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Grow your own drug? by Esther Bezzlehid - Wed, 23 Apr 2014 23:03:20 EST ID:SneqK8/u No.74586 Ignore Report Reply Quick Reply
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Why do you think no one has tried to grow their own coca/poppies indoors? Just surprised since weed and shrooms have been cultivated indoors for quite a while now. Granted processing cocaine and (probably) heroine takes more work but still, hydroponics have become complex. So, I would reason that drug extraction from other plants doesn't seem too difficult for some of the more curious in the age of the internet.
>Anyway, why do you think this hasn't been tried yet?
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WIAKR+Pa - Thu, 23 Jul 2015 09:57:46 EST ID:lfUESqVd No.76834 Ignore Report Quick Reply
Would supplementing their growth with l-tyrosine do anything? I couldn't find anything online and /crops/ is 99% how do I marijuana
Bombastus !!HToBa9dh - Fri, 24 Jul 2015 17:14:39 EST ID:vbS8CtHn No.76842 Ignore Report Quick Reply
Hey there, WIAKR+Pa. Nice to see you on /chem/ ^o^
I wouldn't know much about the l-tyrosine. As far as I know, the only thing that has been shown to noticeably increase alkaloid content is carbon dioxide. You may be able to stimulate growth by ramming metal blades across the lawn every week as they respond to stress and stuff but the thing is you can't really be sure.
Oh and also, water all opium poppies with soda water. Or make your own soda water by tossing a piece of dry ice in water in a thermos. I think they have home carbinators at walmart, too, though.
WIAKR+Pa - Fri, 24 Jul 2015 18:47:39 EST ID:lfUESqVd No.76843 Ignore Report Quick Reply
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Nice to be here Bombastus. They sell bulk tyrosine as a supplement, and it's used at a rate of 2mol tyrosine/1mol morphine in the biosynthetic pathway of the opium poppy, so I definitely get the feeling that if it can be reasonably absorbed by the plants then it should increase the alkaloid content. Maybe I'll do a little unofficial test with a few plants. Nothing huge, but if the chance arises then I'll see what I can do.
Bombastus !!HToBa9dh - Fri, 24 Jul 2015 19:41:48 EST ID:vbS8CtHn No.76844 Ignore Report Quick Reply
if i didn't fucking hate fucking botany with a fucking wrath, then i'd probably go around growing poppy plants and analysing the difference in morphine. you could always do that and report back?
i'm sure a lot of people would be quite greatfull for that. but my guesses (with my limited understanding of biosynthesis) is that just because you have a precursor doesn't mean you will get more end product

the complex pathway you posted up probably has a limiting reaction that isn't just the starting precursor. this is just me speaking for a statistical point of view. it could very well increase morphine production but i don't think it's likely
Caroline Gashhine - Sun, 26 Jul 2015 22:24:26 EST ID:uGD5aNS6 No.76849 Ignore Report Quick Reply
>just because you have a precursor doesn't mean you will get more end product
This, 1000X
enzyme kinetics are tricky because in a test tube you can force a reaction with high concentrations of substrate, but often enzymes are highly regulated, including inhibition by the products of the reaction or biosynthetic pathway.

Simple equilibrium dynamics and mass action, that sort of thing, doesn't really apply to biosynthetic pathways. It's worth a try though.

How many great grandparents do I have? by Eliza Brecklekedging - Thu, 23 Jul 2015 19:47:38 EST ID:AFCPP6XZ No.76836 Ignore Report Reply Quick Reply
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Has anybody roughly calculated the number of generations separating us from the oldest known organisms?
Nigel Bipperson - Thu, 23 Jul 2015 23:05:11 EST ID:pSzcCxpL No.76837 Ignore Report Quick Reply
That would be impossible because we don't know all of our antecedents or their average generation times.
Reuben Gongerwater - Sun, 26 Jul 2015 08:55:04 EST ID:pXaPdrMd No.76846 Ignore Report Quick Reply
It would be impossible to get an exact number, but it would be only difficult to generate a reasonable approximation. It comes down to a matter of how many orders of magnitude off you might be.

I'm not into this evolutionary stuff, so I don't know the numbers BUT apparently there's 3.5 billion years between us and the first cell. Assume 1 hour generation time until 610 million years ago when multicellular organisms appear. Let's move on to a 10 hour generation time. Animals popped up pretty soon, so 600 million years ago the generation time jumped to 10 days. 500 million years ago things crawled on the land with, say, a 1 month generation time. Around 360 million years ago amphibians appears so let's go with a 6 month generation time for a seasonal sorta thing goin on. 150 million years ago amniotes appeared, so let's finally reach a 1 year generation. Mammals 130 million years, so jump up to 2 years. Homininae 10 million years ago; big jump to 15 years. Modern humans 250,000 years so 20 years.

Despite my pulling this out of my ass/wikipedia, let's do a tally:

1 hour generation time: 2.89 billion years * 8760 hours per year *1 gen/hr = 25.3 trillion generations
10 hour generation time: 10 million years * 8760 hours per year * 1 gen/10 hrs = 8.76 billion generations
10 day generation time: 100 million yr * 365 day/yr * 1gen/10day = 3.65 billion generations
1 month generation time: 140 million yr * 12 month/yr * 1 gen/month = 1.68 billion generations
6 mo. gen time: 210 million yr * 12mo./yr * 1 gen/6mo = 0.42 billion gen
1 yr gen time: 20 million yr = 20 million gen
2 yr gen time: 120 million yr = 60 million gen
15 yr gen time: 975000 yr = 650000 gen
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alternatives to unattainable chemicals by Simon Sommlebark - Thu, 23 Jul 2015 17:20:43 EST ID:SazBGrfb No.76835 Ignore Report Reply Quick Reply
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If one would like to do Kash's advaned lsa extraction but didnt have access to toluene or DCM, what could they use? lsa crystals would be ideal for that person imo.
Nigel Bipperson - Thu, 23 Jul 2015 23:08:40 EST ID:pSzcCxpL No.76838 Ignore Report Quick Reply
Toluene is readily available at hardware stores. You could also try xylene.
Cedric Grandshit - Fri, 24 Jul 2015 21:29:39 EST ID:mEgh7QsF No.76845 Ignore Report Quick Reply
dcm you can order from ebay (from europe but mine came through to canada)

and like the above dude said you can buy decently pure toluene at the hardware store

Toxic house by Charles Biddlechat - Sun, 19 Jul 2015 13:05:19 EST ID:WlN9uuNp No.76821 Ignore Report Reply Quick Reply
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>live in 200 year old house
>window is 200 years old and made of wood
>live in climate where the wind is blowing 60 mph every single day
>wind comes in through my window 24/7
>the smell that comes from my window is musty and makes me sick

I'm pretty sure there is lead or something toxic in this window because I feel like shit every single day. There's paint chipping off it and the window isn't even sealed. What do?
3 posts omitted. Click Reply to view.
Bombastus !!HToBa9dh - Sun, 19 Jul 2015 17:44:39 EST ID:vbS8CtHn No.76825 Ignore Report Quick Reply
then cut out some wood and buy a window that fits the dimensions.
This is why I linked you to >>>/howto/. They'll have better ideas than me for replacing outdated windows as long as you have the house information.

Also, ask them how to remove mold.

No; This is the basis of homeopathy, lol. I know you didn't want it to be but you've just proposed a homoeopathic toxin, lmao.
Nicholas Turveygold - Sun, 19 Jul 2015 19:36:24 EST ID:pDka/jle No.76826 Ignore Report Quick Reply
You made a thread about this before. Go to the doctor. If it's lead poisoning, then they will very easily be able to tell by a simple blood test. It's probably not the lead, though.
Bombastus !!HToBa9dh - Mon, 20 Jul 2015 16:09:18 EST ID:ElYFdcKO No.76827 Ignore Report Quick Reply
That's what I thought. But I don't think it's the same guy as kNWNBofZ in this post: >>76584

Ebenezer Gummershit - Wed, 22 Jul 2015 15:21:56 EST ID:cM6rhCgJ No.76832 Ignore Report Quick Reply
Use an epoxy paint coating over the edges on the inside and the outside.
Beatrice Bobberway - Wed, 22 Jul 2015 18:07:25 EST ID:t+gXfaEF No.76833 Ignore Report Quick Reply

Kratom synthesis by Hedda Wonkinstock - Tue, 16 Jun 2015 09:24:38 EST ID:hBwYKLP1 No.76685 Ignore Report Reply Quick Reply
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hello chem/ im a complete noob to chemistry but i have been thinking if there is any way to synthesize kratom alkaloids to make a more powerful "drug"?
I read somwhere scientists were making a replacement for opiate drugs using kratom
3 posts omitted. Click Reply to view.
Shitting Dunnercocke - Wed, 17 Jun 2015 22:14:32 EST ID:0FJPg3OJ No.76692 Ignore Report Quick Reply

Nobody has any chance of doing that without access to a full lab, chiral resolution techniques, it has 5 chiral centers FFS, 32 potential isomers, fuck that.

If you can synthesize that, you might as well just make a fuck ton of LSD or a synthetic opiate like a fentanyl derivative because you are a fucking amazing chemist and apparently, very well equipped for organic synthesis.

Its already synthesized for you in kratom, its much easier to design an extraction to isolate the active/actives from kratom than it is to synthesize kratom from serotonin.
Bombastus !!HToBa9dh - Thu, 18 Jun 2015 12:48:40 EST ID:qb2qUOr3 No.76695 Ignore Report Quick Reply
Hey! I was just offering a glimmer of help.

As I mentioned above: " It won't be buttfuck impossible! It'll just be incredibly hard." Eluding to its nature of still being incredibly hard.
Shitting Dunnercocke - Thu, 18 Jun 2015 17:19:18 EST ID:0FJPg3OJ No.76696 Ignore Report Quick Reply

Incredibly hard is realistically impossible in this case, lets be practical. We're talking kitchen chemistry not a full lab situation.
Hugh Fanwater - Thu, 16 Jul 2015 09:09:07 EST ID:WoOdvzFR No.76817 Ignore Report Quick Reply
total noob in this field but would an alkaloid extraction be possible with sodium carbonate/bicarbonate and a solvent like alcohol or acetone for fast evaporation?
Samuel Clodgetat - Thu, 16 Jul 2015 17:33:18 EST ID:mEgh7QsF No.76818 Ignore Report Quick Reply

7-hydroxymitragynine and mitragynine are both water soluble and likely soluble in ethanol aswell. you could try making "tea" with ethanol and evaporating it to yield some alkaloids.

i have literally zero experience with kratom though i could be wrong

Animal with endocrine system most similar to humans by Eliza Hicklegold - Wed, 15 Jul 2015 19:19:10 EST ID:AhXCC5C1 No.76813 Ignore Report Reply Quick Reply
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Doing a 4k report on addiciton, just need some confirmation so I can use certain sources

Is it white lab rats like my initial thought is, or is it something else. I know ferrets have a similar immune system to ours...
Thomas Doddleman - Wed, 15 Jul 2015 20:39:32 EST ID:pSzcCxpL No.76815 Ignore Report Quick Reply
Here's a journal article titled "Animal Models of Substance Abuse and Addiction: Implications for Science, Animal Welfare, and Society" to help you, and a relevant quote from the 5th-ish paragraph of the article.
>Although rodents are most often used in these studies, this model has been used with a variety of species including nonhuman primates, dogs, and cats.

LITERALLY THE FIRST GOOGLE RESULT FOR "addiction research animals". What the fuck, man? Seriously. What the fuck?
Walter Songerford - Wed, 15 Jul 2015 21:11:07 EST ID:AhXCC5C1 No.76816 Ignore Report Quick Reply
thankyou, thankyou, thankyou!

The report is on the human aspects of successful treatment in terms of subsequent relapse, so i hadn't geared my head to think about it in terms of organisms other than humans

I am sorry, it's been a long day and i'm pretty beat. I'll brain harder from here on

Color Differences in Dansylation by Shit Clandlestutch - Wed, 15 Jul 2015 16:16:23 EST ID:6U9qqpUA No.76808 Ignore Report Reply Quick Reply
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So, during my lab's standard dansylation protocol (for wheat, in this case) , I have found that the colors in each microtube vary. I don't know if this is because each tube contains a different genotype of wheat, or if the process isn't thorough enough to get the dansyl chloride mixed up in the tube to produce more yellow color. I don't know if that will have an effect on the results when I run the samples through HPLC at the end, but thought I'd ask.

Jobs in Biochemistry by Slippery Jim - Fri, 15 May 2015 11:17:42 EST ID:5rbJvqan No.76539 Ignore Report Reply Quick Reply
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Anyone know of any good job types in the biochemistry field that don't usually random drug test? Will they randomly drug test pharmaceutical reps? I like smoking weed on the weekends and don't want to work for Gattaca Corp.
7 posts omitted. Click Reply to view.
Jack Brerringspear - Wed, 01 Jul 2015 21:41:55 EST ID:Zi8GiUIa No.76752 Ignore Report Quick Reply
I'm temporarily working in a Plant Biochem and genetics research lab at my University. Not great pay, but good on a resume at least. No drug tests yet.
Fucking Dasslewock - Sun, 05 Jul 2015 00:32:05 EST ID:BF148c9+ No.76756 Ignore Report Quick Reply
This isn't related but since there's so many biochem majors in one place: I've only got the gen eds down for biochem. Should I keep going or switch to something like public health? I was going to switch to just biology but that's a b.a. at my university. I've heard not the greatest things about the field.

OP I've found most jobs don't piss test after the initial hiring, if they test at all.
Wesley Misslenidge - Sun, 05 Jul 2015 20:34:51 EST ID:roMD3xgx No.76759 Ignore Report Quick Reply

Biology is useless in comparison to biochemistry. The job markets for biology are much tougher for biology majors because biology is easier.

I don't know much about public health, but it sounds like a degree where you need to know people to break into the field. Not that you don't need to know people for chemistry, but the skillset in biochem is more versatile.

If I was going to advise you in things that are worthwhile in college, I would say go in the opposite direction; instead of doing something easier, challenge yourself and go into engineering. There's always jobs for engineers, and they generally have more influence on the world around them (if that's something your'e looking for).
Wesley Misslenidge - Sun, 05 Jul 2015 20:36:26 EST ID:roMD3xgx No.76760 Ignore Report Quick Reply

Oh yeah.

Source: Graduated with biochem degree, doing a mashup of physical chemistry and chemical engineering at the moment.
Eugene Fovingsud - Wed, 08 Jul 2015 14:28:35 EST ID:L5+Uc7hP No.76768 Ignore Report Quick Reply

There are a lot *more* biochemistry jobs, but you should work for the job you really want rather than what's most available or easiest. If you don't like biochem then why bust your ass for it? Don't be afraid to switch paths, especially if you're young. If the two share enough required classes you could maybe even major in both. Both are really cool fields imo.

psychedelic visuals by Jarvis Gidgewell - Wed, 01 Jul 2015 00:35:27 EST ID:s6fjKs0p No.76750 Ignore Report Reply Quick Reply
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why are these visuals similar to psychedelic visual?
Alice Crobberdock - Wed, 01 Jul 2015 09:55:07 EST ID:HlJC3ujQ No.76751 Ignore Report Quick Reply
Because Hell is real.
Just look at those fucking faces.
Doris Coddlebud - Fri, 03 Jul 2015 11:54:45 EST ID:pDka/jle No.76754 Ignore Report Quick Reply
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It recursively applies pattern-recognition to an image. Each step alters parts that look like a pattern to look *more* like a pattern. Psychedelics apparently do the same thing.
Bombastus !!HToBa9dh - Fri, 03 Jul 2015 18:31:04 EST ID:V1Ngvki3 No.76755 Ignore Report Quick Reply
Much how humans try to find faces in everything, facial detection software does pretty much the same thing inadvertantly. It's more because our idea of a face is so fucking simple that we can distil it down to two dots and a stroke( ie: " :| ").

It's not that there are inherent faces. Rather, we just find it everywhere.

//pss/ off

How to educate myself by Just some guy - Sun, 21 Jun 2015 19:19:42 EST ID:dvfeY7tm No.76704 Ignore Report Reply Quick Reply
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I'm looking to educate myself as much as possible in the way of chemistry, botany and biology in general.. where should I start in the way of learning material? Most courseware out there requires some prior knowledge, I'm looking to start out as basic as possible and work my way up to more intricate and detailed information.

Are there any good resources out there to help me out here? Pic unrelated
5 posts omitted. Click Reply to view.
Clara Claywater - Fri, 26 Jun 2015 00:00:15 EST ID:EPHXMC+Q No.76744 Ignore Report Quick Reply

Fuck Clayson - Sat, 27 Jun 2015 22:47:41 EST ID:uGD5aNS6 No.76746 Ignore Report Quick Reply
lol I do cell biology, study neurons specifically.

It's really not brute memorization as you say. My research as of late has been on neuronal cytoskeleton, so its mostly biochemistry and protein chemistry.

A lot of it is really abstract, like having to visualize these really arcane ideas and picturing what's actually happening in your head, coupled with understanding kinase pathways and the regulation thereof. Its like a super complex really cool puzzle and tweaking aspects of it can change the size and shape of an axon quite robustly. Kind of interesting IMO.
Bombastus !!HToBa9dh - Sun, 28 Jun 2015 10:34:30 EST ID:ElYFdcKO No.76747 Ignore Report Quick Reply
Oh no, research is fucking awesome. Culturing cells are really nice cus it's like Cookie Clicker - you set it up and see it exponentially grow. Centrifuging and protein coding is nice, too. I've always been interested in the AcChol-A biosynthesis routes that take plants 1 day to react with no chemicals at all besides simple air and carbon dioxide.
The labwork is all quite fun to fuck around with.

But I just didn't have the balls to do all those undergraduate courses. Damn biologists... Oh, u so cray cray. I appreciate it as a science. I abhorr how its taught.
Samuel Drungerford - Mon, 29 Jun 2015 22:51:33 EST ID:uGD5aNS6 No.76749 Ignore Report Quick Reply
>But I just didn't have the balls to do all those undergraduate courses.
lol yea I get that man. It gets convoluted so quickly.

Are you just a straight chemist? Because I have mad respect for chemists, I wish it was integrated more into our curiculum as biologists. In essense you can't really understand anything biological without some knowledge of chemistry and biochemistry.

I mean look at any disease that involves mismanaged protein (Alzheimer's comes to mind) and you are going to come across thermodynamics. I'm just glad I took some extra chem classes back in the day as electives.
Bombastus !!HToBa9dh - Thu, 02 Jul 2015 18:53:37 EST ID:V1Ngvki3 No.76753 Ignore Report Quick Reply
Most people wish there was less chemistry in their biology. we call those people jobless ;). Rly, doe. they're ecologists or so. Most other branches and the major paying ones are all in need of chemistry knowledge.

Good on you for wanting more chemistry. Fuck me on wanting more biology. To hell with that! I'm gonna go respond to your post on /pss/ now

(M)ethylphenidate by Rebecca Fubberdale - Wed, 06 Aug 2014 02:45:02 EST ID:KTpmMq3U No.75126 Ignore Report Reply Quick Reply
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What process turns ethylphenidate in to methylphenidate and why isn't it done more? I am not interested in doing so myself, but I was confused as to why I can't find info on this given that ethylphenidate is so cheap and methylphenidate is so expensive.
3 posts omitted. Click Reply to view.
Molly Deckleman - Wed, 06 Aug 2014 22:41:39 EST ID:oFx1SQoH No.75131 Ignore Report Quick Reply
The conversion should be really easy. The conversion between the two is a basic acid catalyzed Transesterification reaction.
You might only need methanol and sulfuric acid.
The basic procedure would be something like put ethylphenidate in methanol. Then add sulfuric acid. Heat it up for a few hours. Evaporate off all of the methanol. Then purify it through recrystallization with ethanol (this is a good way to wash off the methanol which is poisonous). The conversion wont be 100% but more like 95%. you could separate it via flash column if you really cared a lot.
Doris Noblingdat - Thu, 07 Aug 2014 03:40:18 EST ID:KTpmMq3U No.75133 Ignore Report Quick Reply
Thanks for the info, but I was interested in why people aren't turning ethylphenidate (Legal RC in EU) in to methylphenidate (prescription only, illegal without.)
Thanks, interesting and informative.
Wesley Dadgehadge - Fri, 08 Aug 2014 23:57:03 EST ID:uGD5aNS6 No.75135 Ignore Report Quick Reply
Could be just an availability of reactant. Maybe one reactant, used to make the methyl version, isn't available or tightly regulated, and the ethyl version is easier to get. Maybe its a legal grey area, as you said, and its a semi-legit business making it because its less controlled. And if someone catches on, less likely anything will happen to them, and they can just stop making it, and are good to go.

I know with the Analogue Laws in the US, they are regulated federally. Drug enforcement on a state level is carried out according to that state's laws. For instance, in my state of massachusetts, I think there are quite a few of the 2C-x compounds, possibly even 2C-B, that are not regulated by state law, so technically you couldn't get arrested for their possession, or at least not charged in court. Unless of course they turn it over to a federal prosecuter.
Reuben - Thu, 25 Jun 2015 15:01:01 EST ID:6nQxvw77 No.76739 Ignore Report Quick Reply
I probably wouldn't touch this one, but I can tell you want to make it work.

Focus on propelling the methyl group into an amino-base or something chemistry-like.
Bombastus !!HToBa9dh - Thu, 25 Jun 2015 17:58:43 EST ID:vbS8CtHn No.76742 Ignore Report Quick Reply
It's quite readily available. Just buy an aspirin synthesis kit on ebay or Amazon.

Also, my current thought is that you'd have to demethylate it and then ethylate it. That's a pain the the ass. It's also not worth it cus ethylphenidate is so much smoother and relaxing than fucking SODAPOPANDRITALIN

Science books by Matilda Chuvingridge - Wed, 24 Jun 2015 17:14:13 EST ID:EALu1k1z No.76727 Ignore Report Reply Quick Reply
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I'm going back to college to get my gcse in the 3 sciences so I can go on to do an access course then onto uni.
Do you people know of any good books to buy to learn from ?(I know there are plenty of sites but I want proper books)
Bombastus !!HToBa9dh - Sun, 28 Jun 2015 15:34:41 EST ID:ElYFdcKO No.76748 Ignore Report Quick Reply
There's a thread that's really similar to this one. So I'm gonna nb and quote it here:


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