/psy/ Psychedelic Discussion
Hey I was wondering what company makes the best cough syrup/candies to trip on I'm living in Austria so if you know I would appreciate a response
>>894360This belongs in dissociative discussion, by the way.
we'll when I hear the term Robotripping I assume that it's psychedelic sorry
>>894383See what happens when you assume?
>>894383Well honestly pretty much everyone agrees that high dissociative doses are psychedelic in nature as well. That guy was just being a fucker. Robocough is probably your best bet but if you can't get it just look for something that is DXM hbr only. Next if your smart you'll find one that doesn't have sugar alcohols in it.
>>894407>Well honestly pretty much everyone agrees that high dissociative doses are psychedelic in nature as wellYeah, but not like classical 5-HT2A psychedelics like LSD, shrooms, DMT, etc. It's somewhat similar and the effects take enough of a departure from typical dissociative hallucinogens that "psychedelic" is used as a blanket term.>we'll when I hear the term Robotripping I assume that it's psychedelic sorryTripping is a pretty ubiquitous term used to refer to an experience had on just about any hallucinogen--psychedelics, dissociatives, even fuckin deliriants. I wouldn't ever just assume that anything that you've been told can make you trip is a 5-HT2A psychedelic or is in any way similar in experience as one. That's the kind of shit that's going to get you to try nutmeg or benadryl/diphenhydramine and having a nightmare experience, not knowing that those are literally just the nature of the trips deliriants produce. You really need to do some basic level research on shit you're planning on taking from now on for your own sake. Or don't, doesn't really matter to me if you have a bad time or get hurt or hurt anybody else. Do whatever you feel is best.
>Well honestly pretty much everyone agrees that high dissociative doses are psychedelic in nature as well
>we'll when I hear the term Robotripping I assume that it's psychedelic sorry
>>894408Yeah but DXM is one of the few dissos that has some 5HT activity as well as μ-opioid activity. It's a weird fucking drug, but as far as dissos go it's about dosing schedule and staggerIng for it to lean more on the psychedelic side of the dissociative experience, at least with DXM.
>>894411It being an unselective serotonin reuptake inhibitor doesn't make it psychedelic. SSRIs aren't psychedelic, are they? That's not to say it doesn't play a role in its effects, I'm just saying that assuming that just because a substance has 5-HT activity means it should be expected to have psychedelic effects. Also, it's mu opioid activity is nearly clinically negligible even when taken at the super-therapeutic doses required to get high. Also, there are other dissociatives that act as serotonin reuptake inhibitors. MXE has relatively weak but still (barely) clinically relevant affinity for SERT, and both 3-MeO-PCP and 3-MeO-PCE have moderately high affinity for SERT being nearly, but not quite, comparable to DXM.For sure, it's a weird fucking drug, and the only other dissociatives that bind to SERT are RCs, but that doesn't really change the fact that DXM isn't psychedelic in the same sense as the word is usually meant--that being a reference to a 5-HT2A agonist hallucinogen of some kind.Since OP was confused over even just the term "trip" being used when talking about robotripping and taking it to mean it was a psychedelic like acid or shrooms. it's worth the clarification right now,
>>894413>I'm just saying that assuming that just because a substance has 5-HT activity means it should be expected to have psychedelic effects. ... meant to say it DOESN'T mean it should be expected to have psychedelic effects.
>I'm just saying that assuming that just because a substance has 5-HT activity means it should be expected to have psychedelic effects.
>>894413It's still a weak 5HT1a and 5HT2a receptor agonist as well, look it up man. I wasn't talking about its function as a strong SRI.
>>894411Staggering dxm leads to sigma plateau, if this shit is fun for you, go ahead
bump from fellow Austrian
>>894415Which pretty much means it has no activity. You know what weak means, right?By the way, "weak" agonist activity is a massive overstatement. It has a Ki (nM) value >1,000, meaning it was so high that they didn't bother specifying it. It was likely found to bind to those receptors at extremely high concentrations and in cloned neurons. Sometimes when they clone neurons they can get different results when it comes to a substance binding at the same receptor sites, so the results gathered from these aren't an especially good indicator of how the substance is going to affect brain activity. This isn't even mentioning that it makes it impossible to take into account how any downstream effects from various feedback systems is going to affect brain activity, whether it be related to other neurotransmitter systems inhibiting activity in response to the increased acitivty, or how the neurons being activated themselves affects the cell membranes polarization and ability to respond to future action potentials.All in all, a lot of the knowledge we get from cloned neurons hardly tells us shit, and even when ignoring that, the information we've gathered from DXM on 5-HT1A and 5-HT2A activity already indicates it ain't doin shit at even large recreational doses.
>>894439>By the way, "weak" agonist activity is a massive overstatement.Understatement*
>By the way, "weak" agonist activity is a massive overstatement.
shapiro doesn't have real arguments either. he just uses strawmen and fallacies
he's j... ↵
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