>>361048
Just be careful not to fall into the trap of using all the ket "therapeutically" because it's shown promise in experiments under controlled conditions. It happens more often than you'd think. I can say from experience that it's really easy to start taking dissociatives every day instead of opiates/to avoid opiate PAWS.

>>361049
I'm hoping to avoid that too. I'm in the process of starting to dose MDMA once a week along with a personal journal. I'm hoping this will have a positive effect overall and hopefully in the next couple months I'll be able to function to some degree again.

My idea with the ketamine is to dose as infrequently as possible. Once a week if not less. My idea was that maybe a threshold dose would carry me through individual days where I'm just extremely depressed. Which I'm still likely to have even if the mdma works as planned.

Honestly though I have thought about that and it does give me pause. I'm just kind of praying I can show some willpower and only take when I really need it. Only buying a gram to start and if I can't control myself with that gram I'll avoid buying more. It's not common where I'm from so buying it in the first place is a chore.

Personally, I wouldn't take MDMA since it depletes your seretonin receptors, and dopamine to an extent.

If you are depressed, you are already lacking in these chemicals, taking MDMA might make you more depressed in the long run

>>361068
Well my first job has to be addressing my PTSD because without getting that sorted first I wouldn't even be able to tell where my depression is at. And more so my depression isn't the product of chemical deficiencies, it's rooted in life circumstances.

I used and studied psychedelics heavily for years and Ive still never seen convincing evidence that serotonergics have permanent effects on neurochemistry. So I'm not too worried, more worried about the ketamine just because I know so little about it yet.

Benadryl (DPH) is such a weak SSRI that its effects as one are almost entirely clinically negligible. It's discovery as one, albeit such a weak one, meant simply that its structure was a good point to look into for developing future drugs with SSRI effects.

Chlorpheniramine (CPM) is more accurately an SNRI, but unlike benadryl/DPH, it is actually fairly potent as one. As long as we are being informative and shit, both are first-generation antihistamines and potent antimuscarinic anticholinergics... although, sometime ago I read that CPM is about 25% potent as an anticholinergic as DPH (couldn't ever find receptor binding assays to go off of, so that was the best figure I was capable of finding).

CPM's half-life is generally listed as ~21 hrs, but ranges from ~13-43 hrs. Its metabolism is hepatic, via CYP2D6.
DPH's half-life is generally listed as ~9 hrs, but ranges from ~2-13 hrs. Its metabolism is hepatic, via CYP2D6 heavily, CYP3A4 very minorly.

Taking large quantities of the guaf a la Kerflap can also lead to kidney stones. It also acts as a mild skeletal muscle relaxant. Skeletal muscles are the ones you normally think of--the ones in your arms, legs, etc. It's mostly just a title meant to make a distinction between that type, smooth muscle, and cardiac muscle.

Someone above me covered the dangers of Serotonin Syndrome pretty well (or rather the relative lack of any real risk when combining reuptake inhibitors).

A pretty big misconception about DXM and DXO is the claim that you experience greater Sigma 1 Receptor activity (or just "Sigma Activity") from DXM than from DXO (or in other words, when you have a higher DXM to DXO ratio); it simply isn't true. There are somewhat conflicting binding assays I've read out there on this matter, but the majority I've seen actually show that DXO has greater affinity for Sigma 1 Receptors than DXM does, albeit by a somewhat narrow margin.

The numbers are (Ki (nM)):
DXM: 142–652 nM

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>>361019
Every thing he said was valid. It's not word games he's pointing out obvious flaws in the OP. He wasn't being a dick either so I don't understand your angle here. Seriously man 2mg sublingual dph tabs don't exist or aren't common. Never seen em or heard of em.

>>360972

While I think the OP demonstrates that taking drugs like cocaine or dxm can feel like being in a sort of intensely traumatic delerious heat stroke that may lead to brain damage/permanent loss of motor/speech function and even death.

I would like to add that not only do anticholinergic drugs potentiate certain aspects of DXM intoxication but they also decrease sweating which may contribute to rises in body temperature. However I have heard that benadryl can be very useful for infant fevers at the right dosages.

I wonder how people still die after we explain to them that not all drugs are not 'cool' much less temperature neutral and that certain drugs are literally a 'piping hot frying pan' =[. Stay cool out there!

I love you. Just got done following along with the portals on stopmedicineabuse.org btw

=[

>>361050
You certainly seemed pretty cooked.
Or perhaps you were really just trolling as you said in >>360988
nb

1 Samuel:16-23 And it came to pass, when the tormenting spirit from God was upon Saul, that David took an HARP, and played with his hand: so Saul was refreshed, and was well, and the evil spirit departed from him

Jesus- 'Matthew 6:28-29' New International Version (NIV)
28 “And why do you worry about clothes? See how the flowers of the field grow. They do not labor or spin. 29 Yet I tell you that not even Solomon in all his splendor was dressed like one of these.

>>361065
I used 20 of these as a booster to a 600mg bottle some time back and didn't get any laxative effects. I'm generally pretty sensitive to sorbitol too. They're probably better as a booster, they're really hard to swallow but they do kill the taste of syrup effectively.

>>361039

>Don't you just

No.

>>361041
Someone is sensitive.

>>361042

Someone likes replying to people on the internet.

>>360979
O-PCE nasal spray success. 50mg/mL turned into ~5mg/spray. Perfect for concerts. Looking forward to combos with K and Nitrous, hopefully L and possibly M. Gotta love that my favorite band is also a traveling drug circus.

> bumping on ~20mg O-PCE

Hope everyone has good plans for Bicycle Day and/or 4/20!
Have an art. George Lemmen is cool. So is pointillism.
Peace, love, and god bless the pharmacy.

>>357970

900mg of DXM chilling with my fiancee. coming up right now.

>>360999
have fun

ignite that weed borther

>>352812
Roll oh destiny board?

>>352812
roll

Is tonight the night we tread back into that world?

DICKS EVERYWHERE

>>361054
Nah you can totally deviate your deptum, or at least do
Major damage to the mucosal tissue. All my liver and kidneys and shit are healthy as can be, but my doctor looked up my nose and told me I had fucked it up good and proper, possibly permanently.

>>361056
Septum but yeah. Septal perforation is what you should really be worried about. If you destroy the mucosal tissue in your nose it can lead to exposed cartilage which leads to many very bad things including losing your nose.

Nosebleeds could be a sign the walls of your nostrils aren't handling the chemical very well.

When I did opiates I would try and alternate between snorting and plugging (cuz I didn't shoot). Plugging almost always has higher bioavailability and onset and duration times are roughly equivalent to snorting. I just use a small syringe without the needle. 2 or 3ml syringe is ideal because their only about as wide as a pencil.

That or ingest orally. Take more but trip longer.

>>361001
Did you check the inactives for sorbitol?

Actually, I just did online and it's packed full of the stuff. Laxative effects for days.

>>361030

What is this with the 50 trip limit? Where does it come from and what does it mean?
I've taken 100+ DXM trips and the magic is still there for me.

>>361001
If there's sorbitol/other active ingredients you can do an acid extraction to remove all the anti-recreational stuff

>>361030
50 trip limit?

>>361030
not gonna lie, usually when i take dxm i wait for the first little tinglings of the come up & immediately get in the shower to ride the body load out. i don't stand up much tho, only when i feel like it. plus, once you've come up all the way & you leave the shower you feel all cleansed and ready to journey into the dextroverse

>>361030
just sit in the shower and let the hot water pour down on the top of your head its bliss

The universe is yin and yang and life is yin and yang fucking

hey i dont trust this guy

Always preferred zoning to Soma.fm meself, trippy alternative radio that has given me some of the best CEVs during those long /dis/ nights

try it out fam

>>360963
v
DXM

>>360963
v
ketamine

>>360983

I'm very similar to you. Forceps finally got me into this world after an exhausting childbirth for my mother. My parents always joked when I would bitch about tough life things "he wishes he was still in the womb."

For the last 6 years I've done copious amounts of DXM, then onto MXE, then DCK and most recently O-PCE. I've been drinking heavily on top of that, almost always mixing my disso's with a tiny bit of liquor.

When I started with DXM I was surprised at how right dissociatives felt for me. I had just graduated high school, no idea what I wanted to do with my life (I work in a cubicle now, fuck me) and only found out about DXM through stumbling on this board nonetheless. I gave it a try and through multiple trips into a dimension I could only dream of discovered a love that has carried me through quite a lot over the last few years. Most notably helping to morph my personality into a more improved one, curing my depression (I was on the verge of suicide) and just generally building my confidence up and beating my anxiety down which has helped my time sober tremendously.

Touching on the gut flora thing, my stomach was always pretty tolerant to DXM whether it be syrup or gels. Whereas some people reported horrible nausea I never got any of that. Nowadays I can't hold it down, but I suspect that to getting a few years older, drinking too much booze, and eating too much spicy food. That's the beauty of powder though baby. DCK was wonderful but nothing in my life will ever compare to the bliss and the experiences I had on MXE. I'd literally sell my soul to go back to that point in time in my life.

V
Ephenidine (or DCK they hold a nice spot in their experiences within my memories)
I was born 2 or 3 weeks earlier than I should've been and according to my mother, it was really easy to give birth to me.

>>360963

>DXM because haven't tried nuffin else yet
>v, but I did get all my bacteria wiped clean as a baby

DXM feels like home to me too, OP. thats just the feeling of DXM.