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I meant that the larger container of solution is sitting there open and exposed while you're trying to use the dropper top, it's slowly evaporating. When it comes to larger amounts >50-100mg, it really starts to add up. I recently used ~700mg of etiz that I ended up receiving somewhat unexpectedly, alongside various custom/"rare" psychedelics such as DPT in particular, and IIRC 4-aco-dmt and ALD-52.
Since I was in a situation where acquiring PG would have been infinitely more inconvenient than in the past, including the fact that I was slightly lorazepam dependent at the time and had run out, I ended up using ethanol, which I'll likely try to never do again. The ethanol I used was 151 proof (75.5%), the highest legally available from a store in my state. I simply bought a 750ml bottle, measured out and removed 50ml, before weighing and dumping in approx. 702.5mg, followed by adding another 2.5ml back into the bottle.
After I used used up perhaps 1/3rd or so of the bottle, I noticed, at least subjectively, that doses didn't seem to be ~99-100% accurate, even when every time I went to measure out a dose, I of course provided adequate ~30-60 second shaking/agitation followed by at least around ~30-60 seconds of gentle botle swirling to allow for any settlement/etiz precipitation to hopefully dissolve again. Even still, it seemed nowhere near as consistent as PG.
Then, by the time there was maybe under 50 or definitely 40% volume remaining, the solution became, subjectively speaking, progressively more concentrated in dosage. At first I thought maybe this coincided with the (only "proven" to be short term, and only in non-humans so far) supposed partial reverse tolerance that begins sometime between around week ~2-6 of dosing, though the study only "proved" said reverse tolerance lasts at least two weeks.
However, as a solid 2 months or more went by, the subjective strength continued to increase, even when factoring in moderate to rapid acute tolerance increase from near daily use. I'm now down to definitely <10% of the original 700ml volume, and it has become both more potent and convincingly less equally distributed.
The only plausible conclusion to make it that evaporation as occurred while the bottle cap has been removed, even if only for short time periods. It adds up.
So definitely stick with PG, though I will say that ~98-99.9% pure powder etiz's solubility in PG at presumably room temp aka 25C/77F is definitely debatable. IIRC, solutions as unconcentrated as just around 4mg/ml have been difficult to fully dissolve in the past, and doing so required a minimum of 2-4 days of swirling, shaking, possibly mixing (I never mixed using a foreign object touching the solution for many reasons), alongside holding the air/liquid tight blue/amber containers under the hottest tap water possibly in order to raise the PG's temperature.
Even then, I recall consistent settling concerns at concentrations as low as maybe ~4-6mg/ml. IIRC, solutions containing 2mg/ml or less were little to no problem, though still often required multiple agitation sessions and ~12-24+ hours of patience.
>tl;dr I meant evaporation from main container while open and exposed to air whilst you are presumably using the dropper top to attempt to dose candies/other objects.
If you are dosing candies/jellies, then yeah use 95% or higher ethanol. I think someone sells ~99% ethanol "for medical purposes" on Amaz0n. Just make sure you make all the powder in one solution container before quickly yet carefully distributing the solution into multiple smaller say, ~4-12+ ~30-60ml amber/blue bottles, again only doing so after being 99%+ confidence it's equally distributed, i.e. patiently waiting ~3+, maybe even 5-7 days, wherein you agitate the solution at least ~1-4x per day, utilizing non-microwave heat methods at least at the beginning.
Then, when dosing, if using ethanol, use a different dropper/syringe etc. dosing tool than the one actually attached to the top of the bottle, so the solution is exposed to the air as little as possible. Does that make sense?
You'll want 190 proof (95%) minimum to dose candies, otherwise they'll likely end up soggy/kinda nasty/possibly leaking. 151 proof (75.5%) definitely wouldn't be suitable.