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noob question by Clara Chorrysed - Fri, 20 Oct 2017 01:21:17 EST ID:OkvCJobi No.356642 Ignore Report Reply Quick Reply
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Hey /dis/, if I wanted to trip strong (3 plat+) how much dxm shoudl I do if I'm smoking a Joint on the comeup? I've done DXM 3 times and on the 3rd I did 300 mg + weed and it was the most profound experience ive ever had (including multiple 200-300ug acid trips and one 450). I was going to do 450 but I wanted to ask yal first.
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Cyril Goodwater - Fri, 27 Oct 2017 05:12:01 EST ID:Yp0OGhOz No.356794 Ignore Report Quick Reply
Dude, don't give up on enzyme inhibition potentiation then. Star fruit or maybe to a lesser extent blood oranges can do it to. Also pomelos but most places dont have them and if you didn't like grapefruit you might not like pomelo. It taste like a less sower completely not bitter grapefruit.
Reuben Nicklespear - Fri, 27 Oct 2017 10:30:07 EST ID:5MSM4AZg No.356795 Ignore Report Quick Reply
When I started potentiating I hit my tolerance really fast, I wouldn't start. After only less than 10 trips, IIRC.
Isabella Gaddleman - Fri, 27 Oct 2017 16:01:20 EST ID:bBbM9Fwz No.356803 Ignore Report Quick Reply
I have no experience with combining weed with DXM, but the usual 3rd plat for me, before tolerance, and at 120lbs, was something like 525mg-below 600mg. Basically 1.5 bottles of syrup (531mg), if you're not keen on measuring shit out too much. Two bottles (704mg) was a definite fourth plat, so if you overshoot you're in for something dysphoric but also completely awesome at the same time.
Isabella Gaddleman - Fri, 27 Oct 2017 16:02:08 EST ID:bBbM9Fwz No.356804 Ignore Report Quick Reply
but who really cares
Albert Goodforth - Fri, 27 Oct 2017 18:15:04 EST ID:tk4VI4I5 No.356811 Ignore Report Quick Reply
Well DPH offers some degree of CYP3A4 inhibition I believe, but no CYP2D6. I recall also taking ranitidine at one point but I don't know if this was for enzyme inibition but rather as an acid reducer to decrease the amount of DXM destroyed by gastric acid.

I'm also reading now that cannabidiol (CBD) is probably a CYP2D6 inhibitor, though I'd never heard this before. Aren't the more recreational strains higher in THC and lower in CBD? I'm more familiar with the medicinal strains at this point, which follow the reverse preference.

This is a good point. I'm not sure what the precise mechanism would be for this, but if anything it makes it more difficult to gauge how much DXM you really need to be taking, so you wind up taking more than you need to be taking for your desired plat, even if it's less than you'd normally be taking without potentiation.

Ketamine by Jack Billingman - Tue, 24 Oct 2017 11:55:16 EST ID:THU4EHtn No.356736 Ignore Report Reply Quick Reply
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Just bought some ketamine for the first time. How much to do and what to expect?
Fucking Fushtodge - Tue, 24 Oct 2017 14:45:46 EST ID:+LdGW9Qc No.356743 Ignore Report Quick Reply

Do 100mg and another 100mg if the first one doesn't say much. Expect nothing and say no to others controlling your freedom of experience )
Henry Mundlewater - Tue, 24 Oct 2017 15:49:38 EST ID:F60ybwoU No.356744 Ignore Report Quick Reply
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.1 isn't a bad starting dose if you don't mind potentially having a heavy experience depending on the batch it could be a slapper and always wait at least 5-1& minutes to judge your bump cuz it can take a minute Ute to kick in
Phyllis Deshpan - Tue, 24 Oct 2017 23:51:48 EST ID:WOAMjuUx No.356748 Ignore Report Quick Reply
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keep doing small bumps until you get more and more disoriented. Then do one big line to finish off

Expect beautiful landscapes and a blissful psychedelic trip

Dxm + Kratom by Lydia Sunkindock - Sat, 21 Oct 2017 20:18:11 EST ID:GUvaSG+d No.356687 Ignore Report Reply Quick Reply
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Long time /dex/er here. I just recently got into using kratom for the first time and like it quite a bit. While researching negative interactions between kraton and dxm, and how long to go between using one before using the other, I found out that not only is it apparently safe to mix, but is said to be an amazing combo.

I didn't read much into the actual effects of the combo itself, as I was originally just interested in knowing whether or not it would be safe to ingest dxm with 24 hours after dosing kratom. I'm a little interested now to know if anybody here has mixed the two?

I had never heard of the combo before, what are your thoughts/experiences? Thanks
Eliza Disslestock - Sat, 21 Oct 2017 20:59:01 EST ID:Yp0OGhOz No.356690 Ignore Report Quick Reply
Well, the half-life of the active ingredients are all relatively short if I'm not mistaken. I encourage you to fact check that, but I think they clear in 24-48 hours. Its a good place for you to start looking anyway.
Eliza Disslestock - Sat, 21 Oct 2017 21:06:15 EST ID:Yp0OGhOz No.356691 Ignore Report Quick Reply
Almost forgot kratom looks on paper like it would basically work like grapefruit juice(questionable efficiency) for potentiation and as a cns depressant its overlapping effect could theoretically cause heart failure. Especially if you were physically exhausted and tried dosing for some reason. That is to say also it looks dangerously synergistic, like dissociative speedball. Seems a little iffy to use for potentiation though the thought crossed my mind too. Especially considering the much MUCH safer alternatives.
Caroline Hingerhit - Sun, 22 Oct 2017 01:01:19 EST ID:IqgnmU+/ No.356702 Ignore Report Quick Reply
Never tried with kratom but DXM and opioids is great combo.
If you don't have much of an opi tolerance then codeine goes great with DXM as they both compete for the same enzyme (codeine -> morphine, DXM -> DXO). This does mean you get less conversion to morphine, but since ~60-80% of codeine's activity is unrelated to conversion to morphine it's not too important.
Basil Drullerwater - Tue, 24 Oct 2017 00:00:11 EST ID:L2nf9aIq No.356734 Ignore Report Quick Reply
I've been meaning to try but the last time I did Kratom it made me vomit something bad.

DXM to an unfamiliar person by Shit Hacklefoot - Fri, 06 Oct 2017 19:53:02 EST ID:OcRh0oMq No.356404 Ignore Report Reply Quick Reply
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How would you describe or tell about it? Without coming off like a weirdo when you introduce someone to the idea of ingesting cough syrup drugs to get high.
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Martha Chubberforth - Sun, 22 Oct 2017 00:13:35 EST ID:lZDHLx8H No.356698 Ignore Report Quick Reply
coming up on two bottles and reading this to fix you and smoking a joint. damn.
Ebenezer Dollerfuck - Sun, 22 Oct 2017 13:59:41 EST ID:qItLFK8L No.356714 Ignore Report Quick Reply
Go ahead. There is nothing I would love more than to be fixed.
Ebenezer Dollerfuck - Sun, 22 Oct 2017 13:59:41 EST ID:qItLFK8L No.356715 Ignore Report Quick Reply
Go ahead. There is nothing I would love more than to be fixed.
Reuben Grandworth - Mon, 23 Oct 2017 15:42:49 EST ID:gRdywvo3 No.356726 Ignore Report Quick Reply
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Prepare to be tricked - by reality kicked and yet made tranquil, like from the frog who'd been licked

Feeling poison in the body gloopy gloison in the head revealing naughty bits of noise and even something that was read

I don't remember what it said, slipping sliding all over the bed like a ship inside a bottle that's been sped towards galaxies both green and red
Graham Dettingstick - Mon, 23 Oct 2017 20:09:32 EST ID:BPsfH5pP No.356729 Ignore Report Quick Reply
dissociatives are just boneless consciousness

how to into dis by Nell Gemblefoot - Thu, 19 Oct 2017 21:11:27 EST ID:KTkxjSeX No.356639 Ignore Report Reply Quick Reply
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Hi, total noob here. I'm interested in dissociatives but don't know how to start and I don't have a dealer atm. I have experieces with psys and opis. How would you describe dis drugs compared with these other two?
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Shitting Grandcocke - Fri, 20 Oct 2017 22:30:25 EST ID:L2nf9aIq No.356665 Ignore Report Quick Reply
This is me but I feel kind like I've exhausted what I can see on DXM, and would like to start getting into ketamine or a psychadelic like shrooms.
Unfortunately I'm autistic so finding a dealer without getting extremely lucky seems hard. I have no idea if you guys buy shit online, or HOW you buy shit online, but I sure would like to find out.
Caroline Hingerhit - Sun, 22 Oct 2017 01:02:43 EST ID:IqgnmU+/ No.356703 Ignore Report Quick Reply
I really can't be bothered explaining in too much detail, but basically VPN, TAILS, and a list of DNMs can be found on plebbit, or so I'm told.
Caroline Hingerhit - Sun, 22 Oct 2017 01:04:02 EST ID:IqgnmU+/ No.356704 Ignore Report Quick Reply
And depending on what part of the world you're in shrooms can be found by venturing out into the real world, probably into someone else's paddock.
Jenny Pickway - Sun, 22 Oct 2017 06:47:59 EST ID:pQ1dq1Dp No.356709 Ignore Report Quick Reply
I feel there's some validity to what you say, but to some extent you never lose that "magic" as long as you practice moderation. Hell, I have taken mushrooms enough times and close enough together to get used to it even without a tolerance and its a true psychedelic. Point is, if you take enough it will build to that unpredictability, and like with any powerful hallucinogen after a point it doesn't matter what your tolerance is like or how experienced you are shit WILL get crazy. You can get used to it to some extent, but that's just your brain rubber banding really. For me if I have herb I dont need a liver destroying huge dose. Just last night I took 600mg and I was sitting there trying to convince myself I was sober, and I could kinda bat it back until that deep bong bowl of sour diesel informed me otherwise. Then I remebered the grapefruit juice and like I do every time I wondered if it really helps before I started melting through the fucking floor. Having done this several hundred times now I can say with certainty part of the reason you don't always remeber all of your 3rd plat and up moments is because it fucks with your ability to form memories; if your like me and you love to potentiate as well then expect further disorientation and memory impairment as well. Not say it all defeats the purpose but sitting there last night I really had to question the supposed 50 trip limit, because while medium doses of dex can be truly comfortable just one toke over the line and you're tripping balls man.
Albert Charryfoot - Mon, 23 Oct 2017 00:40:10 EST ID:GvOEEqaF No.356719 Ignore Report Quick Reply
Just research how to like you would anything else on the internet.

Tri-Trip tips by Wesley Ceshhidge - Tue, 17 Oct 2017 19:09:43 EST ID:n/3a9MBq No.356589 Ignore Report Reply Quick Reply
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Who here has done a tri-trip meaning they mixed dis+del+psy? Im curious to give it a shot along with nitrous. Im thinking 200mg of dph, 300-400mg of dxm, and half a tab of lsd for this trip along with copious amounts of nitrous at the peak. Anyone done this before? Whatd you think? What should i expect? Im extremely experienced with dxm with probably 1000 trips under my belt at the least, a ton of dph trips including past 1g (but its been years since ive done it), and ive done tons of psychedelic trips, including dmt, so im not worried about freak outs or anything. I am just hoping to have the most vivid hallucinatipns and delusions ive ever had in my life. My gf will be present as well so i wont be alone.
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John Claydock - Sat, 21 Oct 2017 17:45:10 EST ID:NmQMp7ny No.356681 Ignore Report Quick Reply

Also, i redosed 120mg of dxm not long ago.
Wesley Tillingshaw - Sun, 22 Oct 2017 00:36:56 EST ID:FDw4oep4 No.356700 Ignore Report Quick Reply
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>200 whippets!

Caroline Hingerhit - Sun, 22 Oct 2017 00:56:02 EST ID:IqgnmU+/ No.356701 Ignore Report Quick Reply
If you haven't done over 200 whippets in a session then you haven't really done whippets.
Cornelius Pickwater - Sun, 22 Oct 2017 08:46:10 EST ID:NmQMp7ny No.356711 Ignore Report Quick Reply

I wanted to go get more but somehow during the trip i hurt my throat. Idk if it was from nitrous or if i swallows a pill wrong or what but it hurt to swallow or move my neck or yawn or pretty much anything. It wasnt unbearable, just really unpleasant. Im sure it'll pass in a couple days. Just sucks it made me not want to get more nitrous lol
Sidney Shittinglock - Sun, 22 Oct 2017 19:14:16 EST ID:64wd9yPY No.356716 Ignore Report Quick Reply
You haven’t REALLY done nitrous till you’ve spent a whole party sitting around a 20lb tank.

NAUSEA by Albert Sunderfick - Tue, 17 Oct 2017 10:14:01 EST ID:Qt58CjR7 No.356580 Ignore Report Reply Quick Reply
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how do i combat the nausea meme, i used to be ok at keeping the shit down but now i just projectile vomit as soon as i start coming up
Priscilla Beffingworth - Tue, 17 Oct 2017 12:21:25 EST ID:ww+fm8dW No.356583 Ignore Report Quick Reply
I don't know. I'm the opposite. I used to vomit every time, now I don't vomit. I always thought it got easier.
Molly Dasslenit - Tue, 17 Oct 2017 12:25:48 EST ID:7DPewo7l No.356584 Ignore Report Quick Reply
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It's always hit or miss for me sometimes I get sick, then liquid shits the next day, and sometimes I don't, then I'm constipated the next day.

Only solution I've found to beat the nausea is a nice benzo before the Dex. But be careful with this, I've made an ass out of myself a few times by blacking out, dosing my robo, forgetting or not caring, then going on a walk usually to buy more robo
Oliver Puzzlepet - Wed, 18 Oct 2017 05:40:12 EST ID:Yp0OGhOz No.356597 Ignore Report Quick Reply
Well I have found that taking some beano right before dosing can help a lot. Also a benadryl might help or I guess should help considering first generation antihistamines are used as anti-emetics all the time. Beware though, while antihistamines can help they also potentiate the DXM.
Jarvis Furringway - Thu, 19 Oct 2017 18:24:16 EST ID:arDQEB2E No.356637 Ignore Report Quick Reply

Same. I used to vomit every single time when I first started. Now I don't even get nauseous.

Then again, I always used to drink syrup. Now I exclusively take gels.

Best DCK Starting Dose? by Emma Seblingstut - Sun, 15 Oct 2017 20:22:13 EST ID:arDQEB2E No.356550 Ignore Report Reply Quick Reply
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I'm gonna be ordering some DCK soon and I was wondering what a good starting dose would be for someone who has a tolerance to dissociative and has extensive experience with DXM and a little experience with Ketamine.

Das pretty much it, fam.

>SLAYER and thanks in advance
Betsy Hemmlehudging - Sun, 15 Oct 2017 22:56:59 EST ID:SGcxEJsH No.356555 Ignore Report Quick Reply
>>356550 depends how you're going to consume, but try 30 mg orally and redose 15mg nasally in an hour and see how that gets you.
Emma Seblingstut - Mon, 16 Oct 2017 02:07:40 EST ID:arDQEB2E No.356558 Ignore Report Quick Reply
I figured sniffing it would be easier but I have no idea how to use it. I'd assume eating it or sniffing it would be the best optiom
Fucking Dartspear - Mon, 16 Oct 2017 02:27:08 EST ID:YOgaOVAj No.356559 Ignore Report Quick Reply
I personally favor plugging over sniffing, but 9/10 I do it nasal so that I can get that sweet nose gratification.

But uh, my vote goes for 100 mg taken in 50 mg increments. But then again my tolerance might make me a not-very-credible source
Hugh Shittingridge - Mon, 16 Oct 2017 23:57:55 EST ID:yVyr2UVT No.356577 Ignore Report Quick Reply
Not OP but do the different ROA's feel different with DCK as they did with MXE? I remember every route of ingesting MXE way back in the day had a different set of effects.

If it is different, how is oral/sublingual DCK?
Edward Blagglesure - Thu, 19 Oct 2017 13:08:28 EST ID:+LdGW9Qc No.356632 Ignore Report Quick Reply

I once did a hefty redosing orally (2 40-60mg doses. Second was after the first peak). For some reason the duration of the second peak got extended so much that I was still on comedown after 10-12hours after the second dose

1800mg dose during hurricane Irma by Martha Pallystock - Thu, 05 Oct 2017 13:58:51 EST ID:U2WOX3/r No.356375 Ignore Report Reply Quick Reply
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So I have a pretty interesting story to tell.

Last month, I decided to go to rehab.
I had been completely sober for about four months, but relapsed on Klonopin and Dilaudid. I was homeless, broke, and depressed so I made the decision to go into treatment.
I was able to get into a place in Lake Worth, FL but I had 3 days before they could come get me and verify insurance and all that jazz.
With the last of my money, I got a hotel for two nights in Boca Raton, a little bit of food, and 8 bottles of dollar store gel caps.
The first night at the hotel I slow dosed 4 bottles (900ng) had a decent trip, right in the border of 2nd and 3rd plat (I've been heavily using dxm for 7 years so I have a crazy tolerance).
At around noon the following day I was afterglowing heavily and started to slow dose 675ngs. It was an e en better trip due to the potentiation of the previous nights dose, solid 3rd plat experience. It had been several years since I have been able to hit the 3rd plat so I was thrilled.
So I had been awake for over 48 hours now and was extremely intoxicated from the past two days, and I realized that I had to check out of the hotel.
I had about 4 hours between check out and when the treatment center could come pick me up, so I ate the last bottle of gels (225mg) and headed for the beach.
Again, due to potentiation, it hit me hard. I met a guy on the beach who offered me a few hits off his joint +I love people in Boca) and spent a few hours swimming and meditating on the beach.
Finally, I got the call. I was so fucked up that it took me awhile to find the driver, but I eventually did and we started heading south.
"So what have you been taking?" He asked.
"Opiates and benzos, but I've been binging on dxm for a few days " I replied.
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Thomas Pottingdone - Wed, 11 Oct 2017 13:42:09 EST ID:IqgnmU+/ No.356509 Ignore Report Quick Reply
But none quite so much as your positivity and optimism.
Nicholas Shittingfuck - Fri, 13 Oct 2017 09:56:09 EST ID:p97HjB3E No.356525 Ignore Report Quick Reply
no it's called tough love bruh. it totally works. basil changes lives with a single post.
Cedric Buzzwill - Mon, 16 Oct 2017 05:03:39 EST ID:Tr+0tvZX No.356562 Ignore Report Quick Reply
it can be seen as nonsense. rehab tries to leverage on some parts of the human personality, but the problem is that not everybody has the same one, so it might seem like nonsense to some.
Rehab serves the purpose of giving input to somebody so that they "click" internally and finally understand that daily dosing has nothing to give, so that they can go without drugs or just taking them occasionally (i'm talking 1 month in between usage of drugs in the same category).
Hedda Memmerfoot - Mon, 16 Oct 2017 16:57:16 EST ID:U2WOX3/r No.356569 Ignore Report Quick Reply
OP here
I don't know about dying in less than a decade, but you were right about me relapsing.

Oh well.
Eliza Hoffingtere - Tue, 17 Oct 2017 10:34:12 EST ID:Tr+0tvZX No.356582 Ignore Report Quick Reply
It's pretty straightforward when you think about it: if you don't give a shit about quitting, you won't ever quit. You *might* reduce usage if you give a shit about health and getting shit done and also money, but that's going to be as better as it'll get. Which is not necessarely a bad thing if you take the right conclusions.

302 warning mane by Samuel Drovinghed - Fri, 13 Oct 2017 14:04:35 EST ID:qJrRLvuF No.356527 Ignore Report Reply Quick Reply
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8 days ago I came into one of my college classes high on cough syrup; I became ill and wanted to go to the Nurse, who then proceeded to deem the two bottles of robitussin gelcaps i had imbibed as a "suicide attempt" . She 302'd me :
Involuntary Commitment (aka “a 302”) An involuntary commitment is an application for emergency evaluation and treatment for a person who is dangerous to themselves or others due to a mental illness.
So while I was high I answered the questions about suicide, crassly....to put it mildly. I am not suicidal, and I did not take the cough syrup to kill myself; despite this:
I spent 5 days in a hospital where I could not leave the room I was in and had to have a nurse watching me constantly.
I then spent 3 days in an actual mental clinic, which while better than lying in a hospital bed, was still a loss of freedom.
I've learned a lot from the experience. I mature'd da fuck up.
My token advice? Be wary of what you say when you are inebriated, all it takes is one "concerned" individual, and you too could be 302'd.
Better to not lose control in the first place:
#straightedge lifestyle here I come.
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Barnaby Feppershit - Sun, 15 Oct 2017 07:51:52 EST ID:fTQnMToi No.356542 Ignore Report Quick Reply
op in a month:
>i won't do anything that stupid again, but this single bottle won't hurt now heh
John Borringforth - Sun, 15 Oct 2017 11:37:54 EST ID:wRsjWFt6 No.356543 Ignore Report Quick Reply
so much this
we all been there
Fucking Fevingpack - Sun, 15 Oct 2017 17:18:24 EST ID:jCabIawJ No.356545 Ignore Report Quick Reply
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nigga maybe just get dissd after class.

cmon now fam.
dont make panda bear disappoint....keep getting dissd but do so responsibly k.
William Nobbernadge - Sun, 15 Oct 2017 19:59:46 EST ID:7DPewo7l No.356549 Ignore Report Quick Reply
Ya it took me a while to learn to diss responsibly too but for real it's so much better when you don't have the thought of real world troubles like I don't know, having to be in public on dxm, in the back of your mind. That one always seemed like a no brainer to me
Albert Sunderfick - Tue, 17 Oct 2017 10:11:37 EST ID:Qt58CjR7 No.356579 Ignore Report Quick Reply
>going to class on DXM
nigga you couldve stayed home and learned about as much

Dxm migraine by Emma Pillerpodge - Sun, 01 Oct 2017 02:58:53 EST ID:l0ciCWnK No.356299 Ignore Report Reply Quick Reply
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Does anyone else get these? When i use dxm i more often than not get a serious migraine at some point. Its like a pressure on the sides or front of my head. Some people describe it as feeling like its empty or like there is holes in your brain and i fully agree. It can also feel like there is some unseen force trying to crush my skull. Does anyone else get this when they do dxm? I tried looking it up and found a few rwsults but there wasnt too much on it. Whats your exoerience with dxm headaches?
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Thomas Clurringstone - Mon, 09 Oct 2017 17:53:56 EST ID:sjql3eTW No.356458 Ignore Report Quick Reply
got a weird ringing in my ear on my afterglow after my firt legit 900mg but i was also smoking hella weed (I know ironic)
Jarvis Facklebene - Tue, 10 Oct 2017 14:02:28 EST ID:ySUWi8NQ No.356479 Ignore Report Quick Reply
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Are you drinking enough water?
Basil Saffingwill - Wed, 11 Oct 2017 06:45:43 EST ID:fTQnMToi No.356501 Ignore Report Quick Reply
could be blood pressure going through the roof
Fanny Noffingdock - Mon, 16 Oct 2017 20:31:04 EST ID:tk4VI4I5 No.356572 Ignore Report Quick Reply
Fanny Noffingdock - Mon, 16 Oct 2017 20:35:37 EST ID:tk4VI4I5 No.356573 Ignore Report Quick Reply
Migraine headaches are almost invariably unilateral in presentation. This sounds like something else. I've gotten headaches before on DXM but usually they don't last very long and often happen to me during the transition from 2nd to 3rd plat.

whoops, finger slipped.

I want to go there again. by Betsy Snodshaw - Tue, 10 Oct 2017 02:00:19 EST ID:MRPexWuG No.356468 Ignore Report Reply Quick Reply
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Hi friends.
I haven't done DXM in a long time. I'm 24 now and the last time I did it was when I was 16. I thoroughly enjoyed every time, and did a whole lot of research into it to be sure I was safe.

However, when I turned about 20 I started on anti-depressants, and though it was easy enough to find info about serotonin syndrome, I'm now on new medication and I'm having trouble finding anything concrete, especially in regards to recreational use.

I take 175mg Venlafaxine (Effexor) daily, as well as 50mg quetiapine (Quetapel) at night to sleep. I really miss the high and would like to revisit it someday, is that possible on these medications? I'm quite sensitive to DXM too, my high (high 2nd plat to low 3rd plat) will usually last about a day and a half and the afterglow will stay around for almost a week.

Also in saying this, I recently tried what I believe was DMT while on these medications. I felt the dissociation but nothing intense really happened, hence my skepticism. My friends who did it with me saw some things, even on lower doses than the rest of us, one even went full seizure mode. Is my medication blocking my - to put it generally - 'third eye'? I get more CEV on pot nowadays..

Just tell it to me straight, doc. Can I ever go back?
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Hugh Bivingnitch - Thu, 12 Oct 2017 18:59:34 EST ID:IqgnmU+/ No.356521 Ignore Report Quick Reply
MDMA is just a waste of time if you're on SSRIs or SNRIs. Seriously, your friends will be gurning and PLURed out of their heads and you'll just be sitting there like 'ho hum'.

at 50mg of seroquel you'd probably only need to skip one dose. My friend on 1200mg only skipped a night or maybe 2 before we tripped, and that's extended release stuff. He probably did have to take more but he was still tripping balls from 2.5tabs.
Hugh Bivingnitch - Thu, 12 Oct 2017 19:25:00 EST ID:IqgnmU+/ No.356522 Ignore Report Quick Reply
My last response was a bit unclear, I'd just take the venlafaxine as normal and skip it the day you do DXM and probably not worry about it any days you're still tripping.
It's probably not a big deal either way though.
As for MDMA even taking a few days off your meds will still leave you with reduced effects in my experience.
Ebenezer Gizzlenodge - Thu, 12 Oct 2017 21:05:29 EST ID:FlnTFRXn No.356523 Ignore Report Quick Reply
No idea about the science but I did dex too many times to count during my youth while I was on various SSRIs including effexor and in retrospect my trips were wayy more intense at the lower plats but the higher regions never really changed
Sophie Smallfield - Mon, 16 Oct 2017 18:58:18 EST ID:tk4VI4I5 No.356570 Ignore Report Quick Reply
1508194698380.png -(22867B / 22.33KB, 1416x682) Thumbnail displayed, click image for full size.
this is an oversimplification but it's the basic idea.
Ebenezer Ciddlewater - Mon, 16 Oct 2017 19:27:39 EST ID:QJR3IVHE No.356571 Ignore Report Quick Reply
i'd say that at lower plats the effects of the CYP2D6 potentiation would be more readily evident?

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