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Recommendations? by Cornelius Blatherhall - Thu, 10 Jan 2019 07:49:35 EST ID:iSPFpExm No.894360 Ignore Report Quick Reply
File: 1547124575080.jpg -(234465B / 228.97KB, 671x895) Thumbnail displayed, click image for full size. 234465
Hey I was wondering what company makes the best cough syrup/candies to trip on I'm living in Austria so if you know I would appreciate a response
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Hedda Bloddlemeg - Fri, 11 Jan 2019 13:13:05 EST ID:avE+ORpa No.894378 Ignore Report Quick Reply
1547230385108.jpg -(241601B / 235.94KB, 1151x1150) Thumbnail displayed, click image for full size.
>>894360
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Hedda Bloddlemeg - Fri, 11 Jan 2019 13:13:50 EST ID:avE+ORpa No.894379 Ignore Report Quick Reply
>>894360
This belongs in dissociative discussion, by the way.
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Phoebe Trothall - Fri, 11 Jan 2019 16:54:03 EST ID:hOw19wfu No.894383 Ignore Report Quick Reply
we'll when I hear the term Robotripping I assume that it's psychedelic sorry
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Lillian Wusslegold - Sat, 12 Jan 2019 02:09:49 EST ID:oOF5j0ib No.894395 Ignore Report Quick Reply
>>894383

See what happens when you assume?
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Barnaby Buffingbug - Sat, 12 Jan 2019 10:46:21 EST ID:bDYMg8HY No.894407 Ignore Report Quick Reply
>>894383
Well honestly pretty much everyone agrees that high dissociative doses are psychedelic in nature as well. That guy was just being a fucker. Robocough is probably your best bet but if you can't get it just look for something that is DXM hbr only. Next if your smart you'll find one that doesn't have sugar alcohols in it.
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David Febbledock - Sat, 12 Jan 2019 12:43:41 EST ID:Jg89S9xM No.894408 Ignore Report Quick Reply
>>894407
>Well honestly pretty much everyone agrees that high dissociative doses are psychedelic in nature as well
Yeah, but not like classical 5-HT2A psychedelics like LSD, shrooms, DMT, etc. It's somewhat similar and the effects take enough of a departure from typical dissociative hallucinogens that "psychedelic" is used as a blanket term.

>we'll when I hear the term Robotripping I assume that it's psychedelic sorry
Tripping is a pretty ubiquitous term used to refer to an experience had on just about any hallucinogen--psychedelics, dissociatives, even fuckin deliriants. I wouldn't ever just assume that anything that you've been told can make you trip is a 5-HT2A psychedelic or is in any way similar in experience as one. That's the kind of shit that's going to get you to try nutmeg or benadryl/diphenhydramine and having a nightmare experience, not knowing that those are literally just the nature of the trips deliriants produce.

You really need to do some basic level research on shit you're planning on taking from now on for your own sake. Or don't, doesn't really matter to me if you have a bad time or get hurt or hurt anybody else. Do whatever you feel is best.
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Barnaby Buffingbug - Sat, 12 Jan 2019 13:09:31 EST ID:bDYMg8HY No.894411 Ignore Report Quick Reply
>>894408
Yeah but DXM is one of the few dissos that has some 5HT activity as well as μ-opioid activity. It's a weird fucking drug, but as far as dissos go it's about dosing schedule and staggerIng for it to lean more on the psychedelic side of the dissociative experience, at least with DXM.
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Sidney Grandham - Sat, 12 Jan 2019 14:45:45 EST ID:HM3iry7J No.894413 Ignore Report Quick Reply
>>894411
It being an unselective serotonin reuptake inhibitor doesn't make it psychedelic. SSRIs aren't psychedelic, are they? That's not to say it doesn't play a role in its effects, I'm just saying that assuming that just because a substance has 5-HT activity means it should be expected to have psychedelic effects. Also, it's mu opioid activity is nearly clinically negligible even when taken at the super-therapeutic doses required to get high.

Also, there are other dissociatives that act as serotonin reuptake inhibitors. MXE has relatively weak but still (barely) clinically relevant affinity for SERT, and both 3-MeO-PCP and 3-MeO-PCE have moderately high affinity for SERT being nearly, but not quite, comparable to DXM.

For sure, it's a weird fucking drug, and the only other dissociatives that bind to SERT are RCs, but that doesn't really change the fact that DXM isn't psychedelic in the same sense as the word is usually meant--that being a reference to a 5-HT2A agonist hallucinogen of some kind.

Since OP was confused over even just the term "trip" being used when talking about robotripping and taking it to mean it was a psychedelic like acid or shrooms. it's worth the clarification right now,
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Sidney Grandham - Sat, 12 Jan 2019 14:47:26 EST ID:HM3iry7J No.894414 Ignore Report Quick Reply
>>894413
>I'm just saying that assuming that just because a substance has 5-HT activity means it should be expected to have psychedelic effects.
... meant to say it DOESN'T mean it should be expected to have psychedelic effects.
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Barnaby Buffingbug - Sat, 12 Jan 2019 15:45:07 EST ID:bDYMg8HY No.894415 Ignore Report Quick Reply
>>894413
It's still a weak 5HT1a and 5HT2a receptor agonist as well, look it up man. I wasn't talking about its function as a strong SRI.
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Isabella Nacklehall - Sat, 12 Jan 2019 18:22:52 EST ID:ESCq42WN No.894416 Ignore Report Quick Reply
>>894411
Staggering dxm leads to sigma plateau, if this shit is fun for you, go ahead
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Martin Crossledale - Sun, 13 Jan 2019 11:30:00 EST ID:sl7DyCSC No.894431 Ignore Report Quick Reply
bump from fellow Austrian
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Edward Serringstone - Mon, 14 Jan 2019 01:39:53 EST ID:4kDNtM+v No.894439 Ignore Report Quick Reply
>>894415
Which pretty much means it has no activity. You know what weak means, right?

By the way, "weak" agonist activity is a massive overstatement. It has a Ki (nM) value >1,000, meaning it was so high that they didn't bother specifying it. It was likely found to bind to those receptors at extremely high concentrations and in cloned neurons.

Sometimes when they clone neurons they can get different results when it comes to a substance binding at the same receptor sites, so the results gathered from these aren't an especially good indicator of how the substance is going to affect brain activity. This isn't even mentioning that it makes it impossible to take into account how any downstream effects from various feedback systems is going to affect brain activity, whether it be related to other neurotransmitter systems inhibiting activity in response to the increased acitivty, or how the neurons being activated themselves affects the cell membranes polarization and ability to respond to future action potentials.

All in all, a lot of the knowledge we get from cloned neurons hardly tells us shit, and even when ignoring that, the information we've gathered from DXM on 5-HT1A and 5-HT2A activity already indicates it ain't doin shit at even large recreational doses.
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Edward Serringstone - Mon, 14 Jan 2019 01:40:41 EST ID:4kDNtM+v No.894440 Ignore Report Quick Reply
>>894439
>By the way, "weak" agonist activity is a massive overstatement.
Understatement*


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