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Substituting Tryptamines by Fiend !!1C9jE+w+ - Sat, 26 Sep 2015 02:19:51 EST ID:SPL8SH61 No.77200 Ignore Report Reply Quick Reply
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So precipitated by Bombastus I've decided to actually use my brain and time on handling drugs as opposed to just procuring them. I haven't been to school in years and I don't know anything practical about chemistry, just the names of lots of functional groups, not how they work. Anyway, that's just disclaimer.

What I want to talk about is tryptamines, and substituting therein. It was mentioned over in /psy/ that there's a way to convert DMT to 4-HO-DMT. As well as talk of changing 4-subs, to get things like 4-Bromo-DMT and 4-Vinyl-DMT.

I'm not exactly sure what my question is. I think it's a better idea for me to put this thread here and just read what more educated people say to each other. I guess what I want to hear is about how difficult it would be to change substitutions on existing tryptamine material.

Obviously it depends, but since I have no idea what I'm talking about, some examples I'm wondering about:
DMT > another unsubbed tryp, like DPT or MET. What would be entailed?
DMT > 4-HO-DMT or vis versa? I need to get up the gumption to extract DMT anyway; could I convert from there? I suppose that's gotta be easier that extracting alkaloids from mushrooms, separating 4-PO-DMT, from 4-PO-NMT, and modifying from there?
What about 4-AcO-DMT into either 4-HO-DMT or DMT? Working from there could answer a lot of questions about the nature of the 4-AcO-tryps as prodrugs. Also as Bombastus suggested that would make mail order psilocin a possibility.

Anyway, talk. I will do my best to keep up and ask not stupid questions.
25 posts and 4 images omitted. Click Reply to view.
Fiend !!1C9jE+w+ - Sun, 25 Oct 2015 21:53:30 EST ID:dnZGP2Dj No.77326 Ignore Report Quick Reply
I was actually agreeing with you about it not being worth it, despite what you know (accurately) about my 4-sub-MET preference. I guess I phrased it unclearly.

And what do you mean where did I get DPT? Internet. Duh. I had 4-AcO-DPT for a while too, but I didn't get a real sense for it the 2 times I did it. I'd love to have another go at it. Plus DPT is kind of a bitch to dose. I don't intend on touching it again until I either perfect IV technique, or decide to freebase it (which I should really do to gain some confidence about kitchen chemistry);
Ebenezer Fisslewodging - Tue, 27 Oct 2015 16:58:07 EST ID:4AZAqA2e No.77331 Ignore Report Quick Reply
DPT has been fairly common in the RC scene for the last few years, Sir
Bombastus !!HToBa9dh - Wed, 28 Oct 2015 16:39:30 EST ID:ElYFdcKO No.77333 Ignore Report Quick Reply
I've only gotten into the alkyl substituted substances only a few days ago. I took 4-AcO-DET which is the first non-DMT substance I've ever tried. DPT is something to look at for sure, then.
But I think all creations can and should be done with DET instead of DMT considering the stability and relative similarities to DMT molecules.

Why is DPT hard to dose? Can't you just eat it?
Fiend !!1C9jE+w+ - Wed, 28 Oct 2015 21:54:39 EST ID:dnZGP2Dj No.77335 Ignore Report Quick Reply
Eating it is a massive waste of material, and snorting it is vile beyond anything. Plugging it was far less effective than snorting, also a waste of my money, and injecting it is problematic since it is not wonderfully soluble in water. IM was by far the best route, I just was using several of the 1ml insulin syringes that are easily accesible in US pharmacies.
Beatrice Fanford - Tue, 03 Nov 2015 11:21:50 EST ID:Ja2fAPPl No.77350 Ignore Report Quick Reply
>Why is DPT hard to dose? Can't you just eat it?

>Although it was mentioned in TIHKAL that DPT is orally active, we found this route to be quite unpredictable when taking it without an MAOI. Recent reports indicate that propyl-huasca works very well using the standard amount of MAOI combined with 75-150 mg of DPT.

anything relevant to comp sci by Martin Commlechitch - Tue, 05 Jan 2016 01:43:01 EST ID:63B22mtZ No.77501 Ignore Report Reply Quick Reply
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im currently studying comp engineering/ comp sci, and am doin fairly well, but i feel like 95% of my program is more focused on comp sci and coding and we are never really learning about actually engineering.
what i'm wondering is, what other fields of science (or any other subject) do you guys think are important for someone in my field to have a decent understanding of? also, what are good resources to check out for staying up to date with whatever you recommend / good starting points? any subreddits, news sources, podcasts, anything that's a good resource for learning i'm most interested in graphics programming as well as anything audio related, sound manipulation, etc. but really any recommendations are appreciated
thanks in advance!
A Wizard - Wed, 13 Jan 2016 03:52:59 EST ID:U/pEBCij No.77519 Ignore Report Quick Reply

Study the teachings of Pythagoras. They pretty much fill all of your interests. There's as much about harmonics as there is about geometry.
Vehk !7HYGxe5v5c - Sun, 17 Jan 2016 15:54:37 EST ID:uxs5rJ20 No.77531 Ignore Report Quick Reply

Whenever I read your posts, I pretend that you are David Brent from the UK Office and read them in his voice.
Vehk !7HYGxe5v5c - Sun, 17 Jan 2016 16:01:30 EST ID:uxs5rJ20 No.77532 Ignore Report Quick Reply

Pharmaceutical Chemistry by Fucking Huddleford - Thu, 03 Dec 2015 17:49:54 EST ID:dhY+6e5d No.77401 Ignore Report Reply Quick Reply
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Are any of you guys pharmaceutical chemists? I want to go to college for it, but Im curious what your guy's work day is like and also what to expect from college, and what classes I'll have to take.
2 posts omitted. Click Reply to view.
Molly Fudgetat - Sun, 06 Dec 2015 21:14:42 EST ID:Dqu7ojT7 No.77411 Ignore Report Quick Reply

This is a question for an adviser. or just go look at the course catalog of a university you are interested in.
Thomas Gickleforth - Fri, 01 Jan 2016 23:45:56 EST ID:3nQ8foZE No.77487 Ignore Report Quick Reply
I got my degree in Bio Chem simply because the Chem major at my school required liner algebra as a co-rec for quantum chemistry...
Thomas Gickleforth - Fri, 01 Jan 2016 23:47:40 EST ID:3nQ8foZE No.77488 Ignore Report Quick Reply
my bad, linear algebra
Phyllis Bosslehag - Sat, 02 Jan 2016 20:13:45 EST ID:0LQJvC/t No.77491 Ignore Report Quick Reply
Its fucking hard.
Theres a lot of math and physics based math and constant algebra.

Also pharmacology and medicinal chemistry are pretty much exclusively graduate level.

So you would likely be getting a chemistry degree and then sitting on your ass unless you plan on going to grad school.
Vehk !7HYGxe5v5c - Thu, 14 Jan 2016 17:56:02 EST ID:0kilcEvV No.77522 Ignore Report Quick Reply
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One of the big boys of English-speaking pharmaceutical academia here tbh

> Theres a lot of math and physics based math and constant algebra.

> Theres a lot of math

Pre-calc, Calc I and II, and eventually statistics/bioinformatics. Learning new maths will probably make up less than a fifth of what you spend your time on, though you will use basic maths for almost everything you're working with.

> physics based maths

Literally understanding vectors, electromagnetism and other mostly linguistic or spatial concepts with a few formulas to plug numbers into/transpose mixed in.

> constant algebra
Comment too long. Click here to view the full text.

Ideas for senior project by Nigger Drondleshit - Sun, 27 Sep 2015 07:11:37 EST ID:D6W9PxnV No.77204 Ignore Report Reply Quick Reply
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I'm planning to take a senior course on cancer research and do some benign project on cancer as my thesis.

I'm either going to expose cells to carcinogens and see of ways to prevent this, or basically use cancerous cells and see what can inhibit or affect cancer growth with some run-of-the-mill cancer drug unless something interesting is suggested. My uni can get me pretty much anything I want.

Thoughts? I don't want it to be a simple experiment since I'm seriously considering going into the field later and need something that will give me good insight. Signal transduction inhibitors, certain protein overexpression or underexpression, binding to certain proteins that are transported to the plasma membrane?

Anybody have experience with this?
5 posts and 1 images omitted. Click Reply to view.
David Bumblelock - Sat, 10 Oct 2015 09:13:33 EST ID:cM6rhCgJ No.77274 Ignore Report Quick Reply

I know it's been done to death, but have you thought about using CBD and studying the growth rate of the cancerous cells?

For a while I've believed that a localized injection of CBD could cure cancer.
A Wizard - Tue, 13 Oct 2015 14:08:04 EST ID:PtGx5SYm No.77285 Ignore Report Quick Reply

You could just coat your nanomolecular gold particles with the CBD and watch them have affinity for the cancer cells on their own. Also, the cbd penetrates cell walls then, very effectively xD
Shitting Grimville - Sun, 18 Oct 2015 13:28:55 EST ID:uGD5aNS6 No.77309 Ignore Report Quick Reply
Thanks man. It wasn't a huge impact factor journal because it was just a small manuscript. Not a bad journal but not a great one either.

As for how I picked that protein, well its a critical protein to axonogensis and neurodifferentiation. I did some basic experiments characterizing the effect, made some claims (hypothesizes) about why it was happening, then did mutagenesis on it, as well as used kinase inhibitors to block phosphorylation of the protein. So the original protein and base experiment was given to me and I ran with it. Was solid at the end though.

That is cool that you are working with astrocytoma, astrocytes being something that I am quite familiar with. Best way to figure out a target is to read papers, and when you get a good idea of the landscape as to what is known, start writing down questions.
If you can find the answer to that question somewhere, cross it off. If search generates no leads, keep it as a possible avenue. But don't go for the thing with nothing known about it right off the bat. Too risky, its a total gamble and you don't want to waste 6 months only to find out your research is fruitless. Save that for a Phd student who has that kind of time. Start with something that may have been confirmed to have a role but it is not entirely characterized, and think of ways to design experiments to further characterize its role. Have a list of them and try a bunch, because more than a few will not work for specific reasons and nuances related to that protein.

That make sense?
Betsy Baffingmat - Wed, 06 Jan 2016 20:02:53 EST ID:9qBRUbDq No.77505 Ignore Report Quick Reply
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You could do an experiment where you treat cells with sulforaphane (a plant extract with histone deacetylase inhibitor activity) in the presence or absence of a methyl donor (like vitamin B12 or SAM) that could push the system in one direction or the other by adding extra substrate for changes in DNA methylation. http://www.ncbi.nlm.nih.gov/pubmed/26703571
Lydia Febblechan - Sat, 09 Jan 2016 14:16:51 EST ID:FHFwCltH No.77512 Ignore Report Quick Reply
That's a pretty solid idea. Not too complicated, just need to make sure he orders folate/B12 and SAMe deficient media so he can control the dose.

a "sandwich" filled with FUSION by A Wizard - Thu, 07 Jan 2016 00:45:39 EST ID:t9woUZlS No.77506 Locked Ignore Report Reply Quick Reply
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>A sandwich is a food item consisting of one or more types of food, such as vegetables, sliced cheese or meat, placed on or between slices of bread, or more generally any dish wherein two or more pieces of bread serve as a container or wrapper for some other food.[1][2][3] The sandwich was originally a portable food item or finger food which began to be popular in the Western World. Today sandwiches in various versions are found worldwide.

>Sandwiches are a popular type of lunch food, taken to work, school, or picnics to be eaten as part of a packed lunch. The bread can be used plain, or it can be coated with one or more condiments such as mayonnaise or mustard to enhance the flavours and texture. As well as being homemade, sandwiches are also widely sold in restaurants and cafes, and are sometimes served hot as well as cold.[4][5] There are both savoury sandwiches, such as deli meat sandwiches, and sweet sandwiches, such as a peanut butter and jelly sandwich.

>The sandwich is considered to be the namesake of John Montagu, 4th Earl of Sandwich, because of the claim that he was the eponymous inventor of this food combination.[6][7] The Wall Street Journal has described it as Britain's "biggest contribution to gastronomy".[8]

lets bio enginer a sandwich?
Thread has been locked
Thread was locked by: SeVeNaD
Reason: another great thread

Light by Cedric Tillingstone - Fri, 26 Dec 2014 02:34:37 EST ID:5BjIx1Ou No.75944 Ignore Report Reply Quick Reply
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Is it visible without anything to reflect off of and if you cannot see the source of it? I'm in a room lit only by the computer monitor, waiting for someone by my open window at night and the thought just randomly occurred to me and I thought I'd hear your guys' thoughts on the subject.
3 posts omitted. Click Reply to view.
Rebecca Shakelock - Fri, 14 Aug 2015 02:55:12 EST ID:NkX3onth No.76913 Ignore Report Quick Reply
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>Literally thinking about this very topic today
>Through a series of events visit 420chan in the first time in years
>Hit random thread button
>End up here

Ohhhh mmmaaaaaaaaaaaaannnnnn
Bombastus !!HToBa9dh - Sat, 15 Aug 2015 18:05:16 EST ID:V1Ngvki3 No.76916 Ignore Report Quick Reply
light bounces off a lot of shit: walls, cloth, air, etc. the last one not so much but try the experiment at home.
go to a windowless room, turn the light off and just practice with a small, dim fleashlight
Hedda Fanforth - Sun, 13 Dec 2015 16:31:39 EST ID:YHmno3wJ No.77430 Ignore Report Quick Reply

even if you could violate the laws of physics to do this you would still need to do it in an environment free from gravity and close off the sides to prevent erratic protons escaping and the mirror would have to be a perfectly smooth surface of quarks gluons or some other subatomic particle and even still entropy would eventually cause the protons to just slow down oh god why am i even bothering
Angus Novingstone - Sun, 13 Dec 2015 16:35:02 EST ID:u8+Bwmjx No.77431 Ignore Report Quick Reply
or just ya know, use a half reflective plate that way some light passes through anyway
Molly Sabbercocke - Sat, 02 Jan 2016 18:31:11 EST ID:5xtVf077 No.77490 Ignore Report Quick Reply
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Not so fast!
This isn't completely wrong.
If you could build a box out of PERFECT mirrors
If you could keep the mirrored box from losing ANY energy over time...
then following troll's procedure would result in
the input light bouncing around ~forever
However, you could never use the light for anything for anything or observe it, since doing so would consume the meager amount of energy stored by the endlessly reflecting photons.
There is an electromagnetic component to this as well, but I'm pretty sure that a PERFECT mirror keeps reflected radiation from losing energy due to electric or magnetic forces.
Given, perfect mirrors don't exist, and likely never will... however with really fucking good mirrors you could get the light to hang around for longer.
Cooling the entire setup to nutsack shattering levels would help with duration as well.

4-aco in water by Nigger Berryshit - Mon, 21 Dec 2015 21:50:10 EST ID:ZSDfWEkg No.77454 Ignore Report Reply Quick Reply
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Usually I put some in a small glass of water and drink it so I was wondering: if I dumped some in a water bottle would it be as potent a few hours/days later? I'm sorry if that sounds like a stupid question, but i dont know much about chemistry and i don't really feel like wasting some to test it out.
7 posts and 1 images omitted. Click Reply to view.
Whitey Daffingfut - Thu, 24 Dec 2015 12:14:15 EST ID:3uFtL7cp No.77465 Ignore Report Quick Reply
Esters, like 4-aco tend to degrade when exposed to water, though the effect is larger at higher temperatures. Also it'd just degrade into psylocin, but that is pretty unstable in solution, and would probably oxidize. I'd agree with Simon and Bombastus on this one and say it was prolly a bad idea.
Molly Blupperstock - Thu, 24 Dec 2015 13:46:41 EST ID:Iko+aZ/1 No.77466 Ignore Report Quick Reply
Is this something that happens right away, or does it take sometime? I have never kept 4-AcO in water, I was just wondering what would happen if I did. Usually it only stays in water for a couple seconds before I chug it down.
Edwin Brittinghall - Fri, 25 Dec 2015 00:03:28 EST ID:LB+wr31L No.77468 Ignore Report Quick Reply
Just because it exists in nature doesn't make the stuff you order online organic. Isn't it lab-synthesized from other things?! Or is it really just purified/concentrated.
Bombastus !lnkYxlAbaw - Sat, 26 Dec 2015 15:49:17 EST ID:LuHWyaDS No.77472 Ignore Report Quick Reply
Exactly. There's a big difference between "synthetic", "organic", "natural", and all these other buzzwords.
The labelling of these substances with these words and drawing conclusions from the labels is not only meaningless, but it is harmful to any line of communication we draw.
press !QUHukXEvkY - Mon, 18 Jan 2016 12:40:11 EST ID:trptNJfh No.77539 Ignore Report Quick Reply
that whole area of semantics is so highly infected with ideology when it comes to their common usage that it seems futile to discuss them since everybody involved in science knows how to use them correctly

and fuck whatever they call organic agriculture. that shit is whack, mostly because none of those hippie ass pansies care to mention peak phosphorous or the eutrophisation. nb because im drunk and offtopic

I bought a dental x-ray machine from a dentist... by Sophie Bonninggold - Sat, 19 Dec 2015 00:52:33 EST ID:DicPbMF8 No.77442 Ignore Report Reply Quick Reply
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$250, not a bad deal. What should I x-ray?
3 posts and 1 images omitted. Click Reply to view.
Nell Smallway - Mon, 21 Dec 2015 21:36:01 EST ID:dU2Bj8Vk No.77453 Ignore Report Quick Reply
I second blasting your dick with x-rays
Betsy Bommerwater - Tue, 22 Dec 2015 01:39:54 EST ID:ljoFE2/4 No.77460 Ignore Report Quick Reply
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Convert it into a death ray.
Caroline Bozzletare - Thu, 24 Dec 2015 23:41:12 EST ID:S2HH5VMq No.77467 Ignore Report Quick Reply
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do the thing with your dick, do it!
pics or it didnt happen
Whitey Samblegold - Sat, 26 Dec 2015 13:50:12 EST ID:dFtFOzdL No.77471 Ignore Report Quick Reply
Radioisotope Thermoelectric Generator gogogo
Nell Mattingstitch - Thu, 07 Jan 2016 14:28:14 EST ID:o4577b9W No.77507 Ignore Report Quick Reply
shoot xrays through your neighbour's bedroom window

its for a book im sorry by Shitting Havingnork - Fri, 25 Dec 2015 17:33:03 EST ID:7Nwhnu1y No.77469 Ignore Report Reply Quick Reply
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you know those really heavy ass elements they make and collapse straight away and there's basically no point even having them on the periodic table?

Could they react to form compounds if they didn't fall apart straight away? What kind of compounds would they form or what properties could they have? If we were to continue to discovering new elements, is it theoretically possible one could not be a metal?
Whitey Samblegold - Sat, 26 Dec 2015 13:43:55 EST ID:dFtFOzdL No.77470 Ignore Report Quick Reply
Possibly, it depends on which element, and probably. Google/wiki island of stability. The properties of compounds made with these elements can be partially inferred from compounds made from elements in the same group and period on the table, however they will have novel properties that nobody is even positive of at this point. I don't know enough to really give you much more than that, but some web searches and reading research papers will get you enough to get by writing a book.

EM Electromagnetic Waves Damage by Martha Pembleded - Fri, 15 May 2015 18:39:31 EST ID:RLSN+6eM No.76541 Ignore Report Reply Quick Reply
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Apparently these things are quite dangerous.

16 posts and 4 images omitted. Click Reply to view.
Lydia Chiblingstone - Tue, 01 Sep 2015 02:14:34 EST ID:8P0TA/0u No.77097 Ignore Report Quick Reply
man you are so fucking out of it I hardly believe you're a wizard anymore.
A wizard is wise, wise people observe other when they communicate, they are loving and kind, they don't want to destroy shit as their life purpose as they grasp that every moment is eternal, they understand that everyone is a part of them so they wish good onto others, they wish sheeple to overcome their obstacles, they don't care about their sense of entitlement and don't get offended on 420chan, they don't communicate to everyone of their high horse, their humble, they grasp the nature of money therefore they don't think they need much of it etc etc.

tl;dr this guy is no fucking wizard and just calling himself that almost proves it, he's a magician at best. He's also barely older than 18 y/o seniors as he has hardly seen suffering in his life yet. Suffering is what makes a wizard wise. Experience.

Take a week to water fast man, you'll learn so much. It'll also help eliminate those toxins from cheese (or any other industrial animal fat that you eat or ate) from your brain.

Insulted wizard... 21 century. I wish you actually become wise one day nigga.
Edwin Blythehood - Wed, 02 Sep 2015 18:24:49 EST ID:GpX7lxsF No.77111 Ignore Report Quick Reply
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Interesting how no one replied to this.
Eugene Dumblebanks - Wed, 02 Sep 2015 18:49:42 EST ID:cM6rhCgJ No.77112 Ignore Report Quick Reply

Cause they were obviously a shill making up lies about how the world works. I feel the world works a different way so that guy is wrong.
Whitey Dellerfuck - Thu, 01 Oct 2015 17:36:15 EST ID:ezYtnjXB No.77212 Ignore Report Quick Reply

It all looks pretty fact driven and objective to me.
OP - Tue, 22 Dec 2015 13:54:25 EST ID:vFjYr6dk No.77461 Ignore Report Quick Reply
I told you guys, I'm not crazy:

Creating a human by Ernest Callyforth - Sun, 26 Oct 2014 23:31:12 EST ID:kEuMwRGV No.75620 Ignore Report Reply Quick Reply
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Toss the ingredients together in the large hadron collider...
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Ernest Noddlenot - Tue, 15 Dec 2015 18:56:05 EST ID:YHmno3wJ No.77435 Ignore Report Quick Reply
I suppose if you tried it enough times MAYBE you'd get something. Not a human but... something.
Sophie Washlock - Tue, 15 Dec 2015 19:51:06 EST ID:YhREOUdy No.77436 Ignore Report Quick Reply
>Your god is a product of your mind, a hallucination.

Whoa, Nelly... You can't make a claim like that without even knowing where the mind came from.

This whole thread is really a subject for /pss/, so that's all I'll say about that.
William Debblefeck - Mon, 21 Dec 2015 01:36:03 EST ID:FHFwCltH No.77447 Ignore Report Quick Reply
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You should be locked in a basement prison in the Vatican for this level of Necrobumping
Lydia Fashwill - Mon, 21 Dec 2015 04:43:15 EST ID:3/YgpCVT No.77449 Ignore Report Quick Reply
can't get a human without building it
can't get lego land without building it
can't get god without building it
Simon Nablingpid - Mon, 21 Dec 2015 22:54:36 EST ID:FHFwCltH No.77457 Ignore Report Quick Reply
The mind is a collection of neurons. If you believe it is anything more you are ignoring the massive problems with the mind, overglorifying it, and its likely you know little about it.

On that note there have been plenty of studies on the brain related to faith.

Tolerance effects by Phoebe Buzzwell - Thu, 10 Dec 2015 22:39:38 EST ID:nEGqw/mp No.77422 Ignore Report Reply Quick Reply
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This is kind of a quick question. From the way I understand tolerance, it's your bodies neurotransmitter production/release adjust to drugs you frequently adjust (correct me if I'm wrong). So if this is true, would having a tolerance to one drug cause a person to feel different effects from another drug in an entirely different class due to abnormal production of neurotransmitters?
2 posts omitted. Click Reply to view.
Green Fox - Wed, 16 Dec 2015 23:18:30 EST ID:cBu2QAZQ No.77440 Ignore Report Quick Reply
I'm more of a chem person than biochem, but I just did some lazy wikipedia searching because this is a really neat question. A legitimate book probably deals with this in detail.

Since there are lots of factors at play obvs, I looked into opiate tolerance, which has a strong physiological component.

Opiates like morphine are strong (100%) agonists for opioid receptors, meaning they bind to them and cause the same effect as endogeneous opioids like oxytocin, but stronger.

Opi tolerance is caused significantly by downregulation of opioid receptors in the brain, meaning you grow less of these receptors/they die off, in response to an excess of the artificial neurotrasmitter (ie heroin).

Opiate antidotes like Naloxone are antagonists to these receptors - they simply bind strongly to them, but do not cause them to fire. This has the effect of blocking agonists like heroin from interaction (competitive inhibition).

So what would the difference be in naloxone tolerance between a normy and a junkie? The junkie has less active receptors, so they actually require less naloxone. The opioid article confirms this:

"In patients taking opioids regularly it is essential that the opioid is only partially reversed to avoid a severe and distressing reaction of waking in excruciating pain. This is achieved by not giving a full dose but giving this in small doses until the respiratory rate has improved."

someone feel free to tear me to shreds if I'm wrong
Jenny Gushshit - Thu, 17 Dec 2015 00:48:01 EST ID:mEgh7QsF No.77441 Ignore Report Quick Reply

good advice.
Hannah Clubberhall - Sat, 19 Dec 2015 09:14:50 EST ID:Dqu7ojT7 No.77443 Ignore Report Quick Reply
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  • Receptor
-Down regulation
-Up regulation
-Ki value
-competitive agonist
-competitive antagonist
-feedback loop
Whitey Bombleshit - Mon, 21 Dec 2015 04:57:12 EST ID:BF6CJxDN No.77450 Ignore Report Quick Reply
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Tolerance is caused by decreasing the number of receptors for that neurotransmitter. I go a little bit more into that below. Basically the fewer there are, the less places there are for the drug to 'attach' to the brain.
Different types of drugs affect different receptors, though. So while benzos activate the gaba-b receptor, amphetamines active adrenaline, noradrenaline, and dopamine, meanwhile weed for the most part just affects cannabinoid receptors. So a weed tolerance doesn't make amphetamines feel any different. But a spice(synthetic weed) tolerance would make weed feel different because spice works on cannabinoid receptors just like weed does.
For the most part, though, feeling 'different' just means feeling weaker. A spice tolerance doesn't turn weed into some strange and different experience, it just makes it so that you can't get high no matter how much you smoke.

I'm afraid you're partly wrong.
>So what would the difference be in naloxone tolerance between a normy and a junkie? The junkie has less active receptors, so they actually require less naloxone.

The junkie would require more naloxone if there are fewer receptors. If there are fewer receptors, there's a smaller chance that the drug will bind to a receptor. You can think of receptors and drugs as cups sitting out in the rain; the movement of raindrops(drugs) are random, so the more cups(receptors) there are lying around the more likely it is that a given raindrop will fall in a cup. If there aren't that many cups out, there needs to be a lot more rain for the same amount of water to enter a cup.
There's a different reason they say to give a small amount. You need a small amount of chemicals activating your opiate receptors at any time to feel normal. The chemicals that do that are called endorphins. When you have a tolerance to opiates like heroin, you can't feel that small amount of endorphins, which makes you feel shitty. This is what withdrawal is. Since naloxone blocks the opiate receptor, it blocks endorphins from attaching and actually causes withdrawal to happen. So if you have a tolerance and are injected with naloxone, you're put into…
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Shit Monkinbury - Mon, 21 Dec 2015 14:32:52 EST ID:tBE1xsOJ No.77452 Ignore Report Quick Reply
I think you may have lost the right to post on /chem/

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