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I like to post pictures of interesting molecules by Martha Dottingset - Tue, 14 Nov 2017 23:00:42 EST ID:k6ZWDP32 No.78906 Ignore Report Quick Reply
File: 1510718442981.png -(9001B / 8.79KB, 749x297) Thumbnail displayed, click image for full size. 9001
Thread premise stolen from Bluelight. Post molecules you think would make promising drugs. They can be totally novel, or known substances that, for whatever reason (synthetic difficulty, obscurity, poor effects) have never hit the recreational market. Relevant links (literature papers, PiHKAL, trip reports, syntheses, etc.) encouraged.

I’ll start with this one. This molecule is 3-methoxy-4-propoxyamphetamine (“POMA”). It’s active as a mildly psychedelic stimulant and mood elevator. Someone has already synthesized and trialed this compound; you can read the full report here (https://bitnest.netfirms.com/external.php?id=%25087%253B%250B9%2501%2509Czzy%2505)

Not terribly exciting, but interesting all the same. He starts with clove oil (containing eugenol), but an alternative route would be to start with vanillin (much cheaper than clove oil), O-propylate, condense with nitroethane, and reduce.
>>
Walter Cruttinghood - Fri, 08 Dec 2017 14:35:14 EST ID:+YUSEic8 No.78936 Ignore Report Quick Reply
1512761714049.png -(10354B / 10.11KB, 482x116) Thumbnail displayed, click image for full size.
>>78906
Chlorobutanol, seems easy enough to make. Maybe not the safest of drugs though.
>>
press !XIxc6BpKnU - Tue, 12 Dec 2017 15:59:51 EST ID:Gd6TrUcG No.78937 Ignore Report Quick Reply
1513112391523.jpg -(31534B / 30.79KB, 492x354) Thumbnail displayed, click image for full size.
>>78936
seems interesting. not too familiar with that substance but if it is anything like chloral hydrate, chances are high its shit, from a purely organic chemistry viewpoint i find chloral hydrate a bit more interesting since its an exception to erlenmeyers rule, but i still have like 50g lying around and wont be arsed to take them any time soon.
seems as if all youd need to get crude chlorbutanol would be acetone, hypochlorite and some basic glass ware. not too sure about the purification.



>>78906
vanilline is my phenylethylamine precursor waifu. your route seems pretty straight forward. all yourd need would be propanol, iodine, RP, vanilline, some suitable base, sone solvents, nitroethanea proper reductant and glass ware. perhaps a vacuum pump if you want to go by the books.

id like to mention ibogaine, eventhough its most likely a meme drug whose benefits are blown out of proportion, id love to get enough iboga root to isolate enough material for a few sessions if only for the fact that it seems the most astonishing initiation rite and is a bitch to synthezise
>>
press !XIxc6BpKnU - Tue, 12 Dec 2017 16:13:36 EST ID:Gd6TrUcG No.78939 Ignore Report Quick Reply
>>78937
i guess nitroethane would be the hardest to procure though some years ago some rc fuel actually used nitroethane instead of nitromethane
>>
Ebenezer Smallman - Wed, 13 Dec 2017 14:40:38 EST ID:hBAZGxou No.78941 Ignore Report Quick Reply
>>78939
Nitroethane is no longer in RC fuel because it's listed. It can still be bought from non-US suppliers but you have to find someone who doesn't care about shipping something that's technically illegal. Google "DEA list of chemicals".
>>
Nathaniel Honeyfoot - Wed, 13 Dec 2017 16:55:11 EST ID:hNU9DBLP No.78942 Ignore Report Quick Reply
1513202111091.png -(8614B / 8.41KB, 214x299) Thumbnail displayed, click image for full size.
This.

Basically a racetam/LSD hybrid. Could prove both a potent cognitive enhancer and psychedelic.
>>
Betsy Sillerbanks - Sun, 17 Dec 2017 22:42:27 EST ID:dwNsd07l No.78953 Ignore Report Quick Reply
>>78942

As far as I know, the indole amine needs to be free to interact with one of the amino acids at the 5-HT2a active site, so I'm not sure this would work as a classical psychedelic with the 1-acetamide.

David Nichols said something similar about 1P-LSD; that it's plausible the 1-propionyl is hydrolyzed in vivo (i.e. 1P-LSD is just a prodrug for LSD) because otherwise it should not be able to interact with 5-HT2a.
>>
Betsy Sillerbanks - Sun, 17 Dec 2017 22:45:29 EST ID:dwNsd07l No.78954 Ignore Report Quick Reply
... the oxo group next to the amine might also interfere with 5-HT receptor interactions. Not sure.
>>
Bombastus Werrywag - Mon, 18 Dec 2017 01:59:00 EST ID:ECO8pP96 No.78955 Ignore Report Quick Reply
>>78953
This would explain the 14+ hour duration of 1-LSD. Friend recently got some tabs of acid that he said were "less potent but so fucking long". Propionic acid has a pka of 4.87 as opposed to acetic acid of 4.75. Pretty high considering blood pH and the stearic inhibition. Plus your body is used to acetates and not propionates.

Free rotation and electron swap at the tertiary amine (especially since it doesn't engage in resonance) should make it active regardless. Propionyl would make it more lipid soluble (not that it needs to be considering the size of LSD itself).

This is confirmed by a quick wikipedia search for full agonists of the 5HT2A site which looks to have room for tertiary amines on indoles. Searching again, experimental full agonists includes a few tertiary amines that can definitely not be metabolised by the body listed:
https://en.wikipedia.org/wiki/OSU-6162
https://en.wikipedia.org/wiki/PHA-57378
and especially https://en.wikipedia.org/wiki/O-4310

So not only is 1-propionyl indole hydrolyzed (not plausible - quite likely) into the indole, but the 1-propionyl should itself be active. The question now is if different BAs would affect the effects of 1-P-LSD. In academia, it is shown that ROA does not change LSD's effects and onset but 1-p-LSD oral, sublingual, injection might differ. That could be interesting.
>>
Fanny Nozzlestat - Tue, 02 Jan 2018 08:08:56 EST ID:xTIigKo1 No.78957 Ignore Report Quick Reply
1514898536800.jpg -(665799B / 650.19KB, 1600x969) Thumbnail displayed, click image for full size.
Elemicin used to be interesting to me and there is a pretty good wikipedia article on it.
Elemicin by itself seemed to have psychoactive effects and adding a nitrogen could make it even more effective.
It made me hornyer and want to dance more and very easy to come by.
>>
Bombastus Werrywag - Fri, 05 Jan 2018 16:43:49 EST ID:uvAHW/WE No.78962 Ignore Report Quick Reply
>>78957
what does it mean to adding an nitrogen?
>>
press !AX.nZBombY - Fri, 05 Jan 2018 17:38:07 EST ID:4D6UnT/b No.78964 Ignore Report Quick Reply
>>78957
i think alpha methyl mescaline
>>
Schepperschop - Sun, 14 Jan 2018 04:38:11 EST ID:KfNa6wwZ No.78969 Ignore Report Quick Reply
>>78962
Exposing it to air because I heared there is nitrogen in air...
Alot of nitrogen concentration in air and the breaking of the allylbenzene may create a new substance at a specific temperature.
>>
Schepperschop - Sun, 14 Jan 2018 04:38:49 EST ID:KfNa6wwZ No.78970 Ignore Report Quick Reply
>>78969
allylbenzene double bond
>>
Schepperschop - Sun, 14 Jan 2018 07:49:48 EST ID:KfNa6wwZ No.78971 Ignore Report Quick Reply
>>78957
Does it make me high, or highly flamable?
>>
Fanny Pittforth - Tue, 16 Jan 2018 22:28:53 EST ID:hBAZGxou No.78975 Ignore Report Quick Reply
>>78957
https://www.erowid.org/library/books_online/pihkal/pihkal157.shtml
>(with 140 mg) There were not the color changes of mescaline there, but certainly a good humor and an over-appreciation of jokes. The images behind the eyes were remarkable and tied in with the music, and I became annoyed at other people's conversations that got in the way. I was out of it in eight hours. I would equate this to 300 or 350 milligrams of mescaline and I rather think that I would prefer the latter.
itt: people have never heard of trimethoxyamphetamine
>>
press - Wed, 17 Jan 2018 04:40:55 EST ID:PJ0/E4z+ No.78976 Ignore Report Quick Reply
>>78975
as far as i know its a bit over indulging to respond to dear schepperschopenhauer with too much sincerity
>>
schepperschop - Sat, 27 Jan 2018 13:22:40 EST ID:xTIigKo1 No.78989 Ignore Report Quick Reply
>>78906
I think that extraction of arecoline from betel nut and reacting with bitter almond oil would be interesting.
>>
schepperschop - Fri, 09 Feb 2018 12:05:08 EST ID:xTIigKo1 No.78996 Ignore Report Quick Reply
>>78989
a guy is visiting my moms house lately, today he wanted to take a look inside the shed
>>
Shit Callyted - Mon, 12 Mar 2018 16:39:24 EST ID:xTIigKo1 No.79013 Ignore Report Quick Reply
>>78996
kermiet seksman
>>
A_Wizard !cMZsY.BCnU!!vVWR8L52 - Sun, 25 Mar 2018 06:11:01 EST ID:H2dReURr No.79024 Ignore Report Quick Reply
>>78906
Can you add some deso and phenyl to that?
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:54:44 EST ID:pMrrl6aC No.79120 Ignore Report Quick Reply
1527184484841.png -(222471B / 217.26KB, 2027x2417) Thumbnail displayed, click image for full size.
>>78906
This one's kind of interesting. It keeps binding though, I'm not sure where it ends.


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