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Olney's Lesions by Thomas Binnernin - Mon, 29 Jan 2018 08:19:40 EST ID:aCZW6Wd6 No.358829 Ignore Report Quick Reply
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It's been 15-20 years since the whole fiasco: https://erowid.org/chemicals/dxm/dxm_health1.shtml

Are you worried about brain damage from dissociatives? Not worried?
Doris Pockcocke - Mon, 29 Jan 2018 08:40:31 EST ID:izjWB8vZ No.358831 Ignore Report Quick Reply
There was that study that showed ketamine does cause brain damage, but all of the participants were taking over a gram of ketamine a day.

I think it's probably likely dissociatives at a high enough dose/frequency will cause brain damage. Polydrug use involving dissociatives and other neurotoxic drugs probably increases the rate/risk of brain damage. But even regular, spaced out, reasonably dosed use probably will not be significantly damaging.
Polly Dracklehood - Wed, 31 Jan 2018 04:54:40 EST ID:aCZW6Wd6 No.358882 Ignore Report Quick Reply
It's so interesting to me that psychedelics are said to be totally physiologically safe, but yet they have given me the absolute worst trips, when DXM and other dissociatives are said to be very potentially neurotoxic, when DXM has given me such a great trip every time. I can't even conceive of having a bad trip on DXM as it totally takes away your anxiety.
Cornelius Crengerwell - Wed, 31 Jan 2018 07:21:54 EST ID:Aic8Bi4e No.358883 Ignore Report Quick Reply
>>358882 that has nothing to do with anything. mdma gives you best euphoria and is neurotoxic.
Graham Gorringbury - Wed, 31 Jan 2018 17:29:39 EST ID:BZJG7d6e No.358885 Ignore Report Quick Reply
not worried

maybe dose a half shot of alcohol if you are worried
Phoebe Nickleham - Thu, 01 Feb 2018 01:27:45 EST ID:E3N7HGfp No.358892 Ignore Report Quick Reply
>mdma gives you best euphoria
someones never done meth
Fuck Snodbury - Thu, 01 Feb 2018 16:35:42 EST ID:Wf414xHT No.358908 Ignore Report Quick Reply
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More than anything, the thing that stopped my use of DXM was the way it made me feel in the days afterwards. Although the effect wasn't as bad as a stimulant come-down, it lasts a lot longer, I have this inescapable feeling of not feeling joy or excitement about things that normally would make me feel such things. It's like there's a layer of glass between me and the rest of the world, and it takes several days to shake off that feeling. I don't think that has anything to do with whether it's neurotoxic or not, but I think that can be reasonably avoided by smart and conscientious use. After a few dozen trips over the course of 3-4 years I don't feel any worse for the wear, although there were times where I felt a bit alienated from the rest of the world, or I didn't feel like my coordination/sense of my body in space was spot-on, and I'm normally a very coordinated person.

Just typing this out makes me miss it.
Isabella Fellerpeck - Thu, 01 Feb 2018 18:09:38 EST ID:m4BKYieN No.358913 Ignore Report Quick Reply
MDMA has given me more euphoria than meth ever has. Although if you are talking meth + heroin then that's another story.

also vaped 25i-nbome is more euphoric than meth >fite me
Cedric Murdcocke - Thu, 01 Feb 2018 19:24:41 EST ID:wp16nQJP No.358915 Ignore Report Quick Reply
it does have to do with proving that dis is neaurotoxic aight>
Angus Wopperhat - Thu, 01 Feb 2018 22:35:15 EST ID:IqgnmU+/ No.358928 Ignore Report Quick Reply
No it doesn't. You can't just assume whether or not something is neurotoxic based on how it makes you feel.
Nigel Benningnet - Fri, 02 Feb 2018 01:58:08 EST ID:9D4ONxqC No.358935 Ignore Report Quick Reply
lolol i guess it depends who you are, meth alone at a high dose gave me unparalleled bliss from any other drug, it was so insane, i know 25i is good but i think its a whole other ballpark, more of a happy rush, ive mixed it with oxy though , and the shits like... pure pleasure, i probably smoked up to half a gram in a sitting, all i can say is keep smoking till you're satisfied and make sure you have a good heart lol.Im not much of a fan of mdma myself personally, it makes me feel weird and i dont like the emotional aspect, i like the sharp quick thinking pleasurable euphoria of amps, and the wacky robotic high of dissociatives...

which gets me thinking of some combos i wanna try

meth + K or 3-meo-pcp
meth + LSD or 2c-b

also usually I meditate and listen to a lot of music when im high so that probably contributes, who knows, who cares lol

I guess everyone has their own tastes
Cedric Murdcocke - Fri, 02 Feb 2018 03:47:11 EST ID:wp16nQJP No.358937 Ignore Report Quick Reply
but you have to admit that very stupid assumtions do hint at a decreased cognitive function which I extrapolate from the fact that the guy you replied to thinks that if a drug produces pleasurable experience it can't be bad for your health. Since he's on dis I assume he's most likely a user and you know if you had hundreds of guys like that all on dissociative discussion forums you could begin to build evidence so it does have to do with proving that dis is neaurotoxic aight>
Angus Wopperhat - Fri, 02 Feb 2018 04:54:03 EST ID:IqgnmU+/ No.358941 Ignore Report Quick Reply
That... that's borderline word salad, my dude. You might be able to assume that someone is stupid based on their post, but it's a big leap to assume that 1. it's caused by dissociative use and 2. they weren't intoxicated when they posted.
I agree that the subjective effects of a drug are no indicator of neurotoxicity.
Angus Wopperhat - Fri, 02 Feb 2018 04:55:26 EST ID:IqgnmU+/ No.358942 Ignore Report Quick Reply
I mean, maybe disso use just appeals to idiots?
I'm not saying that's the case, just saying that you can't establish causality like that.
Cedric Murdcocke - Fri, 02 Feb 2018 06:20:00 EST ID:wp16nQJP No.358943 Ignore Report Quick Reply
sure mane, but I'd still consider it a contributing factor to the proof of such causality, because even if the stand alone evidence is underwhelming itself you can have enough of it to make it overwhelming at some point.
Lillian Nibblewedge - Sat, 03 Feb 2018 00:24:24 EST ID:aCZW6Wd6 No.358986 Ignore Report Quick Reply
It's harsh to call me stupid for having that thought
Henry Fezzlefoot - Sat, 03 Feb 2018 02:16:02 EST ID:wp16nQJP No.358991 Ignore Report Quick Reply
i'm sorry man, it's prolly just a stupid thought.. your fine.
Clara Worthingfield - Sat, 03 Feb 2018 19:22:50 EST ID:aCZW6Wd6 No.359011 Ignore Report Quick Reply

I don't think it's a stupid thought.
Walter Sengertare - Sat, 03 Feb 2018 21:29:44 EST ID:Rhym7e0Y No.359018 Ignore Report Quick Reply
Punctuating sentences with "aight" I would guess you're the expert and living study on brain damage. Seriously though you do come off as an arm chair scientist ignoramus who couldn't even pass for an especially pedestrian dilatant. Truly exemplary perfromance my good sir.
Rebecca Popperstun - Sun, 04 Feb 2018 03:30:09 EST ID:jlt1SALR No.359025 Ignore Report Quick Reply
you do come off as having autism, specifically aspergers, with those big pretentious college words that you can't even spell correctly. i believe you meant pedestrian dilettante.
Caroline Ginkinford - Sun, 04 Feb 2018 06:18:48 EST ID:pAZn5ow/ No.359027 Ignore Report Quick Reply
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I'm glad i derailed this thread, cause now it's taking an unexpected turn for the good.
Eugene Trotbury - Mon, 05 Feb 2018 05:34:20 EST ID:ixSyVbMN No.359082 Ignore Report Quick Reply
Nigra it was satire in and if itself. You do realize how fucking retarded it is to come one here and start calling people dumb for and by the drugs they do. Likr it's some kind of great scholarly chicken and question but with dissociatives. Besides, the studies done were conclusive and White got his ass ripped for offering conjecture as fact, and c'mon bro diagnosing through a screen and I'm the pretentious aspie?
Henry Wishwill - Mon, 05 Feb 2018 06:02:35 EST ID:4ToZ+/Ts No.359083 Ignore Report Quick Reply
There was a big anti-drug push back then and scientific funding was low...

... figure it out for yourselves.
Oliver Madgebanks - Wed, 07 Feb 2018 23:02:27 EST ID:LDVPmJhZ No.359191 Ignore Report Quick Reply
I did about 10g of 3MeO in about 3 months. If you don't know, that's kind of a shit load. I am also FOR SURE brain damaged. I can't balance very well, my thoughts are extremely foggy, and I have a difficult time speaking now. Also, I have a much higher tolerance for pain, so there's that too.
Hamilton Nidgenot - Thu, 08 Feb 2018 05:54:33 EST ID:0P894Wg3 No.359201 Ignore Report Quick Reply
Anyone who needs to do this to recognize the gap between their subjective awareness and embodied reality is at least a little bit stupid and probably fairly shallow.
David Fungersed - Thu, 08 Feb 2018 06:19:55 EST ID:6g2CtrdL No.359202 Ignore Report Quick Reply
Sure are a lot of pompous people in a thread on a board about doing cough syrup.
David Fungersed - Thu, 08 Feb 2018 06:20:55 EST ID:6g2CtrdL No.359203 Ignore Report Quick Reply
What gap? Dualism is nonsense.
Nicholas Turveyson - Thu, 08 Feb 2018 08:54:38 EST ID:pAZn5ow/ No.359206 Ignore Report Quick Reply
aren't we the embodied reality? What do you mean by "embodied reality", sir?
Hamilton Nidgenot - Thu, 08 Feb 2018 13:56:08 EST ID:0P894Wg3 No.359213 Ignore Report Quick Reply
Subjective perception as a floating cloud of awareness (the naive theory), vs its contingent reality as a product of the body.
Charles Barryfit - Fri, 09 Feb 2018 06:40:14 EST ID:pAZn5ow/ No.359250 Ignore Report Quick Reply
so which one of those are you aware of/experiencing?
Augustus Brepperdod - Sun, 11 Feb 2018 20:59:14 EST ID:zLLpyikc No.359352 Ignore Report Quick Reply
>Erowid Note: William White retracted the conclusions of this document in 2004.

Not worried.
Nigel Saddlesun - Sun, 11 Feb 2018 21:11:47 EST ID:xYivG6It No.359353 Ignore Report Quick Reply
I'm not particularly worried. I first did dxm about 6-7 years ago, and have done it hundreds of times since, at many different doses. I feel comfortable (lel) saying that I've used dxm as many times in the last year and a half than the entire rest of the six-seven years, and I've had two psychotic breaks relating to dxm, and have experienced varying degrees of negative effects here and there depending on frequency of use and use of other drugs.

Still, my mental state has always returned when put in a haze, and despite much heavier and more frequent dosing, my memory and cognitive functioning has become noticeably better in the last year. My memory straight up astounds me at times, that I can so easily recall even the most minute details about an event that occurred days and days ago. I've become especially good with numbers lately, particularly since my strongest dxm trips which occurred within the last twelve months.
Nigel Saddlesun - Sun, 11 Feb 2018 21:18:57 EST ID:xYivG6It No.359354 Ignore Report Quick Reply

For clarification I'll be thirty in a year, and I've used dxm for days on end before, as well as other drugs, particularly lsd, dotted with heavy Molly doses. I have a very heavy drug history, minus the normally addictive dugs like opiates and other pills, although I have experimented with opiates and various types of pills in the past.

The thing that gets me is simply that my cognitive abilities have only gotten better the more I have taken dxm. I have been spending a lot of time studying in the last couple of years as if I were in college, so that obviously might be playing a big part in that. But I'm yet to experience any lasting negative effects from dxm. The worst I've had is a psychotic break, but I recovered, and the psychotic breaks could easily have been related to my at the time heavy abuse of lsd and mdma, as well as heavily abusing dxm.
Caroline Bloffingstock - Mon, 12 Feb 2018 01:13:22 EST ID:plRSCk64 No.359361 Ignore Report Quick Reply
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If I may:

I have found psychic locks not around id, ego or superego, nor those in debt, nor around those who have a drug addiction, but oddly around those people "with no identifiable problem" like myself. No wind to cry mary, no cause for blame, nothing.

A psychic lock is part lock, part cyclical, part mental abboration, whatever it is, it is invisible to the conscious, unconscious, even to everyone around the psy-locked. Most of all it is fed by drug use, negative habits, really anything can be used as a steady food source.

Psychiatry and Psychology exist as field of expertise for a reason. These people learn what is effectively a method of loci set of instructions and secret triggers which are a RAMlike "psuedo-brain" that they can parade around as the brain of the person, the therapist, for which this is not true.

Again, obvious to the intitiated, obvious to those in debt, obvious to the scientologist, but is it obvious to you? No. It is designed to be a bait and switch for good (hopefully, in the scientologists case i question)
in the discharge of the eventual waterworks of tears that fill us when we encounter that deep withheld shame that is so ugly, it rings truthfully as the explanation of our doubt and fear.

What I am getting at is, Disso's and the dissociative anestheic in general are mostly harmless, but tied to a psylock ,well, you can really get deep physical, social, mental harm. (Hence the plat per week rule, hence why people can eventual the stuff, I'm no saint myself)

Most importantly, It is easy to be comfortable with the idea that if you are talented at one thing (in my case it is art) you must be talented at multiple things. Man, have I never been glad to be wrong. You only know it when you meet someone who is, my russian ex-gf was, stupendously talented and wrigging out even my deepest held and memory palace x method of loci guarded trauma (dead puppies you name it) She was put in a scientologist thing as a kid, and basically decided to make the most of it, she was not brainwashed but instead studied the techniques, which when you see it in action, it'll make a believer of you yet.

For the untalented like myself, might i recommed some hot cocoa with whisky combined with a furry living animal or plant, some melatonin to induce the temporal aspect, and a listening ear (who is effecively playing therapist)
and then watch the combined influence inebrieate your darkest to light, This is a highly effecive method for getting even the most stoic to cry. Then you can get back to where you once belong.

tl;dr- anything combined with deep seated trauma is dangerous, but i don't think think dissos met with common sense do much harm, if anything i would say they are ultimately good for a 24+ year old person and debateable for anyone younger who may be too emotional and underdeveloped.
Shit Pockhood - Mon, 12 Feb 2018 12:52:09 EST ID:F3X0kEgc No.359378 Ignore Report Quick Reply
You have some interesting ideas man, especially the part about Scientology, I remember this Louis Theroux documentary and the ex-Scientologist really looked different in his interactions and seemingly immune to psychological adversity. Would you mind expanding about that when you come down a bit?
Angus Collykatch - Mon, 12 Feb 2018 14:04:43 EST ID:pAZn5ow/ No.359384 Ignore Report Quick Reply
you sir are high
Reuben Gemblelock - Mon, 12 Feb 2018 14:17:01 EST ID:g29yz5ue No.359385 Ignore Report Quick Reply
that nigga is always high gat damn
Edward Blobblebedge - Tue, 13 Feb 2018 04:50:41 EST ID:plRSCk64 No.359407 Ignore Report Quick Reply
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they see it as a religious level "devotion" to psychology but funny enough
the guido responsible for all these ramblings is I in this video
did you know i was interviewed by infowars while on dxm

just watch from 3:19 i just robowalk up

this was in 2014 so i was 21 im 25 now and do less /dis/ and dont live in austin anymore
Cyril Turveycocke - Tue, 13 Feb 2018 05:52:42 EST ID:1jGxki8d No.359408 Ignore Report Quick Reply
thats M kek
Edwin Sedgebere - Wed, 14 Feb 2018 00:15:44 EST ID:11/FDmTQ No.359427 Ignore Report Quick Reply
lol can you even remember if he asked you anything else?
you're the ambassador of /dis/
Cyril Gallersere - Wed, 14 Feb 2018 12:18:30 EST ID:plRSCk64 No.359440 Ignore Report Quick Reply

its edited to shit

it was like 20 mins long
Eugene Woddledale - Wed, 14 Feb 2018 13:00:34 EST ID:tG7Vv0x7 No.359442 Ignore Report Quick Reply
Died laughing at the dorky 'thumbs in pocket robo walk'
Matilda Giblingdale - Thu, 15 Feb 2018 20:02:47 EST ID:tk4VI4I5 No.359480 Ignore Report Quick Reply
Olney's research is all bunk, the guy is a total quack. I've yet to find any real research backing up his claims other than his own studies. And there just hasn't been any significant data on measurable brain damage or cognitive impairment in long-term dissociative users (and there are a few good quality studies out there).

So no, I'm not worried.
Esther Fanfoot - Sun, 18 Feb 2018 12:18:58 EST ID:vPR2hmqd No.359551 Ignore Report Quick Reply
I'm sure there's some neurotoxicicity and problems regarding the heart and NDMA antagonists but it's probably on the level of MDMA and not BIG SCARY HOLES IN YOUR BRAIN.
Esther Fanfoot - Sun, 18 Feb 2018 12:44:16 EST ID:vPR2hmqd No.359552 Ignore Report Quick Reply
This is how I imagine I come off to my graders as when I write papers.
But they still let me pass anyways.
We're fucked lol.
Phineas Clorringdale - Mon, 19 Feb 2018 17:20:01 EST ID:g29yz5ue No.359581 Ignore Report Quick Reply
forgot about that post. i have no idea wtf you're even talking about, as i didn't even read the other posts. i seen your post and made a joke about autism when i was dis. making fun of aspie stereotypes isn't a diagnosis lol.
Phineas Pocklewell - Wed, 21 Feb 2018 13:46:28 EST ID:tk4VI4I5 No.359644 Ignore Report Quick Reply
More likely all that adrenergic activity is messing with our hearts than the glutamate.
Reuben Mozzlecocke - Wed, 21 Feb 2018 14:26:14 EST ID:EDn0alml No.359645 Ignore Report Quick Reply
I think we're all just high
Sidney Sosslespear - Wed, 21 Feb 2018 20:27:31 EST ID:QSpzs8QC No.359659 Ignore Report Quick Reply
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>can you remind me what the bill of rights is?
You're a fucking legend man
Isabella Pankinwill - Thu, 22 Feb 2018 01:55:59 EST ID:Ill8DcCM No.359666 Ignore Report Quick Reply
that's weird because i always felt really nice the next day, a little nausea but that's it
Cornelius Bunworth - Thu, 22 Feb 2018 12:45:12 EST ID:pAZn5ow/ No.359675 Ignore Report Quick Reply
I think mdma is much worse than any classic dis.
Charles Wuvingridge - Fri, 23 Feb 2018 20:45:36 EST ID:Qt58CjR7 No.359737 Ignore Report Quick Reply
im pretty sure the Olney's Lesions meme comes from Nitrous Oxide
Hugh Cogglelet - Sat, 24 Feb 2018 04:36:20 EST ID:0P894Wg3 No.359759 Ignore Report Quick Reply
I think it’s “worse” in the sense the damage it causes is much coarser and definitively irreversible to some extent. Heavy dissociative use takes a toll, but its neurobiological substrate is unclear, as opposed to “you killed all your 5-HT axons, asshole.”
Nathaniel Blablingmadge - Sat, 24 Feb 2018 14:23:47 EST ID:tk4VI4I5 No.359772 Ignore Report Quick Reply
This is because of depletion of serotonin after MDMA use, right? And it can take months or years for serotonin reserves to replenish themselves after frequent MDMA use, and I guess those axons die as I've seen in MRIs, though I never bothered to learn the exact mechanism that kills them. What I don't get is what sets MDMA apart from other serotonergic drugs, other than that it's a releasing agent as opposed to a reuptake inhibitor or agonist. But shouldn't DXM cause similar (but less severe) depletion of serotonin since it's capable of inducing serotonin toxicity on its own? This is opposed to agonists (classical psychedelics), which on their own typically cannot induce serotonin toxicity (no matter how much you take).
Hugh Cogglelet - Sat, 24 Feb 2018 14:54:18 EST ID:0P894Wg3 No.359773 Ignore Report Quick Reply
SNRIs do not cause axon damage. MDMA does because it releases DA and 5-HT simultaneously.

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