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Using Ketamine medicinally by Ernest Hankindatch - Wed, 18 Apr 2018 22:07:24 EST ID:iPCGsB0n No.361048 Ignore Report Reply Quick Reply
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Been reading a steady influx of of articles the last few months about ketamine and it's effects on depression. At the very least I find it's ability to treat acute instances of depression interesting.

I'm an experienced psy user from a few years back and took my share of heroic doses when I was younger, but I never touched dissociatives. Dis I guess always had that image of teenagers chugging cough syrup and it was never attractive to me. Never heard anything bad about ket though, even psy users seemed to enjoy it I just never got around to it.

I have a couple questions though. I've started taking MDMA periodically again to try and help my PTSD. I also have major depression outside of that which is the reason for experimenting ket as well. I'm trying like fuck to stay off opiates which is why I need alternatives.

Anyways. If I take MDMA and ketamine in the same day will they interact in some way? I've read ket affects serotonin so I'm wondering if there's any kind of cross tolerance? How fast does ket tolerance build? How often can I take it without a major boost in tolerance? I assume plugging and snorting have about the same bioavailability? Is it worth it to ingest orally? And finally can someone explain the difference between regular ket and S-Isomer? The S-Isomer is somehow better from what people say?

Thank you guys for your help.
Archie Sibbleson - Wed, 18 Apr 2018 22:27:51 EST ID:hqUlBq1M No.361049 Ignore Report Quick Reply
Just be careful not to fall into the trap of using all the ket "therapeutically" because it's shown promise in experiments under controlled conditions. It happens more often than you'd think. I can say from experience that it's really easy to start taking dissociatives every day instead of opiates/to avoid opiate PAWS.
Ernest Hankindatch - Wed, 18 Apr 2018 22:50:26 EST ID:iPCGsB0n No.361051 Ignore Report Quick Reply
I'm hoping to avoid that too. I'm in the process of starting to dose MDMA once a week along with a personal journal. I'm hoping this will have a positive effect overall and hopefully in the next couple months I'll be able to function to some degree again.

My idea with the ketamine is to dose as infrequently as possible. Once a week if not less. My idea was that maybe a threshold dose would carry me through individual days where I'm just extremely depressed. Which I'm still likely to have even if the mdma works as planned.

Honestly though I have thought about that and it does give me pause. I'm just kind of praying I can show some willpower and only take when I really need it. Only buying a gram to start and if I can't control myself with that gram I'll avoid buying more. It's not common where I'm from so buying it in the first place is a chore.
Barnaby Blibbleban - Fri, 20 Apr 2018 12:19:51 EST ID:WOAMjuUx No.361068 Ignore Report Quick Reply
Personally, I wouldn't take MDMA since it depletes your seretonin receptors, and dopamine to an extent.

If you are depressed, you are already lacking in these chemicals, taking MDMA might make you more depressed in the long run
Beatrice Fandale - Fri, 20 Apr 2018 18:02:08 EST ID:iPCGsB0n No.361070 Ignore Report Quick Reply
Well my first job has to be addressing my PTSD because without getting that sorted first I wouldn't even be able to tell where my depression is at. And more so my depression isn't the product of chemical deficiencies, it's rooted in life circumstances.

I used and studied psychedelics heavily for years and Ive still never seen convincing evidence that serotonergics have permanent effects on neurochemistry. So I'm not too worried, more worried about the ketamine just because I know so little about it yet.

esophagus problems by Angus Fusslehood - Fri, 20 Apr 2018 14:55:57 EST ID:KMbSN7fX No.361069 Ignore Report Reply Quick Reply
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just got back from the hospital after being put under and having a robot shoved up my ass to find the source of terrible abdominal pain ive had for months is a irritated esophagus. Not 100% but i suspect its from the constant chugging of delsym. So a word of warning, be careful guys this stuff isn't exactly good for you and if you've got them weak genes like me you could be risking your health. Take it with a grain of salt because who knows if this came from an infection. Happy 4/20 either way guys

Dxm and the Stomach, Seratonin Syndrome , Bromine & Cyp2d6 inhibition(sp?) by Hugh Nickleshit - Sat, 14 Apr 2018 10:16:27 EST ID:6Extcnhn No.360972 Ignore Report Reply Quick Reply
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Tobacco contains harmine an maoi, one would think is not a big deal as smoking is an ordinary practice among 'mdma' users.
Tobacco also inhibits cyp2d6.

Benadryl is an ssri and in high doses has strong effects on the vagus nerve.

Chlorpheniramine is an ssri.

300/300 is a meme,

John Constantine: But when you cross over... time stops. Take it from me, two minutes in hell is a lifetime.
Drugs affects everyone differently and am not trying to fear monger. if you still do not understand imagine time going backwards whilst divorced from short term memory/knowledge of your water intake.

taking grams of cough guafinessin can cause stomach bleeding.

dxm can cause black outs.
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Fucking Somblelock - Tue, 17 Apr 2018 13:53:49 EST ID:s/LsdI2k No.361023 Ignore Report Quick Reply
Benadryl (DPH) is such a weak SSRI that its effects as one are almost entirely clinically negligible. It's discovery as one, albeit such a weak one, meant simply that its structure was a good point to look into for developing future drugs with SSRI effects.

Chlorpheniramine (CPM) is more accurately an SNRI, but unlike benadryl/DPH, it is actually fairly potent as one. As long as we are being informative and shit, both are first-generation antihistamines and potent antimuscarinic anticholinergics... although, sometime ago I read that CPM is about 25% potent as an anticholinergic as DPH (couldn't ever find receptor binding assays to go off of, so that was the best figure I was capable of finding).

CPM's half-life is generally listed as ~21 hrs, but ranges from ~13-43 hrs. Its metabolism is hepatic, via CYP2D6.
DPH's half-life is generally listed as ~9 hrs, but ranges from ~2-13 hrs. Its metabolism is hepatic, via CYP2D6 heavily, CYP3A4 very minorly.

Taking large quantities of the guaf a la Kerflap can also lead to kidney stones. It also acts as a mild skeletal muscle relaxant. Skeletal muscles are the ones you normally think of--the ones in your arms, legs, etc. It's mostly just a title meant to make a distinction between that type, smooth muscle, and cardiac muscle.

Someone above me covered the dangers of Serotonin Syndrome pretty well (or rather the relative lack of any real risk when combining reuptake inhibitors).

A pretty big misconception about DXM and DXO is the claim that you experience greater Sigma 1 Receptor activity (or just "Sigma Activity") from DXM than from DXO (or in other words, when you have a higher DXM to DXO ratio); it simply isn't true. There are somewhat conflicting binding assays I've read out there on this matter, but the majority I've seen actually show that DXO has greater affinity for Sigma 1 Receptors than DXM does, albeit by a somewhat narrow margin.

The numbers are (Ki (nM)):
DXM: 142–652 nM
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Albert Feblingdurk - Tue, 17 Apr 2018 18:11:11 EST ID:OoMgiDDf No.361025 Ignore Report Quick Reply
Every thing he said was valid. It's not word games he's pointing out obvious flaws in the OP. He wasn't being a dick either so I don't understand your angle here. Seriously man 2mg sublingual dph tabs don't exist or aren't common. Never seen em or heard of em.
Thomas Brezzlewadging - Wed, 18 Apr 2018 22:38:04 EST ID:6Extcnhn No.361050 Ignore Report Quick Reply
1524105484735.png -(632215B / 617.40KB, 1440x900) Thumbnail displayed, click image for full size.

While I think the OP demonstrates that taking drugs like cocaine or dxm can feel like being in a sort of intensely traumatic delerious heat stroke that may lead to brain damage/permanent loss of motor/speech function and even death.

I would like to add that not only do anticholinergic drugs potentiate certain aspects of DXM intoxication but they also decrease sweating which may contribute to rises in body temperature. However I have heard that benadryl can be very useful for infant fevers at the right dosages.

I wonder how people still die after we explain to them that not all drugs are not 'cool' much less temperature neutral and that certain drugs are literally a 'piping hot frying pan' =[. Stay cool out there!

I love you. Just got done following along with the portals on stopmedicineabuse.org btw

Cyril Deddlemedging - Thu, 19 Apr 2018 01:13:01 EST ID:ztdupcg2 No.361052 Ignore Report Quick Reply
You certainly seemed pretty cooked.
Or perhaps you were really just trolling as you said in >>360988
Esther Brennerville - Fri, 20 Apr 2018 10:28:40 EST ID:6Extcnhn No.361067 Ignore Report Quick Reply
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1 Samuel:16-23 And it came to pass, when the tormenting spirit from God was upon Saul, that David took an HARP, and played with his hand: so Saul was refreshed, and was well, and the evil spirit departed from him

Jesus- 'Matthew 6:28-29' New International Version (NIV)
28 “And why do you worry about clothes? See how the flowers of the field grow. They do not labor or spin. 29 Yet I tell you that not even Solomon in all his splendor was dressed like one of these.

Does anyone know the effective range of Sorbitol? by Clara Clomblehene - Fri, 20 Apr 2018 01:44:29 EST ID:mi47hF4q No.361065 Ignore Report Reply Quick Reply
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Hey /dis/! Missed u guys

I have a question about the laxitive effects of the sweeteners Sorbitol and Maltitol in some DXM products like the one i have and displayed in the pic.

To take an effective trip dose I'd need to consume these 40 pastilles super quickly and that will only get me to about 400mg, the problem is that the packet thankfully warns the customer that the maximum daily dose is 12 pastilles, which contain at least 10.2g of maltitol and 0.8g of sorbitol. Unfortunately I'm not able to find too much about how much sorbitol & maltitol is 'too much' and causes severe fluid retention.

One source claims: https://www.zocdoc.com/answers/15444/how-much-sorbitol-is-too-much-sorbitol
"In terms of the amount that can cause symptoms, 5-20 grams can cause abdominal pain, bloating and gas, and greater amounts (20-50g) can cause diarrhea."
Wiki: https://en.wikipedia.org/wiki/Sorbitol#Overdose_effects
Known to be incorrect when it comes to drugs, claims 20g of Sorbitol is dangerous.

Maltitol on the other hand.
"While the International Journal of Food Sciences and Nutrition offers that Maltitol levels for children have an ideal tolerance of no more than 15 g daily, a European Journal of Clinical Nutrition study shows that diarrhea occurs at daily consumption levels 60 - 90 g in adults."

I t h i n k I'll be safe! But I'm wondering if anyone has any personal experiences that they could share?
Nathaniel Senderway - Fri, 20 Apr 2018 04:17:35 EST ID:ztdupcg2 No.361066 Ignore Report Quick Reply
I used 20 of these as a booster to a 600mg bottle some time back and didn't get any laxative effects. I'm generally pretty sensitive to sorbitol too. They're probably better as a booster, they're really hard to swallow but they do kill the taste of syrup effectively.

BWD by Doris Clandlegold - Thu, 07 Dec 2017 16:54:10 EST ID:XcDTD/Ra No.357970 Ignore Report Reply Quick Reply
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Im off that 3-ho and making a new thread cuz the old one is auto-sage

I'm smoking this shit now, gonna test out shooting it sometime soon, probably this weekend.

I post a lot on other boards mostly stim and opi but disso will always be my favorite drug class. Supa dupa smooth gonna watch a shit load of Star Vs The Forces of Evil on dissos for a hot min.

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Albert Hackletuck - Wed, 18 Apr 2018 10:37:22 EST ID:Nuu7CDa1 No.361041 Ignore Report Quick Reply

>Don't you just

Phoebe Duttingstadge - Wed, 18 Apr 2018 12:20:26 EST ID:a5zyt7ML No.361042 Ignore Report Quick Reply
Someone is sensitive.
Martha Sankinbanks - Wed, 18 Apr 2018 15:25:53 EST ID:KRBQNTrZ No.361044 Ignore Report Quick Reply

Someone likes replying to people on the internet.
Beatrice Druckleketch - Wed, 18 Apr 2018 16:21:24 EST ID:YfgCJ32R No.361045 Ignore Report Quick Reply
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O-PCE nasal spray success. 50mg/mL turned into ~5mg/spray. Perfect for concerts. Looking forward to combos with K and Nitrous, hopefully L and possibly M. Gotta love that my favorite band is also a traveling drug circus.
> bumping on ~20mg O-PCE
Hope everyone has good plans for Bicycle Day and/or 4/20!
Have an art. George Lemmen is cool. So is pointillism.
Peace, love, and god bless the pharmacy.
Nathaniel Cellerford - Thu, 19 Apr 2018 23:17:50 EST ID:arDQEB2E No.361064 Ignore Report Quick Reply
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900mg of DXM chilling with my fiancee. coming up right now.

ɳεω 尺ØŁŁ ɬɧཞɛąɖ by Basil Droddlelock - Mon, 20 Mar 2017 19:38:29 EST ID:n+9WxiwR No.352812 Ignore Report Reply Quick Reply
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Old one hit bump limit. You know the drill.

Odd dose that shit
Even maybe not
Zero re-roll
Dubs take double/hole dose
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Cedric Dillystone - Tue, 17 Apr 2018 22:42:41 EST ID:3fAH/Sb4 No.361028 Ignore Report Quick Reply
have fun
Albert Girringleck - Wed, 18 Apr 2018 01:05:03 EST ID:8++R7wj5 No.361033 Ignore Report Quick Reply
ignite that weed borther
Samuel Dartshit - Thu, 19 Apr 2018 15:37:21 EST ID:Y8Ew2/KU No.361059 Ignore Report Quick Reply
Roll oh destiny board?
Alice Gettingford - Thu, 19 Apr 2018 18:27:03 EST ID:DPIZM8mZ No.361061 Ignore Report Quick Reply
Martin Wezzlehirk - Thu, 19 Apr 2018 22:20:02 EST ID:Wf414xHT No.361063 Ignore Report Quick Reply
Is tonight the night we tread back into that world?

snorting ketamine and nose shape by Beatrice Tootwell - Thu, 19 Apr 2018 07:27:17 EST ID:FLK5eicf No.361054 Ignore Report Reply Quick Reply
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can snorting k affect the shape of your nose or it will only cause nosebleed?
Ernest Wumbleford - Thu, 19 Apr 2018 08:42:18 EST ID:Qt58CjR7 No.361055 Ignore Report Quick Reply
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Emma Clarringbad - Thu, 19 Apr 2018 08:43:10 EST ID:E7/gP2xE No.361056 Ignore Report Quick Reply
Nah you can totally deviate your deptum, or at least do
Major damage to the mucosal tissue. All my liver and kidneys and shit are healthy as can be, but my doctor looked up my nose and told me I had fucked it up good and proper, possibly permanently.
Beatrice Fandale - Thu, 19 Apr 2018 20:30:41 EST ID:iPCGsB0n No.361062 Ignore Report Quick Reply
Septum but yeah. Septal perforation is what you should really be worried about. If you destroy the mucosal tissue in your nose it can lead to exposed cartilage which leads to many very bad things including losing your nose.

Nosebleeds could be a sign the walls of your nostrils aren't handling the chemical very well.

When I did opiates I would try and alternate between snorting and plugging (cuz I didn't shoot). Plugging almost always has higher bioavailability and onset and duration times are roughly equivalent to snorting. I just use a small syringe without the needle. 2 or 3ml syringe is ideal because their only about as wide as a pencil.

That or ingest orally. Take more but trip longer.

i have no legal middle name by Cyril Smalldock - Thu, 19 Apr 2018 18:01:56 EST ID:SE4ddR3A No.361060 Ignore Report Reply Quick Reply
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so my name has always been john ( no legal middle name) Smith

right ?or people go you have no middle name.
maybe im making a mountain out of a molehill but its fucking with me
after experimenting a lot with everything, i found i am attached to the fact my middle name is nothing, but i want it to be a kind of implicated =nothing=

because fuck yeah voidness and all that but not fuck yeah not having a middle name. i feel like i'm missing something but want to fill it with nothingness etc idk
could've sworn there was an eastern character that is a kind of implicit silence like 間 ma

but yeah what should i do guys? I live in america, originally russian and honestly the western languages just seem incapable of expressing that "good empty" that is always seen it as negative.

Like "the canoe is empty, good! We can go into it and use it!"
Useful emptiness...like that, i want that to be my middle name, but i dont know how exactly to go about it help

DXM by Phyllis Cizzlewater - Sat, 14 Apr 2018 17:17:13 EST ID:N7kuGN6M No.360978 Ignore Report Reply Quick Reply
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Whats the deal with DXM in the UK? Am i able to legally buy cough syrup with the active ingrediant? Or do i need prescreption? I understand if i got to a counter with 10 bottles they wont sell to me, but i could go to different stores. Also, is there any products that have the threshold dosage?
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Polly Pocklebury - Wed, 18 Apr 2018 01:30:30 EST ID:ztdupcg2 No.361035 Ignore Report Quick Reply
Did you check the inactives for sorbitol?

Actually, I just did online and it's packed full of the stuff. Laxative effects for days.
Augustus Wellerfutch - Wed, 18 Apr 2018 06:03:42 EST ID:IjFte2SK No.361036 Ignore Report Quick Reply

What is this with the 50 trip limit? Where does it come from and what does it mean?
I've taken 100+ DXM trips and the magic is still there for me.

If there's sorbitol/other active ingredients you can do an acid extraction to remove all the anti-recreational stuff
William Dodgecocke - Wed, 18 Apr 2018 13:59:23 EST ID:rON4N5xl No.361043 Ignore Report Quick Reply
50 trip limit?
Ernest Wumbleford - Thu, 19 Apr 2018 09:51:28 EST ID:Qt58CjR7 No.361057 Ignore Report Quick Reply
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not gonna lie, usually when i take dxm i wait for the first little tinglings of the come up & immediately get in the shower to ride the body load out. i don't stand up much tho, only when i feel like it. plus, once you've come up all the way & you leave the shower you feel all cleansed and ready to journey into the dextroverse
Nathaniel Pinninglere - Thu, 19 Apr 2018 13:09:00 EST ID:KMbSN7fX No.361058 Ignore Report Quick Reply
just sit in the shower and let the hot water pour down on the top of your head its bliss

Can you do me a favor /dis/ ? by Eliza Nuttinghan - Tue, 17 Apr 2018 12:32:02 EST ID:SE4ddR3A No.361021 Ignore Report Reply Quick Reply
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Can you find a comfortable headspace and open "boards.420chan.org/dis/" for me please?

. . .

Oh? You say you are already doing that? Magnificent, outstanding as always /dis/ ; never doubted you for a second.
Having said that, I've heard word around the office, from some coworkers that would prefer not be named, that your performance in one key area, well, is a bit lacking.

I'm talking about trolling and clickbait /dis/. Don't make that face, you know you aren't falling for it like you used to. It's gotten to the point that we have to have to this talk /dis/.

Manipulating you through a psuedo-interview? Of course not! We love having you around /dis/, the banter, the memes, couldn't be better. But see, that's the problem, /dis/, you're too genuine.
We at Trolling You & Manipulative Clickbait Co. have one goal, we want you to thrive, to excel.
Profit? What Profit? /dis/ I drink cough syrup for a living, my wife is solid 10/10 on any given tuesday morning, I golf on the weekend and my penis is so big it takes up 90% of my body mass in the place of functioning organs. We're talking about you, not some strange appeal to the authority I have over you.

/dis/ what if I told you,
>5 Amazingly No Bullshit Methods that Caimbridge Scientists and Experts Can't Explain Why This Trick Increases Clickbait Detection Satisfaction by (!!!) 69%....
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Emma Granddock - Wed, 18 Apr 2018 10:12:06 EST ID:yCrsf9rn No.361040 Ignore Report Quick Reply
The universe is yin and yang and life is yin and yang fucking
Edward Bunridge - Thu, 19 Apr 2018 05:02:30 EST ID:Xstfshaf No.361053 Ignore Report Quick Reply
hey i dont trust this guy

Sooooo... by Albert Feblingdurk - Tue, 17 Apr 2018 18:23:04 EST ID:OoMgiDDf No.361027 Ignore Report Reply Quick Reply
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I tried a little experiment the other day. I ate a 10mg the gummy, took 650mg of DXM (hbr), waited for it all to kick, took 3 bong rips and then started my experiment. I put on darkness blind folds kinda like the pic then popped in headphones and turned on white noise of the static variety and ho-lee-fuk. It was strance how fast everything warped and how quickly the static turned into cascading prisoner cinema style madness. Some one else should give this ganzfeld-esque mindfuckey madness a shot. It was rather intense and the time dilation was absurd.
Phyllis Grandgold - Wed, 18 Apr 2018 00:12:09 EST ID:CYHCqsNV No.361032 Ignore Report Quick Reply
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Always preferred zoning to Soma.fm meself, trippy alternative radio that has given me some of the best CEVs during those long /dis/ nights

try it out fam

Are people born through C-section more likely to enjoy /dis/ ? by Angus Clayford - Fri, 13 Apr 2018 19:06:31 EST ID:SE4ddR3A No.360958 Ignore Report Reply Quick Reply
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Stay with me, this is a longshot:

Preface: I was born with my umbilical cord wrapped around my neck 4 times, mother went through c-section (cesarian section) to save my life.
I enjoy /dis/ and it feels like home, but what is that home feeling?

If i had to guess, people born through cesarian section are born in a (semi, putting it midly) sterile enviroment in comparison to the vaginal birth in which the infant is swabbed with one of three types of bacteria that eventually make up the flora of the body.

>Bacterial Ecosystems Divide People Into 3 Groups, Scientists Say
>the following is from a different article but sums it up nicely:
>So while a baby born vaginally gets almost all of his or her gut bacteria from mom, a baby born via c-section picks up bacteria from the environment and other people he or she comes into contact with when first exiting the womb.

This shouldn't be terribly hard to digest (pun-ho!) but the next part is where it gets dicey:

I guess it struck me with nuance, that quote "Dissociatives, 33% of people hate it, 33% of people don't care for it, and 33% of people love it."
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Jack Blarrylan - Sun, 15 Apr 2018 11:36:07 EST ID:dkmLWNmL No.360989 Ignore Report Quick Reply
Molly Grimcocke - Sun, 15 Apr 2018 14:23:30 EST ID:r+d3upSZ No.360990 Ignore Report Quick Reply
William Fondledock - Sun, 15 Apr 2018 23:25:32 EST ID:/AxbUTn1 No.360996 Ignore Report Quick Reply

I'm very similar to you. Forceps finally got me into this world after an exhausting childbirth for my mother. My parents always joked when I would bitch about tough life things "he wishes he was still in the womb."

For the last 6 years I've done copious amounts of DXM, then onto MXE, then DCK and most recently O-PCE. I've been drinking heavily on top of that, almost always mixing my disso's with a tiny bit of liquor.

When I started with DXM I was surprised at how right dissociatives felt for me. I had just graduated high school, no idea what I wanted to do with my life (I work in a cubicle now, fuck me) and only found out about DXM through stumbling on this board nonetheless. I gave it a try and through multiple trips into a dimension I could only dream of discovered a love that has carried me through quite a lot over the last few years. Most notably helping to morph my personality into a more improved one, curing my depression (I was on the verge of suicide) and just generally building my confidence up and beating my anxiety down which has helped my time sober tremendously.

Touching on the gut flora thing, my stomach was always pretty tolerant to DXM whether it be syrup or gels. Whereas some people reported horrible nausea I never got any of that. Nowadays I can't hold it down, but I suspect that to getting a few years older, drinking too much booze, and eating too much spicy food. That's the beauty of powder though baby. DCK was wonderful but nothing in my life will ever compare to the bliss and the experiences I had on MXE. I'd literally sell my soul to go back to that point in time in my life.
Nell Chigglechirk - Mon, 16 Apr 2018 04:38:08 EST ID:IjFte2SK No.361000 Ignore Report Quick Reply
Ephenidine (or DCK they hold a nice spot in their experiences within my memories)
I was born 2 or 3 weeks earlier than I should've been and according to my mother, it was really easy to give birth to me.
Lillian Dishbanks - Tue, 17 Apr 2018 23:59:47 EST ID:5MSM4AZg No.361031 Ignore Report Quick Reply

>DXM because haven't tried nuffin else yet
>v, but I did get all my bacteria wiped clean as a baby

DXM feels like home to me too, OP. thats just the feeling of DXM.

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