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DIY Vacuum filtration by The Cat SWIMs - Mon, 16 Feb 2015 12:26:29 EST ID:YG3vlR23 No.76108 Ignore Report Reply Quick Reply
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So I was looking at vacuum filtration and found a site that recommended water-jet pumps. So I thought, like a fish tank, right? So I want to know what a good, inexpensive fish tank pump or water- jet pump would be and cost. I can add a lamp switch to toggle on and off, so if anyone knows a good pump with a decent pressure for a 500ml flask, let me know please.
2 posts and 1 images omitted. Click Reply to view.
>>
The Cat SWIMs - Mon, 16 Feb 2015 12:50:46 EST ID:YG3vlR23 No.76111 Ignore Report Quick Reply
>>76110
Lol a shop vac. That might be a bit too much, but thanks for the help. I thought that an aquarium pump might not be enough, but I wonder about for a 100-50ml flask if they even exist. I might have to do some glass work but it would be a nice novelty nonetheless.
>>
The Cat SWIMs - Mon, 16 Feb 2015 13:49:16 EST ID:YG3vlR23 No.76112 Ignore Report Quick Reply
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>>76111
I read that the hand pump was shitty, but saw a 12V pump. Someone wrote a review about vacuum filtration. It looks pretty solid i'll probably splice in a toggle button or more likely a contact switch. Maybe i'll be really lazy and use a light switch.

Still looks solid as fuck. Any thoughts or notes?

http://www.amazon.com/gp/aw/d/B00DYA21PU/ref=pd_aw_sbs_5?pi=AC_SX230_QL60
>>
trypto - Mon, 16 Feb 2015 14:58:41 EST ID:f/SJzTz5 No.76113 Ignore Report Quick Reply
>>76112
Yeah, that looks pretty good. Needs a 12V dc supply, though. An old computer PSU would be perfect.
>>
Fuck Comblebot - Mon, 16 Feb 2015 18:19:14 EST ID:W1YYDCFB No.76114 Ignore Report Quick Reply
Are you intending to vacuum off VOC's? (volatile organic compounds) because if that's the case what some of these folks has suggested will lead to a rather nasty explosion...
>>
trypto - Mon, 16 Feb 2015 22:04:52 EST ID:f/SJzTz5 No.76115 Ignore Report Quick Reply
>>76114
If you use the cheapest shop vac available for explosive solvents on the advice of an internet stranger, you deserve whatever happens. LOL. Good point though.

Not sure the amazon pump would be safe either.

You might want to stick to aqueous stuff, OP.


GHB synth and chem by The Cat SWIMs - Thu, 05 Feb 2015 14:32:55 EST ID:QvWZKaF3 No.76072 Ignore Report Reply Quick Reply
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So I was pondering the use of Glucono Delta Lactone (GDL) as the precursor to GHB with KOH or Lye (NaOH) to synth GHB.
Dry it out in a pan and disolve it in the minimal ammount of ethanol at room temperature.
What would be expected from this; exothermic reactions, yield, and by products?
The last question, will it work?
5 posts omitted. Click Reply to view.
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Rebecca Sibbleman - Mon, 09 Feb 2015 03:20:37 EST ID:9Opqdgsf No.76088 Ignore Report Quick Reply
I have made GBL from GABA and nitrite. Fairly easy, didn't even bother with solvent extraction just distilled it off. Time consuming but at least i got to try ghb. Date rape drug my ass. Who doesn't notice 10 grams of salt in their fucking drink? Maybe my shit was impure, but it took me a few grams (dryed over calcium chloride) to feel good. The smell and taste is making me shutter. How anyone could consume that shit without knowing is beyond me. Maybe the calcium salt or something? fuck knows.
>>
Jenny Wivingmine - Tue, 10 Feb 2015 21:50:05 EST ID:uGD5aNS6 No.76095 Ignore Report Quick Reply
>>76088
Do you have a protocol for that?

Also did you mix the powder with water first before consuming it?
>>
Archie Drommerstidging - Wed, 11 Feb 2015 14:00:55 EST ID:9Opqdgsf No.76098 Ignore Report Quick Reply
>>76095
Was a long time ago, i forget. There is a nice writup under "sandmeyer gaba".

Put it in capsules, but ran out of caps and was trying to parachute it and shit. Took weeks to dry over cacl2. Kinda pointless.
>>
Isabella Suvingdick - Wed, 11 Feb 2015 23:31:46 EST ID:uGD5aNS6 No.76102 Ignore Report Quick Reply
>>76098
thanks a bunch man, found it
>>
The Cat SWIMs - Mon, 16 Feb 2015 12:13:44 EST ID:YG3vlR23 No.76107 Ignore Report Quick Reply
>>76084
Thanks a ton man. I figured as much, but i'm not the best at chem. I know enough to follow a recipe out of T/Pihkal and to know when I'm about to blow something up.
Also hydrogen gas has never been a big issue. Flask + stand + weather balloon + inch wide rubber band = collection of hydrogen gas so I can pump it into an empty CO2 tank.


Methylation of Acetylfentanyl by Oliver Blunningfore - Mon, 19 Jan 2015 16:57:44 EST ID:9Opqdgsf No.76023 Ignore Report Reply Quick Reply
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Hopefully someone knowledgeable in organic chemistry can help me out. Is it feasible to methylate acetylfentanyl? How would you go about it?
4 posts omitted. Click Reply to view.
>>
Albert Clanningladge - Tue, 20 Jan 2015 08:30:30 EST ID:9Opqdgsf No.76028 Ignore Report Quick Reply
Thanks, i may try this if i can make some propionic anhydride. What concentration of sodium hydroxide would you think is necessary? I have been reading and some reactions call for 40% by weight.
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Rebecca Sibbleman - Mon, 09 Feb 2015 03:10:39 EST ID:9Opqdgsf No.76087 Ignore Report Quick Reply
Bump, seems a 2% sol of KOH and a few days sitting converted 75% of it into something else, oily floating shit. Will be making a ketene lamp someday when its not -15 and i can do some tig welding. I think copper wire connected though spark plugs should work, im not going for tungsten because copper is a catalyst. That's the plan anyhow. I love the glowing copper penny over acetone trick. Catalytic heat production may melt me wire and i won't be able to see though my steel vessel. This whole thing is just by denial and error. Highly doubt it will work, won't be the first time. God knows how much codeine chemistry i have failed at. The dream of a sustainable habit is just alluring.
>>
Green Fox - Tue, 10 Feb 2015 15:13:59 EST ID:0YyKnwjY No.76092 Ignore Report Quick Reply
>>76087

Try not to die until you have the drugs at least. lulz
>>
Ernest Crorringwat - Tue, 10 Feb 2015 19:53:24 EST ID:sYWmhmdQ No.76093 Ignore Report Quick Reply
Uh, you realize that ketene will just give back your acetylfentanyl, right? If you want methylketene you might be able to put MEK through the system, but I have no idea if that will work at all, or simply explode, etc.

A better solution is to make propionic anhydride from sodium propionate and sulfur monobromide or monochloride.
>>
Archie Drommerstidging - Wed, 11 Feb 2015 13:58:45 EST ID:9Opqdgsf No.76097 Ignore Report Quick Reply
>>76093
Ketene will dehydrate proprionic acid to the anhydride no?


What's wrong with this piece of meat? by Hedda Hebberstine - Thu, 22 Jan 2015 11:17:57 EST ID:KCS86o4a No.76030 Ignore Report Reply Quick Reply
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Hi guys,

I'm not sure if I should have started this thread in /nom/, but I'm gonna try it here anyways.

What is wrong with this meat? Are microorganisms responsible for the green discoloration or has it something to do with enzymes? I can't tell whether the meat smells bad or not (pic is not mine). Is the discoloration a proof of bacteria or mold infestation, or is it safe to eat?
9 posts and 1 images omitted. Click Reply to view.
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Lillian Mubbershaw - Tue, 27 Jan 2015 22:59:08 EST ID:uGD5aNS6 No.76044 Ignore Report Quick Reply
>>76043
Its partly this and partly my poor description.
Its very hard to describe because it is such an innate ingrained thing to me. But the color is definately more of a grey than the ring pictured there, with a green, almost bluish hue. In general.
Smell is a better indicator. Fresh meat shouldn't really smell like much, maybe a little like blood or beef. Bad meat has a pungent smell, its quite obvious and detectible.
My point is color is sort of a tough indicator as perfectly fine meat can turn brown if its relatively oxygen deprived. Go with your gut, is it slimy, does it smell funky? Even then, as long as its not totally degraded you'll probably be fine if you cook it right, since the microbes get boiled off it anyway.
>>
Reuben Geshhetch - Thu, 29 Jan 2015 10:21:07 EST ID:mPxNc9mh No.76050 Ignore Report Quick Reply
>>76044
Does OP's meat look dyed though?
>>
Alice Snodwater - Thu, 29 Jan 2015 19:53:47 EST ID:iiBda9a+ No.76053 Ignore Report Quick Reply
>>76050
definitely dyed/co treated. looks very much like fluid penetration to me
>>
William Bocklefuck - Fri, 30 Jan 2015 10:12:24 EST ID:uGD5aNS6 No.76054 Ignore Report Quick Reply
>>76050
Yea possibly, but its hard to say through a picture. Its not the inner dark red area, its that outer lighter red area. The red looks unnatural.
>>
Fucking Heckleforth - Tue, 10 Feb 2015 13:44:42 EST ID:Hh65axAf No.76091 Ignore Report Quick Reply
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Could be thin film interference maybe?

http://www.optics.rochester.edu/workgroups/cml/opt307/spr11/xi/origin.html


Tesla's Tower by Martin Bibberspear - Wed, 16 Jul 2014 02:13:51 EST ID:ZFwui662 No.75020 Ignore Report Reply Quick Reply
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Was just lamenting on the tower after watching a Tesla documentary....
Why do people have to be so greedy?
We could all have free electricity now!
Even the poor!
I wish there was a way this could be built...
.. Maybe someday.
17 posts and 2 images omitted. Click Reply to view.
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William Sigglewater - Thu, 15 Jan 2015 22:53:15 EST ID:st1K9a/U No.76016 Ignore Report Quick Reply
How do you avoid indiscriminately electrifying metal surfaces?
>>
Graham Brirrykene - Sat, 17 Jan 2015 01:02:12 EST ID:BumlS4dU No.76020 Ignore Report Quick Reply
>>76016
The oscillating fields are too weak to produce anything noticeable unless a receiver tower is used to focus the energy. Kind of like tuning in to a radio station. Still, I would have to question what effect the oscillations would have on wildlife and the quality of our atmosphere, given that we're kind of fucking with the charge of the ionosphere. I wonder if the HAARP discovered anything related to this before it was shut down.
>>
Jarvis Bunville - Sat, 17 Jan 2015 20:40:46 EST ID:waskwCCx No.76021 Ignore Report Quick Reply
>>76020
> HAARP
The weather adjusting thingamagik ?
Weaponizing weather sounds nice
>>
Thomas Cammlewill - Mon, 26 Jan 2015 11:31:11 EST ID:PHMeBx/k No.76042 Ignore Report Quick Reply
>>76021
>HAARP
>weather adjusting
>>
Jarvis Sangerstidge - Sat, 07 Feb 2015 04:15:22 EST ID:09LfhiJX No.76081 Ignore Report Quick Reply
From what i remember Tesla experimented with some sort of tower, much similar to a RADIO TOWER.
P.s. Edison stole the patent, end of story. RIP


Gen Chem and O-Chem Books. by Amature - Thu, 05 Feb 2015 17:42:19 EST ID:W1YYDCFB No.76073 Ignore Report Reply Quick Reply
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There is a disturbing lack of chemistry literature in my library. Could you good chaps recommend some books on Orgo and Gen Chem? Ones covering retrosynthetic analysis is *very* much appreciated. I plan on spending around $300.

PS: Had quite a few book son the subject but they got lost in a move. :(
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Edwin Fanbanks - Fri, 06 Feb 2015 03:31:08 EST ID:W1YYDCFB No.76075 Ignore Report Quick Reply
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Shameless self bump!
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Ernest Chindledadge - Fri, 06 Feb 2015 05:05:35 EST ID:DR5khdMb No.76076 Ignore Report Quick Reply
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Some years ago we had an /r/ thread. It was quite a thing.
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Wesley Buzzworth - Fri, 06 Feb 2015 09:34:09 EST ID:f/SJzTz5 No.76078 Ignore Report Quick Reply
>>76075
Gen chem books are pretty much all equal. Same with introductory organic textbooks. Beyond that is where the textbooks start to have character. I suggest Intermediate Organic Chemistry by Hoffman. It's very good for retrosynth.

Quantitative Chemical Analysis by Harris is a good reference to have around. You should be able to get those four books for under $150. Old editions are fine. Not first editions though, those are usually riddled with errors.
>>
Wesley Buzzworth - Fri, 06 Feb 2015 09:53:07 EST ID:f/SJzTz5 No.76079 Ignore Report Quick Reply
>>76076
libgen.org for all your pdf needs. It's almost as good as library.nu was.


Experiments at home by Matilda Duckgold - Tue, 03 Feb 2015 19:50:15 EST ID:hYuk7OQn No.76070 Ignore Report Reply Quick Reply
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I have (2E)-2-(3,4-Dimethoxybenzylidene)-1-indanone (pic related)
I was wondering if there's any experiments or fun things to make with as i'm trying to get into organic chemistry. I know it's fairly specific, but does anyone see any structure related things I can screw around with and make something? Doesn't have to be drug related, although i'm not against it.
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Syllogism - Thu, 05 Feb 2015 06:48:33 EST ID:stqlrmZK No.76071 Ignore Report Quick Reply
If you're seriously looking to just fuck around with it there's plenty of shit really. O.chem is about the transformation of functional groups into other functional groups. In that regard your molecule becomes far less specific, and far more a sum of familiar parts.

Your molecule has a ketone, a double bond, ethers, and aromatic rings, and so it would be suspectible to any conditions that would transform those functions into other functions.

For instance you could try oxidizing the double bond with KMnO4, affording a diol in place of the double bond. You'll get to see a fancy decoloration of your KMnO4 solution if you use a 1:1 molar ratio.

Then, you could use extraction and chromatography techniques to seperate the end product from the reaction pot. plenty of fun.


Looking for advice. by Phyllis Tootridge - Mon, 02 Feb 2015 23:14:06 EST ID:iSJN1igQ No.76067 Ignore Report Reply Quick Reply
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Hey everyone! I'll try and keep this as straight forward as possible, I'm a freshman in college I'm 90% positive of what I want to do with my life. I know I wan't to work in a lab, doing research and development, or just something that's more ground breaking? I also get a chubby when I see long ridiculous equations because I want to understand what they mean so I have an affinity for math and physics yet I've never taken a physics course in my life sadly. Luckily that'll change by next semester. So the things I worry about is just having a chem degree I know the chem industry isn't booming job wise I know chem eng however is in demand right now but I'm at least 4 years away from entering the field so by then I believe the market will be saturated and job availability there would be scarce. So my question to you guys is what fields of science use a lot of physics and chemistry? I'm currently looking into quantum chemistry for fun and I really enjoy what I'm hearing but I have no concept of how to major in that I, if that's such a thing? So I'll just do some research for myself but does anyone know what its like to be a physicist like opportunity wise, work environment, etc
>>
Hedda Songernutch - Tue, 03 Feb 2015 11:15:16 EST ID:T3+BR5r7 No.76068 Ignore Report Quick Reply
>>76067
Engineering degrees (or at the very least the 'main' engineering degrees of mechanical, electrical, civil, chem) has been in demand for a while and will still probably be in demand in the future. Why? Because engineering is hard compared to most majors.
Physical chemistry would be a degree that has chemistry, math and physics. Mainly chemistry though.
Physics has a lot of math. Quantum physics deals with really small things. Smaller things than most chemists would even deals with.
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Barnaby Simmlebudge - Tue, 03 Feb 2015 14:44:56 EST ID:oDbdEczN No.76069 Ignore Report Quick Reply
Don't be surprised if you end up feeling like you want to change or get interested in something else a few years into your degree. I'm a second year chem major, Ochem was my thang, but it's getting tiring already. Physical chemistry sounds right up your alley, although at a US 4 year-uni you probably won't be taking it until your junior year, just because there is a lot of prerequisite knowledge needed from physics, math, and gen chem. Physical chemistry is basically the physics of chemistry, meaning you need a lot of physics math and chem to do well. I can't say much about the job prospects of any field, but if that's what your interested in you should go for it. Science degrees in general seem to have really saturated the market.


Chemistry vs. Chemical Engineering major by Fornification - Wed, 31 Dec 2014 12:43:38 EST ID:PFu1aymB No.75978 Ignore Report Reply Quick Reply
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I want to major in Chemistry and Chemical Engineering. Is this possible/advisable?

I'm already going for chemical engineering, but I'm not sure about chemistry.
11 posts omitted. Click Reply to view.
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Polly Blackshit - Sun, 18 Jan 2015 21:08:22 EST ID:5Rq6QanS No.76022 Ignore Report Quick Reply
>>76018
A Chemistry degree might require a phd and it still might be hard to find a job.
http://www.bls.gov/ooh/life-physical-and-social-science/chemists-and-materials-scientists.htm
http://www.bls.gov/ooh/architecture-and-engineering/chemical-engineers.htm
Granted chem engineering is a little slow at the moment due to the fall in gas prices but still it's a good job. Finding a job as a chemist has been hard for a while. It might get better but it might not.
Chem engineering has plenty of explosion topics (you'll be dealing a lot with heat and such). You'll have to take at least O chem 2 for chem Engineering. You'll take the same amount of lower level chemistry and roughly about the same amount of math for both degrees so if you want to change degrees it wouldn't be too rough.

Not to dissuade you from a chemistry degree. I really like my upper level chemistry classes. I just like to mention these facts because I've know a few chemist who have said that in retrospect they would have gone for chemical engineering due to jobs.
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Doris Drogglepitch - Tue, 20 Jan 2015 13:22:58 EST ID:f/SJzTz5 No.76029 Ignore Report Quick Reply
>>76022
>Granted chem engineering is a little slow at the moment due to the fall in gas prices but still it's a good job.
Why? Deflation affecting exports?
>>
Caroline Blizzlelodging - Wed, 28 Jan 2015 18:55:33 EST ID:wmjgglFR No.76047 Ignore Report Quick Reply
>>76029
The petroleum industry employes some chem engineers.
>>
Graham Doshstone - Wed, 28 Jan 2015 18:58:02 EST ID:T3+BR5r7 No.76048 Ignore Report Quick Reply
>>76029
Anyway, its just a short term thing.
>>
John Cozzleked - Sun, 01 Feb 2015 20:34:19 EST ID:0FJPg3OJ No.76064 Ignore Report Quick Reply
>>76022

For what its worth, i got a job in industry doing analytical chem and i only have a BS. You do not need to get an MS or PhD to get a job as a chemist. It helps, but if you can interview well and only apply to positions you're actually qualified for, then you can definitely get a job as a chemist with only a BS. You won't be starting above entry level, but i wouldn't want to start above entry level in industry if your only other experience with chem was in undergrad and grad school. Its way different.

If you major in chem or chem E, truly learn and understand the chemistry well and don't just memorize things for tests, and can do well in the interview, you will get a job eventually with only a BS. You have to be in an area with a decent number of chemistry jobs though, meaning you might have to move.

Hell the VP of my company only has a BS.


Just a little question about subjects needed for chemistry at degree level by Angus Shakelock - Sat, 24 Jan 2015 08:08:42 EST ID:mWHp41fC No.76037 Ignore Report Reply Quick Reply
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So i love chemistry, and all sciences if im truly honest. Just wondering what base knowledge i need, obviously math, but what are the main parts of math involved, also any other basic subjects i should know will be applied or Organic / Medical Chemistry?
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Betsy Brimblesedging - Sat, 24 Jan 2015 23:29:21 EST ID:+0Ci6TLP No.76039 Ignore Report Quick Reply
>>76037
Firstly, you need to take general chemistry; this will teach you how to read the periodic table and stoichiometry. The only math required is basic algebra.

After that, for organic chemistry, you'll just be memorizing a lot of terminology. You'll need gen-chem and algebra.

For physical chemistry and quantitative analysis, you'll need gen-chem and calculus (usually calculus 2, though some schools require calc 3).

If you have the required math, you could take all of those courses concurrently or in any order.
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Skeetch !xbRTl.ntC2!!XEDjiGeI - Wed, 28 Jan 2015 07:48:38 EST ID:mWHp41fC No.76045 Ignore Report Quick Reply
>>76039
Ok lets say i know nothing, i mean nothing, no base math knowledge, no chemistry. Where would be a good place to start (i mean book wise, something in layman's terms if you will) Should i maybe read into that area of math first? I'm thinking learning as a hobby wise, currently. Its something i've always been interested in. If i can get it as a .PDF that'd be great. Just give a title or something, author maybe.
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David Sollermadge - Wed, 28 Jan 2015 11:19:57 EST ID:YwrKBX+S No.76046 Ignore Report Quick Reply
>>76037
My school requires Calc 3 but I'm a math minor so i have some extra class to take.
for organic you basically need to know general chem, look up the 8 pillars of organic chemistry and learn everything you can about those. Medicinal Chemistry will most likely have a lot of biology going along with it, i have no idea though. Im going for my ACS Chemistry degree or whatever it is btw.
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Lydia Brobberpetch - Wed, 28 Jan 2015 23:50:01 EST ID:mEgh7QsF No.76049 Ignore Report Quick Reply
>>76045


you know nothing? buy a good general chem textbook (changs "chemistry" 10th or 11th edition) and just read through it at your leisure with a notebook on your lap


Low yield nukes by Angus Neshwell - Fri, 23 May 2014 06:43:15 EST ID:sBVjj75A No.74752 Ignore Report Reply Quick Reply
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>The smallest nuclear weapons actually deployed have had yields around 10 tons (like the W54), and have been intended for short range tactical or nuclear demolition use (e.g. blowing up roads and bridges).

>The absolute minimum possible mass for a bomb is determined by the smallest critical mass that will produce a significant yield. Since the critical mass for alpha-phase plutonium is 10.5 kg, and an additional 20-25% of mass is needed to make a significant explosion, this implies 13 kg or so. A thin beryllium reflector will reduce this, but the necessary high explosive and packaging will add mass, so the true absolute minimum probably lies in the range of 10-15 kg.

>The W54 warhead used in the Davy Crockett had a minimum mass of about 23 kg, and had yields ranging from 10 tons up to 1 kt in various mods (probably achieved by varying the fissile content). The warhead was basically egg-shaped with the minor axis of 27.3 cm and a major axis of 40 cm. The W-54 probably represents a near minimum diameter for a spherical implosion device (the U.S. has conducted tests of a 25.4 cm implosion system however).

http://www.veteranstoday.com/2014/05/22/constructing-the-nuclear-child/comment-page-1/#comment-539600

Low yield mini nukes. And if you're fretting OMG what if these fell in the wrong hands -

they already have. Pic related.
5 posts omitted. Click Reply to view.
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Henry Chankincocke - Mon, 02 Jun 2014 10:48:14 EST ID:Nbu7dGdg No.74771 Ignore Report Quick Reply
>>74769
Can you at least try to discuss something rather than just posting links? Are you asking something? Do you have a point to make? I'm not gonna read some random-ass papers because you said to.

Are you just saying that tactical nukes have been used? If so, could you find something better written? The articles you've posted are very rambling. And is the second link saying that 9/11 was caused by nukes? That's asinine. I'm sympathetic towards /tinfoil/ers, but it seems pretty obvious that 9/11 didn't use nukes. Like you said,
>people have been filming nuclear explosions for a long time, that's how we know what they look like.
And 9/11 didn't look like a nuke.

nb
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Edwin Drodgebury - Mon, 02 Jun 2014 18:29:48 EST ID:e4BjoeoE No.74774 Ignore Report Quick Reply
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>>74771

It's for discussing nukes in general and where they are field tested.

Davy Crocket nuke is pretty small.

They used that kind of nuke on Syria, fired by artillery.

> The Mk-54 weighed about 51 lb (23 kg), with a yield equivalent to somewhere between 10 or 20 tons of TNT
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Fuck Pecklegold - Tue, 13 Jan 2015 05:37:38 EST ID:p2Y8WyNI No.76012 Ignore Report Quick Reply
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>>74752
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Ernest Giffingwill - Tue, 13 Jan 2015 18:43:06 EST ID:mPxNc9mh No.76013 Ignore Report Quick Reply
>>76012
WHy the fuck would you bump a 6 month old thread?
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CrazyFolksTribe !loJSOMZg0g - Thu, 29 Jan 2015 19:44:25 EST ID:DHa/QsRX No.76052 Ignore Report Quick Reply
>>76013
Why not?


Insulin Suppliments by Edward Tootshaw - Sun, 28 Sep 2014 21:18:10 EST ID:RLSN+6eM No.75467 Ignore Report Reply Quick Reply
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Okay just spitballin here. So you're not supposed to eat a whole tub of Ice Cream because it forces your pancreas to produce a whole lot of insulin in order to break down all those sugars, right? So that strain on your pancreas is bad. So what if we could help out the pancreas by supplementing some some insulin?
What if you bought some insulin and took it orally? Would it work that way? Or would you have to IV some?

And how the pancreas even detect how much to produce? I heard that it can even start producing some in advance based only on the taste of sweet foods on your tongue.
3 posts and 1 images omitted. Click Reply to view.
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Lydia Baddlebury - Thu, 09 Oct 2014 09:19:14 EST ID:+0Ci6TLP No.75517 Ignore Report Quick Reply
Insulin doesn't break down sugar; it signals cells to sequester sugar. Basically you have all this sugar floating around, and your cells are like "eh, whatevs", then insulin walks by and says "GODDAMNIT THIS IS THE THIRD TIME TODAY I'VE STEPPED ON SOME FUCKING GLUCOSE! PICK THIS SHIT UP, YOU STUPID FUCKS!", and then the cells panic and absorb all the glucose they can.
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Martin Gossleshaw - Tue, 06 Jan 2015 15:04:20 EST ID://0Qtc/R No.75998 Ignore Report Quick Reply
I always have type 1.

Insulin is the brother to Glucagon. Insulin tells cells/the liver to take up all the glucose. The liver stores it as glycogen, cells eat it or store it as glycogen in muscles. In non-diabetics, the pancreas also utilizes glucagon. It's sort of the opposite. Blood sugar too low? Glucagon unlaces glycogen in the liver so that your blood glucose levels are sufficient. I'm trying to be an armchair endocrinologist, but I can't understand why us type 1's can't utilize our glucagon. What gives? We still have it, but it doesn't do its job when we're low.
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Jack Soggleman - Fri, 09 Jan 2015 13:47:46 EST ID:5Rq6QanS No.76004 Ignore Report Quick Reply
Sort of a fun fact:
Central Diabetes Insipidus (unrelated to DM) can be cured using oral tablets. http://en.wikipedia.org/wiki/Diabetes_insipidus#Treatment
But yea, not how DM works.
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Albert Crorrystone - Sat, 10 Jan 2015 22:16:43 EST ID:uGD5aNS6 No.76007 Ignore Report Quick Reply
>>75998
If I am not mistaken, isn't the problem with type 1 diabetes not the receptor (as in type 2), but in insulin production itself?
So if I remember correctly, type 1 diabetics can't make insulin. Thus, when you take in glucose, not that much of it makes it into the cells. Most of it, though not all, is excreted.
So with glucagon, you are causing the cells to release their glucose. But if there really isn't that much glucose in the cells, there won't be enough to excrete.

I know insulin and glucagon also have a lot of other side effects, like affecting the balance between gluconeogenesis, glycolysis, and glycogenesis. Also they affect beta-oxidation and fatty-acid synthesis, as well as glucagon's well established role in hormone-sensitive lipase activation (fatty acid mobilization from adipose tissue). And a host of genetic regulatory events.

My point is its quite complicated, but probably due to the fact that your body has very little glucose to release into the bloodstream from storage, and thus must come from the diet.
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Cornelius Sallyshit - Mon, 12 Jan 2015 15:53:46 EST ID://0Qtc/R No.76010 Ignore Report Quick Reply
>>76007

Type 1 diabetics, in order to be alive, take insulin in some form. Far from effective but it still delivers glucose to cells. Otherwise we would die. Our glucagon just doesn't do its job. A study I read showed that type 1 diabetics won't respond to hypoglycemia with glucagon. But glucagon release could be stimulated by arginine.

We have glucagon that works, our bodies just don't understand synthetic insulin induced hypoglycemia (I guess) enough to utilize natural glucagon.


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