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Nanobots GET HYPE by Esther Pendlemit - Thu, 01 Mar 2018 09:17:27 EST ID:f7q9aPIo No.37410 Ignore Report Quick Reply
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https://www.nature.com/articles/nbt.4071
So these brilliant motherfuckers have actually tested the first successful use of a nanomachine used medically in vivo. Oh, and it's also a cancer treatment that is able to release devascularizing drug (or theoretically any drug payload) directly into tumors the nanomachines distinguish from healthy tissue on their own.

They're basically sheets of DNA that have been arranged into tubes, that fold up to hold the drug and open under certain conditions. With other recent advances in nanomachines like the 'gold walker' nanoscale chicken-bot that can walk on gold sheets, and others, it seems like the age of (Gen 1) nanotech is finally upon us!

What's the first drug *you* would put into a DNA nanotube and blast into your tissues? (one possible application of such bots could be assisting drugs which normally can't cross the BBB cross it, so the possibilities are endless)
>>
John Tillingman - Sun, 08 Apr 2018 08:42:52 EST ID:BgLkvGFY No.37426 Ignore Report Quick Reply
>>37410
I can't begin to express how excited I am for the potential of this. I have always dreamed of perfect specificity in targeting subpopulations of neurons.

I very briefly looked into neuronal biomarkers- all systems nominal- but how long does it take to develop the aptamers I wonder?

X B O X~
>>
Bornstellar - Wed, 11 Apr 2018 02:21:48 EST ID:3O3PAtcN No.37428 Ignore Report Quick Reply
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>>37410
>>
Betsy Pittwater - Wed, 11 Apr 2018 13:29:40 EST ID:oFYTPf3B No.37429 Ignore Report Quick Reply
>>37426
Finding the aptamers will probably be a bottleneck at first, but since the binding sites and folding structure of our targets are well known, as our protein folding simulation techniques (especially those using genetic algorithms) get more and more advanced, I suspect this will be less and less of a problem. Eventually running through the trillions of permutations to find the compatible aptamer of a newly discovered molecule will take a millisecond.
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Kleech Ampersand - Sat, 28 Apr 2018 15:46:50 EST ID:Lm1OYw7O No.37438 Ignore Report Quick Reply
Well... nano bots are nice but there's still so much testing to be done, idk, seems faster to repurpose opsins or some other type of stimulable protein if you want to manipulate neural codes in any sort of in precise way. Between the aptamers, the capsules and the drugs themselves it would be too much work, but adenovirus + microbial protein combinations are already here they just need to be tailored to humans a little more
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Walter Simblehood - Sun, 29 Apr 2018 23:43:50 EST ID:6NufK7un No.37439 Ignore Report Quick Reply
>>37438
How could it be too much work if they've already done it?
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Kleech Ampersand - Tue, 01 May 2018 14:46:19 EST ID:Lm1OYw7O No.37440 Ignore Report Quick Reply
>>37439
but they haven't? where are the aptamers?
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Beatrice Blytheford - Tue, 01 May 2018 15:45:38 EST ID:Zu3QHl65 No.37441 Ignore Report Quick Reply
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>>37440
>> where are the aptamers?
The aptamer used (for target identification) in the study in the OP is apparently called AS1411, this guy <-----
So clearly they have already done the work in reference to this specific nanomachine.

I ignored your bit about 'neural codes' because I've never heard of such a thing, but if what you meant is they have to find aptamers for other potential uses of the drug delivery nanobot, your solution isn't any better. Manipulating opsins would ultimately require researching the same aptamers we would have to for the nanobot solution. Moreover, DNA is a lot safer to use as the structural element of a delivery system than a protein, because it is more inherently stable and less likely to induce its own metabolic effect.

Viruses are good and fast, they already are nanomachines for all intents and purposes, but being able to replicate their functionality without their limitations and drawbacks will be a necessary step for us (even if we do eventually develop opsin and adenovirus based therapies, which we most likely will.)
>>
Kleech Ampersand - Wed, 02 May 2018 19:59:54 EST ID:Lm1OYw7O No.37442 Ignore Report Quick Reply
>>37441
Oh I was talking about neuron specific aptamers- hence addressing neural codes (also called population codes) which is the information content being passed around by a region of brain tissue. Generally the region is homogeneous so if you target one cell type with an aptamer you're going to be targeting them all and if you do that you lose precision. For instance the fabled Halle Berry neuron wouldn't be able to be differentiated from its neighbors... and what if I want everyone walking down the street to look like Halle Berry? They'll be weird ass amalgamations instead. Is this the stuff dreams are made of? No. Hence we use lasers.
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Clara Hinnerspear - Thu, 03 May 2018 02:04:51 EST ID:Zu3QHl65 No.37443 Ignore Report Quick Reply
>>37442
I see what you're saying now and definitely agree, but I don't think anyone is planning on relying on these kinds of primitive nanomachines to solve the kinds of problems you're considering. Fine grained manipulation like 'this neuron is responsible for your memories about Halle Berry/your mom/last thursday' would, I think, lead us to using nanomachines that are electrodes -- so moving on from biological analogues to molecular sensors and emitters of EM radiation.

Ultimately, we need to learn to replicate the functionality of the neuron, in something that has approximately the same physical and chemical footprint as the neuron, but as something that is completely fabricated.
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9n - Sun, 06 May 2018 23:25:05 EST ID:Xdy9vR1P No.37444 Ignore Report Quick Reply
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>>37410
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Phyllis Dremmleford - Wed, 09 May 2018 23:27:19 EST ID:ToNHQu20 No.37445 Ignore Report Quick Reply
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Dextromethorphan.
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Martin Fepperforth - Thu, 10 May 2018 15:08:44 EST ID:xnmW28Zy No.37447 Ignore Report Quick Reply
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>>37445
Thank you for being the first person to actually reply to my question in the OP.
Personally I'd like to test out Huxley's assertion about potatoes being psychedelic if they could cross the BBB. Could be fun!
>>
Wesley Puddlehall - Fri, 11 May 2018 17:19:23 EST ID:Lm1OYw7O No.37449 Ignore Report Quick Reply
>>37443
We definitely need those artificial neurons if we want immortality to be within reach. Biological things are just so entropic. Futuristic though, we'd need to include things like organelle function, indirect signalling and so many other "background" and esoteric processes it would be restricted to the most straightforward and isolated cells types at first. A massive undertaking for a lazy guy like myself

>>37447
Wait a minute you could literally just put dopamine in those things couldn't you? What are the authorities going to do, raid my stash of nu-meth?
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mika - Fri, 18 May 2018 10:10:12 EST ID:ffFinF4R No.37452 Ignore Report Quick Reply
>>37445
enjy your broekn nervous system
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Ebenezer Clesslekatch - Sun, 20 May 2018 18:33:01 EST ID:WrRFf82K No.37453 Ignore Report Quick Reply
>>37452
Yeee if I don't die first faggot


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