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Substituting Tryptamines by Fiend !!1C9jE+w+ - Sat, 26 Sep 2015 02:19:51 EST ID:SPL8SH61 No.77200 Ignore Report Reply Quick Reply
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So precipitated by Bombastus I've decided to actually use my brain and time on handling drugs as opposed to just procuring them. I haven't been to school in years and I don't know anything practical about chemistry, just the names of lots of functional groups, not how they work. Anyway, that's just disclaimer.

What I want to talk about is tryptamines, and substituting therein. It was mentioned over in /psy/ that there's a way to convert DMT to 4-HO-DMT. As well as talk of changing 4-subs, to get things like 4-Bromo-DMT and 4-Vinyl-DMT.

I'm not exactly sure what my question is. I think it's a better idea for me to put this thread here and just read what more educated people say to each other. I guess what I want to hear is about how difficult it would be to change substitutions on existing tryptamine material.

Obviously it depends, but since I have no idea what I'm talking about, some examples I'm wondering about:
DMT > another unsubbed tryp, like DPT or MET. What would be entailed?
DMT > 4-HO-DMT or vis versa? I need to get up the gumption to extract DMT anyway; could I convert from there? I suppose that's gotta be easier that extracting alkaloids from mushrooms, separating 4-PO-DMT, from 4-PO-NMT, and modifying from there?
What about 4-AcO-DMT into either 4-HO-DMT or DMT? Working from there could answer a lot of questions about the nature of the 4-AcO-tryps as prodrugs. Also as Bombastus suggested that would make mail order psilocin a possibility.

Anyway, talk. I will do my best to keep up and ask not stupid questions.
25 posts and 4 images omitted. Click Reply to view.
>>
Fiend !!1C9jE+w+ - Sun, 25 Oct 2015 21:53:30 EST ID:dnZGP2Dj No.77326 Ignore Report Quick Reply
>>77325
I was actually agreeing with you about it not being worth it, despite what you know (accurately) about my 4-sub-MET preference. I guess I phrased it unclearly.

And what do you mean where did I get DPT? Internet. Duh. I had 4-AcO-DPT for a while too, but I didn't get a real sense for it the 2 times I did it. I'd love to have another go at it. Plus DPT is kind of a bitch to dose. I don't intend on touching it again until I either perfect IV technique, or decide to freebase it (which I should really do to gain some confidence about kitchen chemistry);
>>
Ebenezer Fisslewodging - Tue, 27 Oct 2015 16:58:07 EST ID:4AZAqA2e No.77331 Ignore Report Quick Reply
>>77325
DPT has been fairly common in the RC scene for the last few years, Sir
>>
Bombastus !!HToBa9dh - Wed, 28 Oct 2015 16:39:30 EST ID:ElYFdcKO No.77333 Ignore Report Quick Reply
>>77331
I've only gotten into the alkyl substituted substances only a few days ago. I took 4-AcO-DET which is the first non-DMT substance I've ever tried. DPT is something to look at for sure, then.
But I think all creations can and should be done with DET instead of DMT considering the stability and relative similarities to DMT molecules.

>>77326
Why is DPT hard to dose? Can't you just eat it?
>>
Fiend !!1C9jE+w+ - Wed, 28 Oct 2015 21:54:39 EST ID:dnZGP2Dj No.77335 Ignore Report Quick Reply
>>77333
Eating it is a massive waste of material, and snorting it is vile beyond anything. Plugging it was far less effective than snorting, also a waste of my money, and injecting it is problematic since it is not wonderfully soluble in water. IM was by far the best route, I just was using several of the 1ml insulin syringes that are easily accesible in US pharmacies.
>>
Beatrice Fanford - Tue, 03 Nov 2015 11:21:50 EST ID:Ja2fAPPl No.77350 Ignore Report Quick Reply
>>77333
>Why is DPT hard to dose? Can't you just eat it?

>Although it was mentioned in TIHKAL that DPT is orally active, we found this route to be quite unpredictable when taking it without an MAOI. Recent reports indicate that propyl-huasca works very well using the standard amount of MAOI combined with 75-150 mg of DPT.


anything relevant to comp sci by Martin Commlechitch - Tue, 05 Jan 2016 01:43:01 EST ID:63B22mtZ No.77501 Ignore Report Reply Quick Reply
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im currently studying comp engineering/ comp sci, and am doin fairly well, but i feel like 95% of my program is more focused on comp sci and coding and we are never really learning about actually engineering.
what i'm wondering is, what other fields of science (or any other subject) do you guys think are important for someone in my field to have a decent understanding of? also, what are good resources to check out for staying up to date with whatever you recommend / good starting points? any subcirclejerks, news sources, podcasts, anything that's a good resource for learning i'm most interested in graphics programming as well as anything audio related, sound manipulation, etc. but really any recommendations are appreciated
thanks in advance!
>>
A Wizard - Wed, 13 Jan 2016 03:52:59 EST ID:U/pEBCij No.77519 Ignore Report Quick Reply
>>77501

Study the teachings of Pythagoras. They pretty much fill all of your interests. There's as much about harmonics as there is about geometry.
>>
Vehk !7HYGxe5v5c - Sun, 17 Jan 2016 15:54:37 EST ID:uxs5rJ20 No.77531 Ignore Report Quick Reply
>>77519

Whenever I read your posts, I pretend that you are David Brent from the UK Office and read them in his voice.
>>
Vehk !7HYGxe5v5c - Sun, 17 Jan 2016 16:01:30 EST ID:uxs5rJ20 No.77532 Ignore Report Quick Reply
https://www.youtube.com/watch?v=CW20AQJ6Iig


Pharmaceutical Chemistry by Fucking Huddleford - Thu, 03 Dec 2015 17:49:54 EST ID:dhY+6e5d No.77401 Ignore Report Reply Quick Reply
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Are any of you guys pharmaceutical chemists? I want to go to college for it, but Im curious what your guy's work day is like and also what to expect from college, and what classes I'll have to take.
2 posts omitted. Click Reply to view.
>>
Molly Fudgetat - Sun, 06 Dec 2015 21:14:42 EST ID:Dqu7ojT7 No.77411 Ignore Report Quick Reply
>>77407

This is a question for an adviser. or just go look at the course catalog of a university you are interested in.
>>
Thomas Gickleforth - Fri, 01 Jan 2016 23:45:56 EST ID:3nQ8foZE No.77487 Ignore Report Quick Reply
>>77407
I got my degree in Bio Chem simply because the Chem major at my school required liner algebra as a co-rec for quantum chemistry...
>>
Thomas Gickleforth - Fri, 01 Jan 2016 23:47:40 EST ID:3nQ8foZE No.77488 Ignore Report Quick Reply
>>77487
my bad, linear algebra
>>
Phyllis Bosslehag - Sat, 02 Jan 2016 20:13:45 EST ID:0LQJvC/t No.77491 Ignore Report Quick Reply
Its fucking hard.
Theres a lot of math and physics based math and constant algebra.

Also pharmacology and medicinal chemistry are pretty much exclusively graduate level.

So you would likely be getting a chemistry degree and then sitting on your ass unless you plan on going to grad school.
>>
Vehk !7HYGxe5v5c - Thu, 14 Jan 2016 17:56:02 EST ID:0kilcEvV No.77522 Ignore Report Quick Reply
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>>77491

One of the big boys of English-speaking pharmaceutical academia here tbh

> Theres a lot of math and physics based math and constant algebra.

> Theres a lot of math

Pre-calc, Calc I and II, and eventually statistics/bioinformatics. Learning new maths will probably make up less than a fifth of what you spend your time on, though you will use basic maths for almost everything you're working with.

> physics based maths

Literally understanding vectors, electromagnetism and other mostly linguistic or spatial concepts with a few formulas to plug numbers into/transpose mixed in.

> constant algebra
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Ideas for senior project by Nigger Drondleshit - Sun, 27 Sep 2015 07:11:37 EST ID:D6W9PxnV No.77204 Ignore Report Reply Quick Reply
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I'm planning to take a senior course on cancer research and do some benign project on cancer as my thesis.

I'm either going to expose cells to carcinogens and see of ways to prevent this, or basically use cancerous cells and see what can inhibit or affect cancer growth with some run-of-the-mill cancer drug unless something interesting is suggested. My uni can get me pretty much anything I want.

Thoughts? I don't want it to be a simple experiment since I'm seriously considering going into the field later and need something that will give me good insight. Signal transduction inhibitors, certain protein overexpression or underexpression, binding to certain proteins that are transported to the plasma membrane?

Anybody have experience with this?
5 posts and 1 images omitted. Click Reply to view.
>>
David Bumblelock - Sat, 10 Oct 2015 09:13:33 EST ID:cM6rhCgJ No.77274 Ignore Report Quick Reply
>>77245

I know it's been done to death, but have you thought about using CBD and studying the growth rate of the cancerous cells?

For a while I've believed that a localized injection of CBD could cure cancer.
>>
A Wizard - Tue, 13 Oct 2015 14:08:04 EST ID:PtGx5SYm No.77285 Ignore Report Quick Reply
>>77274

You could just coat your nanomolecular gold particles with the CBD and watch them have affinity for the cancer cells on their own. Also, the cbd penetrates cell walls then, very effectively xD
>>
Shitting Grimville - Sun, 18 Oct 2015 13:28:55 EST ID:uGD5aNS6 No.77309 Ignore Report Quick Reply
>>77245
Thanks man. It wasn't a huge impact factor journal because it was just a small manuscript. Not a bad journal but not a great one either.

As for how I picked that protein, well its a critical protein to axonogensis and neurodifferentiation. I did some basic experiments characterizing the effect, made some claims (hypothesizes) about why it was happening, then did mutagenesis on it, as well as used kinase inhibitors to block phosphorylation of the protein. So the original protein and base experiment was given to me and I ran with it. Was solid at the end though.

That is cool that you are working with astrocytoma, astrocytes being something that I am quite familiar with. Best way to figure out a target is to read papers, and when you get a good idea of the landscape as to what is known, start writing down questions.
If you can find the answer to that question somewhere, cross it off. If search generates no leads, keep it as a possible avenue. But don't go for the thing with nothing known about it right off the bat. Too risky, its a total gamble and you don't want to waste 6 months only to find out your research is fruitless. Save that for a Phd student who has that kind of time. Start with something that may have been confirmed to have a role but it is not entirely characterized, and think of ways to design experiments to further characterize its role. Have a list of them and try a bunch, because more than a few will not work for specific reasons and nuances related to that protein.

That make sense?
>>
Betsy Baffingmat - Wed, 06 Jan 2016 20:02:53 EST ID:9qBRUbDq No.77505 Ignore Report Quick Reply
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You could do an experiment where you treat cells with sulforaphane (a plant extract with histone deacetylase inhibitor activity) in the presence or absence of a methyl donor (like vitamin B12 or SAM) that could push the system in one direction or the other by adding extra substrate for changes in DNA methylation. http://www.ncbi.nlm.nih.gov/pubmed/26703571
>>
Lydia Febblechan - Sat, 09 Jan 2016 14:16:51 EST ID:FHFwCltH No.77512 Ignore Report Quick Reply
>>77505
That's a pretty solid idea. Not too complicated, just need to make sure he orders folate/B12 and SAMe deficient media so he can control the dose.


a "sandwich" filled with FUSION by A Wizard - Thu, 07 Jan 2016 00:45:39 EST ID:t9woUZlS No.77506 Locked Ignore Report Reply Quick Reply
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>A sandwich is a food item consisting of one or more types of food, such as vegetables, sliced cheese or meat, placed on or between slices of bread, or more generally any dish wherein two or more pieces of bread serve as a container or wrapper for some other food.[1][2][3] The sandwich was originally a portable food item or finger food which began to be popular in the Western World. Today sandwiches in various versions are found worldwide.

>Sandwiches are a popular type of lunch food, taken to work, school, or picnics to be eaten as part of a packed lunch. The bread can be used plain, or it can be coated with one or more condiments such as mayonnaise or mustard to enhance the flavours and texture. As well as being homemade, sandwiches are also widely sold in restaurants and cafes, and are sometimes served hot as well as cold.[4][5] There are both savoury sandwiches, such as deli meat sandwiches, and sweet sandwiches, such as a peanut butter and jelly sandwich.

>The sandwich is considered to be the namesake of John Montagu, 4th Earl of Sandwich, because of the claim that he was the eponymous inventor of this food combination.[6][7] The Wall Street Journal has described it as Britain's "biggest contribution to gastronomy".[8]

lets bio enginer a sandwich?
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Light by Cedric Tillingstone - Fri, 26 Dec 2014 02:34:37 EST ID:5BjIx1Ou No.75944 Ignore Report Reply Quick Reply
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Is it visible without anything to reflect off of and if you cannot see the source of it? I'm in a room lit only by the computer monitor, waiting for someone by my open window at night and the thought just randomly occurred to me and I thought I'd hear your guys' thoughts on the subject.
3 posts omitted. Click Reply to view.
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Rebecca Shakelock - Fri, 14 Aug 2015 02:55:12 EST ID:NkX3onth No.76913 Ignore Report Quick Reply
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>Literally thinking about this very topic today
>Through a series of events visit 420chan in the first time in years
>Hit random thread button
>End up here


Ohhhh mmmaaaaaaaaaaaaannnnnn
>>
Bombastus !!HToBa9dh - Sat, 15 Aug 2015 18:05:16 EST ID:V1Ngvki3 No.76916 Ignore Report Quick Reply
>>75944
light bounces off a lot of shit: walls, cloth, air, etc. the last one not so much but try the experiment at home.
go to a windowless room, turn the light off and just practice with a small, dim fleashlight
>>
Hedda Fanforth - Sun, 13 Dec 2015 16:31:39 EST ID:YHmno3wJ No.77430 Ignore Report Quick Reply
>>76913

even if you could violate the laws of physics to do this you would still need to do it in an environment free from gravity and close off the sides to prevent erratic protons escaping and the mirror would have to be a perfectly smooth surface of quarks gluons or some other subatomic particle and even still entropy would eventually cause the protons to just slow down oh god why am i even bothering
>>
Angus Novingstone - Sun, 13 Dec 2015 16:35:02 EST ID:u8+Bwmjx No.77431 Ignore Report Quick Reply
>>76913
or just ya know, use a half reflective plate that way some light passes through anyway
>>
Molly Sabbercocke - Sat, 02 Jan 2016 18:31:11 EST ID:5xtVf077 No.77490 Ignore Report Quick Reply
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>>76913
Not so fast!
This isn't completely wrong.
If you could build a box out of PERFECT mirrors
and
If you could keep the mirrored box from losing ANY energy over time...
then following troll's procedure would result in
the input light bouncing around ~forever
However, you could never use the light for anything for anything or observe it, since doing so would consume the meager amount of energy stored by the endlessly reflecting photons.
There is an electromagnetic component to this as well, but I'm pretty sure that a PERFECT mirror keeps reflected radiation from losing energy due to electric or magnetic forces.
Given, perfect mirrors don't exist, and likely never will... however with really fucking good mirrors you could get the light to hang around for longer.
Cooling the entire setup to nutsack shattering levels would help with duration as well.


4-aco in water by Nigger Berryshit - Mon, 21 Dec 2015 21:50:10 EST ID:ZSDfWEkg No.77454 Ignore Report Reply Quick Reply
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Usually I put some in a small glass of water and drink it so I was wondering: if I dumped some in a water bottle would it be as potent a few hours/days later? I'm sorry if that sounds like a stupid question, but i dont know much about chemistry and i don't really feel like wasting some to test it out.
7 posts and 1 images omitted. Click Reply to view.
>>
Whitey Daffingfut - Thu, 24 Dec 2015 12:14:15 EST ID:3uFtL7cp No.77465 Ignore Report Quick Reply
Esters, like 4-aco tend to degrade when exposed to water, though the effect is larger at higher temperatures. Also it'd just degrade into psylocin, but that is pretty unstable in solution, and would probably oxidize. I'd agree with Simon and Bombastus on this one and say it was prolly a bad idea.
>>
Molly Blupperstock - Thu, 24 Dec 2015 13:46:41 EST ID:Iko+aZ/1 No.77466 Ignore Report Quick Reply
>>77465
Is this something that happens right away, or does it take sometime? I have never kept 4-AcO in water, I was just wondering what would happen if I did. Usually it only stays in water for a couple seconds before I chug it down.
>>
Edwin Brittinghall - Fri, 25 Dec 2015 00:03:28 EST ID:LB+wr31L No.77468 Ignore Report Quick Reply
>>77463
Just because it exists in nature doesn't make the stuff you order online organic. Isn't it lab-synthesized from other things?! Or is it really just purified/concentrated.
>>
Bombastus !lnkYxlAbaw - Sat, 26 Dec 2015 15:49:17 EST ID:LuHWyaDS No.77472 Ignore Report Quick Reply
>>77468
Exactly. There's a big difference between "synthetic", "organic", "natural", and all these other buzzwords.
The labelling of these substances with these words and drawing conclusions from the labels is not only meaningless, but it is harmful to any line of communication we draw.
>>
press !QUHukXEvkY - Mon, 18 Jan 2016 12:40:11 EST ID:trptNJfh No.77539 Ignore Report Quick Reply
>>77472
that whole area of semantics is so highly infected with ideology when it comes to their common usage that it seems futile to discuss them since everybody involved in science knows how to use them correctly

and fuck whatever they call organic agriculture. that shit is whack, mostly because none of those hippie ass pansies care to mention peak phosphorous or the eutrophisation. nb because im drunk and offtopic


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