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life extension by Hannah Chungerstock - Fri, 01 Aug 2014 00:25:35 EST ID:39YJHElf No.75091 Ignore Report Reply Quick Reply
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anybody here into anti aging research?
first a few discovered methods that extend mouse lifespan


now note how some of these studies don't require huge amounts of infrastructure or delicated treatments to make it work. simple diets or drug administration may lead to a powerful increase on lifespan (look at the bucky balls or SkQ experiment).
there already are people out there shoving liters of olive oil with bucky balls down their throats and spending a serious amount of money on it, even though there are no experiments on humans, or even if no one has replicated the experiment, or even if they are taking much less than the dosage used, or even if some of those substances are expensive as shit, with no guarantees it will work on them. i'd bet a few bucks there might even be researchers doing genetic therapies on themselves, if i put my tin foil hat on i'd bet there are extremely rich people that already did all the things listed on the first link on themselves or more.

what do you guys think about it? couldn't we crowd fund something to try all that shit at once on mice or just to see if it actually works? what is your opinion on life extension, self trial or self funded experiments?
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Eliza Nengerfetch - Mon, 22 Sep 2014 21:37:38 EST ID:XWSYBqwQ No.75446 Ignore Report Quick Reply
SkQ1 and buckyballs have been proven to work, resveratrol worked only in fat rats but it will probably get your health better in general. i don't know if SkQ1 is already being sold, and buckyballs are expensive as shit, even if you dissolve them on your own, and drinking almost a liter of olive oil everyday is tough. don't bother with vitamin C, E or any of this bullshit. in doubt, use pubmed.
Shitting Wommlehall - Tue, 23 Sep 2014 04:51:15 EST ID:rybJ4K29 No.75447 Ignore Report Quick Reply
Not to mention you'd have to severely limit your carbs if you want to have any insulin sensitivity left after that.
Nigger Bondlefuck - Wed, 24 Sep 2014 06:43:39 EST ID:2UoP/bZw No.75450 Ignore Report Quick Reply
Sounds really fascinating! So theoretically you would be able to demonstrate (or study) these findings and combine it with you education?

Was determined to go neuroscience but decided otherwise and landed on Biochemistry and Molecular Biology in order to focus on broad range longevity. But it seems ideal to study longevity from at neuroscience perspective.
Eliza Blinkinnotch - Fri, 26 Sep 2014 05:21:14 EST ID:GH0d3k+a No.75458 Ignore Report Quick Reply
Hi, I am more interested in regeneration.
I know it's as unrealistic as a comic I saw from, but I really would prefer a good maintained and repaired, self aligning body over living over 9000 years.

I also say it because i have severe hernia, have hypothyroidism, and some unhapinness which I may link to my htyroid being out of shape...
Charlotte Wobblebanks - Fri, 26 Sep 2014 09:46:59 EST ID:uGD5aNS6 No.75460 Ignore Report Quick Reply
I am not a neuroscientist. My degrees are in biotech and same with everybody I work with. You are better off studying biochem or molecular bio (probably cell bio more than molecular but that's ok). Honestly those are the tools you use in any biomed related lab, you just need to apply them different.
Like I will give you an example. Make yourself procifient in, let's say, cell signalling. In all cells, there are a lot of the same signalling molecules, CDK5, MAP5, and other kinases as well. In a normal (non neuronal cell), the are involved in boatloads of function. But if you wanna call yourself a "neuroscientist" know that on top of their normal function they also contribute to building axons by phosphorylating things like neurofilaments, tau, GSK3B, things like that.

What I am getting at is it is just a frame of mind, a familiarity with neural cell types. But if you delve too deep you limit yourself in terms of job hunting, to some degree to only neuroscience related jobs.

>>75446 I agree with the vitamins statement, the only time taking vitamins is going to help your health is if you are deficient. Some are toxic in high levels, like vitamin A. Some, like vitiman C, have renal thresholds and are rapidly excreted if you go over the threshold.

That really depends man. Supplements in general will only really help to some degree if your body is deficient. But there are deficiencies that are really hard to measure.
You guys should read up on the Folate-B12 loop. Essentially these 2 vitamins are linked and its extremely hard to tell the difference betweeen deficiencies of one or the other.
Also there is an enzyme called MTHFR that converts Folate into a form that can donate methyl groups to make S-adenosyl-methionine. SAMe is the universal methyl group donor, and methylation of not only genes but many proteins such as Receptor Tyrosine Kinases and Histones is very very important. There has been a lot of science in the past decade or so showing that large swaths of the population
that have low activity versions of MTHFR, and thus are less efficient at converting between the forms of folate and producing SAMe. Also, there have bee…
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Take some more calsses to get a toxology cert? by Eliza Blinkinnotch - Fri, 26 Sep 2014 04:31:03 EST ID:GH0d3k+a No.75456 Ignore Report Reply Quick Reply
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Studying bioinformatics and genome research, I have to understand general chemistry and organic chemistry.
I heard that I could just take some classes more and get this certificate.
I want it because I want to be versatile.
Like a jack of all trades.
Oh, and I want cheap chem stuff to create my very own useful weightloss supplements and look into stuff that helps the body to be get to maximum without endangering the health of a person.

Am I delusional?

Freebasing tianeptine sodium by Q !57aon8jsJ2 - Fri, 19 Sep 2014 18:00:37 EST ID:BDn/BDHF No.75422 Ignore Report Reply Quick Reply
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How would i go about freebasing this chemical? An ammonia solution of some sort, like chloride or hydroxide? The sodium salt seems to bond and form glue upon contact with anything other than glass and its so annoying to work with. Could I just use baking soda, even though its sodium bicarb, would that separate the sodium from the tianeptine? Then what, would the tianeptine just jump back onto the excess sodium in the solution?
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Q !57aon8jsJ2 - Sat, 20 Sep 2014 22:10:21 EST ID:BDn/BDHF No.75432 Ignore Report Quick Reply
a few more papers




Q !57aon8jsJ2 - Sat, 20 Sep 2014 22:14:10 EST ID:BDn/BDHF No.75433 Ignore Report Quick Reply

trypto - Sun, 21 Sep 2014 13:23:20 EST ID:7W0AMuAo No.75435 Ignore Report Quick Reply
Those won't help. Nothing is going to make a 436 Da molecule with labile and reactive groups easy to vaporize. The best you can do is crystalize it like >>75429 , and then test if it smokes when you try to vaporize (which will be pretty hot, so not very good for your lungs). It's possible it would work, but there's no guarantee. And there's definitely no guarantee it's healthier.
Phineas Ninderhig - Wed, 24 Sep 2014 10:40:32 EST ID:dba4dQ0g No.75451 Ignore Report Quick Reply
Careful with those TCA's bro. I've multiple patient's OD on this stuff before.
Q !57aon8jsJ2 - Thu, 25 Sep 2014 17:16:42 EST ID:BDn/BDHF No.75454 Ignore Report Quick Reply
Ok thanks guys will research more.

ochem & synthesis by Reuben Duckford - Tue, 23 Sep 2014 10:10:49 EST ID:8JJsH6mv No.75448 Ignore Report Reply Quick Reply
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hey /chem/!

can you recommend some textbooks for learning about organic chemistry and chemical synthesis?

I've taken a few university courses and labs as part of my studies. I'm considering going more towards biophysics and biochemistry for my degree (i'm in straight physics now) and I wanna get more knowledgable about this shit! I'm fascinated with everything from the logistics of how to design reactions to the underlying physics that causes everything to happen the way it does.


GE'ing RuBisCO to defeat Global Warming. by Doris Draffingbury - Sat, 19 Apr 2014 19:22:00 EST ID:EwWywDvg No.74549 Ignore Report Reply Quick Reply
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For the uninitiated, RuBisCo is the photosynthetic enzyme responsible for taking CO2 out of the atmosphere, combining it with RUB5, and making 3-Phosphoglycerate, which creates energy for the plant/bacteria/whatever. However, there's one fatal problem with this system. RuBisCO is a fucking piece of shit enzyme.

First off, normal enzymes can make tens or even hundreds of thousands of molecules a second. How many molecules can RuBisCO make per second, you ask? Fucking 3. 3 Molecules a second. Plant make up for this by creating a lot of RuBisCO, but the amount of Co2 they take up is still pathetic compared to what it could be.

What's worse, it can't differentiate between CO2 and plain old O2. The problem? For one thing, the O2 can't even catalyze a reaction, cutting the production of molecules (and CO2 uptake) by half, meaning that instead of making 3 molecules of 3-Phosphoglycerate, it only makes 1 or 2 per second. Oh yeah, and BTW, when RUB5 combines with O2, it makes a compound which actually *poisons* the fucking plant.

Anyways, researchers have been trying for a while now to genetically engineer RuBisCO to not be a fucking piece of shit, but progress is slow. This link ( http://en.wikipedia.org/wiki/Rubisco#Genetic_engineering ) can give you a decent primer on why. One thing that it doesn't mention is that recent methods of trying to GE RuBisCO to take in less O2 also lead it to take in less CO2, making that route of study less viable for the time being.

The best route, however, may be to simply increase the rate of molecule production by RuBisCO instead of limiting O2 intake. I just got finished reading a paper here (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503183/) which suggests that carbamylation activates RuBisCO and nitrosylation inactivates it, trapping the CO2 or o2 in the active site. Thus, nitrosylation could be a means of controlling RuBisCO activity .

How does any of this "defeat" Global Warming? Simple. If the activity of RuBisCO were to be doubled in the majority of plant species, It would halt the increasing concentrations of CO2 the atmosphere,. What's more, it could end up dropping the concentration by 25-50ppm. If the activity level were tripled, it could drop CO2 levels by as much as 100ppm. CO2 levels could be back to pre-industrial levels in just a few decades.

My main reasoning for posting is that I'm looking for a few experts to answer some questions for me:

>Has there been any progress in the past year on controlling RuBisCO activity?
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Alice Niggerford - Sun, 27 Apr 2014 18:02:12 EST ID:gDHcxa93 No.74629 Ignore Report Quick Reply
If we engineer a cellular component to be that much more efficient I fear it could sweep across the Earth and out-compete everything else. This could decimate diversity for a few hundred million years.
Oliver Bishwater - Mon, 28 Apr 2014 22:08:17 EST ID:/oDrJq4q No.74636 Ignore Report Quick Reply

No wonder the enzyme's rate is so shitty: even with stabilization from Mg2+ that's a pretty energetically unfavorable reaction.
Syllogism - Tue, 29 Apr 2014 02:54:14 EST ID:stqlrmZK No.74637 Ignore Report Quick Reply
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CO2(aq) + NHR2(aq) -> carbamate actually isn't as awful as it looks. There's a big entropy difference when considering gaseous and aqueous CO2, after all. CO2(aq) is a very ordered system, so by comparison the carbamate formation is an entropy increase. And a system with +ΔH and +ΔS will move toward spontaneity as temperature increases.

The problem is that this reaction is in competition with the phase change between aqueous and gas state, which makes the reaction very case dependant on exposure to the atmosphere. It doesn't matter how favorable carbamate formation from aqueous CO2 is... if there's no aqueous CO2.

In the blood, where respiration is pumping CO2 out like it was going out of style, an aqueous -> gas equilibrium system can't exist until the volume of blood reaches the lungs. So here CO2 can dock to hemeglobin via carbamate formation, and will undock when the opportunity to undergo gas exchange presents itself. In plants, gas exchange occurs much more frequently near the tissues that undergo photosynthesis, and so the PCO2 for rubisco just doesn't compare.
Emma Dodgeture - Fri, 02 May 2014 15:04:58 EST ID:gWgs9bU0 No.74643 Ignore Report Quick Reply
Aww shit. P chem is voodoo magic.

That picture. Aw man, learning about membrane depolarisations in electrophysiology. Dat K+ current.
Jenny Tootfuck - Mon, 22 Sep 2014 14:12:38 EST ID:f5OSHUfT No.75442 Ignore Report Quick Reply
FUCK YEAH! This thread is still somehow alive. I haven't read it yet, but this newish (June) paper is very relevant:

I Hallucinated Fractals as a Kid by Shitty Fattits - Sat, 13 Sep 2014 00:46:13 EST ID:kz7XJlxs No.75399 Ignore Report Reply Quick Reply
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I like to think of atoms as three-dimensional fractals. Each one is a piece of a puzzle, branching out infinitely in a self-replicating string of itself. They combine, however, when their maths add up with another fractal entity. Some pieces of the fractals lock into each other really well, like two Hydrogens and one Oxygen -- and make water. Helium, Argon, and the rest of the noble gasses are kind of "closed off" fractals, and don't bond with others because they're self-solving. Elements which form crystals do so when a ton of them are all around each other, self-replicating and falling into each other perfectly. When you get a few hundred billion of them, you get a nice-sized crystal. This crystal is a large fractaloid semi-modular scale of the element itself on a smaller scale.

I hallucinated fractals as a kid and experienced a few seizures which went pretty largely unexplained. I think about math all the time and am obsessed with number pyramids (5 4 3 2 1 : 4 3 2 1 : 3 2 1: 2 1 : 1) and the concept of infinity.
Augustus Shakestone - Tue, 16 Sep 2014 19:11:14 EST ID:uGD5aNS6 No.75408 Ignore Report Quick Reply
Prolly better just to think of atoms for what they actually are, nothing. Mostly just empty space.
Jack Fonningwork - Fri, 19 Sep 2014 06:17:26 EST ID:8tQGzRP2 No.75420 Ignore Report Quick Reply
i have a hard time pcituring the bonds as all empty space. could you say atoms are kind of like legos made of empty space that you put together to build things?
Emma Gumblechodge - Sat, 20 Sep 2014 11:54:31 EST ID:uGD5aNS6 No.75427 Ignore Report Quick Reply
Kind of, but consider that the nucleus is about 1/100,000 of the size of the atom, yet it makes up 99.9% of its mass. So consider the nucleus of an atom to be the size of a pea, the entire atom including the electron cloud would be the size of a race track. Which means its just a bunch of nothing essentially.

What makes up the bonds between atoms is mostly electromagnetic force. This force is incredibly strong. Consider the earth, the sheer size of it and the gravity it generates. Yet you, a mere fraction of a fraction of the mass of the earth can generate enough force to seperate from it for a time by jumping. Yet magnets not even that large can seperate heavy thing like cars from the earth with ease (think of those huge magnetic cranes at junkyards).

So the combined electromagnetic force between these atoms are what hold them in place and give things there solid seeming nature. Which is why a bunch of seemingly empty space can feel hard and support your weight. Its the tight and powerful forces that give things their solidity, yet forces don't really have mass (unless you consider force carrying particles, but let's not get into particle physics).
Reuben Cremmerlotch - Sun, 21 Sep 2014 14:52:50 EST ID:Sp7S8c2L No.75436 Ignore Report Quick Reply
Have you experienced Euler's identity yet?

circiling lights by Nathaniel Hiddleville - Mon, 15 Sep 2014 10:12:13 EST ID:e5ZUwijp No.75405 Ignore Report Reply Quick Reply
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whenever I look into the light, like a cloudy day of white sky. I see lights circling each other. I can focus them and change their pattern and intensity. what am I seeing?
Shit Greenson - Tue, 16 Sep 2014 10:35:18 EST ID:e5ZUwijp No.75406 Ignore Report Quick Reply
when I focus in different meditations, they can straighten out in lines or circle and look like stars. our minds are physics and we can control out minds, therefore we can control physics with our minds. boom.
Simon Bublingstone - Tue, 16 Sep 2014 15:22:59 EST ID:rxu+Q3BT No.75407 Ignore Report Quick Reply
and if I drink water and gin and get drunk, then drink whiskey and water and get drunk, I can therefore prove that water gets me drunk.
Angus Brishman - Wed, 17 Sep 2014 20:46:47 EST ID:e5ZUwijp No.75414 Ignore Report Quick Reply
sure thing buddy
Fuck Bleddlesot - Thu, 18 Sep 2014 18:06:42 EST ID:iHZcrM0s No.75418 Ignore Report Quick Reply
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What you are describing is an placeboe affect.
Phyllis Gobbertudge - Sat, 20 Sep 2014 19:53:54 EST ID:NrQIXSPn No.75431 Ignore Report Quick Reply
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Does it look like this? if so,

hey guys by Betsy Fancocke - Sun, 07 Sep 2014 15:15:45 EST ID:8tQGzRP2 No.75355 Ignore Report Reply Quick Reply
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i was the guy posting about orbitals. I got a new queston about finding formal charges. pretty much I get the formula for it but I am confused about what happens when (# of bonding electrons/2) is not a whole number. For example, carbon with a formal charge of +1 does this it seems.

There's 4 valence electrons. 3 are bonding and none are nonbonding.

So it would be 4 - (3/2) - 0...
oh wait i fucked up and got it now. You take the number of bonds and double that to get your electrons huh? ok well thanks for the help!!!
Angus Tootfoot - Mon, 08 Sep 2014 16:29:11 EST ID:ONOV2XnS No.75364 Ignore Report Quick Reply
That's right. This raises a worthwhile point - a formal covalent bond found in most organic chemistry is composed of two valence electrons. If you break this bond, the bonding pair of electrons will not each go to a different atom, but rather stay together attached to the more electronegative element. When they ARE separated, a chemical species called a radical is produced.

In general, the order of stability goes:
covalently bonded atoms > two isolated ions (one with the bonding electron pair) > two radical species
Esther Wucklekitch - Thu, 11 Sep 2014 00:27:14 EST ID:8tQGzRP2 No.75389 Ignore Report Quick Reply
Jarvis Furrystock - Thu, 11 Sep 2014 18:20:53 EST ID:yhZ5GLN3 No.75391 Ignore Report Quick Reply
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HEERE OMG I drew a picture.

The blue mechanism is a "curly arrow", found in almost all common organic reaction mechanisms. It shows the PAIR of electrons going to chlorine. The red "fish hook arrows" show something called heterolytic cleavage, giving two radical species with odd numbers of electrons (the dot means it is a radical, even though chlorine would actually have 7 dots if you were drawing the electrons like at the top).

Radicals are unstable because the pairing of electrons is very energetically favourable (afbau principle).
Jack Fonningwork - Fri, 19 Sep 2014 06:19:38 EST ID:8tQGzRP2 No.75421 Ignore Report Quick Reply
im late but thanks dude i really appreciate the explanations

uni science courses-What field to study by Priscilla Bapperman - Thu, 18 Sep 2014 18:04:04 EST ID:EALu1k1z No.75417 Ignore Report Reply Quick Reply
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First ff it' going to take me about 3 years to even get to the point where I can apply for uni as I done shit when I was back in school 8 years ago and I went off and done a plastering course.

My basic english and maths skills are terrible becuase my school was shit and I jsut never paid attention.(I still read a fair bit though,when I get into my reading phases ill read 3-5 books a month,except in the sumemr then I jst workout hard and party harder )

But hey im going back at the age of 25 so im more motivated to do it now(also gotta pay £450 for each course so thats going to make me work harder)

> Im starting to wonder what I Should go into uni to do though

Im into health and fitness so my basic plan is to become a physiotherapist and aim high and one day have my own sports clinic.

But then im thinking once I get taught what to do thats it,im just teaching people what I know there wont be no real challenge and I think I would rather have a job where im figureing shit out my self,so I think I would want to do research.

Then im thinking becaus im into health and fitness why not become a chemist and botany and be involved in either actualy making suplment or herbal medicines.

Then I have other interests like things about Consciousness mental health problems like schizophrenia,psycopaths,alzheimer's and how the brain works and shit like that so maybe cognitive science or neuroscience.
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Priscilla Bapperman - Thu, 18 Sep 2014 18:07:24 EST ID:EALu1k1z No.75419 Ignore Report Quick Reply
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wrong pic

chem tv by Cornelius Wannerstack - Thu, 06 Feb 2014 17:42:04 EST ID:GKCTh1jS No.74165 Ignore Report Reply Quick Reply
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Nigger Clogglepen - Wed, 17 Sep 2014 18:50:07 EST ID:3tmSRK6q No.75413 Ignore Report Quick Reply
just me and carl sagan
CrazyFolksTribe !loJSOMZg0g - Wed, 17 Sep 2014 22:51:19 EST ID:WWbBPTNo No.75415 Ignore Report Quick Reply

obtaining phosphoric acid in australia by Shitting Turveyfield - Wed, 10 Sep 2014 04:12:52 EST ID:XjpcBuGN No.75374 Ignore Report Reply Quick Reply
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looking to get some phosphoric acid, i don't really mind if i have to buy in bulk but i don't want to have to order it over the internet as i intend to cook DMT with it, also any acids that work just as well would fine
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Basil Pabberbud - Wed, 10 Sep 2014 22:25:29 EST ID:wydHeI1M No.75386 Ignore Report Quick Reply
Why don't you just use hydrochloride acid? It should be much easier to find (I think it is sold a muric acid) and should work just as well for protonating the DMT. It is also harmless once neutralized. Does anyone here know why Phosphoric acid is used instead of HCl?
John Ninningwuck - Wed, 10 Sep 2014 22:32:42 EST ID:USTQ/RsL No.75387 Ignore Report Quick Reply
i don't know exactly why but all the research ive done tells me phosphoric is the way to go
Basil Pabberbud - Wed, 10 Sep 2014 22:53:50 EST ID:wydHeI1M No.75388 Ignore Report Quick Reply
I read a little bit on the extraction here : http://catbull.com/alamut/Bibliothek/DMT_Handbook.pdf . Hydrochloride acid is listed as an alternative while other sources don't even claim there is a need for the acid cook at all. Hydrochloric acid will work just as well as phosphoric acid and can be bought at a hardware store as muric acid. Lye can be bought under the name Red Devils drain cleaner.
Hedda Clayhood - Thu, 11 Sep 2014 13:49:53 EST ID:72wOh3Tw No.75390 Ignore Report Quick Reply
>pH up?

Choose one.
Phoebe Gecklepin - Sun, 14 Sep 2014 21:04:57 EST ID:tukF6vI+ No.75404 Ignore Report Quick Reply
It's used for removing rust on engine parts, so try an auto shop?

psychidelic self-synthesis by Sidney Trothood - Thu, 10 Jul 2014 16:09:26 EST ID:NyBW95X8 No.74986 Ignore Report Reply Quick Reply
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if i eat tryptamine, methionine and a reversable MAOI will i make dmt and trip? it was mentioned in the tryptamine chapter of tikhal
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Matilda Crullerfidge - Fri, 11 Jul 2014 21:44:50 EST ID:jKtOSqrn No.75002 Ignore Report Quick Reply
Hugh Bishchane - Sun, 13 Jul 2014 22:15:17 EST ID:NyBW95X8 No.75010 Ignore Report Quick Reply
Methionine acts as a methyl donor, and there are two enzymes specifically I was thinking of, HIOMT and INMT.
Samuel Wacklechone - Tue, 22 Jul 2014 01:47:38 EST ID:uGD5aNS6 No.75045 Ignore Report Quick Reply
Oh ok, makes sense, I shouldn't have called you retarded, my bad man. Chan culture gets to you sometimes, makes me impersonal. But yea supposedly INMT isn't really expressed in the brain, its mostly found in the lungs, so IDK what effect it would have. I know there's that study that showed that rats supposedly have DMT in their pinal gland, but even that's fishy because no one knows exactly what parts of the brain are effected by DMT and the pinal gland lies outside the of the blood-brain barrier in relation to the rest of the brain. So even then, still doubt it would work.
But good thinking none the less OP
Frederick Dartdock - Fri, 05 Sep 2014 19:29:56 EST ID:wydHeI1M No.75345 Ignore Report Quick Reply
DMT is the easiest drug to get. No one cares if you buy ____________ online, including the government.
Charlotte Nombleham - Sat, 13 Sep 2014 06:11:34 EST ID:jSOgRiGC No.75400 Ignore Report Quick Reply
You have my condolences if the easiest drug for you to acquire literally requires you to extract it from the plant. This isn't about doing DMT, this isn't about getting DMT, like you said, it's easy. This about biogenic DMT.

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