Leave these fields empty (spam trap):
Name
You can leave this blank to post anonymously, or you can create a Tripcode by using the format Name#Password
Subject
Comment
[i]Italic Text[/i]
[b]Bold Text[/b]
[spoiler]Spoiler Text[/spoiler]
>Highlight/Quote Text
[pre]Preformatted & Monospace Text[/pre]
[super]Superset Text[/super]
[sub]Subset Text[/sub]
1. Numbered lists become ordered lists
* Bulleted lists become unordered lists
File

Sandwich
Harm Reduction Notes for the COVID-19 Pandemic

~~B W D~~

View Thread Reply
Hide
- Fri, 31 Jan 2020 22:46:36 EST IloN6QLN No.370568
File: 1580528796229.jpg -(749416B / 731.85KB, 1080x1073) Thumbnail displayed, click image for full size. ~~B W D~~
Here's to enjoying a brand new year of dissociation
199 posts and 64 images omitted. Click View Thread to read.
>>
Jenny Greenway - Thu, 04 Jun 2020 09:54:05 EST Qv4eF0jQ No.372154 Reply
150mg first thing in the morning followed by rucking for 30 minutes with a 63lb backpack and focusing on posture training. Been losing fat and building muscle at the same time. Most of my coworkers have commented on my figure slimming down a lot and I didn't believe it because I was staying at the same weight. Now one of my favorite pair of shorts is falling off like Im some wannabe gangster. Kinda sucks because I have complementary shirts and a hat that I like to wear with it but I guess a belt will work until they're just too loose.

>>372147
can you provide proof of this?
>>372149
you on steroids on something bruv? that's just plain unnatural
>>
Thomas Greenson - Thu, 04 Jun 2020 11:30:30 EST OoMgiDDf No.372155 Reply
1591284630451.jpg -(2070353B / 1.97MB, 5312x2988) Thumbnail displayed, click image for full size.
>>372154
No roid, no rods, nothing, but I do need rest now. I'm all natural and lift raw only. As it stands I'm maybe too 2 or 3 and if I lift wrapped I'm number one by a factor of 1.5 -3.
It's just a bloodlines trait like kekei genkai I guess. I'm actually a runt but a high ape index helped. Plus my striation density is different than regular humans. So I'll be super mega heavy weight champ undisclosed for now but I'll be surpassed very quickly.
>>
James Fuckingbury - Thu, 04 Jun 2020 22:21:56 EST Qv4eF0jQ No.372160 Reply
>>372155
I literally have no idea wtf you just said but keep rockin homie, just stay safe out there

Abilify

View Thread Reply
Hide
- Tue, 14 Apr 2020 02:03:28 EST +c9X4ApB No.371508
File: 1586844208725.jpg -(184447B / 180.12KB, 850x1391) Thumbnail displayed, click image for full size. Abilify
anyone on here that is on abilify and has ever used dxm? I'm currently on a once monthly shot of abilify and I've read varying reports, some say it causes SS (I don't think it does considering a few of the posts I've read on that subject), some say it potentiates the fuck out of it, some say it reduces the trip. I just want to do a small tier dose like 300 mg.

to SLAYER or not to SLAYER
4 posts omitted. Click View Thread to read.
>>
Jarvis Fundlestock - Wed, 15 Apr 2020 01:13:17 EST MYA7SC5S No.371516 Reply
>>371511
>Dafuq? I didn't know injections would exist for this kinda shit outside of a hospital or psych ward

a lot of antipsychotics come in depot injections now to increase compliance, it's kind of a fucked up practice tbh, but a good, very convenient option for medications one entirely consents to take
>>
Phoebe Chonderkuck - Thu, 16 Apr 2020 00:05:43 EST +c9X4ApB No.371532 Reply
>>371516
yeah that's the main reason I'm taking the injections, it's convenience and I know I'm not going to forget to take them
>>
Albert Dallerstut - Thu, 04 Jun 2020 19:40:34 EST +c9X4ApB No.372159 Reply
OP here just wanted to update:

No, the abilify did not do anything to the experience. I still tripped and had a good time.

Lower ketamine tollerence and what other dissos

View Thread Reply
Hide
- Thu, 04 Jun 2020 07:20:13 EST g9GH/shY No.372151
File: 1591269613077.jpg -(726305B / 709.28KB, 3648x2736) Thumbnail displayed, click image for full size. Lower ketamine tollerence and what other dissos
So my tollerence to ketamine is that high that I can do an 8th in 2 days and I just feel a little zoned out or high,my body feels warm and very slightly numb and that's it.

No more feeling like I'm in a spaceship sitting in my room,no more trippy thoughts,no more ket legs or arms(thinking they're supper long and I gotta walk silly) and no more hole no more feeling dissociated.
Btw my sources are good and I have different varieties of let to try.

Now last year I barely took any at all then when I did the end of it I had my first hole in a long time and now that's almost impossible .

I'm about to do a long as T break of it right now as I've been taking a lot of it last couple of months because it's cheap for a tenth where I'm from and I normally do that over 4-6 hours 1 or 2 times a week(last 6 weeks give or take)

>Besides abstinening from ketamine and working out eating healthy(what I do any way) are they're any supplements what can help with lowering the tollerence ?

>What other dissociates could I try to get my hands on what cause the trippy thoughts and produce feelings similar to the hole
Is 3 meo PCP worth trying
What about dxm what use all rave about...being a Brit it's not something you hear of people taking in this country...I've read a fair bit about it but read one person saying if you're used to ket you won't find much joy in this

Pic not mine btw
>>
Ernest Murdhall - Thu, 04 Jun 2020 08:06:20 EST g9GH/shY No.372152 Reply
>>372151
Btw I've also come to the conclusion that half the reason I originally fell in love with ketanine 5ish years ago was because of how bizarre and scary it was...the mind frame is very trippy but in a confusing way compared to lsd or shrooms and you can put your self in an absolute state for an hour or two then couple of hours later go to the gym like nothing ever happened.

>I think I'm going to look into these
3-HO-PCP, o-PCE ,3 meo pcp

Any others to look into
>>
William Pedgestock - Thu, 04 Jun 2020 17:19:30 EST 0J7DDP7R No.372157 Reply
>>372151
Peep the other thread. No supplements. Just years of abstinence. Also going to RCs that are like 10x more potent will totally feel like it's working for a while but in the long run that just blows your tolerance even more. When you get used to blowing eyeballed lines of 3-MeO-PCP, it's hard to go back to gator tails of K, that have to be even bigger than before.
>>
Ernest Bungerfuck - Thu, 04 Jun 2020 18:37:01 EST H1cOT3I/ No.372158 Reply
>>372151
I personally believe the /dis/ preference to be completely subjective in nature. I personally love the feeling of dxm and trying K was honestly disappointing. Something about the chaos of the dxm trip is soothing compared to the clean feelimg of K. It feels flat to me tbh. Give dxm a shot though if you already have a /dis/ tolerance you might need to take a bit more to get desirable effects. I dose up low 1st plateau for days I have to function but want a small boost which makes it great if I dose phat at the end of the same day as dxm self potentiates. Learning to push past the chaos of dxm has made me more confident towards the chaos that is life as well. Dxm is honestly a godsend for me personally. I'd be a wreck without it. Otherwise your best option is to take a long break from your fav /dis/ drugs. It may suck but if you keep going down the hole you may never get that magic back fully. It is something meant to be used sparingly if you wish to get the full effect and unfortunately most of us are fiends by nature. Maybe potentiation if you dont want to quit? Do your research before committing to anything of course. Your body is a temple that should be respected and if you go overboard there wont be any foundation left to offer that dank worship of sensation to the one that first dissociated and created all of us. Trip responsibly!

Ketamine tolerance builds

View Thread Reply
Hide
- Sun, 24 May 2020 22:05:21 EST 8s/NlcL6 No.372052
File: 1590372321988.jpg -(3668B / 3.58KB, 112x112) Thumbnail displayed, click image for full size. Ketamine tolerance builds
As trips become less and less vivid and less memorable :'(

How to fix ???
12 posts omitted. Click View Thread to read.
>>
Ernest Murdhall - Thu, 04 Jun 2020 08:39:10 EST g9GH/shY No.372153 Reply
1591274350077.jpg -(319126B / 311.65KB, 1080x1592) Thumbnail displayed, click image for full size.
What is the cause of ketamine tollerence in the body/brain

Aren't there any supplements what can help reverse the effects

What about using a micro dose of shrooms or acid.Could them drugs at those doses provide any uplift to the ketamime without producing trippy effects from the psys

Really missing the days of having out of body experences,looking at objects and thinking they where real,watching scary films and being warped into them making me more scared.Also seen a few entities on it..not very clear but one time I see this shadow figure playing like a flute and could hear a weird alien techno music in the background and the sound was giving of this blue colour



Will plugging in the bum bum work to hole If you have a high tollerence to the point where ketamine just makes you feel warm and fuzzy inside and maybe a little quiet because you're sort of zoned out but functional

Also debtaing trying IM injecting.Ive read a lot about John c lilly and he's made me wanna do it so bad but then I just don't want to use syringes for the simple reason it could in the future think it would be ok to inject other drugs.
>>
William Pedgestock - Thu, 04 Jun 2020 15:36:45 EST 0J7DDP7R No.372156 Reply
>>372153
> Aren't there any supplements what can help reverse the effects?
No.
> Will plugging in the bum bum work to hole?
No. Well, it could theoretically but rectal BA of Ketamine is lower than nasal, so why bother?

Just snort more K. It takes me like 700mg of vet grade to hole. I just blow it in a few lines over the course of 10 minutes so that it doesn't all turn to drip. It's ridiculously wasteful, and the holes aren't as magical as they used to be, but if you wanna get there, right?

Microdosing /psy/s might work. Or you could actually trip on /psy/ then K-hole for some of (IMO) the dopest tripping there is to be tripped.

What beginner dosage should I take?

View Thread Reply
Hide
- Thu, 07 May 2020 10:36:22 EST pLOf11Nj No.371786
File: 1588862182225.gif -(2312366B / 2.21MB, 499x499) Thumbnail displayed, click image for full size. What beginner dosage should I take?
I want to take for 650mg (plateau 3) since I'm experienced with psychedelics but everywhere I see says I should start lower at 350mg (plateau 2). visuals and possibly obe is something I want from the experience.
75 posts and 5 images omitted. Click View Thread to read.
>>
Mr_Shawmeen - Mon, 01 Jun 2020 23:26:36 EST xjm9YnvV No.372133 Reply
>>372132
God dammit double post sorry.

I am a cook and avid weight lifter as well lol
One day I'll scrub the exif and take a pic to show you all my 365lb mestizo outline
>>
Beatrice Clayhall - Tue, 02 Jun 2020 15:59:09 EST 57OBjnxT No.372140 Reply
1591127949002.jpg -(56917B / 55.58KB, 960x720) Thumbnail displayed, click image for full size.
I know a guy who had a major freakout from taking a not even a heroic dose of 2C-B. He had long been a "psychonaut" and a big acid guy, but never used phenethylamines before, and something just went wrong and he wasn't ready for it. and ended up flipping out from over-stimulation or something. and that's both psys.

There's no harm in easing into it.

The lesser plats have their own unique value as well.

Like smoking good weed and listening to music on ~350mg is awesome in a way that is different from the awesomeness of experiencing the higher plateaus, like the lower doses, you're still here just having a great high and weird headspace and effects, and then as you get higher up to me its like you become a non human entity who is processing what a high is through some meat machine called the "human body".

3-MEO-2'-OXO-PCPr, AKA Methoxpropylamine, MXPr just hit the market

View Thread Reply
Hide
- Sat, 05 Oct 2019 11:09:50 EST 5Dag7N+G No.369042
File: 1570288190379.png -(6397B / 6.25KB, 228x244) Thumbnail displayed, click image for full size. 3-MEO-2'-OXO-PCPr, AKA Methoxpropylamine, MXPr just hit the market
I've got a fair bit of good news for my fellow /dis/sociates, a trusted EU vendor just put up a listing for MXPr, the long awaited MXE analogue, and orders should be going out fairly soon, a few people on (r)eddit have already placed orders for it and a couple people have received samples and have already posted trip reports.

I'm beyond stoked, the reports so far are very promising, very similar potency to MXE, duration is very similar as well, maybe slightly longer. Here's the two trip reports I've found:

https://www.eddit.com/r/researchchemicals/comments/daiwoh/methoxpropamine_mxpr_aka_3meo2oxopcpr_launch/ (add an r to the link, 420chan's cat planet is annoying)

https://forum.drug.cafe/Thread-MXPr

HXE (Hydroxetamine, 3-HO-2'-OxO-PCE) appears to have also been synthed, but it's not available yet, though hopefully it will be soon. There's even less information on it than MXPr, but if the reports are to be believed it appears to be a bit less potent than MXPr (and MXE, assuming the potency of MXPr is roughly the same), but much more sedating and with a more opioid-like body high. HXE is one of the active metabolites of MXE so technically anyone who's done MXE has already sampled HXE, but it's unclear how much HXE is produced from a dose of MXE or how much it contributes to the experience. I have really high hopes for this one as well due to its relation to MXE and the fact that it's analogous to Hydroxynorketamine, which is believed to be responsible for a lot of Ketamine's antidepressant effects, however if the reports are to be believed it's a much more potent dissociative itself, Hydroxynorketamine has little effect as an NMDAr antagonist.

And one final thing to add to this wonderful list of good news, there's a rumor that the lab responsible for all of this is also looking into synthesizing Deschloroketamine since it's legal where they're located, so there's a chance that DCK may be making a come back at some point in the future. Take this with a grain of salt though as it's just a rumor.

The future of ACH's is looking bright boys! I'm planning on getting a gram of MXPr at some point in the near future, so if all goes well I'll report back with a trip report of my own when I'm able to. Just thought I'd pass this information on.
125 posts and 8 images omitted. Click View Thread to read.
>>
William Grimwill - Thu, 21 May 2020 09:18:31 EST HZU4kL+X No.372015 Reply
Are you all hyped for exactly MXPr or it's just because it's something that has Methox* in it?
>>
Luxinbuts, Fuxinsluts - Tue, 02 Jun 2020 02:21:45 EST owwH+goD No.372134 Reply
>>369042
It looks like both O-PCE and DCK have made a full comeback, as I've been getting them from a US vendor over the last few weeks. MXPr is en route from such vendor. I'm the most excited for HXE tho!
>>
Graham Diggleworth - Tue, 02 Jun 2020 23:28:08 EST FPPDIK1w No.372148 Reply
>>372134
The 1 huge supplier that makes all the RC lysergamides (1P-LSD, etc) are mass producing arylcyclohexylamines atm. I have a feeling all the novel dissos will disappear when the impending NL blanket ban on RC's happens.

Get them while you can.

too deep into youtube

View Thread Reply
Hide
- Tue, 27 Aug 2019 10:15:12 EST Ezw7w5PG No.368072
File: 1566915312518.png -(1145173B / 1.09MB, 1279x679) Thumbnail displayed, click image for full size. too deep into youtube
careful with the dissos lads. this guy said he smoked a pound of diphenidine in a year. behold, pure dissociated insanity. he countless hours of videos like this. almost no views.
(potentially disturbing)

https://www.youtube.com/watch?v=Xk1f9uigMts

I figure someone's gotta see this
155 posts and 34 images omitted. Click View Thread to read.
>>
Graham Mobbersudge - Mon, 25 May 2020 04:01:45 EST MYA7SC5S No.372063 Reply
>>372058
It's just interesting to me and pretty sad, I don't find it particularly upsetting. Really he can think whatever and however he wants, I just worry about his well-being and with some of the things he says the well-being of others.
>>
Fanny Gobblestone - Mon, 25 May 2020 20:43:04 EST DqdsUJkA No.372076 Reply
He's got some really interesting paintings. Has he made any mention of whether he sells them and where?
>>
Charles Gooddock - Tue, 02 Jun 2020 14:17:49 EST KRBQNTrZ No.372139 Reply
1591121869415.jpg -(109502B / 106.94KB, 900x900) Thumbnail displayed, click image for full size.
I'm just here to keep this thread going because it's had some interesting discussions

DCK on its way!

View Thread Reply
Hide
- Thu, 21 May 2020 02:52:13 EST Dxrzcjf6 No.372012
File: 1590043933415.jpg -(73669B / 71.94KB, 1125x1072) Thumbnail displayed, click image for full size. DCK on its way!
Bout to receive my batch of DCK in the next week or so. Been forever!!!! Let me talk to teh gawds again
>>
Edwin Dartspear - Thu, 21 May 2020 11:26:50 EST z9LU2y+d No.372016 Reply
I always regret buying 2F-DCK/DCK. Ketamine is cheaper. 3-HO-PCP and O-PCE I never regret.
>>
Luxinbuts, Fuxinsluts - Tue, 02 Jun 2020 02:30:03 EST owwH+goD No.372135 Reply
>>372016
Ketamine is definitely cheaper than DCK, but not 2f. Maybe in your location tho. Ketamine in the US (I assume, as I've been to many different regions of the US, and even my well-connected friends who get me drugs of pristine quality at substantially lower prices, as well as domestic darknet prices) is typically $50-100/g (I at least know people who charge 100, I'll personally never pay more than 80 for a single gram of K). I can get 10 grams of 2f-dck for $280, and it's very high quality always, and basically just as good as most K I get that is crystallized in huge rocks. Seems like needle-like and small crystal K is always bomb as fuck. I know when I used to cook vials myself it would end up looking like glittery crystal that would sometimes make these little sheet-like flakes.

This comment is too long but I'm gonna keep going.

Domestic vendor I use now charges normally like $80-90/g for DCK. Then they charge the same for O-PCE. 3-HO-PCP and 3-MeO-PCP are usually a tad more expensive. But 3-HO-PCE is less expensive than K for some reason too.

ketamine isomer

View Thread Reply
Hide
- Sun, 17 May 2020 16:32:11 EST B/PMcZOI No.371955
File: 1589747531177.png -(838870B / 819.21KB, 858x852) Thumbnail displayed, click image for full size. ketamine isomer
Do you prefer racemic or S?

Is pure R-ketamine just not around?

Does the difference even matter if I IM 100mg?
7 posts and 3 images omitted. Click View Thread to read.
>>
Eliza Gezzlelare - Sun, 24 May 2020 15:59:57 EST B/PMcZOI No.372046 Reply
1590350397974.jpg -(14445B / 14.11KB, 225x225) Thumbnail displayed, click image for full size.
>>372041
that might work better with 2-FDCK oral bioavaility. Makes me wonder, how much K would I need to take to have 100mg+ of active metabolites in my urine...
>>
legit poster - Mon, 01 Jun 2020 18:01:43 EST DqdsUJkA No.372129 Reply
1591048903413.jpg -(167727B / 163.80KB, 728x976) Thumbnail displayed, click image for full size.
>>372046
Depends on how hydrated you are. You gotta drink that good deep bladder piss. That stuff that you piss out after waking up at 4pm and it is cloudy and dark as fuck, that's the piss that will have the most ket. So to get that nice mature piss you need to let it sit, which with K is not ideal at all...So really you want to be as hydrated as possible, and drink the most piss as possible to get high, because this is showing that your bladder is never seeing high concentration of ketamine so drinking loads of that is more safe than drinking the deep aged piss


(if you've ever used one of those 420cleaner things for probation, the one I had said right on the bottle not to use your first or your last of your stream of piss, nor your mornings first piss. The longer the piss sits in the bladder, the more shit gets put into it before it gets dumped.

Also, the first piss doesn't work just fyi lol
>>
Jenny Blackhall - Mon, 01 Jun 2020 20:40:09 EST B/PMcZOI No.372130 Reply
OP here again with tangentially related ketamine escapades

I dosed while I was peaking on two hits of acid which I guess was 220 ug total

I have almost never tripped that hard, next to salvia. Good lord does the LSD multiply the dissociative factor of ketamine. I was not expecting it to be so intense. I guess this is what they call a k-hole, because I dipped into it 3 or 4 times as I passed out and eventually regained consciouness. I traveled to a world of pure form where I was no longer in my body, very much like salvia I thought I was seeing alternate lives, but I was at peace with this foray into a film reel of other lives and I felt interconnected with all life, then I just saw organic lifeforms zoom to the miniature scale like one of Haeckel's drawings and I woke up thinking my face was one but it was the way the blanket pressed into my face


Also I think the LSD visuals were potentiated by the ketamine for hours beyond when K would normally taper off into nothing. 1+1 was greater than 2 on that night.

3meopcp is retarded

View Thread Reply
Hide
- Sun, 17 May 2020 05:06:38 EST cT9AUNh4 No.371945
File: 1589706398032.png -(342742B / 334.71KB, 460x449) Thumbnail displayed, click image for full size. 3meopcp is retarded
everytime i take it i seem to lose iq points for the duration
yet i take it again and again
im also on antipsychotics, so i think some of the effects dont happen to me
its just a weird trip each time but im so bored i dont know what else to do with my time
welp
7 posts and 1 images omitted. Click View Thread to read.
>>
Nathaniel Dedgefatch - Mon, 25 May 2020 06:18:47 EST xKVqDKOE No.372066 Reply
>>372038
where does ketamine fit into that list? I would say I had more fun with MXE buts been years and I don't know if its just nostalgia goggles.
>>
Shit Nappergold - Sun, 31 May 2020 16:35:30 EST e9cvOVLj No.372121 Reply
>>371945
From the first moments it started to kick in the single time I got 3g of it a long time ago, I knew it was by far my favorite drug. It felt like finding myself in drug form... or like finding something that perfectly complemented me and made me complete.

I've never really gotten the heavy amounts of dissociation/confusion/cognitive impairment from it that most people talk about experiencing. They also sometimes describe it as being fairly chill, which is something else I can't relate to. By the time I got around to trying 3-MeO, or any RC dis for that matter, I'd already acquired a an huge permatolerance to DXM.

I suppose what I had actually built a permatolerance to was the dissociative effects mediated by NMDA antagonism, because it caused hella cross-tolerance to the RC dissociatives I've tried... or rather, a cross-tolerance mostly to their dissociating effects. The other pharmacological mechanisms contributing to the experience as a whole seem to follow a tolerance building pattern similar to a majority of other drugs.

In any case, 3-MeO didn't get dissociating to me until I was seriously right on the edge of blacking out or temporarily going blind. The threshold and the dose response curve f after reaching it going from actually noticing its dissociative effects and blackout was ridiculously steep.. So, I didn't experience much of the cognitive impairment or dissociation, but instead experienced euphoric mania, supreme confidence, the absolute annihilation of depression or any mood other than feeling incredibly fan-fucking-tastic all the time, an extremely positive outlook on the world and the situations I would find myself in, extreme motivation, endless energy, feeling no pain at all (and something akin to a very clean and stimulatory, rather than depressant/noddy opioid buzz), becoming much more creative a swell as more effective at problem solving tasks partially as a result of that (as well as the positivity, motivation, and endless energy). On top of all that, literally any music I listened to sounded fucking amazing, evne if I knew it was a big pile of horse shit and I shouldn't really be enjoying it at all, let alone as much as I was.

Basically, you get the so-called feelings of being superman that people describe from using vanilla PCP, everything is great all of the time, and it felt better than any other drug I had taken by that point and have ever taken since. It was like the perfect cross between a dissociative, opioid, stimulant, and entactogen mixed ith some literal magic that made it so there wasn't ever a crash, and you felt that good for well over 12-19 hours.
>>
Shit Nappergold - Sun, 31 May 2020 16:37:38 EST e9cvOVLj No.372122 Reply
>>372121
I kind of forgot to actually clarify that because I had a high permatolerance to the dissociative effects of /dis/ drugs, I experienced 3-MeO's stimulant and manic effects to a much greater degree .

Can you take dxm on benzos?

View Thread Reply
Hide
- Sun, 24 May 2020 19:33:30 EST /m75evpI No.372051
File: 1590363210728.jpg -(5873387B / 5.60MB, 4032x3024) Thumbnail displayed, click image for full size. Can you take dxm on benzos?
I've been trying to research this question but I keep finding conflicting information. I take 1mg klonopin twice daily and was wondering how safe it it would be to gor for a low plat dose. I'm shooting for first, maybe second. I'm not sure how high the risk of respiratory depression is.
7 posts and 2 images omitted. Click View Thread to read.
>>
Walter Mommlewill - Sat, 30 May 2020 02:04:55 EST 8o+C2Kwn No.372105 Reply
ah, this is nostalgic
as somebody who made this thread over a decade ago and is still taking clonazepam, get used to people acting like you taking your daily baseline meds is the same thing as popping a xanax
>>
Nell Pazzletut - Sat, 30 May 2020 03:06:48 EST 57OBjnxT No.372106 Reply
>>372104
I didn't say there is no interaction whatsoever, I said "there's no negative interaction", as in like one would see with ssri+dxm, or one that would even be noticeable at all.

We can get into theoretical interactions and whatever possiblities, but the risk is so low that I think going through the chemistry with a fine tooth comb would be like if your doctor insisted on reading you every piece of literature he has on a medication he wants to prescribe you because .0004% of the research group had their dick fall off.
>>
Wesley Crubblebury - Sat, 30 May 2020 15:47:47 EST e9cvOVLj No.372113 Reply
>>372106
my point is that it can cause a negative reaction. dissociative anesthetics are known to increase the depressant effects of depressants, meaning it will increase the respiratory depression xanax can cause. it also interferes with xanax's metabolism, meaning it results in higher plasma levels of xanax in the bloodstream and a longer clearance time, which also means increased respiratory depression.

like i said, as long as it isn't huge doses of either, it's not a big deal, but it's straight up a lie to say there isn't any possible negative interaction.

Paroxetine and DXM

View Thread Reply
Hide
- Sun, 10 May 2020 00:15:37 EST XR2H1RQ4 No.371835
File: 1589084137361.jpg -(194290B / 189.74KB, 820x1024) Thumbnail displayed, click image for full size. Paroxetine and DXM
I consumed 40mg paroxetine a little more than 24 hours ago. I didn't consume any SSRIs for years, only this one dose. Is it safe for me to do a 2nd plat DXM trip now?
7 posts omitted. Click View Thread to read.
>>
Barnaby Nickleway - Mon, 25 May 2020 16:12:07 EST e9cvOVLj No.372073 Reply
>>372072
Oh yeah I also was sweating profusely and was hypothermic/feverish.
>>
Albert Fullernat - Wed, 27 May 2020 08:09:53 EST 4qWwyTtz No.372090 Reply
Sorry guys i forgot about this thread, i did 532mg at the time when i made this thread, and there were no complications. But DXM felt less potent, felt like maybe 300mg. I guess my luck was i only did 40mg paroxetine to try out if it would feel a little like ecstasy like the first time i was prescribed escitalopram, but i didn't take it for extended periods of time, only a single dose.
>>
Wesley Crubblebury - Fri, 29 May 2020 20:09:45 EST e9cvOVLj No.372101 Reply
>>372090
Did you take hbr or poli? 532mg is very close to 534mg, which is how much is in a small bottle of poli/delsym.

Paroxetine is both a substrate and potent inhibitor of CYP2D6, so that means you likely experienced a much greater DXM to DXO ratio. I'm prescribed cymbalta myself, which isn't an inhibitor but is a substrate of CYP2D6 and I notice the same thing myself--the trip is much more mild. DXO is responsible for a majority of the trippiness.

If I take delsym I basically don't even feel a small bottle of it. I have a pretty huge permatolerance to DXM as it is, and taking poli causes the DXM to trickle out of the chained-plastic poli coating at a very slow rate due to its semi-permeability. The DXM self-prevents the metabolism of the DXM still being released into DXO because it is saturating the liver enzymes, and CYP2D6 is what metabolizes it into DXO and is what normally is responsible for metabolizing like 75% of the DXM. With Paroxetine (or for me, cymbalta) inhibiting and also over saturating the CYP2D6 enzyme, more of the DXM is forced to be metabolized by CYP3A4 and flows through the bloodstream longer waiting for enzymes to open up.

PATENTED FLAVOUR BEAM

View Thread Reply
Hide
- Mon, 11 May 2020 09:58:57 EST 4wcThKkV No.371873
File: 1589205537450.jpg -(33786B / 32.99KB, 550x349) Thumbnail displayed, click image for full size. PATENTED FLAVOUR BEAM
Come on, who's got the flavour beam meme? I mean of course the one about.cracking cream bulbs directly into your mouth thanks to the protective magic of shirts.
2 posts and 2 images omitted. Click View Thread to read.
>>
Phineas Bibberforth - Mon, 25 May 2020 00:48:48 EST 8s/NlcL6 No.372057 Reply
1590382128988.jpg -(6387B / 6.24KB, 240x210) Thumbnail displayed, click image for full size.
>>371873
I have stood exactly where that bus is parked hundreds of times
>>
Oliver Gerringkotch - Thu, 28 May 2020 02:26:17 EST F0PvsG4X No.372094 Reply
>>371873
i remember mexican tripping weed
patented flavor beam
whats the other one?

Possible to still get MXE? (no source)

View Thread Reply
Hide
- Tue, 26 May 2020 20:53:25 EST Qj8kYrlb No.372080
File: 1590540805124.gif -(4876862B / 4.65MB, 320x180) Thumbnail displayed, click image for full size. Possible to still get MXE? (no source)
Just wondering if anyone has been able to get their hands on any methoxetamine in recent times? Not looking for source, just wondering if anyone has gotten some.
>>
Betsy Chittingwodging - Tue, 26 May 2020 22:22:11 EST Pjz8tAxm No.372082 Reply
>>372080

It's gone. Nothing but a happy memory. Anybody offering it for sale now are either selling a different chemical or on the extremely unlikely case it is real MXE, selling it for beyond absurdly high prices.
>>
Alice Tootson - Tue, 26 May 2020 22:54:55 EST El2PEU89 No.372083 Reply
>>372082
is this because it was explicitly made illegal (at some point, somewhere)? people sell illegal shit on the internet all the time, why did synthesis suddenly stop?
>>
Edward Brandlemid - Wed, 27 May 2020 04:59:09 EST EJ8vKrGQ No.372088 Reply
1590569949361.jpg -(39611B / 38.68KB, 500x380) Thumbnail displayed, click image for full size.
>>372083
banned in china, where most of the synths went after the eu cracked down on mxe. past its gray market niche since kets the bigger cash crop disso in the family why bother with mxe? places where it's still technically legal either listen to the UN scheduling it like it means something or are the us and have a convoluted system where techincally it might be legal but also not? and the precursor might be controlled in the us too so.

idk bribe some disgruntled grad student or smth
Report Post
Reason
Note
Please be descriptive with report notes,
this helps staff resolve issues quicker.