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weed anxiety killer: extra glutamate + NMDA support + a GABAergic drug? by Edward Sodgelare - Mon, 14 Sep 2015 01:02:33 EST ID:zmbaP4Ph No.77163 Ignore Report Reply Quick Reply
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weed suppresses the release of gaba and glutamate, leading to less NMDA function. NMDA antagonists induce a relatively psychotic state, while less gaba directly leads to higher anxiety levels
if you corrected both those issues would your high be better?
many people think benzos often make weed highs much more enjoyable, and benzos potentiate gaba.
3 posts and 1 images omitted. Click Reply to view.
William Draffingfidge - Sun, 20 Sep 2015 12:33:44 EST ID:uGD5aNS6 No.77181 Ignore Report Quick Reply
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William Draffingfidge - Sun, 20 Sep 2015 12:43:29 EST ID:uGD5aNS6 No.77182 Ignore Report Quick Reply
Where is your source for that? I know it will lead to a surpression of GABA, but have not seen anything on glutamate specifically.

It might fix the problem, but I am not sure, but what is somewhat contradictory is that GABAergic activity usually acts in opposition to glutamate, and glutamate works on AMPA and NMDA receptors. So increasing GABA is going to increase glutamate related activity, at least in terms of action potential activation and cell depolarization
Esther Murdlock - Mon, 02 Nov 2015 00:18:43 EST ID:5WJ2hczX No.77348 Ignore Report Quick Reply
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Albert Sidgebanks - Tue, 15 Dec 2015 17:04:21 EST ID:8jmEL2Jc No.77434 Ignore Report Quick Reply
Free Glutamate is excitotoxic I would not eat it...

It is an amino acid, which are the things that make up proteins. The problem with eating pure glutamate is this: The body is designed to break down proteins OVER TIME in the stomach, releasing the amino acids relatively slowly. When you eat free glutamate, the body can't process it correctly in the short amount of time and it will over stimulate the glutamate receptor, killing it.

Whitey Bombleshit - Mon, 21 Dec 2015 05:10:31 EST ID:BF6CJxDN No.77451 Ignore Report Quick Reply
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I've never heard anything about weed blocking glutamate either. Anyways, you're overthinking things. All you need to do is increase gaba. Benzos do this job perfectly. There isn't even any accessible way to activate glutamate or nmda receptors directly anyways. And all the roundabout ways increase anxiety.

You should just experiment with anxiolytic drugs, though. Look at things from your scientific reverse-engineering perspective you'd never think of opiates, but opiates actually help weed anxiety a lot. It's not a sustainable solution, but it is an example of one you wouldn't ordinarily predict.
Consider giving l-theanine, chamomile, and valerian root a try. They can all be effective for anxiety and all raise gaba. The latter two are best brewed into a tea with some sugar, but you can find capsules if you're in a pinch.

Does activated charcoal filter out metamizole sodium? by Albert Fashdock - Fri, 11 Dec 2015 15:23:51 EST ID:Yed83DJN No.77426 Ignore Report Reply Quick Reply
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Hello /chem/ I am doing a CWE of codeine, but the pills I plan to use contain 300 mg of metamizole sodium.

Since I don't know shit about chemistry and google doesn't help much, does anyone here know if activated charcoal filters it out ? Wikipedia makes me think it does: "It is considered fairly safe on overdose, but in these cases supportive measures are usually advised as well as measures to limit absorption (such as activated charcoal)", but I wanna be sure and ask just in case.
Bombastus !lnkYxlAbaw - Sat, 12 Dec 2015 16:03:15 EST ID:4ppVjZXo No.77427 Ignore Report Quick Reply
Why are you using activated charcoal to filter out caffeine in the first place? With my minor knowledge of spectroscopy, I would guess that a decent amount of codeine would be filtered out with the caffeine. They're mainly light-refracting aromatics (especially large ones) that are filtered by charcoal. Morphinan containing compounds (all semi and full opiates) fall within this group

To answer your question, yes metamizole sodium can be filtered through charcoal but how much is a different story.
Edward Caddlekadge - Sun, 13 Dec 2015 09:00:18 EST ID:Yed83DJN No.77429 Ignore Report Quick Reply
Yeah I understand that some of the product is lost in the filtration, but it can't be helped because this is the easier and most reliable way to remove the caffeine.

Appreciate your answer, it made me think maybe I should stick to the more expensive brand just in case.

Burning a dilute tincture? by Cyril Niggerbury - Sun, 13 Dec 2015 01:33:45 EST ID:WSkWKGa2 No.77428 Ignore Report Reply Quick Reply
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What would happen if one were to dilute an ethanol tincture in water to something like 10% ABV, then ignite it? Would the other constituents of the tincture burn up as well? Would all the alcohol burn out or only some of it?
press !QUHukXEvkY - Wed, 16 Dec 2015 04:36:12 EST ID:/fO8PDhH No.77438 Ignore Report Quick Reply
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It wont burn at all. Aquaeous ethanol solutions are flammable at about fifty percent. Throughout history water has been used to quench fires.

What might happen is the ethanol will evaporate faster than the water, with vapour that is mostly ethanol. That way you could indeed drive out most of the ethanol. Its called destillation

But in order to judge practicality, you should supply more informations on this tincture

Processing Nutmeg by John Billingforth - Mon, 23 Nov 2015 19:58:51 EST ID:IC4NS5Rj No.77385 Ignore Report Reply Quick Reply
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So, I found out recently that nutmeg is a far more interesting plant than I knew it was before. It contains elmincin, d-pinene, limonene, d-borneol, l-terpineol, geraniol, safrol, and myristicin.

Some of these are well known precursors to mmda, mdma I think, and even mescalin.

Is there any simple manner to process these into something a little better, that would require relatively minimal knowledge of chemistry and minimal equipment, or would I be better off calling it good enough and just extract the better components and scrap the sludge?
5 posts omitted. Click Reply to view.
press !QUHukXEvkY - Fri, 04 Dec 2015 07:05:25 EST ID:p3AW4bFv No.77404 Ignore Report Quick Reply
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should be the easiest route since the starting material is dirt cheap and in essence you only have to alter a single functional group.

all the necessary reactions are covered in OC 1, so any undergrad or interested amateur should be able to come up with a synthesis sheme

but id guess itd take around 4 steps to get to MDA.
eventhough the last step seems very straightforward, prepping the acid chloride would be a pain in the ass unless one had access to proper chlorinating/brominating agents. roducing those yourself would make the whole thing a lot more difficult.

perhaps oxidizing the aldehyde could be skipped, but i havent found a way to go straight to the chloride

so, if your raw material contains 1% of the desired compound youd theoretically need a kilo to yield 10g. but that wont happen since the raw material contains a multitude of similar chemicals.

and even after that youd have to factor in the losses at ever synthesis step unless youd manage to get quantitative yields for every reaction.
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press !QUHukXEvkY - Mon, 07 Dec 2015 09:56:14 EST ID:p3AW4bFv No.77413 Ignore Report Quick Reply
fuck me, thats elegant!
thatd offer two routes both with only two steps

ive never done that reaction but ive worked with sodium azide before, to prep some azides via SN2, and it isnt that hard to handle properly if you have lab experience
looking back i shouldve been intimidated by that 2kg container.

but im guessing that the reaction itself might be quite hazardous and producing sodium azide by yourself is an effort unlikely to be fruitful

but one can dream
Walter Hellyshit - Mon, 07 Dec 2015 11:52:40 EST ID:cM6rhCgJ No.77414 Ignore Report Quick Reply

Well, I mean, if you're really interested, you could pry out old airbags and collect the capsules. You just have to make sure the battery is disconnected and that you don't accidentally rupture the container or jar it too much.

I'm interested in hearing your experiences in working with it though, I just assumed the reaction would be too dangerous to attempt for me, but I work with dangerous chemical regularly, I just don't regularly run synth like your organic chemmies.
Schepperschop - Fri, 11 Dec 2015 12:25:47 EST ID:SfzslPvZ No.77424 Ignore Report Quick Reply
I used to extract the oil from mace with acetone, then put the oil in a vaporiser and it tasted pretty good and I was able to get high from it.
When I extracted oil from 100 grams of mace, the oil at the bottom was to thick to pour into my vaporiser and I put it into two 500mg capsules and got pretty fucking high from that.
Schepperschop - Fri, 11 Dec 2015 15:03:43 EST ID:SfzslPvZ No.77425 Ignore Report Quick Reply
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LSA Extraction by Walter Gollernog - Tue, 25 Nov 2014 21:11:02 EST ID:Gz/SgZBZ No.75793 Ignore Report Reply Quick Reply
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I'm looking at Kash's LSA Extraction Tek.
I'm wondering a few things, if anyone could shed some light I'd really appreciate it. Could the acetone used for the initial crude extraction be effectively substituted with %99 isopropyl alcohol? Other LSA teks instruct users to defat before creating a polar solution. Will separating fats with impure naptha after creating aqueous LSA citrate result in less impurities than soaking plant matter in impure naptha then filtering it and leaving it to dry? Are impurities left by very small amounts of naptha and toluene a danger? Are laboratory grade solvents necessary?
10 posts and 2 images omitted. Click Reply to view.
Lillian Creffinghood - Tue, 06 Oct 2015 19:13:54 EST ID:dHbWUW5F No.77248 Ignore Report Quick Reply
My never fail tek is to pick green pods, heavenly blues, the big ones, fill up a quart mason jar, chop them up with a chef's knife, put them back in the jar, fill it with acetone or xylene, shake it up for like 5 minuites, filter it out into a pyrex dish with a fan blowing over it, put a few dropper fulls of hcl in there so it crystalizes rather than goos up, let it dry up, scrape it, weigh it, dilute 100mg to 5ml in a dropper vial, 1000ug hits.
Caroline Granddale - Sat, 05 Dec 2015 15:48:25 EST ID:KuwX3RE6 No.77410 Ignore Report Quick Reply
Does this comletely eliminate the nausea because that is what I'm looking for.
A Wizard - Wed, 09 Dec 2015 16:43:21 EST ID:CDuFdKf+ No.77418 Ignore Report Quick Reply

No... LSA it's self seems to cause nausea in most people, so it can't be completely eliminated. It'll help a lot though.
Hannah Dicklebury - Thu, 10 Dec 2015 20:52:52 EST ID:0LQJvC/t No.77420 Ignore Report Quick Reply
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Check your solvents by drying them on a clean plate. If they leave residue then that is bad, if it dries clear that means there is nothing left behind.

Lab grade solvents are not necessary, most solvents if they have anything in it will be water. Solvents from the hardware store are okay. Test it on a plate. Acetone is good because it evaporates quickly. Whether or not alcohol will work depends on the specific polarity and pKa of the LSA in your solution.
LSD is supposed to be 3.04 D with a pKa of 7.8.

I think this means you want it below pH 8, hence the acid and the best solvent would be acetone, unless you have cyclohexanone. It will be slightly different for LSA but considering there are not really better solvents available in this range its kind of not important.

Alcohol might work in general, but not for the conditions in this tek.

>Will separating fats with impure naptha after creating aqueous LSA citrate result in less impurities than soaking plant matter in impure naptha then filtering it and leaving it to dry?
you would have to base it first or the LSA would stay in the water
Hannah Dicklebury - Thu, 10 Dec 2015 20:54:59 EST ID:0LQJvC/t No.77421 Ignore Report Quick Reply
does anyone know if solid LSA flashes in the dark like LSD?
>A totally pure salt, when dry and when shaken in the dark, will emit small flashes of white light.

Evolution by Matilda Gaddlenat - Mon, 30 Nov 2015 21:38:30 EST ID:tw7MXaV8 No.77389 Ignore Report Reply Quick Reply
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Can someone post a good talk or lecture that goes into extreme detail concerning the evolution of homo sapiens and our common ancestor with other primates?
Vehk !7HYGxe5v5c - Mon, 07 Dec 2015 03:01:48 EST ID:ILVV3idO No.77412 Ignore Report Quick Reply

Campbell covers it well on an undergraduate basis and it's easy to find a torrent of it online. You're not going to get "extreme deal" from a TED talk or whatever.
Shitting Trotwill - Mon, 07 Dec 2015 14:31:50 EST ID:tw7MXaV8 No.77415 Ignore Report Quick Reply
yea i don't want a TED talk, i'm looking for like a 2 hour talk on youtube or something. i found a ton on electromagnetism, hydrologic modeling, etc. was wondering i there was some for evolution from a workshop or classroom or what not.

Amphetamine by Reuben Dattingfield - Fri, 04 Dec 2015 21:34:09 EST ID:UHrzapmo No.77406 Ignore Report Reply Quick Reply
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Im writing a paper about amphetamine synthesis for my Organic chemistry class and there is one thing i am a unsure of. The method i am focusing on is the Leuckart reaction and in the final step shown here acid is added to the N-formylamphetamine intermediate. Is the final product amphetamine freebase or a salt? It shows it as a freebase here, but a lot of amphetamine cooking guides only add acid once at the end and claim a salt is formed. Does the step of adding acid to N-formylamphetamine remove the ketone group AND acidify the amphetamine freebase into a salt? Now that i think about it, ive seen some methods that say to add NaOH after adding HCl and then extract amphetamine with a non polar solvent. Does adding NaOH only serve to neutralize the solution or does it also make amphetamine salt into freebase so it can be extracted?

any help would be appreciated.
Reuben Dattingfield - Fri, 04 Dec 2015 22:44:24 EST ID:UHrzapmo No.77409 Ignore Report Quick Reply

okay i sort of figured that if you add enough acid that the freebase in solution would protonate. So chemical reactions drawn out show the ideal situation but not waht really happens in a lab. Thanks for your input that cleared things up quite a bit.

"I WANT TO STOP THE EARTH FROM SPINNING" reply by Albert Saggletitch - Thu, 03 Dec 2015 14:38:43 EST ID:dejxZIET No.77399 Ignore Report Reply Quick Reply
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if you want to collapse the core your gonna need some VERY STRONG magnets, drills, charges (controlled as fuck as the crust isnt purely solid it has fractures & holes & allsorts which kill miners e.c.t).

First, well need to friends up or kill & impersonate someone "high up", with funds we can become a private interest in the many 'space programmes'. With the severe lack of funding NASA are recieving, they are playing ball to a lot more private interests & with their brains & techonology the charges could easily be places in the least dangerous palces meaning you dont die & can continue your mission).

To bore holes we will have to become frackers, we may need to relocate. The best places would either be the oil fields in asia as that has less crust & population to traverse or the American lands which are heavily fractured & drilled. If we impersonate or friends up the right people we will have access to underground networks, which go deeper than people think & are surprisingly stable. But once we have the licences for that, we will need similar minds to employ who hate things enough not to grass us up for depleting the polarity of the earth & reduction on key natural phases & fields.

With the resources we now currently own, not only do we not have to bury down ourselves, we can send people who hate things more than us & dgaf more than us. Reward their families amply if they get fucked up. That & we have a secure network of illegal activities intent on felling the clouds & allowing our precious shields to wander off into the vacuums of space.

Now you finally have the means to affect the polarity of the earth, you will need to connect the global power network, which there isnt yet. You would have to make one, but with our resources so far this will only take half a life time or so. Dw if you die or me there are plenty of other cunts we can trust. Now with the power, we can safely construct magnets at the entrance to the large bore holes & lower them near the crust before activating. Cables would need to be adamantium alloy as that stands up to even super heroes according to tv & comics so its pretty tough shit.

Now all which remains is for our calculation wizzes to be correct, the hardware not to fault (well have to employ asians & pay them well as were lazy & require cyanide). You now have, as I currently see it, 3 choices... which will be more effective I have not enough time to consider, like ever in my life.... You I recommend you take a shot & flip a coin, yelling fuck yeah.

A: Start both magnets at the same time in the hope this freezes the movement of molten materials & any magnetic materials will hopefully travel to the magnets, disrupting the orbital flow of the plasma & other materials. This could do nothing & just fuck every electronic ever up & stick us all to the ground via our belt buckles/tear things out of people bodies who have pins or heart tickers e.c.t

B:Slowly start one magnet, so that instead of it just doing nothing but making the world uber magnetic, more... It will slowly start to split the contents of the plasma & magma. Making smooth transition in the orbital flow near impossible. One its up to enough power to start physically vibrating, slanting, fucking the earth. Start the opposite magnet up quick, which I must mention has to be made of a poly material or something stronger, so it dosent get broken by the first magnetic pulls. When the 2nd magnet gets stronger, it will effectively be holding the different magnetic & non magnetic elements of the core at either side, without motion except motion similar to that seen in a centrifuge where the contents of the bottle are forced to the side & the pressure helps mix the bottle.
Comment too long. Click here to view the full text.

Desomorphine by Angus Wuckleshaw - Fri, 27 Nov 2015 01:38:29 EST ID:l6B6MIOX No.77387 Ignore Report Reply Quick Reply
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How to reduce codeine to desomorphine and purify?
just red phosphorus, is a solvent involved?
do you need pure codeine powder or is aqueous ok?
press !QUHukXEvkY - Tue, 01 Dec 2015 15:49:18 EST ID:Izj+Mobm No.77392 Ignore Report Quick Reply
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do your own fucking homework.
start with english lessons.
then move on to basic chemistry.

this is a harm reduction site, not an spoon feeding site
spiffytits - Tue, 01 Dec 2015 21:40:20 EST ID:7ZYIcuWv No.77396 Ignore Report Quick Reply
dont even consider that route desomorphine can be made with codeine and thionyl chloride then oxidized and demethlylation. if you dont know what those are you are not even close to prepared i was in your shoes once to but its importent to understand whats going on in chemistry before you attempt and you dont want deso from rp/i its very toxic and impure and with anything yes pure as possible

Processed Meats = Cancer says WHO by Lydia Clibberchid - Mon, 26 Oct 2015 20:21:41 EST ID:RLSN+6eM No.77327 Ignore Report Reply Quick Reply
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Bacon, ham and sausages rank alongside cigarettes as a major cause of cancer, the World Health Organisation has said, placing cured and processed meats in the same category as asbestos, alcohol, arsenic and tobacco.
Eating red meat is also linked to pancreatic and prostate cancer, the IARC says.

It is certainly very inappropriate to suggest that any adverse effect of bacon and sausages on the risk of bowel cancer is comparable to the dangers of tobacco smoke.

So I'm not supposed to eat carbs or gluten, then I can't eat dairy, and now I can't eat meat! Just fish and lettuce for me! FUCK
16 posts omitted. Click Reply to view.
lil' amazing !!vVWR8L52 - Wed, 18 Nov 2015 15:43:13 EST ID:VPQjlo+g No.77377 Ignore Report Quick Reply
lol you guys, it's not about longevity, it's about feeling awesome. Plus feeling awesome and eating tasty as fuck food is not mutually exclusive. Hell you guys don't even know what delicious food is, since it takes health and vitality to be able to taste that shit. Well and some acid. But seriously fast for a few days and taste some fresh RIPE fruit or berry grown in high quality soil and you will realize that you are tasting food for the first time.
Jack Brookridge - Sat, 21 Nov 2015 21:10:03 EST ID:IC4NS5Rj No.77382 Ignore Report Quick Reply

... You could tell them to eat raw flour and it would be delicious, if you starve yourself long enough.
Priscilla Croddleforth - Sun, 22 Nov 2015 14:43:02 EST ID:LcOfVsLV No.77383 Ignore Report Quick Reply
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>Hell you guys don't even know what delicious food is
Tripfags were a mistake
Doris Broffinghure - Fri, 27 Nov 2015 20:38:18 EST ID:B4+8HPFe No.77388 Ignore Report Quick Reply

This is what's up, healthy food is delicious once you start eating it. You gain an appreciation for the awesome nutritional profile and it starts to give you taste bud orgasms. For serious
CrazyFolksTribe !owU3wSU682 - Tue, 01 Dec 2015 03:20:19 EST ID:y04n9ZOx No.77390 Ignore Report Quick Reply
Herring tastes great no matter how much mercury's in it.

sniffin chems for science by Fuck Gemmlewell - Sun, 15 Nov 2015 15:43:47 EST ID:xTJQV3vy No.77368 Ignore Report Reply Quick Reply
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>It is described as having a slightly sweet smell, although inhaling enough vapor to detect its odor would be hazardous.

Then how does anyone know what it smells like? Was somebody's last words "Hey that smells slightly sweet!" and a guy within earshot had his gas mask on?
Bombastus !lnkYxlAbaw - Sun, 15 Nov 2015 18:39:36 EST ID:ElYFdcKO No.77369 Ignore Report Quick Reply
>The toxicity of dimethylmercury was highlighted with the death of the inorganic chemist Karen Wetterhahn of Dartmouth College in 1997. After spilling no more than a few drops of this compound on her latex-glove, the barrier was immediately compromised and within seconds it was absorbed into the back of her hand, quickly circulating and resulting in her death ten months later.
We were all taught this in undergrad and all our supervisors told us that all organo-mercuric research stopped and were disposed of after her death. It was actually applied worldwide so that the compounds (which were thought safe at the time) can be further studied and everything.
Smells are, more often than not, easier to detect because of lax rules or non-attention to them. It's really not that hard to accidentally catch a waft of a toxic compound, especially if you remove it from the fume hood or un-link a Schlenk flask too quickly.

Wilhelm Scheele was very well known to smell and taste everything he made.
Vehk !7HYGxe5v5c - Thu, 19 Nov 2015 13:26:19 EST ID:a+AOCmE5 No.77380 Ignore Report Quick Reply
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It should be noted that this didn't end well for Scheele.

Cyclamate, the artificial sweetener which paved the way for aspartame, was discovered in 1937 when a chemist in Illinois University was synthesizing anti-fever meds and cyclamate was an intermediary. He was smoking a cigarette in the lab, and put it down on the table while he went to do something. While he was gone, cyclamate that had spilled soaked into the cigarette, when he returned, picked it up and relit it, he discovered that the cigarette now tasted sweet and this is how the property was discovered.

Personally I think it's a damn disgrace that you can't smoke in the lab anymore. Smoking while you work is great, and you'd be a fool to do in the presence of flammable gases or volatile chemicals anyway. As long as it's done in a well-ventilated area and away from the aforementioned compounds I don't see why it shouldn't be allowed, and cyclamate never would have been discovered if it wasn't for the noble institution of the in-lab smoking lost to us during the 60's and 70's.

Robert Woodward was probably one of the greatest organic chemists of all time and codified the discipline of total synthesis - he chainsmoked in the laboratory throughout his entire career without ever suffering adverse consequences.

ling by Polly Puddletack - Sat, 17 Oct 2015 23:13:52 EST ID:i+LQ7VHe No.77305 Ignore Report Reply Quick Reply
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Any recommended books on the biology/neurology behind linguistics? Any books on the relationship between language ability and cognitive ability?
Shitting Grimville - Sun, 18 Oct 2015 13:15:04 EST ID:uGD5aNS6 No.77307 Ignore Report Quick Reply
I recommend this book all the time on here. Oliver Sack's "The Man Who mistook his Wife for a Hat."

It is not language specific but there are quite a few parts about language in it. Neurology based book that covers brain function through studying what happens to a person that loses certain parts of the brain.

I remember one part about language talks about 2 areas of the brain, the Broca's area and the Wernicke's area. The book talks about patients who suffer strokes and lose either of these parts of the brain, and how language for them is totally messed up in different ways. It is pretty interesting.
Emma Murdwater - Wed, 18 Nov 2015 06:56:34 EST ID:WAEp68FT No.77375 Ignore Report Quick Reply
Cognitive Psychology: A Student's Handbook

Great textbook, should be available online in the usual places.

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