420chan now has a web-based IRC client available, right here
Leave these fields empty (spam trap):
You can leave this blank to post anonymously, or you can create a Tripcode by using the float Name#Password
A subject is required when posting a new thread
[*]Italic Text[/*]
[**]Bold Text[/**]
[~]Taimapedia Article[/~]
[%]Spoiler Text[/%]
>Highlight/Quote Text
[pre]Preformatted & Monospace text[/pre]
1. Numbered lists become ordered lists
* Bulleted lists become unordered lists


Community Updates

420chan now supports HTTPS! If you find any issues, you may report them in this thread
some chem thoughs by Ernest Fuckinghood - Mon, 17 Aug 2015 16:16:55 EST ID:otaEm3qe No.76928 Ignore Report Reply Quick Reply
File: 1439842615426.jpg -(34513B / 33.70KB, 488x650) Thumbnail displayed, click image for full size. 34513
I just want to say thanks to all fags who post here, great discution and *not so much* shitpost

also, what's your background? obviously no names or personal data

>20 years old
>studying chemist as professional career
>most of my knowledge (70%) has been adquired on personal instruction + experience not related to uni + disscutions + little jobs on small labs
>wondering if uni is useful at all

also I think Bombastus is the man, mah nigga
Sidney Minnerdale - Mon, 17 Aug 2015 20:34:34 EST ID:DIZp74tV No.76929 Ignore Report Quick Reply
I'm a professional chemist with a M.Sc. focused in bioorganic chemistry. Now days I work in industry doing analytical method development for GC, LC, MS. University is indeed essential to being a chemist, especially now that there is a significant oversupply in the job market.

Realistically you would have a tough time landing even a very basic lab tech job without a B.Sc. Your prior knowledge will help you a lot in college and university but you definitely need to get the degree for anyone to take you seriously. It's also important to set yourself apart from the other cookie cutter chemists, do some research with a faculty member, keep a flawless GPA, publish a paper, do an internship. That sort of stuff will help you get a good position when the time comes to interview.
Basil Gackleket - Tue, 18 Aug 2015 13:38:32 EST ID:ee2izQdB No.76930 Ignore Report Quick Reply
Are you from easter Europe or Asia where they don't teach you english in school?
Clara Derrytadge - Wed, 19 Aug 2015 23:00:41 EST ID:A9FsJSdZ No.76935 Ignore Report Quick Reply
I'm a professional chemist with a BS in biochemistry. Accidentally stumbled into the construction coatings industry and now I'm their primary curing compounds research and production chemist/developer.

I found university essential to my success; the theory, the basic theory (and lets be honest, the basics is all you learn), helped me to interprate observations I make in the lab. Without the fundamental knowledge you learn in college, I would never have been able to do what I do now.

And, well, to be honest, I never thought I could know as much as I know now. On the job learning is fucking ludicrous if you manage to put yourself in a position where you do your own personal research on the materials. I learn something new every day. And I guess that's the way I like it.
Bombastus !!HToBa9dh - Fri, 21 Aug 2015 16:06:16 EST ID:4ppVjZXo No.76957 Ignore Report Quick Reply
lol. university is great if you make it great. remember that all the part time opportunites are being paid for by your education tuition. so make the most out of university by attending them.
i'm balancing a few jobs. 2 of them chemistry related one of them not. still doing a few post-grad classes while i get a bit more financially independent to continue with a full thesis afterwards. honestly, any job will teach you more about useful chemistry than the classes/shitty labs ever will.
but it's what you put into it that determines what you get out of it

I love you ernestest fuckinghood

Whooooo Aaaaam Iiiiiiii!??? by Doris Bivingstock - Sun, 26 Jul 2015 10:57:35 EST ID:Zi8GiUIa No.76847 Ignore Report Reply Quick Reply
File: 1437922655912.jpg -(48593B / 47.45KB, 435x571) Thumbnail displayed, click image for full size. 48593
Let me put it to you like this:

There's a student who wants to do science for a living and work in a lab. He loooves to make things that are super pure and super refined. He likes measuring things, but he's not too good at math. He dreams of pulling something out of the ground and throwing it in a glass beaker and starting from there and making super pure this or super pure that. And doing that for a living and getting paid for this sort of all-around fieldwork/labwork kind of job.

What kind of job am I most closely describing, because that's what I want to do and I want to purify stuff, mostly for edible or medical purposes. I have a BS in plant biology with research lab experience.
1 posts omitted. Click Reply to view.
Betsy Monningtidge - Mon, 27 Jul 2015 16:21:06 EST ID:FdXENsN6 No.76852 Ignore Report Quick Reply
Yeah, no shit it's failed me, my schools sucked growing up.
I mean it makes sense that chemistry is the closest option, I guess, but I'm really wondering if I've described a profession that is either phased out of popularity, or hasn't really been expressly defined before. Because, note, the outdoor collection of materials is equally important as the in-lab purification of substances from said outdoor-gathered items. It feels like I'm describing a job that really requires 2 people, one for outdoor collection, and one for lab purification, but I would like to do both because I enjoy the variety so much. I doubt any company or establishment otherwise would find such a proposition efficacious though.
I also think that any such company would already be producing enough of the chemicals I would be producing at a high enough purity and quantity, that I would be muscled out immediately. Maybe I could cater to the "buy local, organic, etc." folks.
Nell Firrynock - Fri, 07 Aug 2015 10:40:29 EST ID:suDCfAlN No.76883 Ignore Report Quick Reply
Maybe I just have a criminal type of mentality but what you were describing perfectly described being a chemist that makes DMT. Well up until you said "for edible or medical purposes."
If you have scarface like aspirations, I believe that's what you're describing. If not, Basil is right.
NB because you probably don't want to be a DMT chemist and end up like Walter White.
Lillian Fublingbere - Fri, 07 Aug 2015 15:26:45 EST ID:FdXENsN6 No.76889 Ignore Report Quick Reply
Yeah, I thought of that when I realized the large companies already have synthesis and manufacture of edible/medicinal chemicals cornered, on the industrial scale no less. So the only way of competing is by producing something that they can't. I may find myself making concentrates and other derivative products in Colorado, or somewhere else that's legalized it, considering I'm a plant biologist.
Nell Firrynock - Fri, 07 Aug 2015 15:39:36 EST ID:suDCfAlN No.76890 Ignore Report Quick Reply
Good idea. You can make hash with top tier chemist equipment or make thc soda or all kinds of other cool things.
Samuel Fuckingfuck - Fri, 14 Aug 2015 06:51:09 EST ID:lqfCRKYj No.76915 Ignore Report Quick Reply

Wait... we can ask those types of questions here?

GHB baking soda synthesis by Albert Babblewill - Fri, 07 Aug 2015 12:16:21 EST ID:XZNJKx79 No.76885 Ignore Report Reply Quick Reply
File: 1438964181620.jpg -(7734B / 7.55KB, 268x172) Thumbnail displayed, click image for full size. 7734
I want to attempt a synthesis of GHB from GBL and sodium bicarbonate. I've researched most information, but can someone tell me how to assess what % of GHB would be in the resulting solution?
2 posts omitted. Click Reply to view.
Martha Dummerson - Tue, 11 Aug 2015 14:10:24 EST ID:XFNn4tRj No.76894 Ignore Report Quick Reply
Don't confuse galvanized and stainless. Zinc plated (galvanized) steel is not used for cookware.

Stainless steel is an alloy containing chromium, which oxidizes when exposed to the surface of the material.
Bombastus !!HToBa9dh - Tue, 11 Aug 2015 16:58:07 EST ID:vbS8CtHn No.76895 Ignore Report Quick Reply
why don't you just pick up some mason jars for a buck a jar?
Polly Heblingman - Thu, 13 Aug 2015 16:02:49 EST ID:OsYa8mFp No.76905 Ignore Report Quick Reply
There's nothing fancy about pH assessment, just use litmus paper if it's not extremely sensitive to pH.

Also any glass will do if you don't require very high temperatures.
George Sassledock - Fri, 14 Aug 2015 00:32:55 EST ID:fnShIRQ8 No.76911 Ignore Report Quick Reply
This. Also hydroponic stores have liquid drops that are pretty good at gauging PH.
press - Sun, 16 Aug 2015 16:22:46 EST ID:SI8UHxC0 No.76927 Ignore Report Quick Reply
never tried anything but sodium hydroxide, but if you do not have access to that, you would be well advised to turn your bicarbonate into carbonate since its a stronger base (and it wont dilute your final solution as much, but thats marginal anyways)

theres videos covering that on youtube, you basically heat the bicarbonate to let it combust to carbonate, carbon dioxide and water. the latter two will be drien out as gasses.

dont use any steelpot, take some pride in your work, mason jars should be fine.
and i wouldnt advise you to use a wooden rod but its unlikely to affect your product at all.

pH check is used to monitor the reaction as the lactone is acidic. so as soon as you hit alkaline you can be sure the hydrolysis is complete, but also be sure that youre left with a clear solution. not an emulsion of ghb in water.
look for any pH indicator you could use.
if the reaction mixture still is acidic and ou see bubbles of oil inside it, let the reaction proceed, if that doesnt help over time add a bit more carbonate solution.
be sure to let patience govern your work otherwise you might have to dilute the mix later on or add more GBL which will use even more of your time.

in order to calculate the percentage of your solution youll have to calculate the mass of GHB (or sodium 4-hydroxybutryoat) youd get from your mass of GBL and divide by all the sum of the mass of all reagents (carbonate, water, GBL, spit). im pretty positve you should know what a mole is, if not learn a bit of chemistry, it cant hurt.

be advised the the resulting liquid will be viscous as oil and smelly. i like the smell of the sodium salt, havent produced the potassium salt yet, since sodium might be the healthiest salt. UNLESS YOU TEND TO GET CRAMPS R HAVE MAGNESIUM DEFFECIENCY THEN GO FOR MG(OH)2 which isnt as hygroskopic anyways
Comment too long. Click here to view the full text.

Phosphoryl chloride by Doris Sunnersirk - Tue, 28 Jul 2015 13:47:35 EST ID:ykDmWZpt No.76855 Ignore Report Reply Quick Reply
File: 1438105655416.png -(12761B / 12.46KB, 453x169) Thumbnail displayed, click image for full size. 12761
Hello, /chem/!

I was wondering, since it's not easy for me to come by, what's the easiest procedure to prepare phosphoryl chloride (or thionyl chloride, although I think it's harder to prepare it than the POCl3).
I think that the phosphorus pentoxide (P2O5) with NaCl route might be the way to go, since I can get P2O5 with relative ease and table salt is table salt. Does anyone have any experience/insight on this procedure? What are the particularities of this reaction? Maybe someone have prepared POCl3 through another route?
What about SOCl2, anyone know a simple procedure to prepare it? Maybe employing chlorine gas (CL2) and sulphur dioxide (SO2) generators to mix those two gases in a third flask (the reactor/reaction vessel)? Would this work at atmospheric pressure?

What I'm willing to do is to convert a carboxylic acid in it's correspondent dialkyl amide. If anyone has a better idea of a catalyst for that reaction than POCl3 or SOCl2 I would love to hear it! Maybe convert the acid to an acyl azide?

Well, guess my real questions are:
>I want to convert a carboxylic acid in it's correspondent amide, what catalyst would you recomend for this reaction?
>If your recomendation is POCl3 or SOCl2, what procedure would you suggest for the preparation of those?

Any ideas are appreciated.
Thanks very much!
2 posts omitted. Click Reply to view.
Charles Turveyford - Wed, 29 Jul 2015 16:27:05 EST ID:ykDmWZpt No.76859 Ignore Report Quick Reply
I was thinking about other catalysts for the amination of acids leading to amides:





What do y'all think of this!?
Lydia Wobbersick - Wed, 29 Jul 2015 22:04:17 EST ID:ykDmWZpt No.76860 Ignore Report Quick Reply
1438221857843.png -(76261B / 74.47KB, 640x355) Thumbnail displayed, click image for full size.
I'm starting to think that producing POCl3 from P2O4 and NaCl is harder than producing lsd itself:

So my question now is: Can propylphosphonic anhydride (pic related) be used in place of POCl3 to prepare LSD from d-lysergic acid and diethylamine? >Specifically on the following procedure, can one substitute the POCl3 with propylphosphonic anhydride:

Another thing, what about using carbonyl imidazole as a catalyst?

And lastly an article relating to already mentioned Tris(2,2,2-trifluoroethyl) borate:

And another interesting possible catalyst, N,N'-Dicyclohexylcarbodiimide:
Comment too long. Click here to view the full text.
Lydia Wobbersick - Wed, 29 Jul 2015 22:39:24 EST ID:ykDmWZpt No.76861 Ignore Report Quick Reply
1438223964843.png -(70659B / 69.00KB, 640x370) Thumbnail displayed, click image for full size.
Now I'm in doubt between this one I just found:
Using this: https://en.wikipedia.org/wiki/Diphenylphosphoryl_azide (Diphenylphosphoryl azide, DPPA)
This one:
Using pic related (Carbonyldiimidazole, CDI): https://en.wikipedia.org/wiki/Carbonyldiimidazole
Or one of the many contained in this very informative article:
Using either:
2-(1H-benzo-triazol-1-yl)-1,1,3,3-tetramethyluronium Hexafluorophosphate (HBTU; https://en.wikipedia.org/wiki/HBTU) or N-Hydroxysuccinimide (HOSu; https://en.wikipedia.org/wiki/N-Hydroxysuccinimide), or Benzotriazolyl N-oxytrisdimethylaminophosphonium hexafluorophosphate (BOP; https://en.wikipedia.org/wiki/BOP_reagent) or Diclohexylcarbodiimide (DCC; https://en.wikipedia.org/wiki/N,N%27-Dicyclohexylcarbodiimide)

>Ok, now my real question is: which one of the following catalysts is the best for the amidation of d-lysergic acid with diethylamine; HBTU, HOSu, BOP, DCC, CDI or DPPA?

P.S.: You may forget about the last questions.
Lydia Wobbersick - Wed, 29 Jul 2015 22:56:18 EST ID:ykDmWZpt No.76862 Ignore Report Quick Reply
1438224978843.png -(101940B / 99.55KB, 524x480) Thumbnail displayed, click image for full size.
Well, looking at the article I posted (https://drugs-forum.com/chemistry/chemistry/lsd.coupling.agents.html) I'd be in doubt between using HBTU/HATU or BOP, because of their yields, but because of the price (of the catalysts), I'd choose the BOP-reagent (pic related).
>Do y'all /chem/ folks think it is a good idea to use BOP to produce LSD?
Bombastus !!HToBa9dh - Tue, 11 Aug 2015 17:16:48 EST ID:vbS8CtHn No.76896 Ignore Report Quick Reply
For your original question, that's very odd. POCl and SOCl are very basic reagents. It'd be more of an engineering question to know how to synthesise them since I've never personally done it or seen it done.

Organo-phosphates to produce LSD. That's interesting but also over-complex as fuck. If you're going to do something like that, you should either simplify it by the classic Shulgin route or go the full mile and draw influence from the Sonogashira cross coupling. That would be an interesting method to synthesise LSD from the organophosphate you proposed.

Chemistry for retards by Doris Bablingstone - Thu, 06 Aug 2015 20:52:30 EST ID:NkniuLXa No.76880 Ignore Report Reply Quick Reply
File: 1438908750770.png -(517553B / 505.42KB, 500x679) Thumbnail displayed, click image for full size. 517553
What are some good introduction's to chemistry, I don't even know the periodic table of elements so what I need is babby chemistry.

I do have General Chemistry by Linus Pauling but its pretty over my head.
Nell Firrynock - Fri, 07 Aug 2015 08:55:42 EST ID:suDCfAlN No.76881 Ignore Report Quick Reply
Here's a free MIT introductory chemistry course.
You have all the lecture notes available, the only thing unavailable is the actual reading, which you can substitute by just reading more on what they cover in the notes on wikipedia or something.
You can pick and choose which topics you want to learn about as well.
You can also look into other free courses.

420 Science by George Brevingketch - Wed, 24 Jun 2015 11:33:35 EST ID:YKD73kVj No.76721 Ignore Report Reply Quick Reply
File: 1435160015743.png -(2764B / 2.70KB, 189x148) Thumbnail displayed, click image for full size. 2764
Hey Guise. Started researching the possibility of analyze the redness of the eyes to determine the levels of "high".
Ended up making this android app: https://play.google.com/store/apps/details?id=com.dowrow.high_o_meter_free
9 posts and 1 images omitted. Click Reply to view.
Bombastus !!HToBa9dh - Wed, 15 Jul 2015 17:13:25 EST ID:vbS8CtHn No.76811 Ignore Report Quick Reply
No one I know will even touch their eye to anything to gauge how high they are.
No offence, OP, but you're incredibly out of touch with your costumer base. Holy bejebuz, mate.

Alice Clayridge - Wed, 15 Jul 2015 18:51:41 EST ID:cM6rhCgJ No.76812 Ignore Report Quick Reply

I think you're out of touch with what the market wants.

It's just a minor incision, you press the needle or blade into the eye and collect a blood sample. SIMPLE! Even a lazy stoner couldn't fuck it up. And then they know how high they are.

I was thinking of making a stoner scale. Like snoop dog heads. Half a snoop dog means you're buzzin. Five snoop dogs means the rooms spinning.

You'll have to make them disposable though so they aren't sharing needles with their friends tho.
Bombastus !!HToBa9dh - Wed, 15 Jul 2015 19:53:03 EST ID:vbS8CtHn No.76814 Ignore Report Quick Reply
Propose it on /weed/, then. See what they say. Maybe O'm wrong.

I don't know about you, but nothing touches my eye except my forearms and some water. And I know I'm not the only one who feels like this.
Basil Pindermat - Fri, 31 Jul 2015 07:30:50 EST ID:cBr2UiWk No.76866 Ignore Report Quick Reply
Wouldnt this be impossible to use this as a scale? For myself, I cant recognize the redness always having much to do with how high I am. It depends on so many things, and also sometimes when you dont have red eyes, you look in the mirror and you do!

Things like are you already tired but trying to keep awake? That puts strain on the eye. Theres too much light where you are at to your high eyes. Sometimes I get red eyes just going outside with barely any wind. Id say the giveaway factor to it is the fogginess of the eyes.

Maybe find out what exactly gives you red eyes, in depth. Because most of the time you dont get red eyes.
3am !/sly9iFJgg - Tue, 04 Aug 2015 09:38:55 EST ID:9h2+e35x No.76873 Ignore Report Quick Reply
They've already discovered how to gauge metabolites of THC which enter the bloodstream immediately after use. IDR offhand, but there's a specific one which is not psychoactive and is a telltale sign of recent use (versus traditional tests which use residues that last for weeks or months, in rare cases).

You can't really rely on symptoms of use as a metric, because cannabis is SO varied in its effect/cannabinoid composition. One of the reasons I don't like many dab batches is because the extraction methodology often excludes non-volatile components which alter the chemical nature of the cannabinoids, so sub-professional-grade dabs are no "clean slate" for comparison either.

Phenylacetic acid by George Siffingworth - Fri, 05 Jun 2015 14:54:14 EST ID:ykDmWZpt No.76624 Ignore Report Reply Quick Reply
File: 1433530454585.jpg -(26248B / 25.63KB, 640x286) Thumbnail displayed, click image for full size. 26248
Hello, /chem/!
I was wondering about this route to phenylacetic acid, and couldn't find it on the internet. Would the following synth work?

>Benzene is reacted with chloroacetic acid in the presence of aluminium chloride catalyst to yield phenylacetic acid. Would the aromatic ring attack the chlorinated position of the acid or the carboxylic one?

Thanks guys!!

Actually, I'm NOT willing to make P2P. I'm willing to make MDP2P, and as such, I woudn't be performing the above reaction with benzene, but with methylenedioxybenzene. So I was also wondering whether or not the AlCl3 would be a problem for the methylenedioxy ring. Would it be demethylenated by this catalyst? If so, I could perform the alkylation with chloroacetic acid before performing the methylenation of pyrocatechol with H2CI2 or H2CSO4. Problem is, in this case I imagine that the phenolic -OH groups would attack the chloroacetic acid instead of the aromatic ring doing the nucleophilic attack.

Any input on the above?
Thanks again!
15 posts and 4 images omitted. Click Reply to view.
Bombastus !!HToBa9dh - Sat, 20 Jun 2015 14:24:48 EST ID:4ppVjZXo No.76703 Ignore Report Quick Reply
Actually, I'm reflecting on this again.

I'm at non-chem related job right now so I don't have access to chemdrawzzz. But my current understanding of aluminium halide catalysed de-o-methylation forms that weird negative aluminium anion complex with the MeO (much like in F-C alkylation). Then a bound halide should attack the methyl group spawning the leaving MeX (MeCl) and generating that as a gas (like all o-demethylations do). Then you can hydrolyse the system to generate the phenol.
It also doesn't seem to be a catalysis as AlCl3 is reacted away.

Reflecting on it further, I don't see why it wouldn't happen, albeit very slowly. I think it wouldn't be worth it since it should exist in equilibrium with the product <-> reagent when it even is demethylated because the chloro-alkane formed would immediately react with the hydroxide to reform the methine-dioxy-benzene.

I'm confident enough in that answer and will revisit when I have more time during the day.
Nathaniel Shakewill - Sat, 11 Jul 2015 01:03:40 EST ID:h6BiFOLD No.76794 Ignore Report Quick Reply
What Bombastus said here. The Dioxy-methine bridge is generally pretty stable due to conjugation. See if you can find a table of pKa for the leaving groups and compare if you aren't confident.
Nathaniel Shakewill - Sat, 11 Jul 2015 01:04:19 EST ID:h6BiFOLD No.76795 Ignore Report Quick Reply
Also I appreciate where you are going with this reaction haha. I approve.
Bombastus !!HToBa9dh - Sat, 11 Jul 2015 15:09:14 EST ID:hNcgQxKK No.76797 Ignore Report Quick Reply
Yupp. Looking at it again, my instincts agree with the methine/methylene bridge being stable. Even if it were to break, the OH- and Cl- should immediately react away to reform alumina and chloride ions (HCl should not be created due to it being too unstable to simply be formed in this reaction).
If you could make HCl this way, let me know. It'd be interesting to follow up on. But my guess is no.
Doris Sunnersirk - Tue, 28 Jul 2015 13:10:32 EST ID:ykDmWZpt No.76854 Ignore Report Quick Reply
>"Anydrous AlCl3 is a relatively strong Lewis acid. It bonds with the lone pairs of electrons on the oxygens in the ethers. When this complex is hydrolyzed, the ether is cleaved. When you do this to safrole, you can definately expect a mess, since the methylenedioxy ring gets cleaved, and things can get even more out of hand from there. In the case of eugenol, this cleavage is exactly what we're looking for."

Nakura #lolwatmox by Nakura !xMsGPnYjBI - Mon, 20 Jul 2015 16:22:19 EST ID:l2jFwqQE No.76828 Ignore Report Reply Quick Reply
File: 1437423739622.jpg -(48257B / 47.13KB, 452x252) Thumbnail displayed, click image for full size. 48257
Interactive Climate Change Thing.
Sophie Worthingwill - Tue, 21 Jul 2015 00:52:01 EST ID:YhREOUdy No.76829 Ignore Report Quick Reply
>climate deniers

So sick of the bull crap. A person would have to be completely delusional to think the climate is going to stand perfectly still. As if we live in a perfectly static artificial world, created just for us with unwaveringly perfect conditions? The term "climate denier" is so full of bias it could explode.

>well this NEW data from ~NASA~ (oooh) proves once and for all that the climate is changing

Yes, fine, the data shows the climate is changing as we swing from one ice age to the next. Alright already. Yeesh.

>and even though we can't ever prove it beyond a hilariously vague correlation, we just KNOW that it's caused by man so we need to buy carbon offsets and tax the living shit out of everyone who uses hydrocarbons and we need to elect these so-called social democrats who will bravely enact more laws and do something about-

Yeah no. Heard this little song and dance before, sweetheart. For the ten billionth time: It's not gonna work.
trypto - Tue, 21 Jul 2015 09:09:57 EST ID:pDka/jle No.76830 Ignore Report Quick Reply
I'm all-in on global warming. I think it's happening and we're responsible. I think governments should take action to cut back greenhouse gas emissions, invest in nuclear and renewables, and research geoengineering to control the climate.

But you're right about the coverage. 'climate deniers' is ridiculous, too many one-off studies are presented as proof (when they're not even newsworthy), and the financial instruments proposed are total scams.
Alice Goodfoot - Tue, 21 Jul 2015 15:43:51 EST ID:JdiGsSqV No.76831 Ignore Report Quick Reply
>People shitting on the west for our emissions.

Not realizing that even if the US and western Europe just went to another dimension, the rest of the world that is considered developing is just shitting on the planet and not giving a rat's ass.

Seriously even if the US went to something completely clean and Europe and Canada followed suit, the whole of everybody else would still be causing climate change.
Caroline Gashhine - Sun, 26 Jul 2015 22:41:43 EST ID:uGD5aNS6 No.76851 Ignore Report Quick Reply
>Yes, fine, the data shows the climate is changing as we swing from one ice age to the next.
You are ignoring rates man. These things typical occur at much slower rates than they are now, which implies something must be causing upsetting the balance and tilting the equilibrium in some way.

Even you have to admit that a reasonable logical deduction is that we are the cause. If CO2 is considered a major factor, and CO2 normally cycles yet is experiencing a dramatically increased rate of buildup, wouldn't it not be that far fetched that some sort of force is behind the acceleration? And since we do produce metric shit-tons of CO2, is it really that far-fetched that we are not the cause?

P-glycoprotein Efflux Transporters by WIAKR+Pa - Fri, 24 Jul 2015 02:05:30 EST ID:lfUESqVd No.76839 Ignore Report Reply Quick Reply
File: 1437717930442.png -(216361B / 211.29KB, 2700x966) Thumbnail displayed, click image for full size. 216361
Does anyone know why loperamide is so easily expelled after it has crossed the BBB when compared to, say, morphine or fentanyl? I vaguely remember reading somewhere that it was because of the chlorine atom, but that could be totally wrong.

I know that the diacetylation of morphine into heroin facilitates its crossing the BBB by making the molecule more nonpolar, but that doesn't explain why it isn't expelled by the P-glycoprotein.

I have a few links, and I've read the majority of them. The third one says removing electronegative atoms should decrease the efflux, so it seems that removing the chlorine would help.


Pic related. I don't want to be 'that guy' who wants to acetylate everything because that's what works for heroin, but if it works then it works. What other changes to the molecule might make this drug more recreational?
WIAKR+Pa - Fri, 24 Jul 2015 03:57:47 EST ID:lfUESqVd No.76840 Ignore Report Quick Reply
1437724667091.png -(71438B / 69.76KB, 912x989) Thumbnail displayed, click image for full size.
Whoops, I fucked up the third molecule. My bad, it's pretty late at night. Here it is fixed. Nb
WIAKR+Pa - Fri, 24 Jul 2015 04:00:05 EST ID:lfUESqVd No.76841 Ignore Report Quick Reply
1437724805386.png -(74769B / 73.02KB, 898x975) Thumbnail displayed, click image for full size.
One last picture since apparently the OH can be acetylated as with morphine. Nb
Caroline Gashhine - Sun, 26 Jul 2015 22:32:18 EST ID:uGD5aNS6 No.76850 Ignore Report Quick Reply
I'm not entirely sure, but do consider that heroin itself is just a prodrug for morphine. By that I mean heroin itself does not cause the affects but deacetylation of said molecule can then generate the affects.
I think 6-monoacetylmorphine has some effects, with 3-MAM not really producing much, and straight morphine having the most affect.

My point being that perhaps heroin can rapidly cross the BBB, both into and out of the brain, but a higher concentration of deacetylating enzymes inside the BBB that sort of "trap" the resulting morphine in the brain. My research advisor jokingly refers to the BBB as the Brain-Blood Barrier because we tend to forget it stops things from leaving the brain, too.

Purely conjecture/speculation, but perhaps Lope is not able to be chemically modified such that it can be trapped within the brain. Adding functional groups wouldn't necessarily remedy this, since the base molecule is already quite permeable?

Grow your own drug? by Esther Bezzlehid - Wed, 23 Apr 2014 23:03:20 EST ID:SneqK8/u No.74586 Ignore Report Reply Quick Reply
File: 1398308600543.png -(822385B / 803.11KB, 1280x720) Thumbnail displayed, click image for full size. 822385
Why do you think no one has tried to grow their own coca/poppies indoors? Just surprised since weed and shrooms have been cultivated indoors for quite a while now. Granted processing cocaine and (probably) heroine takes more work but still, hydroponics have become complex. So, I would reason that drug extraction from other plants doesn't seem too difficult for some of the more curious in the age of the internet.
>Anyway, why do you think this hasn't been tried yet?
31 posts and 4 images omitted. Click Reply to view.
WIAKR+Pa - Thu, 23 Jul 2015 09:57:46 EST ID:lfUESqVd No.76834 Ignore Report Quick Reply
Would supplementing their growth with l-tyrosine do anything? I couldn't find anything online and /crops/ is 99% how do I marijuana
Bombastus !!HToBa9dh - Fri, 24 Jul 2015 17:14:39 EST ID:vbS8CtHn No.76842 Ignore Report Quick Reply
Hey there, WIAKR+Pa. Nice to see you on /chem/ ^o^
I wouldn't know much about the l-tyrosine. As far as I know, the only thing that has been shown to noticeably increase alkaloid content is carbon dioxide. You may be able to stimulate growth by ramming metal blades across the lawn every week as they respond to stress and stuff but the thing is you can't really be sure.
Oh and also, water all opium poppies with soda water. Or make your own soda water by tossing a piece of dry ice in water in a thermos. I think they have home carbinators at walmart, too, though.
WIAKR+Pa - Fri, 24 Jul 2015 18:47:39 EST ID:lfUESqVd No.76843 Ignore Report Quick Reply
1437778059615.jpg -(66995B / 65.42KB, 600x790) Thumbnail displayed, click image for full size.
Nice to be here Bombastus. They sell bulk tyrosine as a supplement, and it's used at a rate of 2mol tyrosine/1mol morphine in the biosynthetic pathway of the opium poppy, so I definitely get the feeling that if it can be reasonably absorbed by the plants then it should increase the alkaloid content. Maybe I'll do a little unofficial test with a few plants. Nothing huge, but if the chance arises then I'll see what I can do.
Bombastus !!HToBa9dh - Fri, 24 Jul 2015 19:41:48 EST ID:vbS8CtHn No.76844 Ignore Report Quick Reply
if i didn't fucking hate fucking botany with a fucking wrath, then i'd probably go around growing poppy plants and analysing the difference in morphine. you could always do that and report back?
i'm sure a lot of people would be quite greatfull for that. but my guesses (with my limited understanding of biosynthesis) is that just because you have a precursor doesn't mean you will get more end product

the complex pathway you posted up probably has a limiting reaction that isn't just the starting precursor. this is just me speaking for a statistical point of view. it could very well increase morphine production but i don't think it's likely
Caroline Gashhine - Sun, 26 Jul 2015 22:24:26 EST ID:uGD5aNS6 No.76849 Ignore Report Quick Reply
>just because you have a precursor doesn't mean you will get more end product
This, 1000X
enzyme kinetics are tricky because in a test tube you can force a reaction with high concentrations of substrate, but often enzymes are highly regulated, including inhibition by the products of the reaction or biosynthetic pathway.

Simple equilibrium dynamics and mass action, that sort of thing, doesn't really apply to biosynthetic pathways. It's worth a try though.

How many great grandparents do I have? by Eliza Brecklekedging - Thu, 23 Jul 2015 19:47:38 EST ID:AFCPP6XZ No.76836 Ignore Report Reply Quick Reply
File: 1437695258522.jpg -(21669B / 21.16KB, 480x327) Thumbnail displayed, click image for full size. 21669
Has anybody roughly calculated the number of generations separating us from the oldest known organisms?
Nigel Bipperson - Thu, 23 Jul 2015 23:05:11 EST ID:pSzcCxpL No.76837 Ignore Report Quick Reply
That would be impossible because we don't know all of our antecedents or their average generation times.
Reuben Gongerwater - Sun, 26 Jul 2015 08:55:04 EST ID:pXaPdrMd No.76846 Ignore Report Quick Reply
It would be impossible to get an exact number, but it would be only difficult to generate a reasonable approximation. It comes down to a matter of how many orders of magnitude off you might be.

I'm not into this evolutionary stuff, so I don't know the numbers BUT apparently there's 3.5 billion years between us and the first cell. Assume 1 hour generation time until 610 million years ago when multicellular organisms appear. Let's move on to a 10 hour generation time. Animals popped up pretty soon, so 600 million years ago the generation time jumped to 10 days. 500 million years ago things crawled on the land with, say, a 1 month generation time. Around 360 million years ago amphibians appears so let's go with a 6 month generation time for a seasonal sorta thing goin on. 150 million years ago amniotes appeared, so let's finally reach a 1 year generation. Mammals 130 million years, so jump up to 2 years. Homininae 10 million years ago; big jump to 15 years. Modern humans 250,000 years so 20 years.

Despite my pulling this out of my ass/wikipedia, let's do a tally:

1 hour generation time: 2.89 billion years * 8760 hours per year *1 gen/hr = 25.3 trillion generations
10 hour generation time: 10 million years * 8760 hours per year * 1 gen/10 hrs = 8.76 billion generations
10 day generation time: 100 million yr * 365 day/yr * 1gen/10day = 3.65 billion generations
1 month generation time: 140 million yr * 12 month/yr * 1 gen/month = 1.68 billion generations
6 mo. gen time: 210 million yr * 12mo./yr * 1 gen/6mo = 0.42 billion gen
1 yr gen time: 20 million yr = 20 million gen
2 yr gen time: 120 million yr = 60 million gen
15 yr gen time: 975000 yr = 650000 gen
Comment too long. Click here to view the full text.

alternatives to unattainable chemicals by Simon Sommlebark - Thu, 23 Jul 2015 17:20:43 EST ID:SazBGrfb No.76835 Ignore Report Reply Quick Reply
File: 1437686443314.jpg -(46380B / 45.29KB, 480x360) Thumbnail displayed, click image for full size. 46380
If one would like to do Kash's advaned lsa extraction but didnt have access to toluene or DCM, what could they use? lsa crystals would be ideal for that person imo.
Nigel Bipperson - Thu, 23 Jul 2015 23:08:40 EST ID:pSzcCxpL No.76838 Ignore Report Quick Reply
Toluene is readily available at hardware stores. You could also try xylene.
Cedric Grandshit - Fri, 24 Jul 2015 21:29:39 EST ID:mEgh7QsF No.76845 Ignore Report Quick Reply
dcm you can order from ebay (from europe but mine came through to canada)

and like the above dude said you can buy decently pure toluene at the hardware store

<<Last Pages Next>>
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Report Post
Please be descriptive with report notes,
this helps staff resolve issues quicker.