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Ephedra extraction questions/theories by Doris Smalldock - Tue, 14 Oct 2014 04:36:19 EST ID:Tt6L9SsJ No.75535 Ignore Report Reply Quick Reply
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what's up my fellow backyard /chem/ist's?
i've come here today to hunt out some help with an ephedra sinica extraction i'm trying to carry out at the moment. i've searched through all the hive/vespiarys forum articles on the topic and i'm still left with quite a few questions.

i've tried steam distilling the powdered plant matter by slowly basing 100g matter in 700ml dh20 in a 2l rbf until it looks like used motor oil and produces a disgusting basey/fishy smell.
from there i heated the mantle to about 105 celsius and bubbled steam into it from a 1l erlenmeyer sitting on a gas cooker and super heated by applying a butane torches flame to the steam-in tube.
from there the steam travels through a sloping splash head, a liebig condenser and finally into the distillate flask where i ph to 6 and evap.

i've found one write up which says i should have acidified and boiled the plant matter for an hour before straining and drying the plant matter and then basing it and continuing on with the distill.

also, does anyone have any history of performing an a/b extraction on ephedra because from what i've read it seems pretty hit and miss.

cheers guys, pic related
>>
Fanny Gerringletch - Tue, 14 Oct 2014 11:07:51 EST ID:cM6rhCgJ No.75536 Ignore Report Quick Reply
>>75535

I'm assuming you're looking for the pseudo and reg ephedrine.

The chem has a mp of around 190 C so good luck trying to distill it.

Acid base would prolly be best but I would start with basic conditions rather than acidic, seems more likely to deprotonate w/ ease than accept protons.


D-Amphetamine Sulfate. Extraction advice needed. by William Brookshaw - Fri, 10 Oct 2014 20:01:03 EST ID:I9cfdn/g No.75525 Ignore Report Reply Quick Reply
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Hey /chem/

A friend of mine is currently has 100x 5mg D-Amphetamine tablets, equaling 500mg of D-Amphetamine.

He's interested in performing an extraction so that he isn't insufflating unnecessary binders/fillers.

He has looked through multiple forums and can't find any reliable information on extraction techniques.

I'll attach photo of the inactive ingredients contained in this brand of D-Amphetamine pills, along with some vague information on solubility.

Any help at all on this subject would be appreciated.
>>
Wesley Dinkinbury - Sat, 11 Oct 2014 21:39:36 EST ID:AO540LvA No.75528 Ignore Report Quick Reply
You can pretty easily reduce the amount of binders and fillers you'll be snorting, but completely eliminating them would be tougher, and I don't have an idea for how to do that.

Assuming that "alcohol 95%" refers to a solution of 95% ethanol and 5% water (which seems likely), here is my suggestion:

Get some 95% ethanol, I'd recommend something food grade like grain alcohol (Everclear for example), but you could probably get away with using rubbing alcohol; just make sure it is ethyl alcohol and not isopropyl alcohol. If you do use rubbing alcohol, you WILL be left with bitterants in your extract that will make the drip taste way worse than it would otherwise.

If you crush up the tablets and then add ethanol (lets say 5mL per tablet, ~1:1000 to ensure you dissolve ALL the amphetamine sulfate) the powder, that will dissolve the amphetamine sulfate and probably the povidone but should leave behind most of the lactose, starch, and magnesium stearate.

Then you take your ethanol/crushed tablet mixture and filter it with something like a coffee filter, and then pour the liquid into a shallow container and allow it to evaporate. Keep in mind that 95% ethanol is very flammable, so be VERY careful if you are going to use heat to speed evaporation (no open flames, don't use an oven etc).
You should be left with powder consisting of amphetamine sulfate and povidone along with some small amounts of lactose/starch, which you can then scrape up and collect.

DEFINITELY READ THIS PART, IT IS SUPER IMPORTANT:
However, there is one MAJOR ISSUE with this plan: dosing. Currently, you know that each tablet contains 5mg of amphetamine. After you extract the amphetamine, you'll have a pile of powder that contains 5 x (the number of tablets used) milligrams of amphetamine. Unless you are comfortable eyeballing your dose using powder of unknown purity (which sounds like a good way to overdose, but I have very little experience with stims so I could be wrong) you will need a very accurate scale to measure your doses. Even then, you're still going to have some binders/etc left over, so the actual dose will be some unknown amount less than the measured weight of the powder.
>>
Green Fox - Sat, 11 Oct 2014 23:51:45 EST ID:7W8QTC+A No.75529 Ignore Report Quick Reply
I would just extract into straight water, see where that gets you.


Cation Stabilization by Nathaniel Beblingback - Tue, 07 Oct 2014 05:11:05 EST ID:V5qF06Hs No.75493 Ignore Report Reply Quick Reply
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'magnesium stabilizes the DNA backbone.' but what exactly is it doing?

it just floats there near negative charges, but never actually forms any bonds? why does simply having a cation around stabilize anything? is this some kind of magnetic attraction, or is there some weird quantum shit going on with the unpaired electrons on oxygen, or what?
6 posts and 2 images omitted. Click Reply to view.
>>
Walter Blatherhood - Wed, 08 Oct 2014 10:51:31 EST ID:GpkW+XRF No.75510 Ignore Report Quick Reply
>>75498
Christ, dude. Sorry. OP's pic threw me. Who the hell drops formal charges when showing coulombic interaction? Fucking biologists.
>>
Charlotte Charryham - Wed, 08 Oct 2014 21:52:54 EST ID:uGD5aNS6 No.75513 Ignore Report Quick Reply
>>75510
Woah woah, easy now, don't let a few rotten apples spoil the bunch. My biochem background is extensive enough to realize that OP's pic is confusing and rediculous
>>
William Pickman - Thu, 09 Oct 2014 02:35:01 EST ID:V5qF06Hs No.75515 Ignore Report Quick Reply
>>75498
when i wrote 'magnetic attraction' i meant electric fields, been too long since i took electricity+magnetism... lol

how does the magnesium stay in place then, if it's floating in the cytosol? wouldn't it be dragged away by the water molecules, or is that just in equilibrium?

>>75510
i just googled 'dna magnesium' and pulled a picture. sorry m8, your post did get me reading a lot of stuff i'd never heard of before though.
>>
Martin Gublinggold - Thu, 09 Oct 2014 15:45:45 EST ID:cM6rhCgJ No.75518 Ignore Report Quick Reply
>>75515

The magnesium has a +2 positive charge, and so it will be drawn to the negatively charged -1 phosphates moreso than a water molecule with a net 0 charge. You could give the water some negative or positive character by adjusting the pH of the system, but without introducing an external component, that magnesium will stay put.
>>
Doris Clecklefuck - Sat, 11 Oct 2014 16:19:39 EST ID:f5OSHUfT No.75527 Ignore Report Quick Reply
>>75515
I was just being overly sensitive. Also, I was disappointed that its mechanism isn't that cool.
>how does the magnesium stay in place then, if it's floating in the cytosol? wouldn't it be dragged away by the water molecules, or is that just in equilibrium?
Yes, it's in equilibrium. They move around, just not as much as if they were completely unassociated. Also, as I was looking for papers hoping that it really was an exotic bond, I saw that the magnesium is actually hydrated while interacting with DNA. So the phosphate groups are actually associating with the water just around magnesium (the O points towards Mg2+, and the hydrogens can then form hydrogen bonds).


Insulin Suppliments by Edward Tootshaw - Sun, 28 Sep 2014 21:18:10 EST ID:RLSN+6eM No.75467 Ignore Report Reply Quick Reply
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Okay just spitballin here. So you're not supposed to eat a whole tub of Ice Cream because it forces your pancreas to produce a whole lot of insulin in order to break down all those sugars, right? So that strain on your pancreas is bad. So what if we could help out the pancreas by supplementing some some insulin?
What if you bought some insulin and took it orally? Would it work that way? Or would you have to IV some?

And how the pancreas even detect how much to produce? I heard that it can even start producing some in advance based only on the taste of sweet foods on your tongue.
>>
Doris Canderbat - Sun, 28 Sep 2014 21:40:59 EST ID:f5OSHUfT No.75469 Ignore Report Quick Reply
>>75467
/med/ will probably give you a good answer
>>
Edwin Dollerdad - Sun, 28 Sep 2014 21:43:13 EST ID:uGD5aNS6 No.75470 Ignore Report Quick Reply
>>75467
Not all all man. Totally off the mark
First off, as far as I remember, insulin has to be injected. Its a protein, only way its getting into your bloodstream is after its been chopped up by proteases.

Secondly, what you are thinking of is type 1 diabetes, where islets of langerhan in the pancreas no longer produce insulin. Type 2 diabetes is insulin insensitivity. so yea eating a shit load of carbs will make you produce a ton of insulin. But the problem arises in the rest of the body, the cells that take up the sugar in response to insulin.
Those cell, the receptors get over sensitized, to the point of essentially burning them out. Thus you can't get sugar to the organs that need it most. There are also chemical signals that tell the pancreas to produce insulin. But anyway, think of it not being a problem of insulin, but a problem of receiving insulin as a signal.

>Like giving a speech to a room full of deaf people.
Doesn't matter how loud you yell, they still aren't going to hear you. So doesn't matter how much insulin you flood the body with, it still isn't going to respond to it at the same level.
>>
!2wSandOZH6 - Mon, 29 Sep 2014 18:13:28 EST ID:tC7xMpoh No.75474 Ignore Report Quick Reply
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>>75469

As a Type 1 Diabetic and a med chemist, let me weigh in. Firstly, don't do it.

Secondly:
>What if you bought some insulin and took it orally? Would it work that way? Or would you have to IV some?

Insulin is not orally active, you have to take it SC, IM, IV or else it is broken down by proteases. Using something like metformin would work better, but still, I wouldn't do it. Hypoglycemia is fucking horrible.
>>
Lydia Baddlebury - Thu, 09 Oct 2014 09:19:14 EST ID:+0Ci6TLP No.75517 Ignore Report Quick Reply
Insulin doesn't break down sugar; it signals cells to sequester sugar. Basically you have all this sugar floating around, and your cells are like "eh, whatevs", then insulin walks by and says "GODDAMNIT THIS IS THE THIRD TIME TODAY I'VE STEPPED ON SOME FUCKING GLUCOSE! PICK THIS SHIT UP, YOU STUPID FUCKS!", and then the cells panic and absorb all the glucose they can.


Which Reaction Would Be Easier For a Layman by Caroline Harringspear - Tue, 07 Oct 2014 00:17:46 EST ID:uw3liBiQ No.75491 Ignore Report Reply Quick Reply
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So, I have been snooping around and have found that Eugenol is pretty cheap and readily available. Problem is that there is a methoxy group which I want to ultimately turn into a hydroxyl group.

Through literature, I've read that aluminum bromide, iodide, or chloride, in the presence of a phase-transfer catalyst would be ideal, but have never really read of an account of someone doing this reaction. It's only existed in literature. I think nitrobenzene was in the reaction as well, but the problem would be pretty much acquiring any of those ingredients.

And this got me thinking if it would be easier to build a methoxy group out of the other hydroxy group, making two methoxy groups, and if there was a way to cleave the methyl groups off of both of the methoxy groups, leaving just a couple of hydroxy groups. The reason why this would be done is because anything that would attack the methoxy group would likely attack the alcohol too, which would not be desired.

Ultimately, the hydroxy groups is desired. From there, I would know what to do, but getting there is tricky.
7 posts and 1 images omitted. Click Reply to view.
>>
Green Fox - Tue, 07 Oct 2014 21:59:14 EST ID:7W8QTC+A No.75505 Ignore Report Quick Reply
>>75504

I know what you mean about keeping you up at night. It's easier to make money honestly if you have half a brain. I'd love to be able to try these syntheses for the satisfaction, though.

Anything in common lab use is probably nothing to be afraid of. LAH is nothing compared to picric acid, hydrazine, and other 'vintage' reagents. Spending the rest of your life in prison is a much scarier prospect than any fire or explosion to me.

https://www.drugs-forum.com/chemistry/chemistry/safrole.html

This looks pretty damn appealing to me. 40% Yield of safrole from straight catechol. Catechol is a photography chemical, orderable, or you can even make it from phenol and H2O2.
>>
Albert Hunningpadge - Tue, 07 Oct 2014 23:07:31 EST ID:uw3liBiQ No.75506 Ignore Report Quick Reply
>>75505
Fascinating. 40% is what I would consider to be pretty low haha. But that's not too bad overall I suppose.

So there's no easy way of converting two methoxy groups into two hydroxy groups with the allyl group on the other side of the benzene ring? I'm sure it would have been done by now, but who knows.

I never really studied chemistry too much, so how some of these reactions work to me is somewhat of a mystery (just now learning what nucleophiles and whatnot are).
>>
Henry Blembleville - Tue, 07 Oct 2014 23:48:43 EST ID:T3+BR5r7 No.75508 Ignore Report Quick Reply
>>75506
Well I guess some of the magic with organic chemistry is that there are really a ton of different ways to synthesis different compounds.
Though, most probably wouldn't be worth the time
>>
Walter Blatherhood - Wed, 08 Oct 2014 10:44:48 EST ID:GpkW+XRF No.75509 Ignore Report Quick Reply
>>75499
Either demethylation step, though youre right that it could cause problems with the alkene. I think pyridine HCl is a cleaner method, thoguh im not sure its easy to get as an amateur. Look up veratrol-> catechol reactions.
>>
Frederick Clullykid - Wed, 08 Oct 2014 18:05:11 EST ID:mn3jOq7E No.75512 Ignore Report Quick Reply
>>75504

There are other ways to reduce nitroalkenes to alkyl amines without LAH: Red-Al, sodium borohydride with boron trifluoride, or, I think it's on the Rhodium archive, sodium borohydride with some kind of nickel salt that generates nickel boride in situ.


Let's talk about renewable energy and sustainability by Simon Fanwell - Wed, 01 Oct 2014 18:45:11 EST ID:CC0/W06s No.75476 Ignore Report Reply Quick Reply
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Sustainability in a real sense, not a marketing buzzword sense.

Keep in mind I have no background in science other than my own casual research and books on the environment and such (never even posted on this board before), so bear with me.

How much hope is there for renewable energy? Will it be capable of satisfying future energy demands? Do future energy demands need to be reduced for us to survive as a species? What about the fact that even things like solar panels are made from ultimately finite materials? We know petroleum is going to become scarce, what do we do about that when so much, even industrial agriculture (as harmful as that is) depends on it?

The process of production itself is destroying our planet and killing humans and nonhumans. Deforestation, pollution, acid rain, dioxin in human breast milk...what can be done about this? Like I asked before: Do we need to consume less to survive?

How is global climate change going to impact things?

What does the future look like?
>>
Simon Fanwell - Wed, 01 Oct 2014 18:50:32 EST ID:CC0/W06s No.75477 Ignore Report Quick Reply
Also, any sources you could recommend to learn more about this sort of thing?
>>
Hugh Criddlelock - Thu, 02 Oct 2014 04:04:40 EST ID:A2UoWeAl No.75478 Ignore Report Quick Reply
Nuclear energy is the immediate answer to curb greenhouse emissions. Fusion energy is a more long-term goal. Education is crucial. Education has proven to be a determining factor in quelling overpopulation. That's all I got.
>>
Walter Fallysire - Thu, 02 Oct 2014 22:56:19 EST ID:uGD5aNS6 No.75480 Ignore Report Quick Reply
If you think about it, the amount of chemical energy on this planet is relatively static. Nuclear energy even more so. The only thing we have to make up for that loss and what is lost to inefficiency and to space is the sun constantly bombarding us with more energy. So I think if we can find a way to tap into the energy that is expended by the sun, we might have a chance.

Think about how much of the planet is covered by barren desert, no life at all. Sun shining on it for half a day. Maybe its worth looking into.
>>
Jack Fedgecocke - Sat, 04 Oct 2014 10:01:41 EST ID:v4md8dRc No.75483 Ignore Report Quick Reply
I'm pretty sure the idea is that the entire universe runs out energy eventually, right?
Entropy?
the impossibility of the perpetual motion thingy?
I mean, not that I think anyone knows what the future holds...or to be a pessimist.
>>
Walter Blatherhood - Wed, 08 Oct 2014 10:56:09 EST ID:GpkW+XRF No.75511 Ignore Report Quick Reply
Also, the protection step makes no sense. It would be unnecessary, since if youre demethylating the two methoxies, you end up having to demethylate the same exact single methoxy molecule.


Freebase Memantine by Ian Chanderford - Mon, 06 Oct 2014 17:40:42 EST ID:I9cfdn/g No.75489 Ignore Report Reply Quick Reply
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Hey /chem/

I've read reports of people taking high doses and confirming Memantine as a dissociative. I'm curious as to whether or not freebase Memantine would be smokeable and have any psychoactive potential.


Datura TEK by Fucking Buzzford - Sat, 27 Sep 2014 14:55:04 EST ID:pwtDDf84 No.75462 Ignore Report Reply Quick Reply
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How would one go about extracting Tropane alkaloids from Datura?
Would a simple A(B TEK using HCl, NaOH, and Heptane work?
>>
Archie Pallyforth - Sun, 28 Sep 2014 09:02:09 EST ID:xcD4+zVc No.75464 Ignore Report Quick Reply
>>75462
LIkely. I am trying a similar procedure for a school project with datura
>>
Trypto - Sun, 28 Sep 2014 09:06:05 EST ID:f5OSHUfT No.75465 Ignore Report Quick Reply
>>75462
If you need to ask, you probably shouldn't be doing it. Tropane alkaloids are no joke. The powder can be breathed in or absorbed through the skin inadvertently. Worse, with a Datura trip you won't necessarily know that you're tripping. So if you accidentally dose, you might then do extremely stupid things, since you don't know that you're tripping. That's not even getting into the effects on the heart.

If you do decide to go through with it, makes sure to wear gloves compatible with the solvents, a mask and goggles.Some variation of A/B extraction should work. But you need to find the specific guides.

Again, I wouldn't recommend it. Those are dangerous compounds.
>>
Edward Tootshaw - Sun, 28 Sep 2014 21:20:35 EST ID:RLSN+6eM No.75468 Ignore Report Quick Reply
Erowid says that methanol would work:

https://www.erowid.org/experiences/exp.php?ID=11686


Must read Chem Texts by Jenny Crashmock - Sat, 06 Sep 2014 21:46:46 EST ID:aTelocal No.75352 Ignore Report Reply Quick Reply
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Chemistry fan here, with a question.

Could anyone provide me with any must read texts? Or anything that was helpful to you in learning more about chemistry. Popular/Underground/College texts will be appreciated.

I'm interested in chemistry, but I have no foundation or idea where to start (besides self-learning through textbooks, which I am doing) as my backwards-ass country's school system didn't involve chemistry. To be frank, I'm looking for everything and anything that has expanded your knowledge on chemistry or given you a new viewpoint.
13 posts and 1 images omitted. Click Reply to view.
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Trypto !!msNN39YQ - Sun, 14 Sep 2014 02:13:11 EST ID:lTaEZCdO No.75402 Ignore Report Quick Reply
>>75401
Yeah, he came from the old school. His academic papers were concise, but the writing still flowed. PiHKAL and TIHKAL have beautiful synthesis descriptions, but then the Extensions sections give a lot of informal insight into drug discovery. He says things that can't be published in a journal, but let you into the mind of someone who knows what they're doing. The books have a very literary quality. Much of that is because of Anne, who should not be overlooked when talking about Shulgin's work.
>>
Phoebe Gecklepin - Sun, 14 Sep 2014 21:02:16 EST ID:tukF6vI+ No.75403 Ignore Report Quick Reply
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Clayden is one of the best org chem texts, used in a lot of college org chem courses. Start with general chemistry and lab best practice, but this has you covered for learning most of the org stuff.
Also PiHKAL and TiHKAL, but those have been mentioned a ton of times.
>>
Barnaby Febblebodge - Sun, 21 Sep 2014 20:16:19 EST ID:ddoo9aK1 No.75437 Ignore Report Quick Reply
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>>75357
>>The basic college level textbooks are by far the best way to learn chemistry.

This. Textbooks are there to, surprise surprise, teach students. That's their purpose.

I'm only just getting into chemistry too so all I can recommend is *pic related*. It's the required textbook for a couple of intermediate level chemistry subjects at my university. It gives a good overview of all of chemistry plus it has a good 8 or so chapters on organic chemistry which would be good to learn about before you tackle a more specific (and advanced) organic chemistry textbook.
>>
Eliza Blinkinnotch - Fri, 26 Sep 2014 05:42:13 EST ID:GH0d3k+a No.75459 Ignore Report Quick Reply
>>75403
Cool, if this has general chemistry too, then I don't need another book.
-or did I misunderstand something?
>>
John Dashshaw - Sun, 28 Sep 2014 08:02:51 EST ID:wEkiZTjd No.75463 Ignore Report Quick Reply
You can torrent Tro a molecular approach to chemistry. This will get you through gen chem 1 and 2.

Go to your local campus and find a chem teacher. If their any good they will help you out, not because you aren't a student.

You could even lie and say you want to take chemistry next semester and ask for some stuff to study and say you want to take them because they got good reviews on ratemyprofessor.com.


life extension by Hannah Chungerstock - Fri, 01 Aug 2014 00:25:35 EST ID:39YJHElf No.75091 Ignore Report Reply Quick Reply
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anybody here into anti aging research?
first a few discovered methods that extend mouse lifespan

https://www.fightaging.org/archives/2009/08/a-list-of-interesting-longevity-enhancement-methods-in-mice.php
http://www.sciencedaily.com/releases/2012/05/120514204050.htm
http://www.revgenetics.com/wp/buckyballs-and-olive-oil

now note how some of these studies don't require huge amounts of infrastructure or delicated treatments to make it work. simple diets or drug administration may lead to a powerful increase on lifespan (look at the bucky balls or SkQ experiment).
there already are people out there shoving liters of olive oil with bucky balls down their throats and spending a serious amount of money on it, even though there are no experiments on humans, or even if no one has replicated the experiment, or even if they are taking much less than the dosage used, or even if some of those substances are expensive as shit, with no guarantees it will work on them. i'd bet a few bucks there might even be researchers doing genetic therapies on themselves, if i put my tin foil hat on i'd bet there are extremely rich people that already did all the things listed on the first link on themselves or more.

what do you guys think about it? couldn't we crowd fund something to try all that shit at once on mice or just to see if it actually works? what is your opinion on life extension, self trial or self funded experiments?
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Eliza Nengerfetch - Mon, 22 Sep 2014 21:37:38 EST ID:XWSYBqwQ No.75446 Ignore Report Quick Reply
>>75444
SkQ1 and buckyballs have been proven to work, resveratrol worked only in fat rats but it will probably get your health better in general. i don't know if SkQ1 is already being sold, and buckyballs are expensive as shit, even if you dissolve them on your own, and drinking almost a liter of olive oil everyday is tough. don't bother with vitamin C, E or any of this bullshit. in doubt, use pubmed.
>>
Shitting Wommlehall - Tue, 23 Sep 2014 04:51:15 EST ID:rybJ4K29 No.75447 Ignore Report Quick Reply
>>75446
Not to mention you'd have to severely limit your carbs if you want to have any insulin sensitivity left after that.
>>
Nigger Bondlefuck - Wed, 24 Sep 2014 06:43:39 EST ID:2UoP/bZw No.75450 Ignore Report Quick Reply
>>75438
Sounds really fascinating! So theoretically you would be able to demonstrate (or study) these findings and combine it with you education?

Was determined to go neuroscience but decided otherwise and landed on Biochemistry and Molecular Biology in order to focus on broad range longevity. But it seems ideal to study longevity from at neuroscience perspective.
>>
Eliza Blinkinnotch - Fri, 26 Sep 2014 05:21:14 EST ID:GH0d3k+a No.75458 Ignore Report Quick Reply
Hi, I am more interested in regeneration.
I know it's as unrealistic as a comic I saw from, but I really would prefer a good maintained and repaired, self aligning body over living over 9000 years.

I also say it because i have severe hernia, have hypothyroidism, and some unhapinness which I may link to my htyroid being out of shape...
>>
Charlotte Wobblebanks - Fri, 26 Sep 2014 09:46:59 EST ID:uGD5aNS6 No.75460 Ignore Report Quick Reply
>>75450
I am not a neuroscientist. My degrees are in biotech and same with everybody I work with. You are better off studying biochem or molecular bio (probably cell bio more than molecular but that's ok). Honestly those are the tools you use in any biomed related lab, you just need to apply them different.
Like I will give you an example. Make yourself procifient in, let's say, cell signalling. In all cells, there are a lot of the same signalling molecules, CDK5, MAP5, and other kinases as well. In a normal (non neuronal cell), the are involved in boatloads of function. But if you wanna call yourself a "neuroscientist" know that on top of their normal function they also contribute to building axons by phosphorylating things like neurofilaments, tau, GSK3B, things like that.

What I am getting at is it is just a frame of mind, a familiarity with neural cell types. But if you delve too deep you limit yourself in terms of job hunting, to some degree to only neuroscience related jobs.

>>75446 I agree with the vitamins statement, the only time taking vitamins is going to help your health is if you are deficient. Some are toxic in high levels, like vitamin A. Some, like vitiman C, have renal thresholds and are rapidly excreted if you go over the threshold.

>>75444
That really depends man. Supplements in general will only really help to some degree if your body is deficient. But there are deficiencies that are really hard to measure.
You guys should read up on the Folate-B12 loop. Essentially these 2 vitamins are linked and its extremely hard to tell the difference betweeen deficiencies of one or the other.
Also there is an enzyme called MTHFR that converts Folate into a form that can donate methyl groups to make S-adenosyl-methionine. SAMe is the universal methyl group donor, and methylation of not only genes but many proteins such as Receptor Tyrosine Kinases and Histones is very very important. There has been a lot of science in the past decade or so showing that large swaths of the population
that have low activity versions of MTHFR, and thus are less efficient at converting between the forms of folate and producing SAMe. Also, there have bee…
Comment too long. Click here to view the full text.


Take some more calsses to get a toxology cert? by Eliza Blinkinnotch - Fri, 26 Sep 2014 04:31:03 EST ID:GH0d3k+a No.75456 Ignore Report Reply Quick Reply
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Studying bioinformatics and genome research, I have to understand general chemistry and organic chemistry.
I heard that I could just take some classes more and get this certificate.
I want it because I want to be versatile.
Like a jack of all trades.
Oh, and I want cheap chem stuff to create my very own useful weightloss supplements and look into stuff that helps the body to be get to maximum without endangering the health of a person.

Am I delusional?


Freebasing tianeptine sodium by Q !57aon8jsJ2 - Fri, 19 Sep 2014 18:00:37 EST ID:BDn/BDHF No.75422 Ignore Report Reply Quick Reply
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How would i go about freebasing this chemical? An ammonia solution of some sort, like chloride or hydroxide? The sodium salt seems to bond and form glue upon contact with anything other than glass and its so annoying to work with. Could I just use baking soda, even though its sodium bicarb, would that separate the sodium from the tianeptine? Then what, would the tianeptine just jump back onto the excess sodium in the solution?
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Q !57aon8jsJ2 - Sat, 20 Sep 2014 22:10:21 EST ID:BDn/BDHF No.75432 Ignore Report Quick Reply
>>75422
a few more papers
http://wang.scbb.pkusz.edu.cn/uploadfiles/pdf/publications/2011/10/2515254671245c64e24eb5940439ad67db65169ed7d.pdf

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000792/

http://dmd.aspetjournals.org/content/18/5/804.short

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=7&cad=rja&uact=8&ved=0CFgQFjAG&url=http%3A%2F%2Fwww.faqs.org%2Fpatents%2Fapp%2F20100112051&ei=HqQdVMfWGYTeoASzj4DQCA&usg=AFQjCNG4evJT_5xE5WsLVeBwplncp5vpMQ&sig2=yQRZGxbRxt75lLO0DOK_2w&bvm=bv.75775273,d.cGU

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0031-1296985
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Q !57aon8jsJ2 - Sat, 20 Sep 2014 22:14:10 EST ID:BDn/BDHF No.75433 Ignore Report Quick Reply
>>75432
http://books.google.com/books?id=sO_hArhCxwMC&pg=PA305&lpg=PA305&dq=tianeptine+analogues&source=bl&ots=jxsbz13ONN&sig=1uVR-9h7f03g049aXpGNADrJLZw&hl=en&sa=X&ei=nKEdVN6-LNC5ogT5jYLADA&ved=0CEMQ6AEwAw#v=onepage&q=tianeptine%20analogues&f=false

http://www.ncbi.nlm.nih.gov/pubmed/12595031
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trypto - Sun, 21 Sep 2014 13:23:20 EST ID:7W0AMuAo No.75435 Ignore Report Quick Reply
>>75433
Those won't help. Nothing is going to make a 436 Da molecule with labile and reactive groups easy to vaporize. The best you can do is crystalize it like >>75429 , and then test if it smokes when you try to vaporize (which will be pretty hot, so not very good for your lungs). It's possible it would work, but there's no guarantee. And there's definitely no guarantee it's healthier.
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Phineas Ninderhig - Wed, 24 Sep 2014 10:40:32 EST ID:dba4dQ0g No.75451 Ignore Report Quick Reply
Careful with those TCA's bro. I've multiple patient's OD on this stuff before.
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Q !57aon8jsJ2 - Thu, 25 Sep 2014 17:16:42 EST ID:BDn/BDHF No.75454 Ignore Report Quick Reply
>>75435
Ok thanks guys will research more.


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