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Nootropics Textbooks/ Papers/ Literature by He - Thu, 22 Sep 2016 08:55:08 EST ID:XgflcvVv No.78260 Ignore Report Reply Quick Reply
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I'm looking for some textbooks/ literature on nootropics. My boss's brother is a surgeon, and he's heard rumblings from his pharmaceutical friends that there are compounds out there that aren't known to the public, and only given to people like special forces.

I think they're fascinating, and I'd love to better understand their chemistry. While most of my work in the industry has been with things like coatings and adhesives, I'm sure I wouldn't have any trouble with technical stuff, as I took plenty of high level organic classes in college.

C-F Bond Vaporize Harmful? by David Fanwater - Sat, 17 Sep 2016 21:44:07 EST ID:zsw9I8fO No.78254 Ignore Report Reply Quick Reply
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Drugs with that Flourine-Carbon bond, although scary, are supposedly actually safe because the C-F bond is one of the strongest there can be, so not likely to metabolize into free flourine.

So with drugs like 4-FA, 2F-Ketamine, what if we vaporize them? Is a lot of heat enough to break that bond?
Bombastus !uYErosQbLM!!Mybq1UbK - Sun, 18 Sep 2016 03:02:41 EST ID:Req4jw5M No.78255 Ignore Report Quick Reply
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lmfao. i find you cute.
you just stated that C-F bonds are one of the strongest bonds and then asked if heat will degrade it. I know for non-chemistry people, it's hard to put two and two together but I like how you are using your noggin, though. You're already better than three quarters of the students I've TAd.

Anyway, C-F bonds have a bond strength of 550kJ/mol where as regular methyl C-CH3 bonds have a bond strength of around 450kJ/mol. This really means that it's almost impossible to break this bond unless you have a self-feeding reaction like setting it on fire. But even then, the C-C bonds and C-H bonds would burn before the C-F bonds do
You'll be fine vaporizing whatever you legal substances you're sublimating for science, ofc.
Bombastus !uYErosQbLM!!Mybq1UbK - Sun, 18 Sep 2016 03:04:54 EST ID:Req4jw5M No.78256 Ignore Report Quick Reply
Also, is that face reaction from the comic where a guy gets high, walks over to the garbage can with a ziplock bag and his bong, drops the bong in the garbage can with a shattering sound, and then proceed to make that face?

Can't find it right now since I'm on mobile.
David Fanwater - Sun, 18 Sep 2016 04:15:54 EST ID:zsw9I8fO No.78257 Ignore Report Quick Reply
Yes lol, I cropped it from that.

So cool, there is some quantitative way to figure out what it takes to break a bond.

Break a bond... break a bong... pic related.
Bombastus !uYErosQbLM!!Mybq1UbK - Sun, 18 Sep 2016 17:40:24 EST ID:4ppVjZXo No.78258 Ignore Report Quick Reply
Bonds boil down to the electron configuration of the atoms they are bonded to (along with the neighbouring electrons) and the spatial organization of the bonds and atoms in the molecule.
To figure out the spatial organization, you just use your eyes and bond energy tables. To figure out electronical (relating to electrons) configuration, use the DFT program I told people about (http://boards.420chan.org/chem/res/77990.php) and play around with the orbital energy levels.

Phosphate by Shit Dollerwin - Wed, 14 Sep 2016 15:12:54 EST ID:kO6h6vAq No.78238 Ignore Report Reply Quick Reply
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I don't see much info on turning a phosphate, in my case Codeine-Phosphate (how do you even abbreviate phosphate). Perhaps because it's just like turning a salt into a freebase?

How would you go about converting Codeine-Phosphate into Codeine?
Is it even worth the effort to do it with 700mg worth of Codeine-phosphate?
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 15 Sep 2016 17:37:59 EST ID:4ppVjZXo No.78241 Ignore Report Quick Reply
Is it worth the effort? Depends on why you are doing it.
Why are you freebasing codeine? Are you going to smoke it? Are you going to turn it into hydrocodone / morphine / dihydrocodeine? Are you an autist?

I would say just eat this shit by itself. The phosphate anion is abbreviated by PO4-3. When it comes to alkaloids, the phosphate is actually phosphoric acid codeine chelation so it would be:
Codeine H3PO4
Ebenezer Blagglebury - Fri, 16 Sep 2016 12:55:31 EST ID:O07bFEtx No.78248 Ignore Report Quick Reply
>Are you going to turn it into hydrocodone / morphine / dihydrocodeine?
Was thinking about it but I don't know if I've got enough Codeine. What do you think?
Bombastus !uYErosQbLM!!Mybq1UbK - Sat, 17 Sep 2016 02:01:46 EST ID:Req4jw5M No.78249 Ignore Report Quick Reply
50mg of codeine is enough to change it. you'll only get 30-40mg of hydrocodone, 20mg of morphine, or 45mg of dihydrocodine. The more you make, you'll have to use almost as much solvent and other reactants in order to make the reaction work.
It costs as much to turn 50mg of codeine into hydrocodone as it does to turn 500mg. You decie what's worth it.
Bombastus !uYErosQbLM!!Mybq1UbK - Sat, 17 Sep 2016 02:02:45 EST ID:Req4jw5M No.78250 Ignore Report Quick Reply
Also, why do you even need to freebase it? If you separate the codeine phosphate from pill bulkers, you can just use the codeine phosphate to react with the other shit. Most of the time no freebase needed.
Nell Tootwater - Sat, 17 Sep 2016 07:03:47 EST ID:O07bFEtx No.78252 Ignore Report Quick Reply

Alright, thank, I'll keep that in mind

Predict Metabolism by Walter Drabberdale - Wed, 31 Aug 2016 18:40:28 EST ID:gk9dXVsY No.78200 Ignore Report Reply Quick Reply
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Any guesses at to what this gets metabolized into?
1 posts omitted. Click Reply to view.
Henry Fummerstock - Sat, 03 Sep 2016 01:00:27 EST ID:VjvGmScF No.78213 Ignore Report Quick Reply
do you think this is a motherfucking game?
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 15 Sep 2016 17:43:32 EST ID:4ppVjZXo No.78242 Ignore Report Quick Reply
Why do you ask?

The first things you're looking for are oxygen bound molecules since our endogenous enzymes can work with them much better than carbon-carbon bonds unless it is for metabolism for energy.
So the oxygen bridge can be broken by a simple acid, the methyl group on the ester is easily removed, and the phenolic alcohol cannot be oxidised but can be methylated or aceylated depending on where the reaction occurs.

Now, look for other non-carbonous groups and the first I see are two tertiary amines. Demethylation of the N,N, methylamine on the dihydroindole would make sense by the standard demethylation enzymes. Then perhaps amine bridge cleavage to create the nor-equivalent since it's a pretty stressed ring.
Doris Sabberputch - Thu, 15 Sep 2016 19:59:47 EST ID:28FgXo1Q No.78243 Ignore Report Quick Reply
>Why do you ask
Subject effects are opioid-like, but the molecule itself is antagonist, and I don't think we have any studies proving what it metabolizes into.
Edward Wendlegold - Thu, 15 Sep 2016 20:08:20 EST ID:28FgXo1Q No.78244 Ignore Report Quick Reply
>since it's a pretty stressed ring.
Isn't that weird how nature makes these structures that seem so awkwardly formatted. Everything should be lines and hexagons to keep it simple.
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 15 Sep 2016 20:20:31 EST ID:4ppVjZXo No.78245 Ignore Report Quick Reply
Well yes and no. Nature likes to keep nitrogens tertiary and stable and will branch out to go out of the carbon comfort zone in order to satisfy the nitrogenous fetish. It also favors difficulty if it can produce a compound to help it selectively thrive better than the compounds that do not.

MXE Synthesis by James Blatherstock - Sat, 13 Aug 2016 11:00:34 EST ID:xPDjzOso No.78148 Ignore Report Reply Quick Reply
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So, theoretically speaking, how hard would it be to synthesize MXE at home assuming one had no real chemistry experience or knowledge?

I'm curious because this stuff has gone the way of quaaludes and nobody is making it anymore, and after reading /dis/ for a while I've been wondering for the past few days what would making a batch imply in terms of proficiency, equipment and reagents.
9 posts and 1 images omitted. Click Reply to view.
Wesley Clommerchedging - Fri, 02 Sep 2016 06:29:58 EST ID:BClNdd0H No.78203 Ignore Report Quick Reply
Lmao what.
Looks like this is based on a misunderstanding of the nitroaldol condensation, but it's pretty fucking hard to tell.
Vulpine - Thu, 08 Sep 2016 12:14:29 EST ID:AVVmIPkE No.78224 Ignore Report Quick Reply
anything on rdx times and best bromination methods why pull ll this information and make easy to follow guide with the help of rhodium archive

Schepperschop - Sat, 10 Sep 2016 19:23:26 EST ID:xTIigKo1 No.78227 Ignore Report Quick Reply
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Augustus Mimmlestine - Sun, 11 Sep 2016 01:19:15 EST ID:zsw9I8fO No.78228 Ignore Report Quick Reply
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gooby pls. crop. resize.
schepperschop - Sun, 11 Sep 2016 09:19:50 EST ID:xTIigKo1 No.78229 Ignore Report Quick Reply
Sorry I am very bad with computers.

Zika Virus: Is it an ELE? by Nell Snodstock - Sun, 28 Aug 2016 17:35:29 EST ID:5UnrR+r2 No.78188 Ignore Report Reply Quick Reply
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I just had an interesting short chat with a store clerk of a quickie-mart type of place. What he said actually freaked me out. He said that Zika reached our area (Florida) and how it'll take a month before money is released to try to combat the problem. But this wasn't the interesting bit, the interesting bit was him saying: "This is bad because mothers can't have babies. Without babies, we will go extinct; an extinction level event (ELE)." It was one of those moments that it didn't strike me just how dangerous Zika is to the human race. I saw it similar to the Ebola scare we had.

I hoped to him that perhaps science will solve the issue. He replied by saying we aren't exactly Star Trek level so you never know.

It could be that as a store clerk he is searching for something exciting because life as a store clerk is anything but. It could also be a covert-Christian trying to prolysetize. So science-peeeps that may be reading this, set me straight. Why shouldn't I worry about this problem, at least not overly so?

I am sure that I am missing something that makes this problem not as major as the store Clerk made it out to be but don't know where to start. Couldn't we simply make a vaccination? Couldn't we, in the worst possible event, simply do in-vitro fertilization in which the child has a natural immunity to the virus?

What could we do? This is actually scaring me.
Nell Snodstock - Sun, 28 Aug 2016 18:55:38 EST ID:5UnrR+r2 No.78190 Ignore Report Quick Reply
Thought you were quoting Game of Thrones for a moment there.

Are adults ok? I heard about the blood-brain barrier and how because of this barrier can't affect an adult brain. Is this true? I read an article stating that this may not be true and can cause alzheimers or other conditions.

Do you think the CDC or some organization can do a good job on this issue?
Esther Buzzcocke - Wed, 07 Sep 2016 21:54:12 EST ID:Z4xgskMZ No.78223 Ignore Report Quick Reply
It's currently gridlocked to the areas around the equator that have egypti and other tropical mosquito species in terms of mosquito transmission.

The bigger issue is that it's sexually transmitted. I think the main vector is going to be humans. As long as it's still a popular trendy scary disease and the people who have it are on lockdown then it won't spread far enough for the kind of damage you're talking about. I think a vaccine is in the works but who knows.

Molecular sandbox by PotatoSamurai !/sly9iFJgg - Wed, 22 Jun 2016 14:54:50 EST ID:H8Fdbu5S No.77990 Ignore Report Reply Quick Reply
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I found a great free molecular simulator, at http://avogadro.cc/wiki/Main_Page . It's real easy to use, but the fucking thing crashes without warning or apparent reason. There's seemingly nothing I can do to make it run. The only circumstance it DOESN'T crash in is when I first load it and haven't added any atoms/loaded a save.

So unless y'all have a fix that I haven't tried, I'm looking for a program with a similar sandbox-style modeling.
8 posts and 3 images omitted. Click Reply to view.
Bombastus !RZEwn1AX62!!xXxJO70U - Fri, 01 Jul 2016 20:50:35 EST ID:+JCbsCsc No.78058 Ignore Report Quick Reply
It requires a login. ):
How do?
Thomas Turveydock - Fri, 02 Sep 2016 21:04:30 EST ID:BClNdd0H No.78211 Ignore Report Quick Reply
>it takes fucking 8 hours to run. Also a shitload of computing space
Could you elaborate on what computing resources it takes/what gives you the most mileage? I'm buying a new laptop soon and would like to start playing with frontier orbitals, docking, ADME modeling, etc.

If a decent graphics card can speed these computations, that's a real plus.
Bombastus !uYErosQbLM!!Mybq1UbK - Sat, 03 Sep 2016 17:34:10 EST ID:Req4jw5M No.78217 Ignore Report Quick Reply
I'm absolutely computer inept.
trypto - Tue, 06 Sep 2016 16:52:28 EST ID:6/EmvHqc No.78221 Ignore Report Quick Reply
I'm not too familiar with molecular modelling, but I know it uses similar computations as neural networks. That is, it's mostly linear algebra, and having a good graphics card is very useful. In the NN world, an NVIDIA chipset will get you much further because it understands CUDA instructions. On the other hand, AMD chipsets use OpenCL, which is less supported. Last time I tried out modelling software (5 years ago), this was also the case. So I would look for a laptop with NVIDIA graphics... Except I've also read bad reviews about NVIDIA shit in laptops. Maybe that's old, or linux-specific, but be sure to check out reviews.

I sincerely doubt you'll be able to do any modelling on a laptop under $3k. On the other hand, you could probably build a PC with a lower midrange graphics card for $600 that could outperform the $3k laptop.
Clara Cremmerkedge - Sun, 09 Oct 2016 21:50:55 EST ID:mC4q4Hy7 No.78278 Ignore Report Quick Reply
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Anti-GMO nutjobs by James Hushwidge - Fri, 05 Aug 2016 23:27:16 EST ID:JmjQz8t7 No.78130 Ignore Report Reply Quick Reply
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Man I was having such a good day today at work.

There I was, being all kickass at my job, and SOMEHOW the topics of organics and GMOS came up. I am so for GMOs its not even funny - organics, hey, but what you want but don't try to take away my options. Also, don't tell starving kids in India what to eat while they're dying? Follow those two rules and all will be well.

Man, I had no idea. These are people who work for the government, and it was liked I whipped out a baby and started to slaughter it in front of them. I didn't state my opinion, I just appeared neutral, but I was angry inside. How can these people profess for being about knowledge and the cutting edge, but believe that pesticides don't wash off of food? And that " We don't know enough about it to eat it" while eating cheese?! In front of me?!

I'm still mad, and have to go back to work tomorrow. I hate being a pot smoking skeptic sometimes, I feel like a damn unicorn.
5 posts and 1 images omitted. Click Reply to view.
Press - Mon, 29 Aug 2016 16:30:50 EST ID:w5e3C0oo No.78194 Ignore Report Quick Reply
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John Dappernot - Tue, 30 Aug 2016 00:47:02 EST ID:5UnrR+r2 No.78196 Ignore Report Quick Reply
You know what the GMO labeling thing did to crop markets in European nations? It caused consumers to falsely believe that if a food product had a GMO label that it proves that it was bad despite it passing all the oridinary inspections and reguiations nations enact. You know who were the bad guys in this? It wasn't GMO corps. It was so-called "small farmers" tactic to destroy their competition while at the same time charge much more for the same exact food. Making a bundle on peoples gullibility. The big evil corporation here is the "organic" market fooling people into paying more for the same product. Good job ya dunce.
Caroline Babblelork - Tue, 30 Aug 2016 18:05:38 EST ID:82e0TSBV No.78197 Ignore Report Quick Reply
Roundup is less toxic than the herbicides they were using before. It's also pretty easily eliminated from the food supply during rinsing.

Good point about soil ecology.
Hugh Hellysetch - Fri, 02 Sep 2016 14:22:55 EST ID:TtNn9wfR No.78206 Ignore Report Quick Reply
Don't forget that companies like Monsanto are completely happy with the current GMO hate.

It just means that they have a monopoly position, because Monsanto can just set up an experimental farm in South-America and protect it with armed guards, while starting GMO companies have to do their experimental farms in the Western world and have fucking anti-GMO protesters (that may or may not be funded by Monsanto and other big companies) with bulldozers trashing their farms and send fucking bombs, bullet letters and mysterious powders to personnel and geneticists. Hell, people just doing research at universities without any profit gaining are getting death threats.
Shitting Messlepot - Sun, 04 Sep 2016 13:46:25 EST ID:rybJ4K29 No.78220 Ignore Report Quick Reply
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but believe that pesticides don't wash off of food

Chloroform by Graham Banningshit - Tue, 30 Aug 2016 00:39:47 EST ID:zsw9I8fO No.78195 Ignore Report Reply Quick Reply
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Wanna purify H.

Am I going to get watched (even moreso) if I order chloroform?
7 posts omitted. Click Reply to view.
trypto - Sat, 03 Sep 2016 12:34:24 EST ID:s54xL9Hs No.78215 Ignore Report Quick Reply
>In a distiller, you're boiling something, in order to extract those vapors
>So what's the difference?

With a soxhlet, you're extracting soluble solids. Not the vapors.
trypto - Sat, 03 Sep 2016 12:35:47 EST ID:s54xL9Hs No.78216 Ignore Report Quick Reply
>ou could indeed use it for distilling solvents
Perhaps as a reflux, but you'd still need standard distillation equipment. And of course a normal reflux condensor would do a better job (and be cheaper/more widely available)
Bombastus !uYErosQbLM!!Mybq1UbK - Sat, 03 Sep 2016 17:42:58 EST ID:Req4jw5M No.78218 Ignore Report Quick Reply
Not true, if you wash the soxhlet before using it (and i mean really wash it), you can use it as a distillation apparatus if you pour out the solvent before it reaches the siphon tube.

It's ghetto as fuck but can work to save you $150 on a distillation condenser and adapter.
Ebenezer Soshgold - Sun, 04 Sep 2016 04:35:52 EST ID:VjvGmScF No.78219 Ignore Report Quick Reply
Probably just use DCM then, but the guides I were reading didn't mention it. Will just update whenever I attempt.
trypto - Tue, 06 Sep 2016 16:55:40 EST ID:6/EmvHqc No.78222 Ignore Report Quick Reply
>you can use it as a distillation apparatus if you pour out the solvent before it reaches the siphon tube.

Haha. Hadn't thought of that.

Classification by Edward Worthingway - Fri, 02 Sep 2016 15:26:59 EST ID:CfiuryLA No.78207 Ignore Report Reply Quick Reply
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So this might be more semantic than scientific but I wanted your guys thoughts on the matter,

So hypothetically, if we did find life from another world, life evolved from a completely independent source than ours, and even if it was animate, easily recognizable life, maybe even humanoid...

It still couldn't technically be an animal or any of our kingdoms/domains of life, right? Like, when we're talking about the various domains and kingdoms of life, it's kind of implied those can only be terrestrial in origin since we're talking about a tree of life with a common ancestry right? Like if we got an Earth fungus to grow on another planet and it evolved into a new species of fungus to better live on that world, it would still be a fungus because it's ancestors were Earth fungi. But if a life form from somewhere in space from a completely different line of evolution were to travel to earth, even if it coincidentally shared a lot of similar traits to Earth fungi due to functional convergent evolution, it still could never be considered kingdom: fungi right?

tlIf do we sort alien life forms by phenotype traits or genotype ones?
Henry Brobberbitch - Fri, 02 Sep 2016 19:36:46 EST ID:bvtI5MJW No.78210 Ignore Report Quick Reply
i suspect that if and when we discover extraterrestrial life, biologists and zoologists will agree to classify every evolutionary ancestral lineage independently. maybe add a celestial identity marker, e.g. Terra Homo Sapiens Sapiens

iNaturalist by !/sly9iFJgg - Thu, 01 Sep 2016 08:07:03 EST ID:H8Fdbu5S No.78201 Ignore Report Reply Quick Reply
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It has some design flaws, like an inability to delete your own ID's, but it's hella fun and a great way to support the scientific community!

Estimating the relative potency of a fentanyl analogue by Augustus Sarringberk - Mon, 15 Aug 2016 12:02:06 EST ID:Y1ptdQKh No.78154 Ignore Report Reply Quick Reply
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Dearest /chem/,

I wish I were one of you, but I'm not. My knowledge of chemistry trivia might impress at some parties but when actual questions arise, assistance is necessary. I was hoping you could help me estimate the relative potency of cyclopentyl-fentanyl, a novel fentanyl analogue. You will find It's structure displayed in the picture.

My thoughts: Cyclopentyl-F seems to be structurally related to Acryl-F. The latter is said to be active at doses <10 mcg. But on the other hand, cyclopentyl-F also seems related to Acetyl-F which is said to only be 1/20th the potency of regular fentanyl.

Thank you for your time.
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 25 Aug 2016 19:54:09 EST ID:Req4jw5M No.78177 Ignore Report Quick Reply
With most of this shit, you simply can't look at the molecule and guess its relative potency, unfortunately. This is just the reality of biological assays and why they are necessary.

Organic chemistry is simple to estimate but biochemistry requires in depth knowledge of all the enzyme sites around your receptors which can lead to potency changes. This is near impossible to do without high computational machines or more accurately: petri dish bio assays.

Sorry to burst your bubble, Sarringberk.
David Mondlelotch - Sun, 28 Aug 2016 11:12:00 EST ID:wAPrdwU9 No.78185 Ignore Report Quick Reply
Hi, a solution with 120-140mg / 10ml dest. water.
I recieved the powder in oxalate form, it needed alot of heating to solve. This solution was then added to a nasal spray. Akryl recipe, is 20mg/10ml dest water, for nasal sprays.

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