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Toxic house by Charles Biddlechat - Sun, 19 Jul 2015 13:05:19 EST ID:WlN9uuNp No.76821 Ignore Report Reply Quick Reply
File: 1437325519844.jpg -(147030B / 143.58KB, 960x720) Thumbnail displayed, click image for full size. 147030
>live in 200 year old house
>window is 200 years old and made of wood
>live in climate where the wind is blowing 60 mph every single day
>wind comes in through my window 24/7
>the smell that comes from my window is musty and makes me sick

I'm pretty sure there is lead or something toxic in this window because I feel like shit every single day. There's paint chipping off it and the window isn't even sealed. What do?
3 posts omitted. Click Reply to view.
Bombastus !!HToBa9dh - Sun, 19 Jul 2015 17:44:39 EST ID:vbS8CtHn No.76825 Ignore Report Quick Reply
then cut out some wood and buy a window that fits the dimensions.
This is why I linked you to >>>/howto/. They'll have better ideas than me for replacing outdated windows as long as you have the house information.

Also, ask them how to remove mold.

No; This is the basis of homeopathy, lol. I know you didn't want it to be but you've just proposed a homoeopathic toxin, lmao.
Nicholas Turveygold - Sun, 19 Jul 2015 19:36:24 EST ID:pDka/jle No.76826 Ignore Report Quick Reply
You made a thread about this before. Go to the doctor. If it's lead poisoning, then they will very easily be able to tell by a simple blood test. It's probably not the lead, though.
Bombastus !!HToBa9dh - Mon, 20 Jul 2015 16:09:18 EST ID:ElYFdcKO No.76827 Ignore Report Quick Reply
That's what I thought. But I don't think it's the same guy as kNWNBofZ in this post: >>76584

Ebenezer Gummershit - Wed, 22 Jul 2015 15:21:56 EST ID:cM6rhCgJ No.76832 Ignore Report Quick Reply
Use an epoxy paint coating over the edges on the inside and the outside.
Beatrice Bobberway - Wed, 22 Jul 2015 18:07:25 EST ID:t+gXfaEF No.76833 Ignore Report Quick Reply

Kratom synthesis by Hedda Wonkinstock - Tue, 16 Jun 2015 09:24:38 EST ID:hBwYKLP1 No.76685 Ignore Report Reply Quick Reply
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hello chem/ im a complete noob to chemistry but i have been thinking if there is any way to synthesize kratom alkaloids to make a more powerful "drug"?
I read somwhere scientists were making a replacement for opiate drugs using kratom
3 posts omitted. Click Reply to view.
Shitting Dunnercocke - Wed, 17 Jun 2015 22:14:32 EST ID:0FJPg3OJ No.76692 Ignore Report Quick Reply

Nobody has any chance of doing that without access to a full lab, chiral resolution techniques, it has 5 chiral centers FFS, 32 potential isomers, fuck that.

If you can synthesize that, you might as well just make a fuck ton of LSD or a synthetic opiate like a fentanyl derivative because you are a fucking amazing chemist and apparently, very well equipped for organic synthesis.

Its already synthesized for you in kratom, its much easier to design an extraction to isolate the active/actives from kratom than it is to synthesize kratom from serotonin.
Bombastus !!HToBa9dh - Thu, 18 Jun 2015 12:48:40 EST ID:qb2qUOr3 No.76695 Ignore Report Quick Reply
Hey! I was just offering a glimmer of help.

As I mentioned above: " It won't be buttfuck impossible! It'll just be incredibly hard." Eluding to its nature of still being incredibly hard.
Shitting Dunnercocke - Thu, 18 Jun 2015 17:19:18 EST ID:0FJPg3OJ No.76696 Ignore Report Quick Reply

Incredibly hard is realistically impossible in this case, lets be practical. We're talking kitchen chemistry not a full lab situation.
Hugh Fanwater - Thu, 16 Jul 2015 09:09:07 EST ID:WoOdvzFR No.76817 Ignore Report Quick Reply
total noob in this field but would an alkaloid extraction be possible with sodium carbonate/bicarbonate and a solvent like alcohol or acetone for fast evaporation?
Samuel Clodgetat - Thu, 16 Jul 2015 17:33:18 EST ID:mEgh7QsF No.76818 Ignore Report Quick Reply

7-hydroxymitragynine and mitragynine are both water soluble and likely soluble in ethanol aswell. you could try making "tea" with ethanol and evaporating it to yield some alkaloids.

i have literally zero experience with kratom though i could be wrong

Animal with endocrine system most similar to humans by Eliza Hicklegold - Wed, 15 Jul 2015 19:19:10 EST ID:AhXCC5C1 No.76813 Ignore Report Reply Quick Reply
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Doing a 4k report on addiciton, just need some confirmation so I can use certain sources

Is it white lab rats like my initial thought is, or is it something else. I know ferrets have a similar immune system to ours...
Thomas Doddleman - Wed, 15 Jul 2015 20:39:32 EST ID:pSzcCxpL No.76815 Ignore Report Quick Reply
Here's a journal article titled "Animal Models of Substance Abuse and Addiction: Implications for Science, Animal Welfare, and Society" to help you, and a relevant quote from the 5th-ish paragraph of the article.
>Although rodents are most often used in these studies, this model has been used with a variety of species including nonhuman primates, dogs, and cats.


LITERALLY THE FIRST GOOGLE RESULT FOR "addiction research animals". What the fuck, man? Seriously. What the fuck?
Walter Songerford - Wed, 15 Jul 2015 21:11:07 EST ID:AhXCC5C1 No.76816 Ignore Report Quick Reply
thankyou, thankyou, thankyou!

The report is on the human aspects of successful treatment in terms of subsequent relapse, so i hadn't geared my head to think about it in terms of organisms other than humans

I am sorry, it's been a long day and i'm pretty beat. I'll brain harder from here on

Color Differences in Dansylation by Shit Clandlestutch - Wed, 15 Jul 2015 16:16:23 EST ID:6U9qqpUA No.76808 Ignore Report Reply Quick Reply
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So, during my lab's standard dansylation protocol (for wheat, in this case) , I have found that the colors in each microtube vary. I don't know if this is because each tube contains a different genotype of wheat, or if the process isn't thorough enough to get the dansyl chloride mixed up in the tube to produce more yellow color. I don't know if that will have an effect on the results when I run the samples through HPLC at the end, but thought I'd ask.

Jobs in Biochemistry by Slippery Jim - Fri, 15 May 2015 11:17:42 EST ID:5rbJvqan No.76539 Ignore Report Reply Quick Reply
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Anyone know of any good job types in the biochemistry field that don't usually random drug test? Will they randomly drug test pharmaceutical reps? I like smoking weed on the weekends and don't want to work for Gattaca Corp.
7 posts omitted. Click Reply to view.
Jack Brerringspear - Wed, 01 Jul 2015 21:41:55 EST ID:Zi8GiUIa No.76752 Ignore Report Quick Reply
I'm temporarily working in a Plant Biochem and genetics research lab at my University. Not great pay, but good on a resume at least. No drug tests yet.
Fucking Dasslewock - Sun, 05 Jul 2015 00:32:05 EST ID:BF148c9+ No.76756 Ignore Report Quick Reply
This isn't related but since there's so many biochem majors in one place: I've only got the gen eds down for biochem. Should I keep going or switch to something like public health? I was going to switch to just biology but that's a b.a. at my university. I've heard not the greatest things about the field.

OP I've found most jobs don't piss test after the initial hiring, if they test at all.
Wesley Misslenidge - Sun, 05 Jul 2015 20:34:51 EST ID:roMD3xgx No.76759 Ignore Report Quick Reply

Biology is useless in comparison to biochemistry. The job markets for biology are much tougher for biology majors because biology is easier.

I don't know much about public health, but it sounds like a degree where you need to know people to break into the field. Not that you don't need to know people for chemistry, but the skillset in biochem is more versatile.

If I was going to advise you in things that are worthwhile in college, I would say go in the opposite direction; instead of doing something easier, challenge yourself and go into engineering. There's always jobs for engineers, and they generally have more influence on the world around them (if that's something your'e looking for).
Wesley Misslenidge - Sun, 05 Jul 2015 20:36:26 EST ID:roMD3xgx No.76760 Ignore Report Quick Reply

Oh yeah.

Source: Graduated with biochem degree, doing a mashup of physical chemistry and chemical engineering at the moment.
Eugene Fovingsud - Wed, 08 Jul 2015 14:28:35 EST ID:L5+Uc7hP No.76768 Ignore Report Quick Reply

There are a lot *more* biochemistry jobs, but you should work for the job you really want rather than what's most available or easiest. If you don't like biochem then why bust your ass for it? Don't be afraid to switch paths, especially if you're young. If the two share enough required classes you could maybe even major in both. Both are really cool fields imo.

psychedelic visuals by Jarvis Gidgewell - Wed, 01 Jul 2015 00:35:27 EST ID:s6fjKs0p No.76750 Ignore Report Reply Quick Reply
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why are these visuals similar to psychedelic visual?
Alice Crobberdock - Wed, 01 Jul 2015 09:55:07 EST ID:HlJC3ujQ No.76751 Ignore Report Quick Reply
Because Hell is real.
Just look at those fucking faces.
Doris Coddlebud - Fri, 03 Jul 2015 11:54:45 EST ID:pDka/jle No.76754 Ignore Report Quick Reply
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It recursively applies pattern-recognition to an image. Each step alters parts that look like a pattern to look *more* like a pattern. Psychedelics apparently do the same thing.
Bombastus !!HToBa9dh - Fri, 03 Jul 2015 18:31:04 EST ID:V1Ngvki3 No.76755 Ignore Report Quick Reply
Much how humans try to find faces in everything, facial detection software does pretty much the same thing inadvertantly. It's more because our idea of a face is so fucking simple that we can distil it down to two dots and a stroke( ie: " :| ").

It's not that there are inherent faces. Rather, we just find it everywhere.

//pss/ off

How to educate myself by Just some guy - Sun, 21 Jun 2015 19:19:42 EST ID:dvfeY7tm No.76704 Ignore Report Reply Quick Reply
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I'm looking to educate myself as much as possible in the way of chemistry, botany and biology in general.. where should I start in the way of learning material? Most courseware out there requires some prior knowledge, I'm looking to start out as basic as possible and work my way up to more intricate and detailed information.

Are there any good resources out there to help me out here? Pic unrelated
5 posts omitted. Click Reply to view.
Clara Claywater - Fri, 26 Jun 2015 00:00:15 EST ID:EPHXMC+Q No.76744 Ignore Report Quick Reply

Fuck Clayson - Sat, 27 Jun 2015 22:47:41 EST ID:uGD5aNS6 No.76746 Ignore Report Quick Reply
lol I do cell biology, study neurons specifically.

It's really not brute memorization as you say. My research as of late has been on neuronal cytoskeleton, so its mostly biochemistry and protein chemistry.

A lot of it is really abstract, like having to visualize these really arcane ideas and picturing what's actually happening in your head, coupled with understanding kinase pathways and the regulation thereof. Its like a super complex really cool puzzle and tweaking aspects of it can change the size and shape of an axon quite robustly. Kind of interesting IMO.
Bombastus !!HToBa9dh - Sun, 28 Jun 2015 10:34:30 EST ID:ElYFdcKO No.76747 Ignore Report Quick Reply
Oh no, research is fucking awesome. Culturing cells are really nice cus it's like Cookie Clicker - you set it up and see it exponentially grow. Centrifuging and protein coding is nice, too. I've always been interested in the AcChol-A biosynthesis routes that take plants 1 day to react with no chemicals at all besides simple air and carbon dioxide.
The labwork is all quite fun to fuck around with.

But I just didn't have the balls to do all those undergraduate courses. Damn biologists... Oh, u so cray cray. I appreciate it as a science. I abhorr how its taught.
Samuel Drungerford - Mon, 29 Jun 2015 22:51:33 EST ID:uGD5aNS6 No.76749 Ignore Report Quick Reply
>But I just didn't have the balls to do all those undergraduate courses.
lol yea I get that man. It gets convoluted so quickly.

Are you just a straight chemist? Because I have mad respect for chemists, I wish it was integrated more into our curiculum as biologists. In essense you can't really understand anything biological without some knowledge of chemistry and biochemistry.

I mean look at any disease that involves mismanaged protein (Alzheimer's comes to mind) and you are going to come across thermodynamics. I'm just glad I took some extra chem classes back in the day as electives.
Bombastus !!HToBa9dh - Thu, 02 Jul 2015 18:53:37 EST ID:V1Ngvki3 No.76753 Ignore Report Quick Reply
Most people wish there was less chemistry in their biology. we call those people jobless ;). Rly, doe. they're ecologists or so. Most other branches and the major paying ones are all in need of chemistry knowledge.

Good on you for wanting more chemistry. Fuck me on wanting more biology. To hell with that! I'm gonna go respond to your post on /pss/ now

(M)ethylphenidate by Rebecca Fubberdale - Wed, 06 Aug 2014 02:45:02 EST ID:KTpmMq3U No.75126 Ignore Report Reply Quick Reply
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What process turns ethylphenidate in to methylphenidate and why isn't it done more? I am not interested in doing so myself, but I was confused as to why I can't find info on this given that ethylphenidate is so cheap and methylphenidate is so expensive.
3 posts omitted. Click Reply to view.
Molly Deckleman - Wed, 06 Aug 2014 22:41:39 EST ID:oFx1SQoH No.75131 Ignore Report Quick Reply
The conversion should be really easy. The conversion between the two is a basic acid catalyzed Transesterification reaction.
You might only need methanol and sulfuric acid.
The basic procedure would be something like put ethylphenidate in methanol. Then add sulfuric acid. Heat it up for a few hours. Evaporate off all of the methanol. Then purify it through recrystallization with ethanol (this is a good way to wash off the methanol which is poisonous). The conversion wont be 100% but more like 95%. you could separate it via flash column if you really cared a lot.
Doris Noblingdat - Thu, 07 Aug 2014 03:40:18 EST ID:KTpmMq3U No.75133 Ignore Report Quick Reply
Thanks for the info, but I was interested in why people aren't turning ethylphenidate (Legal RC in EU) in to methylphenidate (prescription only, illegal without.)
Thanks, interesting and informative.
Wesley Dadgehadge - Fri, 08 Aug 2014 23:57:03 EST ID:uGD5aNS6 No.75135 Ignore Report Quick Reply
Could be just an availability of reactant. Maybe one reactant, used to make the methyl version, isn't available or tightly regulated, and the ethyl version is easier to get. Maybe its a legal grey area, as you said, and its a semi-legit business making it because its less controlled. And if someone catches on, less likely anything will happen to them, and they can just stop making it, and are good to go.

I know with the Analogue Laws in the US, they are regulated federally. Drug enforcement on a state level is carried out according to that state's laws. For instance, in my state of massachusetts, I think there are quite a few of the 2C-x compounds, possibly even 2C-B, that are not regulated by state law, so technically you couldn't get arrested for their possession, or at least not charged in court. Unless of course they turn it over to a federal prosecuter.
Reuben - Thu, 25 Jun 2015 15:01:01 EST ID:6nQxvw77 No.76739 Ignore Report Quick Reply
I probably wouldn't touch this one, but I can tell you want to make it work.

Focus on propelling the methyl group into an amino-base or something chemistry-like.
Bombastus !!HToBa9dh - Thu, 25 Jun 2015 17:58:43 EST ID:vbS8CtHn No.76742 Ignore Report Quick Reply
It's quite readily available. Just buy an aspirin synthesis kit on ebay or Amazon.

Also, my current thought is that you'd have to demethylate it and then ethylate it. That's a pain the the ass. It's also not worth it cus ethylphenidate is so much smoother and relaxing than fucking SODAPOPANDRITALIN

Science books by Matilda Chuvingridge - Wed, 24 Jun 2015 17:14:13 EST ID:EALu1k1z No.76727 Ignore Report Reply Quick Reply
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I'm going back to college to get my gcse in the 3 sciences so I can go on to do an access course then onto uni.
Do you people know of any good books to buy to learn from ?(I know there are plenty of sites but I want proper books)
Bombastus !!HToBa9dh - Sun, 28 Jun 2015 15:34:41 EST ID:ElYFdcKO No.76748 Ignore Report Quick Reply
There's a thread that's really similar to this one. So I'm gonna nb and quote it here:


Strange Geographic Coincidences by CrazyFolksTribe !loJSOMZg0g - Fri, 19 Jun 2015 00:15:18 EST ID:lFbLB9LK No.76697 Ignore Report Reply Quick Reply
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>Science & Chemistry
(and chemistry)

How about a post related to earth science? Any geography, geology, or maybe even meteorology nerds here?

I love looking at map after map and finding strange and probably unrelated similarities between them. Pic related is my most recent finding. I took a bedrock map of Indiana, then overlaid a map of Indiana's average wind speeds. Strangely, the area with the highest wind speeds is right on top of the Kentland crater, a small bedrock discontinuity near the western border. Isn't that amazing? America's largest wind farm east of the Mississippi is only like 12 miles away from America's second-largest impact crater east of the Mississippi.

Here are the two original maps:

I've also noticed that Serpent Mound, a snake-shaped Indian earthwork in southern Ohio, is right inside of a different crater. I didn't bother to overlay any maps; you can look that one up for yourself.

What are some strange coincidences you've found in maps? Political, physical, or both?
Jessy☥ !7hqGpmbsrA!!booSESQR - Fri, 19 Jun 2015 01:26:31 EST ID:2kmedaK6 No.76698 Ignore Report Quick Reply
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crazy shit dude but pretty interesting
Nathaniel Gibblestock - Sat, 20 Jun 2015 11:37:22 EST ID:uGD5aNS6 No.76700 Ignore Report Quick Reply
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I can't really cite an strange coincidences, however I do also love looking at maps.

However I am really into the cultural aspect of geography. The movement and migration of cultures across distances. This includes languages as well as physical peoples.

Pic related, its a map of the distribution of Indo-European languages, specifically something known as the Centum-Satem igloss. A pronunciation thing without getting too into the details, but I find it fascinating that there is this 1 language all the way in Western China that is more similarly related to, say, Celtic or Western European language than neighboring languages (known as Tocharian). I really find that fucking crazy.

Also there are so many dead languages or branches of language trees. Its really cool to trace them back to their originators. Or to look at still extant languages that are very small, like Provencal in France, or Ladin in Italy. Even in Spain, where you would think they speak only Spanish, you have Catalan, which is more similar to French than Spanish, though it is still distinct from both. Its very interesting to study the deviation of the languages, how they came about, and why the distinctions exist

I think I got into all this because of the Turkish people. You have Turkey, in Western Asia, then all of the Turkish nations in Centeral Asia, and then Turkish peoples in Western Chinese deserts. Their distribution is crazy, their culture is very interesting. And if I am not mistaken they share heritage with the Mongolians, which is cool too.
CrazyFolksTribe !loJSOMZg0g - Mon, 22 Jun 2015 22:56:32 EST ID:zjy7AzWg No.76707 Ignore Report Quick Reply
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Wow. I enjoy some language and culture maps too; I can't believe I've never taken note of this whole Tocharian shindig! Very intriguing. Time to delve into some research on ancient Indo-European languages.
Edward Gorrysene - Mon, 22 Jun 2015 23:27:40 EST ID:uGD5aNS6 No.76708 Ignore Report Quick Reply
Word I'm glad you found all that intersting.
I forgot to mention too I like the spread of religions. That same area they found the Tocharian language, if I am not mistake they used to find ancient Christain churches there from the Asiatic branch of Christianity. I'm not religious anymore but I find the history fascinating.

Same with the spread of other religions too, and with it different cultures, like Manichaeism. Actually you can't really look into that area without understanding the constant spread of religions in that region. Zoroastrianism is really cool too. Too bad the spread of Islam fucked up all up. But its cool that pockets of those old relgions still exist, like the Parsi in India.

None-the-less I won't ramble but just some of my favorite aspects of geography.

Freebasing issues by 3-MeO - Mon, 15 Jun 2015 05:04:11 EST ID:Tgx3HWSu No.76683 Ignore Report Reply Quick Reply
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I tried to make some ethylphenidate freebase by dissolving it in water and adding diluted ammonia one drop at a time, stirring in between drops, until no more precipitate formed.
Then added naptha and mixed well for about a minute, after separation I washed the naptha once with water. After separation and evaporation my dish was empty, no freebase.

I'm fairly certain I didn't mess up the procedure, as I do a similar method for getting DXM occasionally.

Also I used a pretty small amount, about 100mg, so that could be a factor.

Is it possible that the substance is insoluble in naptha?
Green Fox - Tue, 16 Jun 2015 18:01:54 EST ID:0YyKnwjY No.76688 Ignore Report Quick Reply
It's in your aqueous phase/wash.
3-MeO - Wed, 17 Jun 2015 11:20:12 EST ID:gaSgaZYo No.76689 Ignore Report Quick Reply

Well that's pretty obvious, but I want to know why it didn't dissolve in the solvent.
David Pizzlesetch - Thu, 18 Jun 2015 06:27:08 EST ID:+0Ci6TLP No.76693 Ignore Report Quick Reply
Because you used a nonpolar solvent to try and extract a polar molecule.
Shit Nammlemudge - Thu, 18 Jun 2015 10:20:18 EST ID:mEgh7QsF No.76694 Ignore Report Quick Reply

ding ding.

use dichloromethane or chloroform
Rebecca Fimmergold - Fri, 19 Jun 2015 04:02:55 EST ID:0YyKnwjY No.76699 Ignore Report Quick Reply
It probably was soluble in naptha to some degree, but also in water to some degree. (ie an unfavourable partition coefficient). Doing multiple extractions will solve this. I wouldn't do the water wash at the end either.

Thebacon synthesis by Sophie Pobbleville - Wed, 10 Jun 2015 11:41:42 EST ID:+LtBugrK No.76649 Ignore Report Reply Quick Reply
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hey guise i found this synthesis online which claims to be copied from a user here. i will copypasta it and give the link later if interested. from my 3 years of undergrad chemistry i see no reason why this shouldnt work.

acid catalyzed acetylation of codeine's phenolic hydroxyl group (which is in the most reactive position meaning this synth should hopefully be fairly good at making high purity thebacon?) followed by allylic rearrangement (catalyzed by acid) of codeines double bond to give thebacon.

here it is, starting with codeine freebase:

A good chemist friend of mine has figured out how to make Thebacon out of Codeine. Thebacon is an opioid made normally from thebaine and has the same properties and equivilants as hydrocodone. Very nice and easy to make.

Copied over from my friend's post on 420chan:
I turned 0.32g of codeine (32mg morphine equivilants) to 0.32g of thebacon (0.480g morphine equivilant). This is around a 15x efficiency boost.
Thebacon feels almost identical to hydrocodone but it can be smoked. Smoking 1mg gets you high as fck.
>Prepare a small vial or test tube - or anything that holds maximum 10ml and very thin.
>Take 0.3g of codeine (1mmol) and add to it 0.2ml of Glacial Acetic Acid.
>Add two drops of Concentrated Sulphuric Acid
>Add enough water to completely dissolve (under 1ml)
Comment too long. Click here to view the full text.
13 posts and 1 images omitted. Click Reply to view.
Henry Draddleled - Thu, 11 Jun 2015 19:10:04 EST ID:+LtBugrK No.76670 Ignore Report Quick Reply

the hydrogenation ive figured out. already have a tupperware container thatll be perfect, duct taped around all the sides rather tight and a small hole/plug in the top to open when it gets too high.. im worried about not being able to know when its too high, where did u buy your septum?

about the isopropoxide.. if i used dessicated my aluminum and heated my rb flask and condenser up to like 60 celcius and dried my isopropyl with sodium sulfate then dessicated my al ipro3 product you think it would be anhydrous enough?

i have sodium dichromate but im not sure of the efficiency of the oxidation, not very high as i gather. im probably going to make al ipro3 if this thebacon synth doesnt work. already getting sulfuric and a reflux set ordered i have everything else already. ill be trying this next week and if it doesnt produce a potent opi in good yield i'll make some al ipro3 and order some pd/c and cyclohexanone. i assume you just use toluene instead of DCM due to toxicity reasons? I would imagine using the dcm/ketone solution for the next step instead of using toluene.. you use ground up aluminum foil for the aluminum, right?

if you have a steam profile id rather we talk through there, much easier to convey ideas through and IM platform. i know its allowed to share steam acc's here too

greatly appreciated
Bombastus !!HToBa9dh - Thu, 11 Jun 2015 20:23:09 EST ID:gQChGmm1 No.76671 Ignore Report Quick Reply
I made one by wedging a needle into the tupperware container. You might be getting the wrong tupperware if you're needing to tape it. It should be the one with the rubber lining and the 4 locking clasps on each side. Wedge a sewing needle in the rubber to allow some airflow or whatever.
But now that I think about it, you can just leave one clamp unclamped.

Put al bits in a blender and grind them up. Toss them in the flask, put the condenser and air valve in, and heat everything with a propane welding torch. You'll see the vapour column rise. Then set up the CaCl2 drying tube (chloride aailable at pool stores for $10 for 1 kg. Bake that for 1h in an oven) and blow dry air into it.
Take store-bought isopropyl alcohol and set up a vacuum filtration flask with the CaCl2 filled to the top of the funnel. Run it dry for 30 seconds then start pouring the isopropyl alcohol through the layer of CaCl2. Toss out the first 50ml of filtered stuff and filter again (1g/ 2ml just to make sure). You're now set to react away.
I've switched to gallium metal instead of Mercury now, by the way. and of course, magnesium sulfate, sodium hydroxide, etc can all replace Calcium Chloride as a dessicating agent. Calcium Oxide is another cheap option and one of my favourites.

Dichromate for steroid and alkaloid oxidation is highly advised against due to the chromic acid salts it makes. I wouldn't attempt it. Regarding oxidation, it is very strong and can rip the methyl group off the amine and even cleave the ether bridge. It's the quickest method to oxidise the opi AND attach the OH on the 14 position but it is not good due to it being toxic in small quantities and being too reactive.

I can dry toluene with sodium metal. Makes my life easier. Original synthesis calls for benzene. Fuck that.
I used 200mesh al dust. Very fine and shortens reaction time. You may need to reflux for 24h if you're using blender ground Al foil.

It's smarter to keep it here, personally. I'm still waiting for Green Fox to come into this discussion and give us his take on it :).
He may have some extra advice to give. If not, I hope a few onlookers may be interested in these reactions.
Caroline Fonnerstock - Thu, 11 Jun 2015 20:38:24 EST ID:+LtBugrK No.76672 Ignore Report Quick Reply

i appreciate that technique of drying the isopropyl through one of my (i have 500ml and 1000ml) filter flasks with the buchner full of mgso4. perfect, i was just gonna dry it classically by putting 80-100g of mgso4 then decanting the dry isopropyl. this idea is better.

how expensive is the gallium compound that youve substituted? and youve tried it personally?

my question is how efficient (in your opinion) would the isopropoxide synthesis be if i had no drying tube, and used a single neck rb flask and liebig condenser that were dried, all dessicated and dried reagents just no drying tube?

I would still run a simple distillation to purify it; using sand bath to get to 130 then drying the product under vacuum. i had an interesting idea about this:

create a filter paper capsule with the al-ipro3 and place it inside the filter flask with drying agent in the funnel and dry the product that way, creating a partial vacuum of -500mmhg or so and letting it dry for an hour or two to ensure an anhydrous product for the next step?
Caroline Fonnerstock - Thu, 11 Jun 2015 20:43:58 EST ID:+LtBugrK No.76673 Ignore Report Quick Reply

why not dry toluene with conventional drying agent instead of sodium?
Bombastus !!HToBa9dh - Sat, 13 Jun 2015 15:32:49 EST ID:4ppVjZXo No.76682 Ignore Report Quick Reply
I just use gallium metal I got off ebay. I had it around and it's safer. Remember that gallium forms the amalgam by itself and so does mercury. But they use mercury salts so that it is soluble and able to extract out easier than mercury metal.

Dry it all using a welding torch and it should be fine.

Use vacuum distilation with no condenser. Just use the 3 joint tube attached to the vacuum adapter with the two flasks then hook the vacuum up. You don't HAVE to purify it either. You can just go ahead and put a huge excess of isopropoxide into the reaction vessel. Just make sure you filter out the Al pieces and then evaporate the isopropanol over vacuum. The isopropanol will get oxidised if you put it in the reaction vessel with the cody.

It should be anhydrous anyway. Just make sure you get rid of the alcohol.

Toluene drying with sodium is fun. don't judge me.

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