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Piperadone by Rebecca Ginningman - Sun, 23 Oct 2016 05:29:48 EST ID:9Opqdgsf No.78324 Ignore Report Reply Quick Reply
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Any ideas how to synthesize 4-piperidone?
Eugene Dabblekat - Sun, 23 Oct 2016 22:53:02 EST ID:9Opqdgsf No.78326 Ignore Report Quick Reply
OP here again. Tried the dickmann condensation, acrylates are too hard to make and the burnt plastic smell is not tolerable. The mannich seems to only like to make piperadones substituted on the 2&6 (benzaldehyde, acetaldehyde). Although i havn't tried it yet formaldehyde might work with acetonedicarboxylate, hydrolyse and decarboxilate to 4-piperadone. I can tell you it doesn't work with phenethylamine not in water, alchohol, or acetic acid. Not nearly as easy as most of the internet would have you believe, its quite the opposite. Unless its just me, which is possible as well.

Maybe posassium cyanide + epichlorohydrin = 3-hydroxyglutaronitrile. ***Journal of the Chemical Society, , p. 1164,1166 = 4-hydroxypiperidine**** Then oxidize the 4-hydroxypiperidine alcohol to a ketone somehow. Maybe react with phenethylbromide first then the amine is protected.

Or any other possible routes? I'd love to hear it.

Anhydrous AlCl3 by Walter Claggleville - Fri, 29 Jul 2016 15:16:32 EST ID:ykDmWZpt No.78112 Ignore Report Reply Quick Reply
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Hello, chem!
Sorry if this is a stupid question, but here it goes:
I have aluminum (III) chloride hexahydrate but I need it in the anhydrous form.
Can I oven-dry it at ~100ºC?
Thanks in advance!!
20 posts and 2 images omitted. Click Reply to view.
Nigel Sinderforth - Wed, 14 Sep 2016 17:44:05 EST ID:Ng8fVE40 No.78239 Ignore Report Quick Reply
Shit Tillinggold - Thu, 15 Sep 2016 01:08:08 EST ID:zsw9I8fO No.78240 Ignore Report Quick Reply
John Merringbury - Fri, 07 Oct 2016 23:06:18 EST ID:hBAZGxou No.78277 Ignore Report Quick Reply
You can demethylate guaiacols by a radical mechanism using CuSO4 + ascorbic acid. Don't waste your time with AlCl3.
Betsy Pittwill - Mon, 10 Oct 2016 23:37:31 EST ID:yvh9Qry5 No.78285 Ignore Report Quick Reply
>>78277 got a ref for that?
Esther Nossleway - Sun, 23 Oct 2016 22:30:30 EST ID:NIATBazO No.78325 Ignore Report Quick Reply
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mind if I ask you why would you want AlCl3? just wondering

bombastus and press are fucking bosses, I've learnt a lot with this guys

love you all

Freebase vs Salt Vaporize by Nathaniel Worthingfoot - Sat, 10 Sep 2016 00:01:05 EST ID:zsw9I8fO No.78226 Ignore Report Reply Quick Reply
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Two questions
1) What's the reason that freebase drugs are preferred for vaporizing/smoking instead of salts?

2) Will lye and baking soda both freebase a drug the same? I'm guessing it just requires more baking soda because it's a weaker base?
16 posts and 1 images omitted. Click Reply to view.
Edward Nottingpock - Sun, 02 Oct 2016 06:17:06 EST ID:ZcMU69D7 No.78269 Ignore Report Quick Reply
When you evaporate a solution of HCl water the water evaporates and the HCl goes back into the gas phase leaving behind any salts you may have formed.
The problem is that it's just hard to get rid of all the water without leaving a hydrate or some moisture sticking around. You can try drying in the presence of a desiccant like NaOH
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 06 Oct 2016 02:40:38 EST ID:Req4jw5M No.78274 Ignore Report Quick Reply
>hard to dry
Normally true. However. When it comes to opiates. Not really.
Doris Fomblefuck - Thu, 06 Oct 2016 13:08:35 EST ID:QFXcUDR6 No.78276 Ignore Report Quick Reply
Okay great so that's what I was originally asking. You can make the pH of the solution acidic enough to convert all of it, then simply let it evaporate and you should have 1:1 mole of drug:salt. No need for a selective solvent to separate the drug:salt from excess acid and water.
Albert Wiffington - Thu, 20 Oct 2016 12:58:49 EST ID:/9+sroAe No.78317 Ignore Report Quick Reply
>What's the reason that freebase drugs are preferred for vaporizing/smoking instead of salts?

Because most people don't have vaporizers that can heat up to 3000 degrees Fahrenheit.
Clara Blythegold - Fri, 21 Oct 2016 18:17:20 EST ID:zsw9I8fO No.78321 Ignore Report Quick Reply
Then why do people vape Methamphetamine HCl all the time?

the ratman 666 by Cornelius Fogglehedge - Mon, 17 Oct 2016 00:58:05 EST ID:95U922wa No.78303 Ignore Report Reply Quick Reply
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>landlord comes to inspect clandestine meth lab property
>she notices the smell of benzaldehyde and asks what air freshener i'm using
>'almond breeze'
Emma Widgetore - Thu, 20 Oct 2016 15:26:27 EST ID:thDqQFXE No.78318 Ignore Report Quick Reply
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top kek

Convert Codeine Pills (Just Codeine) by Nathaniel Worthingfoot - Fri, 09 Sep 2016 23:56:07 EST ID:zsw9I8fO No.78225 Ignore Report Reply Quick Reply
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What would be the best way to get that methyl group offa there?
Well I don't really require morphine, but just whatever opioid is easiest to convert it to while also being smokeable/snortable/get-me-high-rush?
Augustus Mimmlestine - Sun, 11 Sep 2016 16:54:42 EST ID:zsw9I8fO No.78230 Ignore Report Quick Reply
and here's the paper of that: https://www.dropbox.com/s/khn6dc88btaoeyf/A%20Rapid%20Nearly%20Quantitative%20Conversion%20of%20Codeine%20to%20Hydrocodone.pdf?dl=0

So how feasible is it to do this in your kitchen with chemicals bought from ebay? How available are these chemicals even?

Do we even have good forums available like Rhodium anymore? Sciencemadness doesnt like drug synthesis.
Lillian Fellykudge - Wed, 12 Oct 2016 01:51:03 EST ID:zsw9I8fO No.78293 Ignore Report Quick Reply
>first step
>"Parr hydrogenator jar,"

Why the fuck is it so hard to do anything with fucking codeine, fuck. I'll just IV it.
press - Wed, 12 Oct 2016 04:26:18 EST ID:KOKj6dOY No.78294 Ignore Report Quick Reply
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make some hydrocodone. Pd/C and a mineral acid in ethanol and perhaps sone means of TLC to check conversion
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 13 Oct 2016 11:28:23 EST ID:Req4jw5M No.78297 Ignore Report Quick Reply
hey where you been

Press !QUHukXEvkY - Wed, 19 Oct 2016 02:10:48 EST ID:NyrybZOd No.78311 Ignore Report Quick Reply
Was in a workplace accident, spent a week in the hospital
Was on sick leave for five weeks during which i invested my time solely into mushroom cultivation. Tfw no tyramine
Quit a job, took two new jobs. Nb

VR tech by Beatrice Faffingson - Tue, 20 Sep 2016 11:59:28 EST ID:TAs+XH9Z No.78259 Ignore Report Reply Quick Reply
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with all the VR tech coming out
i wonder what scientific applications it will have.. not only for humans but even for animals

do you think it would be possible to suit a dog with a VR tech and simulate it as another species or put other data into its eyes/mind?
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 06 Oct 2016 02:42:09 EST ID:Req4jw5M No.78275 Ignore Report Quick Reply
Not really due to the issue of their perception, senses outside of the "normal five", memory, critical thinking, sight, etc.
For that, we'll need better brain mapping technology like how we saw a blurry image of what a cat saw on a screen once.
William Bundock - Sun, 09 Oct 2016 23:58:56 EST ID:qtUm3Qxz No.78279 Ignore Report Quick Reply

It will be the only handle the amount of information when piloting a Gundam.

Nootropics Textbooks/ Papers/ Literature by He - Thu, 22 Sep 2016 08:55:08 EST ID:XgflcvVv No.78260 Ignore Report Reply Quick Reply
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I'm looking for some textbooks/ literature on nootropics. My boss's brother is a surgeon, and he's heard rumblings from his pharmaceutical friends that there are compounds out there that aren't known to the public, and only given to people like special forces.

I think they're fascinating, and I'd love to better understand their chemistry. While most of my work in the industry has been with things like coatings and adhesives, I'm sure I wouldn't have any trouble with technical stuff, as I took plenty of high level organic classes in college.

C-F Bond Vaporize Harmful? by David Fanwater - Sat, 17 Sep 2016 21:44:07 EST ID:zsw9I8fO No.78254 Ignore Report Reply Quick Reply
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Drugs with that Flourine-Carbon bond, although scary, are supposedly actually safe because the C-F bond is one of the strongest there can be, so not likely to metabolize into free flourine.

So with drugs like 4-FA, 2F-Ketamine, what if we vaporize them? Is a lot of heat enough to break that bond?
Bombastus !uYErosQbLM!!Mybq1UbK - Sun, 18 Sep 2016 03:02:41 EST ID:Req4jw5M No.78255 Ignore Report Quick Reply
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lmfao. i find you cute.
you just stated that C-F bonds are one of the strongest bonds and then asked if heat will degrade it. I know for non-chemistry people, it's hard to put two and two together but I like how you are using your noggin, though. You're already better than three quarters of the students I've TAd.

Anyway, C-F bonds have a bond strength of 550kJ/mol where as regular methyl C-CH3 bonds have a bond strength of around 450kJ/mol. This really means that it's almost impossible to break this bond unless you have a self-feeding reaction like setting it on fire. But even then, the C-C bonds and C-H bonds would burn before the C-F bonds do
You'll be fine vaporizing whatever you legal substances you're sublimating for science, ofc.
Bombastus !uYErosQbLM!!Mybq1UbK - Sun, 18 Sep 2016 03:04:54 EST ID:Req4jw5M No.78256 Ignore Report Quick Reply
Also, is that face reaction from the comic where a guy gets high, walks over to the garbage can with a ziplock bag and his bong, drops the bong in the garbage can with a shattering sound, and then proceed to make that face?

Can't find it right now since I'm on mobile.
David Fanwater - Sun, 18 Sep 2016 04:15:54 EST ID:zsw9I8fO No.78257 Ignore Report Quick Reply
Yes lol, I cropped it from that.

So cool, there is some quantitative way to figure out what it takes to break a bond.

Break a bond... break a bong... pic related.
Bombastus !uYErosQbLM!!Mybq1UbK - Sun, 18 Sep 2016 17:40:24 EST ID:4ppVjZXo No.78258 Ignore Report Quick Reply
Bonds boil down to the electron configuration of the atoms they are bonded to (along with the neighbouring electrons) and the spatial organization of the bonds and atoms in the molecule.
To figure out the spatial organization, you just use your eyes and bond energy tables. To figure out electronical (relating to electrons) configuration, use the DFT program I told people about (http://boards.420chan.org/chem/res/77990.php) and play around with the orbital energy levels.

Phosphate by Shit Dollerwin - Wed, 14 Sep 2016 15:12:54 EST ID:kO6h6vAq No.78238 Ignore Report Reply Quick Reply
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I don't see much info on turning a phosphate, in my case Codeine-Phosphate (how do you even abbreviate phosphate). Perhaps because it's just like turning a salt into a freebase?

How would you go about converting Codeine-Phosphate into Codeine?
Is it even worth the effort to do it with 700mg worth of Codeine-phosphate?
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 15 Sep 2016 17:37:59 EST ID:4ppVjZXo No.78241 Ignore Report Quick Reply
Is it worth the effort? Depends on why you are doing it.
Why are you freebasing codeine? Are you going to smoke it? Are you going to turn it into hydrocodone / morphine / dihydrocodeine? Are you an autist?

I would say just eat this shit by itself. The phosphate anion is abbreviated by PO4-3. When it comes to alkaloids, the phosphate is actually phosphoric acid codeine chelation so it would be:
Codeine H3PO4
Ebenezer Blagglebury - Fri, 16 Sep 2016 12:55:31 EST ID:O07bFEtx No.78248 Ignore Report Quick Reply
>Are you going to turn it into hydrocodone / morphine / dihydrocodeine?
Was thinking about it but I don't know if I've got enough Codeine. What do you think?
Bombastus !uYErosQbLM!!Mybq1UbK - Sat, 17 Sep 2016 02:01:46 EST ID:Req4jw5M No.78249 Ignore Report Quick Reply
50mg of codeine is enough to change it. you'll only get 30-40mg of hydrocodone, 20mg of morphine, or 45mg of dihydrocodine. The more you make, you'll have to use almost as much solvent and other reactants in order to make the reaction work.
It costs as much to turn 50mg of codeine into hydrocodone as it does to turn 500mg. You decie what's worth it.
Bombastus !uYErosQbLM!!Mybq1UbK - Sat, 17 Sep 2016 02:02:45 EST ID:Req4jw5M No.78250 Ignore Report Quick Reply
Also, why do you even need to freebase it? If you separate the codeine phosphate from pill bulkers, you can just use the codeine phosphate to react with the other shit. Most of the time no freebase needed.
Nell Tootwater - Sat, 17 Sep 2016 07:03:47 EST ID:O07bFEtx No.78252 Ignore Report Quick Reply

Alright, thank, I'll keep that in mind

Predict Metabolism by Walter Drabberdale - Wed, 31 Aug 2016 18:40:28 EST ID:gk9dXVsY No.78200 Ignore Report Reply Quick Reply
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Any guesses at to what this gets metabolized into?
1 posts omitted. Click Reply to view.
Henry Fummerstock - Sat, 03 Sep 2016 01:00:27 EST ID:VjvGmScF No.78213 Ignore Report Quick Reply
do you think this is a motherfucking game?
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 15 Sep 2016 17:43:32 EST ID:4ppVjZXo No.78242 Ignore Report Quick Reply
Why do you ask?

The first things you're looking for are oxygen bound molecules since our endogenous enzymes can work with them much better than carbon-carbon bonds unless it is for metabolism for energy.
So the oxygen bridge can be broken by a simple acid, the methyl group on the ester is easily removed, and the phenolic alcohol cannot be oxidised but can be methylated or aceylated depending on where the reaction occurs.

Now, look for other non-carbonous groups and the first I see are two tertiary amines. Demethylation of the N,N, methylamine on the dihydroindole would make sense by the standard demethylation enzymes. Then perhaps amine bridge cleavage to create the nor-equivalent since it's a pretty stressed ring.
Doris Sabberputch - Thu, 15 Sep 2016 19:59:47 EST ID:28FgXo1Q No.78243 Ignore Report Quick Reply
>Why do you ask
Subject effects are opioid-like, but the molecule itself is antagonist, and I don't think we have any studies proving what it metabolizes into.
Edward Wendlegold - Thu, 15 Sep 2016 20:08:20 EST ID:28FgXo1Q No.78244 Ignore Report Quick Reply
>since it's a pretty stressed ring.
Isn't that weird how nature makes these structures that seem so awkwardly formatted. Everything should be lines and hexagons to keep it simple.
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 15 Sep 2016 20:20:31 EST ID:4ppVjZXo No.78245 Ignore Report Quick Reply
Well yes and no. Nature likes to keep nitrogens tertiary and stable and will branch out to go out of the carbon comfort zone in order to satisfy the nitrogenous fetish. It also favors difficulty if it can produce a compound to help it selectively thrive better than the compounds that do not.

MXE Synthesis by James Blatherstock - Sat, 13 Aug 2016 11:00:34 EST ID:xPDjzOso No.78148 Ignore Report Reply Quick Reply
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So, theoretically speaking, how hard would it be to synthesize MXE at home assuming one had no real chemistry experience or knowledge?

I'm curious because this stuff has gone the way of quaaludes and nobody is making it anymore, and after reading /dis/ for a while I've been wondering for the past few days what would making a batch imply in terms of proficiency, equipment and reagents.
9 posts and 1 images omitted. Click Reply to view.
Wesley Clommerchedging - Fri, 02 Sep 2016 06:29:58 EST ID:BClNdd0H No.78203 Ignore Report Quick Reply
Lmao what.
Looks like this is based on a misunderstanding of the nitroaldol condensation, but it's pretty fucking hard to tell.
Vulpine - Thu, 08 Sep 2016 12:14:29 EST ID:AVVmIPkE No.78224 Ignore Report Quick Reply
anything on rdx times and best bromination methods why pull ll this information and make easy to follow guide with the help of rhodium archive

Schepperschop - Sat, 10 Sep 2016 19:23:26 EST ID:xTIigKo1 No.78227 Ignore Report Quick Reply
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Augustus Mimmlestine - Sun, 11 Sep 2016 01:19:15 EST ID:zsw9I8fO No.78228 Ignore Report Quick Reply
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gooby pls. crop. resize.
schepperschop - Sun, 11 Sep 2016 09:19:50 EST ID:xTIigKo1 No.78229 Ignore Report Quick Reply
Sorry I am very bad with computers.

Zika Virus: Is it an ELE? by Nell Snodstock - Sun, 28 Aug 2016 17:35:29 EST ID:5UnrR+r2 No.78188 Ignore Report Reply Quick Reply
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I just had an interesting short chat with a store clerk of a quickie-mart type of place. What he said actually freaked me out. He said that Zika reached our area (Florida) and how it'll take a month before money is released to try to combat the problem. But this wasn't the interesting bit, the interesting bit was him saying: "This is bad because mothers can't have babies. Without babies, we will go extinct; an extinction level event (ELE)." It was one of those moments that it didn't strike me just how dangerous Zika is to the human race. I saw it similar to the Ebola scare we had.

I hoped to him that perhaps science will solve the issue. He replied by saying we aren't exactly Star Trek level so you never know.

It could be that as a store clerk he is searching for something exciting because life as a store clerk is anything but. It could also be a covert-Christian trying to prolysetize. So science-peeeps that may be reading this, set me straight. Why shouldn't I worry about this problem, at least not overly so?

I am sure that I am missing something that makes this problem not as major as the store Clerk made it out to be but don't know where to start. Couldn't we simply make a vaccination? Couldn't we, in the worst possible event, simply do in-vitro fertilization in which the child has a natural immunity to the virus?

What could we do? This is actually scaring me.
Nell Snodstock - Sun, 28 Aug 2016 18:55:38 EST ID:5UnrR+r2 No.78190 Ignore Report Quick Reply
Thought you were quoting Game of Thrones for a moment there.

Are adults ok? I heard about the blood-brain barrier and how because of this barrier can't affect an adult brain. Is this true? I read an article stating that this may not be true and can cause alzheimers or other conditions.

Do you think the CDC or some organization can do a good job on this issue?
Esther Buzzcocke - Wed, 07 Sep 2016 21:54:12 EST ID:Z4xgskMZ No.78223 Ignore Report Quick Reply
It's currently gridlocked to the areas around the equator that have egypti and other tropical mosquito species in terms of mosquito transmission.

The bigger issue is that it's sexually transmitted. I think the main vector is going to be humans. As long as it's still a popular trendy scary disease and the people who have it are on lockdown then it won't spread far enough for the kind of damage you're talking about. I think a vaccine is in the works but who knows.

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