420chan now has a web-based IRC client available, right here
Leave these fields empty (spam trap):
Name
You can leave this blank to post anonymously, or you can create a Tripcode by using the float Name#Password
A subject is required when posting a new thread
Subject
Comment
[*]Italic Text[/*]
[**]Bold Text[/**]
[~]Taimapedia Article[/~]
[%]Spoiler Text[/%]
>Highlight/Quote Text
[pre]Preformatted & Monospace text[/pre]
1. Numbered lists become ordered lists
* Bulleted lists become unordered lists
File

Sandwich

penis pump

Community Updates

420chan now supports HTTPS! If you find any issues, you may report them in this thread
Classification by Edward Worthingway - Fri, 02 Sep 2016 15:26:59 EST ID:CfiuryLA No.78207 Ignore Report Reply Quick Reply
File: 1472844419342.webm [mp4] -(3594835B / 3.43MB, 540x360) Thumbnail displayed, click image for full size. 3594835
So this might be more semantic than scientific but I wanted your guys thoughts on the matter,

So hypothetically, if we did find life from another world, life evolved from a completely independent source than ours, and even if it was animate, easily recognizable life, maybe even humanoid...

It still couldn't technically be an animal or any of our kingdoms/domains of life, right? Like, when we're talking about the various domains and kingdoms of life, it's kind of implied those can only be terrestrial in origin since we're talking about a tree of life with a common ancestry right? Like if we got an Earth fungus to grow on another planet and it evolved into a new species of fungus to better live on that world, it would still be a fungus because it's ancestors were Earth fungi. But if a life form from somewhere in space from a completely different line of evolution were to travel to earth, even if it coincidentally shared a lot of similar traits to Earth fungi due to functional convergent evolution, it still could never be considered kingdom: fungi right?

tlIf do we sort alien life forms by phenotype traits or genotype ones?
>>
Henry Brobberbitch - Fri, 02 Sep 2016 19:36:46 EST ID:bvtI5MJW No.78210 Ignore Report Quick Reply
i suspect that if and when we discover extraterrestrial life, biologists and zoologists will agree to classify every evolutionary ancestral lineage independently. maybe add a celestial identity marker, e.g. Terra Homo Sapiens Sapiens


iNaturalist by !/sly9iFJgg - Thu, 01 Sep 2016 08:07:03 EST ID:H8Fdbu5S No.78201 Ignore Report Reply Quick Reply
File: 1472731623063.png -(165760B / 161.88KB, 640x1136) Thumbnail displayed, click image for full size. 165760
It has some design flaws, like an inability to delete your own ID's, but it's hella fun and a great way to support the scientific community!


Estimating the relative potency of a fentanyl analogue by Augustus Sarringberk - Mon, 15 Aug 2016 12:02:06 EST ID:Y1ptdQKh No.78154 Ignore Report Reply Quick Reply
File: 1471276926041.png -(13693B / 13.37KB, 554x376) Thumbnail displayed, click image for full size. 13693
Dearest /chem/,

I wish I were one of you, but I'm not. My knowledge of chemistry trivia might impress at some parties but when actual questions arise, assistance is necessary. I was hoping you could help me estimate the relative potency of cyclopentyl-fentanyl, a novel fentanyl analogue. You will find It's structure displayed in the picture.

My thoughts: Cyclopentyl-F seems to be structurally related to Acryl-F. The latter is said to be active at doses <10 mcg. But on the other hand, cyclopentyl-F also seems related to Acetyl-F which is said to only be 1/20th the potency of regular fentanyl.

Thank you for your time.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 25 Aug 2016 19:54:09 EST ID:Req4jw5M No.78177 Ignore Report Quick Reply
>>78154
With most of this shit, you simply can't look at the molecule and guess its relative potency, unfortunately. This is just the reality of biological assays and why they are necessary.

Organic chemistry is simple to estimate but biochemistry requires in depth knowledge of all the enzyme sites around your receptors which can lead to potency changes. This is near impossible to do without high computational machines or more accurately: petri dish bio assays.

Sorry to burst your bubble, Sarringberk.
>>
David Mondlelotch - Sun, 28 Aug 2016 11:12:00 EST ID:wAPrdwU9 No.78185 Ignore Report Quick Reply
>>78177
Hi, a solution with 120-140mg / 10ml dest. water.
I recieved the powder in oxalate form, it needed alot of heating to solve. This solution was then added to a nasal spray. Akryl recipe, is 20mg/10ml dest water, for nasal sprays.


hydrogen by Bob_Johnson - Tue, 23 Aug 2016 04:15:50 EST ID:Ano5zrbo No.78164 Ignore Report Reply Quick Reply
File: 1471940150381.png -(1814256B / 1.73MB, 1920x1080) Thumbnail displayed, click image for full size. 1814256
ik we are carbon based lifeforms but really, arent we hydrogen based life forms?
wouldnt all life be based off hydrogen in some fashion?
I mean look at it
H20 man.
6 posts and 2 images omitted. Click Reply to view.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Sat, 27 Aug 2016 12:21:09 EST ID:4ppVjZXo No.78180 Ignore Report Quick Reply
>>78179
But it's the conclusion drawn by OP that i have the issue with.
Also, pure-carbon catalysts a lot of the time are crucial such as Pd/C, nanotubes, graphite disks, activated carbon filters, etc.

I was also trying to answer OP's original question on why we say organic is carbon and not hydrogen based.
>>
Nathaniel Facklenutch - Sat, 27 Aug 2016 12:22:30 EST ID:gcyBRlAo No.78181 Ignore Report Quick Reply
>>78179

Except in activated carbon, charcoal, fullerines, etc
>>
Caroline Crungermore - Sat, 27 Aug 2016 21:31:05 EST ID:zsw9I8fO No.78182 Ignore Report Quick Reply
>>78167
I wasn't intending for this post to be taken seriously.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Sun, 28 Aug 2016 02:14:08 EST ID:Req4jw5M No.78183 Ignore Report Quick Reply
1472364848352.jpg -(74184B / 72.45KB, 640x480) Thumbnail displayed, click image for full size.
>>78182
Well you clearly underestimated my autism powers.
>>
Thomas Femmerdale - Sun, 28 Aug 2016 02:16:40 EST ID:iyluTHVB No.78184 Ignore Report Quick Reply
1472365000824.gif -(2093260B / 2.00MB, 200x200) Thumbnail displayed, click image for full size.
>>78183


Books, books, more books by Vehk !7HYGxe5v5c - Sun, 12 Jun 2016 22:36:55 EST ID:zn1t5pEx No.77965 Ignore Report Reply Quick Reply
File: 1465785415158.png -(40799B / 39.84KB, 1189x269) Thumbnail displayed, click image for full size. 40799
Recently in the CWE thread someone was asking for book recommendations on chemistry textbooks, and the rest, and Press uploaded a couple of image-rars. I've been thinking we could benefit from our own central thread where we can discuss our collections, what we're reading, with an organic chemistry/synthesis theme. I know they have a good recommendation list at the /sci/ wiki over on the future, but fuck the future. This is /chem/ and we are a proud people. Also, we have a smaller community centered more around org-chem and synthesis, so it's a niche this thread should fill with more in-depth recommendations on the subject, and the provision of papers and other supplemental material.

To anyone looking for books, I'd recommend libgen. I only recently discovered it and I'm quite frankly relieved at not having to scour torrent sites and the awkward interface of #bookz for hours on end only to discover a rare book I'm looking for isn't being seeded.

I recently got Alan F Casy's Opioid Analgesics: Chemistry and Receptors off it, which I'd actually considering buying for about 50 euro used half a year ago. What a travesty that would have been. So far I've only checked out the chapter on 4-phenylpiperidines, but so far it's an interesting read. I used to have a better collection on my old computer but it crapped out, and here's what I'm working with at the moment while I rebuild it. I'm an undergrad, so I assume some of the more seasoned veterans here will have comprehensive collections.
12 posts and 3 images omitted. Click Reply to view.
>>
press !QUHukXEvkY - Tue, 21 Jun 2016 16:25:45 EST ID:fcMijPsC No.77989 Ignore Report Quick Reply
1466540745598.jpg -(39687B / 38.76KB, 480x640) Thumbnail displayed, click image for full size.
>>77986
well the common understanding of yields doesnt aplly to bio applications. once you think a batch is ripe you just kill it.
the real problem is that all those delicious opioids arent peptides. otherwise itd be piss easy to get e. coli to shit them out. the production of non peptid drugs requires a plethora of insertable genes, i dont know a lot about bio engineering but i guess that at the current time itd be more viable to have multiple strain of bacteria perform each step batch wise.

or just modify poppies...
wish we could teach funghi to think theyre poppies.

anywaaaaays, before any of yall nig spend money of files pop a message in here. nb
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Wed, 22 Jun 2016 20:42:29 EST ID:V1Ngvki3 No.77998 Ignore Report Quick Reply
>>77986
Just n1 got horny over it then we smashed his dreams so he smashed his.

youc ould technically tweak them to allow yeast to brew the structure. as long as we have research into it

>>77989
the problem is that reserach on this is being hampered to shit. also. why would we need to research this if we have a weed that gives us morphine and grows in droves that has been genetically modified for the past two millennia in order to produce the most alkaloids?
>>
press !QUHukXEvkY - Mon, 27 Jun 2016 13:39:12 EST ID:fcMijPsC No.78034 Ignore Report Quick Reply
>>77998

id guess that growing yeast or bacteria is a bit simpler and less dependant on sociopolitical bullshit than poppies.
>>
Hamilton Honeylock - Wed, 03 Aug 2016 15:45:47 EST ID:V/qMoGDW No.78127 Ignore Report Quick Reply
Right, so what can you people tell me about them fume hoods? What do you have to consider when setting up a basement lab? I think I can't just go right ahead and pump all the fumes out the fucking window, right? Do I need some kind of filter? Are there any laws for this shit? It's really unfortunate for me because I can only do this in my basement with a window that's facing the backyard. Occasionally there are some fucking brats running around too. I beg for your help! It's the only thing seperating me from doing lab work
>>
Phoebe Gedgekog - Mon, 15 Aug 2016 16:57:16 EST ID:UBUsOujN No.78155 Ignore Report Quick Reply
>>78127
up


Why am I so fucking shit at kitchen chemistry by WIAKR+Pa !1CreRGKd/6!!TfPvomrn - Thu, 07 Jul 2016 21:22:03 EST ID:5Pw/LIPu No.78073 Ignore Report Reply Quick Reply
File: 1467940923077.jpg -(40715B / 39.76KB, 575x383) Thumbnail displayed, click image for full size. 40715
I fucking hate my life. Bombastus, can I please come live with you since you're actually good at chemistry? I promise I will be a faithful lab assistant, am totally willing to get a Canadian visa, and would love to learn all about how to not suck dick at kitchen chemistry.

I really need general tips on how to actually manage to perform kitchen chemistry and not fail at things as simple as fucking morphine extractions. Nothing I attempt ever seems to work. I'm just quite unhappy right now. Pls gib advice.

Sorry for the super low-res photo
4 posts omitted. Click Reply to view.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Mon, 08 Aug 2016 00:35:51 EST ID:HCt0W/hp No.78138 Ignore Report Quick Reply
>>78131
how tf did you get a rotovap. which state are you in!? wowza.

Alright, well if you have that much money, you might as well extract all your seeds with a slightly acidic solution, rinse with hexanes, basify with CaOH and NHx, and filter that off. This way, you're working with all liquids and the rotovap makes everything much easier. The washing of the seeds will be the hardest part.

Please don't go and die on me.
>>
Press - Mon, 08 Aug 2016 07:00:50 EST ID:xrIpEC8o No.78139 Ignore Report Quick Reply
>>78131
What are the petri dishes for?

Morphine is a salt at pH!=8,99 or something.
And even at the isoelectric point its a bitch to liquid-liquid extract.
Dont worry about the layers, those are just precipitation, a coarse filtration will do the same job-itll actually be a bit more efficient- if its followed by a finer filtration
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Mon, 08 Aug 2016 14:46:39 EST ID:HCt0W/hp No.78140 Ignore Report Quick Reply
>>78139
Good watch glasses and lab covers.
Liquid liquid extract everything else. Then filter extract morphine. That sounds easier than other options.

HCN my shit up fam.
>>
Press - Tue, 09 Aug 2016 03:06:51 EST ID:MKujOXWI No.78143 Ignore Report Quick Reply
>>78140
Meh, shits gonna get stuck at the rims.

Just methylmercury my fam, fuck
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Tue, 09 Aug 2016 19:42:54 EST ID:HCt0W/hp No.78144 Ignore Report Quick Reply
>>78143
Methylmercury is probably a great way to suicide. It's like condensed cancer and the doctors would probably give you all the opiates you want. Maybe even some benzos.

pic related of my script
nb


How water goes up straws by James Dinningbanks - Sun, 07 Aug 2016 22:02:44 EST ID:MVUX73Om No.78135 Ignore Report Reply Quick Reply
File: 1470621764791.gif -(1571571B / 1.50MB, 370x288) Thumbnail displayed, click image for full size. 1571571
The reason that liquids go up straws is not because you're sucking it in but because you're displacing the oxygen inside the straw allowing the liquid to shape without the pressure of oxygen.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Sun, 07 Aug 2016 23:32:27 EST ID:HCt0W/hp No.78136 Ignore Report Quick Reply
>displacing the oxygen
You mean the air? Specify. We're on /chem/ afteral
>allowing the liquid to shape
The definition of a liquid is that it has no shape nor does it retain on. what do you mean "the pressure of oxygen"?

Also, why did you start this thread even.
>>
James Dinningbanks - Sun, 07 Aug 2016 23:59:23 EST ID:MVUX73Om No.78137 Ignore Report Quick Reply
>>78136
I don't know, I like pretending like I know science
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Mon, 08 Aug 2016 14:47:21 EST ID:HCt0W/hp No.78141 Ignore Report Quick Reply
>>78137
Good for you for admitting it, at least.

nb


Oxymorphinol and Hydromorphinol by Bombastus !RZEwn1AX62!!xXxJO70U - Mon, 27 Jun 2016 02:29:51 EST ID:G8mu3scS No.78032 Ignore Report Reply Quick Reply
File: 1467008991222.jpg -(92318B / 90.15KB, 790x753) Thumbnail displayed, click image for full size. 92318
Hey faggotqueers. Are these the same fucking thing?
https://en.wikipedia.org/wiki/Oxymorphol
https://en.wikipedia.org/wiki/Hydromorphinol

Possible synthesis discussion below.
9 posts and 2 images omitted. Click Reply to view.
>>
Press !QUHukXEvkY - Thu, 30 Jun 2016 01:16:05 EST ID:JUzW0CgK No.78046 Ignore Report Quick Reply
J. Magano, M. H. Chen, J. D. Clark, T. Nussbaumer, J. Org. Chem., 2006, 71, 7103-7105.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 30 Jun 2016 20:27:42 EST ID:4ppVjZXo No.78047 Ignore Report Quick Reply
>>78045
propanethiol and butanethiol can be smelled when in its airtight glass bottle, vacuum sealed-foil lined bag, inside of a ziplock bag coated with chemical absorbant, all while sealed in a stainless steel can. as you surpass these layers of protection, the smell gets worse and worse.
A reflux condenser is absolute suicide.
humans can smell ethanethiol at concentrations of 4ppb. i think i had propanethiol at at least 500ppm when i opened it to the atomosphere

eu not that bad. go to UK and buy a bunch of dihydrocodeine or regular codeine pills. or get someone else to do it. iunno. that seems legal. call them herbal supplemtns or calcium pills or some fucking shit

that looks promising, actually. i'll take an extra look into J. Magano et al.'s usage of 2-(Diethylamino)ethanethiol. that looks much better and more stable than fucking propane-fucking-thiol. thank god the thiols aren't toxic.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Fri, 22 Jul 2016 21:26:14 EST ID:ycAJxrEI No.78108 Ignore Report Quick Reply
>>78047
I swear these shits are the same fucking thing.
>>
Press !QUHukXEvkY - Sun, 24 Jul 2016 04:37:05 EST ID:YPH/mOya No.78109 Ignore Report Quick Reply
>>78108
You mean in their effects?
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Sun, 24 Jul 2016 14:17:21 EST ID:HCt0W/hp No.78111 Ignore Report Quick Reply
>>78109
No in the molecule. I still can't see the difference and it's NOT in chirality.


microscopic telescope by Eugene Deddleham - Fri, 22 Jul 2016 13:12:29 EST ID:6cilZam8 No.78106 Ignore Report Reply Quick Reply
File: 1469207549120.png -(11018B / 10.76KB, 798x294) Thumbnail displayed, click image for full size. 11018
I just wondered, I have never heard of a microscopic telescope. By this I mean a device along the lines of a large nature-style camera lens or traditional telecope that is able to zoom in to the target area of a physical item and produce a 3d environment of that area through the lens? Surely theres an infinite amount of detail from a physical item We have all this advanced astronomical technology these days to look at things that lie in the distance. What would happen if technology was put into microscopic telecopes thanks everyone

TLDR: a lens of intricately layered magnifying glasses that self multiply
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Fri, 22 Jul 2016 15:51:09 EST ID:ElYFdcKO No.78107 Ignore Report Quick Reply
>>78106
the width of photons and their wave functions still have a measurement and you need to capture a lot of them to concentrate them. this is why a microscopic telescope isn't worth producing because they'd be so damn sensitive, there'd be no point. the curvature of the glass is also then limited due to the angles possible when the radius is limited.


Demethylation - pyridinium pathway by Bombastus !RZEwn1AX62!!xXxJO70U - Sun, 26 Jun 2016 14:02:33 EST ID:LtWIDIP2 No.78028 Ignore Report Reply Quick Reply
File: 1466964153727.png -(3184B / 3.11KB, 120x111) Thumbnail displayed, click image for full size. 3184
Trying 3-4 different demethylation strategies under mild conditions, it seems that pyridinium HX is going to the be easiest and most non-retarded way of demethylating any species.
Any other format either seems to cleave the ether bridge, require too much heat, or is simply impractically tender.

So I wonder - does anyone have any resources on a better yielding demethylation of aromatic methoxides with pyridinium salts? Can anyone find any literature that says PyHBr would be more selective and cleaner than PyHCl with a 15% yield in demethylation of "certain" compounds? Would they be more selective or would it just not matter?

Pic unrelated
8 posts and 3 images omitted. Click Reply to view.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Tue, 12 Jul 2016 15:57:02 EST ID:G8mu3scS No.78085 Ignore Report Quick Reply
>>78084
chemical castration

also because if you can use hbr pyridine to demethylate with a higher yield, it would prove my hypothesis. it's more for science. However, i believe the pyridine has such a low yield due to the high temperatures that the reaction opeates on. 180 burns enough morphinan structures to fuck your shit up fam
do you suppose you could put it under a full vacuum and then heat it up in order to run the pyridine at a lower temperature? can you even use a solvent for the pyridine? if not, then HBr would increase its boiling point and make the decomposition even worse.
>>
press !QUHukXEvkY - Thu, 14 Jul 2016 09:45:19 EST ID:fcMijPsC No.78086 Ignore Report Quick Reply
1468503919115.jpg -(22977B / 22.44KB, 296x394) Thumbnail displayed, click image for full size.
>>78085
well thats good! if you think that you can get enough starting material to invest your theory thatd definetely be the way to go. keep us up to date!

speaking of methyl ethers, i recently came across potassium methanolate and was wondering if it could be used to convert aryl halides to methyl ethers of aromatics. a superficial search didnt reveal anything, id guess that its a bit more hazordous to handle *i dont know* and perhaps a bit too basic to use in the presence of aldehyde groups while in higher concentrations, but whats your take on it?

ive been meaning to restart the mescaline thread with a drawn out compilation of a routes mentioned therein.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 14 Jul 2016 13:50:50 EST ID:II1FH3AD No.78091 Ignore Report Quick Reply
>>78086
don't retard the thread I'd just start a new one because that one has so much information to sift through its not worth rebumpin at this point (sorry fiend)

think I'm too busy to try this demeth though. I like science and shit but I also like my time more
>>
press !QUHukXEvkY - Thu, 14 Jul 2016 23:57:40 EST ID:fcMijPsC No.78093 Ignore Report Quick Reply
>>78091
it already was retarded the minute it started. but i agree with it being too flooded, hence i want to make a simple compilation


what about the potassium methoxide?
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 21 Jul 2016 19:25:38 EST ID:vbS8CtHn No.78105 Ignore Report Quick Reply
>>78093
you'll never make a simple compilation because of the retardation that comes with being 420chan. that's just how life goes and i'm ready to fucking kill myself.

what ABOUT methoxide? i feel like that would be too strong of an electrophile and might just rip the ether open.


Is it possible to make shakenbake with lorantadine10mg/ psuedophedrine by Sidney Bottingwat - Thu, 14 Jul 2016 13:31:03 EST ID:sM4N11VN No.78087 Ignore Report Reply Quick Reply
File: 1468517463055.jpg -(10364B / 10.12KB, 400x300) Thumbnail displayed, click image for full size. 10364
SWIM (someone who isn't me) wants to know if it is possible to make shakeNbake with psuedophedrine aulfate 240mg/loratadine(claritin D behind the counter)
If so, how would you do it, anons?
3 posts and 1 images omitted. Click Reply to view.
>>
Sidney Bottingwat - Thu, 14 Jul 2016 13:54:37 EST ID:sM4N11VN No.78092 Ignore Report Quick Reply
1468518877055.jpg -(35370B / 34.54KB, 637x637) Thumbnail displayed, click image for full size.
>>78090
Eh it's out of respect. Honestly it was my dipshit friend. I know that its acetone, lithium (battery acid), draino, denatured alcohol, and sudafed but I don't want him to try it without knowing what would happen with the loratadine10mg that is per tab
>>
Vehk !7HYGxe5v5c - Mon, 18 Jul 2016 05:23:28 EST ID:0du+stps No.78098 Ignore Report Quick Reply
1468833808801.png -(210872B / 205.93KB, 684x796) Thumbnail displayed, click image for full size.
>>78092
From the ingredients you're describing, I assume he is doing a birch reduction. I don't know if loratadine would react, but Sudafed as far as I'm aware is readily available in formulations which do not contain loratadine in most places.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Mon, 18 Jul 2016 13:13:27 EST ID:AoI9o4UM No.78099 Ignore Report Quick Reply
>>78092
Oh. That's what people are shake and baking now? Fucking weird.
Lorentadine shouldn't iinterfere. But I would also watch the dosage after the fact, though.
>>
press !QUHukXEvkY - Mon, 18 Jul 2016 13:44:22 EST ID:fcMijPsC No.78100 Ignore Report Quick Reply
1468863862961.gif -(1182277B / 1.13MB, 500x579) Thumbnail displayed, click image for full size.
my cats friends mother thinks SWIY is missing some friends of chemicals for that reaction that isnt your friends mothers reaction of something that isnt methamphetamine. maybe you should buy her some cold packs
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 21 Jul 2016 19:17:33 EST ID:vbS8CtHn No.78102 Ignore Report Quick Reply
R A C K S


amphetamine related by Ebenezer Snodhood - Sat, 25 Jun 2016 15:37:35 EST ID:/F1T+Pgt No.78014 Ignore Report Reply Quick Reply
File: 1466883455859.jpg -(130114B / 127.06KB, 960x960) Thumbnail displayed, click image for full size. 130114
Hello guys I've been trying to reduce the P2NP (phenyl-2-nitropropene) to the amine form (amphetamine)

I tried the amalgam procedure described in erowid but this doesn't reduce the double bond (despite the rodium's archives where some people tried this and said it worked I was suspicious and tried it anyway but it doesn't give a single thing) with the "Reduction of unsubstituted P2NP by HyperLab Bee #2."

What would be a good method? LiAlH4 is expensive and difficult to handle, same with palladium or platinum compounds

I was thinking on NaBH4 to reduce the double bond and then Zn/HCl for the nitro group but I'm not sure

thanks a lot
9 posts and 3 images omitted. Click Reply to view.
>>
Phoebe Saggledock - Sun, 03 Jul 2016 13:31:41 EST ID:JyGokHy9 No.78064 Ignore Report Quick Reply
>>78063
I'll see it if
>>78062 doesn't work
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Sun, 03 Jul 2016 14:34:47 EST ID:ElYFdcKO No.78065 Ignore Report Quick Reply
>>78064
There's no reason it won't work.

It's just that us clandestine-oriented chemists (Press n' me) see a more efficient method of achieving the final product compared to the academic route. Borohydride is annoying to work with due to the formation of borates (though, easily separated by a column) and since you're producing hydrogen gas in the second step, you might as well just use it to your advantage in a hydrogenation.

The 1pot reaction also benefits in that you can reuse the palladium on carbon by a simple filtration to be used over and over again. Such is the magic of Pd/C. Buy a sacrificial silica frit so you can reuse it for Pd/C. That's what I have and it works magic.
>>
Rebecca Diddlebick - Tue, 05 Jul 2016 18:18:55 EST ID:FgNFOc9k No.78068 Ignore Report Quick Reply
>>78065
thanks for your response

maybe this is a stupid question but will the aromatic ring of P2NP get reduced too if I use Pd/C? or this could only be achieved with high pressure system
>>
Nicholas Dundleludging - Tue, 05 Jul 2016 20:07:10 EST ID:FgNFOc9k No.78069 Ignore Report Quick Reply
1467763630377.jpg -(9545B / 9.32KB, 171x200) Thumbnail displayed, click image for full size.
>>78065
ok let me see if I get your idea:

In a proper flask I put my P2NP, Zn, HCl and (if I get) palladium black? which solvent can I use? any alcohol? heating? don't I need an H2 bomb? what about the proportions of each chemical?

after a couple of hours under stirring this rxn should be done, then I go for the filter (recover Pd) and extraction, right?

ALSO: I have PcCl2 but not sure if this would work the same as Pd/C, thoughs?

great thread btw
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Tue, 05 Jul 2016 23:27:34 EST ID:LtWIDIP2 No.78070 Ignore Report Quick Reply
1467775654782.jpg -(94072B / 91.87KB, 540x525) Thumbnail displayed, click image for full size.
>>78068
benzene will not be hydrogenated at pressures lower than 60 degree. this is due to rapid isomerization of the products and reisomerization back to the reactants.
you'll need something like 30atm and 300C in order to fully hydrogenate benzene to cyclohexane.

This may be similar to your benzylic alkene but it does not engage in the main conjugation. 3atm of pressure may be necessary for this reaction at 0C. 0C increases hydrogen solubility in water and also prevents side reactions from happening.

>>78069
My idea is to stir a mixture of pd/c, nitrox, zinc, and mild hydrochloric acid in a somewhat closed system for 24hours. water should be good eough since HCl. keep it at 0degrees and run the hydrogenation for 24 hours at the pressure needed to keep the balloon inflated - as per undergraduate reactions. that creates around 3atm and allows extra pressure to leak out through the side.

you might want to do 24hours of stirring as the double bond engages in electron sharing with the aromatic ring. you would filter through a pad of celite, sand, or sacrificial frit, neutralize with baking soda, and extract with toluene, dcm, ether, etc.
Wash the organic solvent with brine, dry with magnesim sulfate, dstill off the solvent, keep it under vaccum for 12 hours or whatever, and recrystallize from ethanol IF necessary.


<<Last Pages Next>>
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Report Post
Reason
Note
Please be descriptive with report notes,
this helps staff resolve issues quicker.