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You'd think after multiple years sober the whole LTP model falls apart. That really should be more than enough time for synapses to have undergone some degree of reversion, if only in response to the required changes for sober cognition over an extended period of time. Yes LTP can cause permanent changes in the brain, but it's hard to believe it'd be so absolute. And remember while LTP is widely studies, we have little hard data on it, especially in proportion to all the theoretical models.
Also just gonna add the only NMDAR agonist I know of off the top of my head is L-theanine. I'd be concerned about mixing NMDAR agonists and antagonists because of the neuromodulatory role of glutamate. It's sort of a one-way street kind of system, unlike the monoamines, for example, where you can take a serotonin agonist and antagonist because even if they hit the same site one just prevents the other from working, or lessens the effect.
>bulging amygdalaNot for me but if that's your ideal psychonaut superbrain then I won't stop you. Regarding the serotonin system, that's really where I'd think the root of the issue is. The types of hallucinations I tended to have were *somewhat* comparable to low dose psy hallucinations (particularly the 2Cs). It leads me to believe that such an extended tolerance break actually bit me in the ass by effectively resetting my P450 system, making the ratio of DXM to DXO much lower, as >>361721 points out. I actually went back and read an long exchange between Fallen, Fiend, Kerflap, and Cursive, about slow dosing and "infrasigma", and it hit me how important those ratios must be (I used to avoid fretting over it because trying to sort out P450 metabolism is kind of a nightmare so I just didn't worry about it). I was a pretty regular user years ago, dexxing once every week or two, sometimes multiple times a week, there's no telling how fucked up my liver enzymes must have been, and how much lingering metabolites there might have been with the regular use, that I was getting more DXM over DXO, and hence more serotonin activity, i.e. more psychedelic, visual trips.
See above but also yeah, it occurred to me I should try breaking up my doses like that. I had a decent trip predosing with a little Nyquil, then taking 450mg, THEN 225mg and that basically was a nice 2nd plat where I was moderately social and then the last dose pushed it into low 3rd. Obviously doing the 225mg last was dumb, I think next time I'd do what you suggest or close to it. I wonder about doing lots of smaller doses and then topping off with a larger dose. For example, 30-60mg every 30 minutes, for a couple hours, then 450mg all at once. That would theoretically push the DXM ratio up a good bit. Any experience with this particular pattern?
ikr? Liver metabolism is like my least favorite thing to sort out, I forget about it all the time.
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