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I did the same type of thing than your friend while loosing my mind on 25i NBOMe, these things can happen to everybody, had taken LSD more than a few time, mixed stuff like LSA and Ketamine, had some hard experiences too, but I never really lost it.
That 25i NBOMe trip was really too strongly dosed, learned that the guy laying them (because it was WoW homemade blotters) had hang himself and a quarter of a blotter was enough to trip (Knowing it was surely an Nbome, it's a luck I didn't have seizures).
So yeah, when you freak out, just try to speak to your friend, say to him that he is well and alive, and try to not repeat things, when I was in his situation, my ego exploaded and died, I thought I was stuck in my head because I was dying, I was in my own conception of death, then I started thinking that If I collided with another atom I might relive in a stronger being, so I started becoming freaky, showing my dick off and asked a lot of people for love, while I had stimdick and no sexual desire, it was just the desesperate move to reborn, to live.
(The badtrip was triggered due to the fact that I tasted the nbome, knew it was strong, and the comming up was too strong I lost it, thought I overdosed, lost track of who I was where I was).
Damn.. now I think of it as a strong experience, I lived something intense, and the fact I lost it and did stupid thing is a lesson, next time I won't fear death, I think I understood the concept of helplessness in front of our death.
But the trip was pure madness, and no benzo could've helped that, still had mild visuals 17h after having dosed on the come down (wasn't DOx, the trip was over long ago, just some residual effets were still there because it was too intense).