charcoal powder. In fact, your gardening store may stock stump remover which is sometimes pure potassium nitrate, meaning you wouldn;t have to make your own.
75 parts potassium nitrate, 15 parts charcoal powder, 10 parts sulfur makes black powder. 50 parts potassium nitrate 40 parts charcoal 10 parts sulfur makes blasting powder.

stop bein a faggot an just look tis shit up for yourself. The limit for black powder purchase WITHOUT ID and without being registered is 75lb. you can buy enough gunpowder completly within your bounds of a regular citizen to bring down an apartment building. feds ccouldnt give a shit what you do if you're not islamic or mexican
so just think of some fun things to do
be creative
find your own answers in life for a fulfilling existance
do not expect to be force fed
Thomas Cluttingforth - Wed, 02 Mar 2016 03:03:17 EST ID:f7nOMwEX No.77701 Ignore Report Quick Reply
Angus Drondleson - Wed, 02 Mar 2016 17:28:57 EST ID:hqftNCGp No.77703 Ignore Report Quick Reply
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Jarvis Shittingman - Fri, 04 Mar 2016 01:09:02 EST ID:RLSN+6eM No.77710 Ignore Report Quick Reply
Any idea what this one is?

press !QUHukXEvkY - Mon, 07 Mar 2016 15:06:33 EST ID:bRQD0jr4 No.77718 Ignore Report Quick Reply
ethanol vapours in a bottle.

just put a small volume of pure ethanol in a big container and shake it around, then wait a bit and light away.

you could use other solvents but it wouldnt look as blue. im also not responsible if you blow yourself up.

Predicting NMR by Edward Cribberbut - Thu, 03 Mar 2016 04:05:56 EST ID:EP6hRsTc No.77706 Ignore Report Reply Quick Reply
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What does Anon use to predict NMR?
I'm currently using Mestrenova which is a step-up from ChemDraw but still lackluster.
I'm looking for something that doesn't need to run on a server farm but is still decent enough to serve as a guideline when interpreting spectra.

Oxycodone Reactions Summed up Neatly by Bombastus !lnkYxlAbaw!!7zlcjO/U - Sun, 24 Jan 2016 16:04:57 EST ID:V1Ngvki3 No.77560 Ignore Report Reply Quick Reply
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Okay, so we had a failure with the reactions of oxycodone with a fucked up friend of mine a while back. He had given me some failed hydrogenated species of 14-hydroxycodeinone which was one of the weirdest highs I have ever experienced in my life. I think I took around 25mg of it.
I think that was a weird kappa-agonist with some mu-effects.

Regardless, a few things that make the last thread obsolete are as follows:
  1. 14-hydroxylation of any morphinan requires the double bond at the 7th position for the enol to occur. Otherwise, the oxyacid cannot form the tertiary alcohol due to lack of reactivity.
  2. Acetic protection group seems to be the easiest way to create 14-hydroxy on the morphinan groups. It has the most yield if not starting from thebaine. The next best thing would be an annoying Cobalt (III) salt which I never knew existed. It seems like this unstable salt can be used as a catalyst for codeinone > hydroxycodeinone. But it's really annoying to make.
With no protection, the yield is an atrocious 20%. With the protection, you can get the yield up to 80%.
3. Almost all side reaction waste products are water soluble after basifying. Unless you're unlucky, there is little requirement for columns during these reactions.
4. You cannot avoid hydrogenation if making oxy from cod.

In summary, unless you want to follow the method step by step on the erwoid page that summarises Codeine > Oxycodone, you won't produce nearly the same results with the available chemicals.
With no protection, you could easily achieve a 20% yield of oxycodone from codeine.

He's also currently working on a more efficient method to oxidise codeine to codeinone (hopefully using bleach and vinegar), a more efficient method to hydrogenate, as well as a better peroxy-acid to put the 14-hydroxy group on.

Pic related. Artefacts. We need those 1900 German artefacts that tell us how to morphine.
12 posts omitted. Click Reply to view.
Cornelius Buzzbanks - Sun, 21 Feb 2016 17:34:34 EST ID:p0QLwGpF No.77684 Ignore Report Quick Reply
It's possible that the reaction creates oripavine. Which has to be extracted to purify the hydromorphone
Cornelius Buzzbanks - Sun, 21 Feb 2016 17:53:58 EST ID:p0QLwGpF No.77685 Ignore Report Quick Reply
Bombastus have you tried that the noble metal catalyst synthesis of hydromorphone?
Bombastus !lnkYxlAbaw!!7zlcjO/U - Mon, 22 Feb 2016 00:44:30 EST ID:sqhxA+9X No.77686 Ignore Report Quick Reply
Yes and it turned me gay. Successful I'd say might do it again one day.
Ian Begglestone - Mon, 22 Feb 2016 15:47:37 EST ID:VuOwbgQK No.77687 Ignore Report Quick Reply
Ok if your really gay then where did you hide your gay gold?
Henry Pombleson - Tue, 23 Feb 2016 14:20:24 EST ID:uPn+UTf4 No.77689 Ignore Report Quick Reply
How did u purify that shit from the rest of the chemicals lmao

VM&P Naphtha by Molly Bannerlock - Wed, 18 Nov 2015 12:15:21 EST ID:u4vCvpNb No.77376 Ignore Report Reply Quick Reply
File: 1447866921478.jpg -(91226B / 89.09KB, 720x900) Thumbnail displayed, click image for full size. 91226
What exactly is VM&P Naphtha? You most likely know it's used for the extraction of DMT, but it's not really accessible if you don't live in America.
Some guides say you can use basic paint thinner. Is that true?
17 posts and 5 images omitted. Click Reply to view.
Vehk !7HYGxe5v5c - Mon, 15 Feb 2016 16:40:26 EST ID:PPkNLWzw No.77661 Ignore Report Quick Reply

> secondary school

Are you Irish, fam?
Charles Bardforth - Sun, 21 Feb 2016 07:17:05 EST ID:TtNn9wfR No.77681 Ignore Report Quick Reply

I used to write down middleschool (that's what all secondary education is called in the Netherlands - Middelbare School) but I was tired of getting banned for being socalled "underage".

Since Dutch "middleschool" can be 6 years long (if you take the "A only class" courses) , and I had to redo a year once, I was able to legally browse 420chan during the last two years of "middleschool".
Ebenezer Sunderwill - Sun, 21 Feb 2016 13:48:38 EST ID:cKZnkWSj No.77682 Ignore Report Quick Reply
Those Dutch Madrasas can't possibly be any good at teaching science, I thought that all European schools tought was pansy social awareness crap?
Bombastus !lnkYxlAbaw!!7zlcjO/U - Sun, 21 Feb 2016 15:57:33 EST ID:Ko/zFYye No.77683 Ignore Report Quick Reply
Hahaha I huff paint thinner
Phyllis Moblingbodging - Wed, 02 Mar 2016 14:01:20 EST ID:TtNn9wfR No.77702 Ignore Report Quick Reply
Go fucking kill yourself you fucking the future cocksucker.

New, Novel, Potent Opioids by Bombastus !lnkYxlAbaw!!7zlcjO/U - Thu, 04 Feb 2016 17:39:55 EST ID:ElYFdcKO No.77619 Ignore Report Reply Quick Reply
File: 1454625595580.png -(9820B / 9.59KB, 372x408) Thumbnail displayed, click image for full size. 9820
Thants (our br/opi/ in Canada) has recently nodded off W-18, which is a totally novel opioids that hasn't seen street time. So /chem/ might as well talk about it.

The current method of synthesis is outlined in patent no. US4468403
>A mixture of 1-phenylethylpiperdylidene-2-(4-chlorophenyl)sulfonamide (1.17 g, 3.11 mmol) W-15, 90% fuming nitric acid (3.0 ml) and concentrated nitric acid (2.0 ml) were stirred vigorously for 4 hours at 25° C.
Preparation of 1-phenylethylpiperdylidene-2-(4-chlorophenyl)sulfonamide is not outlined, unfortunately. But it's pretty easy to figure it out as it's a straight chained molecule.

So uhh ya. W-18. Talk about it. It's legal everywhere except in Sweden right now. I guess that is a thing. It was discovered by Knaus back in the 80s who was a pretty sick guy who liked opioids. He's had a lot of work doing shit like that. Here's some condensed reading:

W-18 is the 18th item on his patent list: http://www.google.com/patents/US4468403
It includes up to 35 different, unscheduled, and very potent, novel opioids that do not rely on the morphinan group. Check em.
9 posts and 1 images omitted. Click Reply to view.
Fanny Bardham - Wed, 10 Feb 2016 18:20:53 EST ID:DIZp74tV No.77648 Ignore Report Quick Reply
Thanks for the info on pipette tolerances. Someone doing careful weighing and serial dilution might be interested in a microliter syringe also.
Bombastus !lnkYxlAbaw!!7zlcjO/U - Sun, 14 Feb 2016 17:21:18 EST ID:vbS8CtHn No.77660 Ignore Report Quick Reply
Ingested, yes. I would not recommend IVing anything that requires volumetric dosing (serial dilution). From what I hear on /opi/, fentanyl and all their analogues as well as other super potent opioids do not have an appreciable nod.
Their oral BAs are all high enough as they don't have metabolizable groups like the conventional morphinan opioids do.

I mean, if you really want to IV, you could just put the 100ml of final solution into a pressure cooker and sterilize it that way for injection every time. But the reality is that you still should not be injecting any random ass powder off the internet.
Emma Turveyford - Sat, 20 Feb 2016 12:52:53 EST ID:p0QLwGpF No.77669 Ignore Report Quick Reply
Hi bombastus sorry to bother but did your oxycodone synthesis tek work?
Bombastus !lnkYxlAbaw!!7zlcjO/U - Sat, 20 Feb 2016 15:03:46 EST ID:4ppVjZXo No.77672 Ignore Report Quick Reply
a few friends of mine and me got together a few years ago and made something like 5g and split it evenly. That was a sweet adventure.
That binge and subsequent withdrawals made them almost all give up opioids after that. Which tk did you talk about?
Lydia Picklock - Thu, 07 Apr 2016 17:59:34 EST ID:IsDQAl0D No.77814 Ignore Report Quick Reply

okay well i have experience with butyrfent. all i have to say is be prepared to poke yourself full of holes if IVing. the highs are so cracky that they will have you compulsively redosing every few hours, effectively turning you into a pin cushion until you flush the sheet.

And that person was me by Henry Bleshdock - Thu, 18 Feb 2016 20:25:38 EST ID:RC13Ktoh No.77668 Ignore Report Reply Quick Reply
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High school chemistry class, we were working on a lab where we had to make little squares on a piece of plastic to perform tests in, and the squares had to have 2 cm long sides.

This kid at my lab table, who had already proven to be not so bright in class many times beforehand, got our teacher's attention, then asked what a centimeter was.

After the teacher thoroughly explained what a centimeter is, and where exactly to find them on the ruler in front of him, the student turned to us and said:

"I'm still not understanding this centimeter thing."

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