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vyvanse 30 mg by brain - Tue, 12 Sep 2017 23:52:16 EST ID:bG7mrX+J No.281702 Ignore Report Quick Reply
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Can i weigh out the amount of whats inside a 30mg pill of vyvanse 30 mg and cut it and half, would it technically be around 15mg or would this fail?

Noob stimer thanks /stim/
brain - Tue, 12 Sep 2017 23:55:11 EST ID:bG7mrX+J No.281703 Ignore Report Quick Reply
To add i would not be snorting i would be bombing them
Cedric Cumblemot - Wed, 13 Sep 2017 02:14:15 EST ID:wLBFTmoc No.281706 Ignore Report Quick Reply
Yeah, that'd work. But you'll probably lose some of the powder in the process.
Dr. M !gWLn19/oKs - Wed, 13 Sep 2017 09:49:48 EST ID:TojVmfRl No.281710 Ignore Report Quick Reply
Hey bud.

Yes I have done it many times. Just be careful of spillage and of course use oral. I use this concept for MANY processes, like ULDN.

My wife used to get Vivys and now we on that d-amph lyfe
Dr. M !gWLn19/oKs - Wed, 13 Sep 2017 09:50:44 EST ID:TojVmfRl No.281711 Ignore Report Quick Reply

Pop 2 tums 30min before to increase pH to decrease d-amph metabolism.
Brain - Wed, 13 Sep 2017 10:32:34 EST ID:bG7mrX+J No.281712 Ignore Report Quick Reply
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Thanks as always Mario!
James Sarrydock - Wed, 13 Sep 2017 11:25:37 EST ID:KkNW0yRw No.281713 Ignore Report Quick Reply
I'm male and do the left thing
TinyTrip !5pb17tfZto - Thu, 14 Sep 2017 19:50:04 EST ID:J2W7GzLI No.281739 Ignore Report Quick Reply
You can just do a water dilution if you'd prefer.

From my understanding Doc, that's a fairly contested method of potentiating vyvanse due to its MOA. Vyvanse is absorbed in the intestine, and unlike most other add drugs which are absorbed in both stomach and intestine. Attempting to alter pH levels of the stomach should have negligible impact on the Vyvamse absorption.

From my understanding it is significantly more important to view urinary pH, as the substance is filtered through your and excreted as urine or reabsorbed within the Kidney.

If the filtrate develops an acidic pH, vyvanse will have a lower rate of absorbtion into the blood.

Since urinary pH is strongly influenced by acid ingestion this is why there is a marked decrease in vyvanse efficacy and consumption of citric acid.

Drugs acting on stomach pH that are not bases in themselves, like tums, and should have minimal change on urinary pH.

Vyvanse isn't strongly impacted by changes in gastrointestinal pH, there may be an indirect impact, but in order to potentiate it you would need to be taking something like intense like Prisolec which changes your GI pH radically

Correct me if I'm mistaken here, fairly benzd and stoned.
Dr. Mario !gWLn19/oKs - Thu, 14 Sep 2017 21:46:05 EST ID:TojVmfRl No.281744 Ignore Report Quick Reply

>tums isn't basic

my whole life has been a lie.
TinyTrip !5pb17tfZto - Thu, 14 Sep 2017 22:19:21 EST ID:J2W7GzLI No.281745 Ignore Report Quick Reply
lol *strong bases in and of themselves
The effects of antacids are in response to the HCL produced in the stomach lining
TinyTrip !5pb17tfZto - Thu, 14 Sep 2017 22:28:39 EST ID:J2W7GzLI No.281746 Ignore Report Quick Reply
Like the reason the most common antacids are used is not due to their pH level, their fairly weak bases in general, it's due to their response in GI pH.
Vyvanse is almost exclusively documented to be influenced by urinary pH. Anyways that was my understanding. Proselac would wipe your urinary acidity out, tums would not.
Panda5 - Fri, 15 Sep 2017 17:34:50 EST ID:8QdMsURn No.281762 Ignore Report Quick Reply
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The best thing for both GI and urinary Ph is sodium bicarbonate (standard household baking soda). Mix a teaspoonful or so (1-1.5 grams) in with a small amount of water and drink that 20 minutes before orally dosing your amp; this actually produces a noticeable boost for me and my addy IRs. In case there is concern about ingesting baking soda, sodium bicarbonate is also a drug you can get at the pharmacy in a powder and is prescribed for a variety of reasons including as an antacid.

That said, according to the official FDA data sheet (which may be BS), vyvanse is not affected by Ph at all as the lysine (may) protect the molecule from metabolism-by-acidity and the cleavage of lysine (in theory - not proven) occurs in the bloodstream where Ph is regulated by your body.
TinyTrip !5pb17tfZto - Fri, 15 Sep 2017 19:41:34 EST ID:J2W7GzLI No.281763 Ignore Report Quick Reply
I get what you are saying but I think you misunderstood my point.

I was stating that VYVANSE should not be influenced by GI pH, UNLIKE other drugs which are (ie your addy)

Yes, buffers (antacids) will reduce stomach acid and should impact your Adderall as it is heavily impacted by GI pH.

Since Vyvanse is inactive until the removal of the l-lysine molecule, it should not be influenced greatly by GI pH but rather urinary.

Afterwards the vyvanse is filtered through your body and either excreted as urine or reabsorbed into the kidney. (This is why not urinating on vyvanse can hypothetically lead to build up no joke ) and also why something that alters urinary pH like citric acid greatly reduces the potency on rats (lots of studies last I checked)

I mean I've talked with everyone from psychs to pharmacologists, to Shire employees about this aspect. Vyvanse should not be influenced by stomach pH in a manner similar to other ADD meds, I've never seen any thing claiming taking a buffer would potentiate vyvanse other than anecdotal experiences (which aren't necessarily false)
Panda5 - Fri, 15 Sep 2017 19:50:37 EST ID:8QdMsURn No.281765 Ignore Report Quick Reply
I gave it another thought, realized that the lysine will obviously be cleaved before urinary Ph is a factor, and I agree with you.

But my point about baking soda stands, as it impacts urinary Ph.

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