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Discord Now Fully Linked With 420chan IRC

OTC alcohol dehydrogenase inhibitor.

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- Fri, 05 Jul 2019 23:10:34 EST QRXMZ2iv No.281967
File: 1562382634230.png -(393885B / 384.65KB, 929x487) Thumbnail displayed, click image for full size. OTC alcohol dehydrogenase inhibitor.
Alcohol dehydrogenase is an enzime that breaks down highly euphoric alcohol into highly toxic acetaldehyde. This is bad. Alcohol dehydrogenase inhibitors allow alcohols to be in the body longer without breakdown, this means:
1: psychoactive alcohols have a lower dose and longer duration of action
2: alcohol protoxins such as methanol and ethylene glycol won't convert to their corresponding toxic aldehydes and acids (formaldehyde, formic acid - glyoxal, oxalic acid) and poisonings can be treated this way.
3: if someone has low levels of aldehyde dehydrogenase enzime (asians, alcohol intolerants), or it is inhibited (disulfiram), acetaldehyde toxicity won't be as bad.

The major alcohol dehydrogenase inhibitor in use is fomepizole. It is nowhere near OTC and nowhere near easy to make. But today i've found a paper about bismuth inhibiting this enzyme. There's stable evidence that it does that in yeast fungi. Enzimes are different in different species, and different species have different absorption rates of different drugs. But, the bindig sites are the same and the catalytic metal and the neighbouring amino acids are the same.

Bismuth subsalicylate is an OTC drug marketed as "Pepto-Bismol" in the US iirc. It is very similar to the bismuth subcitrate they used in the experiment.

Today i'll do an experiment. I've been taking disulfiram (antabuse) 250mg/day for 3 days. Now i'll ingest bismuth subsalicylate 750mg, wait a few hours then start to drink. I'll report back if it was successful or not.
3 posts and 1 images omitted. Click View Thread to read.
Jack Bushbanks - Sat, 06 Jul 2019 11:04:34 EST QRXMZ2iv No.281972 Reply
>but according to this the subsalicylate could theoretically do what you're looking for, but there are a lot of points where things get dubious

that's why i did the experiment

unfortunately i can't really interpret the resutl of my experiment. I didn't have any bad reactions from alcohol, but i only consumend a little (about 0.33l beer.) then instantly fell asleep, idk why. i slept and woke up without any problem, but i have to repeat the experiment on a later date with a larger amount of alcohol.
Angus Gobberville - Sat, 06 Jul 2019 11:43:22 EST zI3IcHAm No.281973 Reply
>but i only consumend a little (about 0.33l beer.) then instantly fell asleep

imo it must've done something because this is not the normal reaction from drinking on antabuse
Rebecca Crunnerham - Sun, 07 Jul 2019 06:54:10 EST Sm/pMuoo No.281992 Reply

i'm thinking the same thing, but also i didn't feel drunk and i didn't wake up in a similar condition to when i go to sleep drunk. My sleep cycle is kinda fucked up, maybe the alcohol just took off my anxiety and my tiredness allowed me to sleep, idk, i have to repeat the experiment because this result can't be interpreted surely.

Alcohol & Life

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- Tue, 20 Nov 2018 07:49:52 EST SPTLykO3 No.280562
File: 1542718192989.jpg -(11803B / 11.53KB, 200x200) Thumbnail displayed, click image for full size. Alcohol & Life
I'm 30 y/o exactly, I started drinking at age 14, but I've never been the kind of alcoholic that drinks often on consecutive days. I binge drink, and always have done. But in my time I've used many many substances, the most prominent were ecstasy and benzos (different time periods) and looking back on it, they were ALL tools to elevate anxiety and ignore reality.

I was diagnosed with severe hypochondria at age 13 and also social anxiety later in life, all of my substance exploration and abuse, well most of it, was a means to cure this I feel. Now that I have naturally overcome this with exercise and meditation, I very rarely drink, like once a week, and then I don't even really get drunk, but I do at times. As for other substances, nothing at all. However, I run a business and things have become very tense lately, and I've found myself finishing the day and thinking, shit, I want a couple of beers to take the edge off!
Is there anything else that isn't so destroying on the liver and life in general that I can use to relieve this anxiety?
2 posts and 1 images omitted. Click View Thread to read.
Sophie Sunnerwill - Tue, 25 Jun 2019 17:16:06 EST DeXHkgaD No.281869 Reply
This post is old but if you are still here kratom is a good, non addictive, alternative.
Nigel Hemmlegold - Sat, 06 Jul 2019 12:23:36 EST MErfXlGl No.281975 Reply
I am also a hypochondriac that depended on drinking say 2, maybe 3 at most beers for 4 or 5 days of the week to take the edge off after work and soothe my anxiety. This was the case for about a year and a half.
Don't do it. See a therapist, maybe try cannabis or meditation. Its not worth it.
Best of luck.

alcohol weird shit disability

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- Tue, 02 Jul 2019 02:56:08 EST /l5SqefS No.281940
File: 1562050568085.jpg -(20649B / 20.17KB, 235x282) Thumbnail displayed, click image for full size. alcohol weird shit disability
what the fuck does this mean? and NO its not withdrawal dont suggest this

>tired as fuck
>like eyes completely black
>cant keep eyes open
>get out of bed light headed
>dont do anything
>dont talk to anyone
>dont even want to drive
>too tired to get out of bed
>literally too tired to sleep
>eyes sting and burn all day
>always feel woozy trying to go back to bed literally bed ridden 24/7 for years on end

and then when i drink alcohol. it goes away. black bags under my eyes go away. it feels like my organs arent failing anymore. even like my hair looks and feels healthier and my entire body. im like getting up wanting to fucking dance hang out with friends talk to people talk to chicks do all this run around town with my friend go to bars run to stores go get mcdonalds do all this shit on foot go walk around meet up with other people i can walk for miles alone.

i didnt realize at first. i was laying in bed smoking weed all day and felt like garbage. i was telling my friend im too tired to even lay down and he just kept telling me that doesnt make sense. i dont actually like alcohol that much so i had to force myelf to take a drink because i was depressed and then i made a typical orange juice vodka screw driver. start sipping on it. ENERGY. black bags go away. im not bed ridden anymore. i wanna walk around and i wanna talk to people i want to go see my friend.

whenever i just smoke weed or im sober my eyes hurt so bad i cant even take a selfie my hari looks all frizzy and messed up my eyes are black im flushed pale sick looking my hairs a mess i look like im dying and have cancer. i get drunk as fuck and i look the next day and i took a bunch of selfies and i look healthier happier my eye bags go away im like dancing to music hanging out with people going out and doing shit

but whenever i do drink i wake up JUST as miserable again plus puking and sick gain a bunch of weight and then i immediately regret everything the next day, im like OMG i was dancing around like a fucking retard last night taking all these selfies and doing stupid shit and talking to people and talking to girls and i just feel immediate shame.

how do i make my mind/body be like the way it is on alcohol normally all the time? i dont even want alcohol i dont even like it. its just like its a vital nutrient that like supplements 75% of my body and it cant live without alcohol. and ive gone a year without alcohol so far its not withdrawals and ive felt like this before i ever had a drink in my life. im just getting more and more and more tired every day without alcohol i need alcoohl to build up in my system
6 posts omitted. Click View Thread to read.
, - Thu, 04 Jul 2019 04:03:22 EST nCGtL17Z No.281956 Reply
Opinion, regardless, if you feel like shit, go for a nice walk. Everyday. If you smoke cigs, kinda ditch em. Use eye drops for eyes to help adjust. The tiredness will eventually go away if you find a program and stick with it.

Knowingly, a few drinks will set one straight, do the motivation routine in between drinks. May find this works well.
Hugh Fuckingfuck - Thu, 04 Jul 2019 13:06:04 EST PvCkfchX No.281957 Reply
liver damage makes you feel constantly tired
Gordon Spunkbubble - Fri, 05 Jul 2019 09:23:31 EST gvvLjrv2 No.281961 Reply
guy above me might be on to something, maybe should see someone about this i know getting help sucks and is a little embarrassing or tiresome but you won't get any solid advice on here.

frosted glasses/mugs

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- Wed, 26 Jun 2019 20:27:16 EST TmiWqarL No.281881
File: 1561595236336.png -(613077B / 598.71KB, 720x902) Thumbnail displayed, click image for full size. frosted glasses/mugs
6 posts omitted. Click View Thread to read.
Betsy Brookhall - Thu, 27 Jun 2019 22:59:47 EST 4H/9l7bZ No.281899 Reply
Beatrice Clummledock - Sat, 29 Jun 2019 14:58:09 EST 9QBBnhFL No.281913 Reply
Depends on what's in it I guess.
I like my beer room temp, but I could imagine it'd be pretty neat for drinks.

Hangover Thread

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- Wed, 04 Jul 2018 19:08:48 EST GZKVYpxN No.278969
File: 1530745728640.gif -(508796B / 496.87KB, 275x155) Thumbnail displayed, click image for full size. Hangover Thread
This thread will be about all things hangover related. Possible topics of discussion include:

>what was your worst ever hangover like
>what is the highest your BAC was ever measured to be
>what bullshit hangover cure do you think is the magic cure-all
>mixing different drinks: does it really make the hangover worse?

You get a bonus point if you have uttered the phrase "I'm never drinking again" at least 3 times in your life.
78 posts and 14 images omitted. Click View Thread to read.
Augustus Mummleshit - Sun, 23 Jun 2019 19:39:25 EST 4H/9l7bZ No.281861 Reply

thanks for the support. on the upside my coke man is back at it so i should be powdering my nose soon
George Worthingshit - Thu, 27 Jun 2019 04:01:17 EST LWg8CWbb No.281883 Reply
1561622477425.jpg -(1740357B / 1.66MB, 1099x1099) Thumbnail displayed, click image for full size.
The nausea for me is the absolute fucking worst, that and throwing up (especially when its just bile and coagulated blood)
>worst hangover
Theres been many as I have hit 30..but my freshman year at uni, I never drank much in high school, and this kid rico brought over a few bottles of jager and we basically each drank one (still cannot drink it to this day). Last thing I remember is just kidding I dont remember shit, that is until I wake up five miles from campus with no shoes, covered in barf down my whole front, underneath a pine tree at the back entrance to the local zoo. Oh also I was soaked cause it had been raining. Also rico stole like $700 worth of adderall from me. Dont drink jager.
>highest BAC
Having a breathalyzer around the house is handy for this. Highest was .3something, at least that I remember (theres tons I dont though so who knows)
Now that I am older they are horrible and have no cure. I legitimately considered suicide after the last wedding I was at because I was so hungover.
Though I do think these are withdrawls as well.
>mixing drinks vs not mixing
I have had bad results with mixing. Just drink liquor mixed with water now
>BONUS ROUD; “im never drinking again”
I dont know why I keep saying it because I am gonna do this till I die, but I do. Constantly lol
Shitting Sibblepet - Thu, 27 Jun 2019 11:17:38 EST nRfUbmcX No.281886 Reply
1561648658262.jpg -(38365B / 37.47KB, 500x350) Thumbnail displayed, click image for full size.
>what was your worst ever hangover like


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- Tue, 25 Jun 2019 19:00:25 EST F/Ux1IJ+ No.281870
File: 1561503625089.jpg -(66737B / 65.17KB, 592x777) Thumbnail displayed, click image for full size. ohahahahahaha
>be me
>have 4 days off
>start drinking on first night off
>fast forwards to today
>drank 4+ liters liquor, mostly vodka, at least 40 ish beers
>stopped drinking 4 hours ago
>have to be at work in 3 hours

ahahahahaha I am in so much pain why do I fucking do this to myself.
Martha Honeyforth - Tue, 25 Jun 2019 22:20:25 EST O/wQLkW0 No.281872 Reply
1561515625865.png -(3453625B / 3.29MB, 1920x1080) Thumbnail displayed, click image for full size.

haha nice, what's your job?

my experience is that if I don't care about the job, I'll be drunk. Maybe do something that motivates you to get sober?
Martha Claylock - Wed, 26 Jun 2019 01:48:10 EST xfJH6pg0 No.281876 Reply
1561528090208.gif -(405624B / 396.12KB, 541x332) Thumbnail displayed, click image for full size.


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- Tue, 18 Jun 2019 13:05:18 EST D4A0WAFi No.281819
File: 1560877518801.jpg -(321162B / 313.63KB, 960x1920) Thumbnail displayed, click image for full size. Everclear
>read a bunch of horror stories about everclear on the internet
>never tried it so think "fuck yeah this is gonna be great"
>invite my "friend" over, dont know what to call her but we are banging right now
>we drink this shit , nothing special
We are both total drunks but am I missing something? I was expecting blackout levels of drunkenness. Between us we drank a 1/4 bottle of everclear, and half a bottle each of vodka and sour puss. We had a decent drunk going but I found it underwhelming. Is it just my tolerance or is this shit overrated?
I'll probably buy it from now on though because it's the only thing that actually got me a good buzz in a while.
5 posts and 1 images omitted. Click View Thread to read.
Frederick Cammerridge - Wed, 19 Jun 2019 19:34:38 EST Y1aPJqhD No.281829 Reply
It's not like there's anything magical about Everclear, it's just highly concentrated alcohol. Anyway Everclear sucks, just buy regular vodka
Basil Brillermare - Mon, 24 Jun 2019 18:53:32 EST W7ob6Luj No.281864 Reply
Not so very subtle bragging.
Fuck off
Fucking Blobblehig - Mon, 24 Jun 2019 19:58:16 EST ZmMOOBMJ No.281865 Reply
>probably buy it form now on though

anyone ever get so drunk that you pissed the bed?

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- Sun, 12 May 2019 19:56:35 EST IfwpEdG7 No.281540
File: 1557705395970.jpg -(94899B / 92.67KB, 640x443) Thumbnail displayed, click image for full size. anyone ever get so drunk that you pissed the bed?
Had about a fifth of whiskey last night drinking with a friend, pus 3 beers. Got so drunk I puked on his floor, and then I went back to my place and passed out with my clothes on. I woke up with my pants and bed soaked with piss. Anyone else ever experience this?
26 posts and 7 images omitted. Click View Thread to read.
Angus Dremmerfeck - Mon, 24 Jun 2019 15:17:26 EST VaBKdjHx No.281863 Reply
>Blackout and fall asleep after I spilled beer all over myself
>Wake up and change into prepositioned pajamas
>Wake up and my clothes are soaked in piss
>Briefly remember half waking up and taking a wild piss all over my clothes
>Jeans, Shirt and socks are KO'd

The Deadly Cycle

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- Sat, 29 Sep 2018 16:09:47 EST 4H/9l7bZ No.280054
File: 1538251787700.jpg -(10769B / 10.52KB, 247x206) Thumbnail displayed, click image for full size. The Deadly Cycle
>Wake up 1 hour before alarm due to glutamate spike from excessive alcohol consumption the night before
>Ignore throbbing head, twsting guts, blurred vision, mouth like the Sahara desert, stinky sweaty sheets, summon all willpower to rise from bed
>Turn off alarm since you're already up
>Shamble outside like a zombie for a morning cigarette to wake up
>Ignore the numerous empty bottles and trash/clutter from the night before
>Take shit of liquid lava
>Make shitty half-assed breakfast after gathering all the empties and putting them in the recycling
>Manage to robotically eat it despite waves of nausea and cold, clammy sweat.
>Pop a multivitamin and a couple aspirin, pray to the gods for mercy
>Brush teeth, shave, shower, make it to work
>First ~2 hours of work not so bad
>Around 12-1PM, last of alcohol has been processed out of bloodstream
>Surprise roundhouse kick to the face of NAUSEA for about 30 minutes as the first moments of withdrawal initiate
>Manage to choke down a decently healthy lunch
>Chugging water and pissing all day until the foam starts to clear up (a sign of kidney damage!) and the piss is just liquid with little to no bubbles
>Make it home, finally starting to feel okay
>Around 5-6PM mild shakes kick in
>Due to powering through the hangover, eating half-decent food and hydrating, finally feeling good enough to consider some drinks at this point
>Pour up that first mixed drink


>Wake up 1 hour before alarm...
12 posts and 3 images omitted. Click View Thread to read.
William Nundlestock - Sun, 23 Jun 2019 19:26:35 EST zSF2cUPE No.281858 Reply
Absolute madman, you can’t keep getting away with it!

Bump when breakfast

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- Sun, 23 Jun 2019 09:04:20 EST q+Iuujth No.281854
File: 1561295060125.jpg -(18402B / 17.97KB, 1041x692) Thumbnail displayed, click image for full size. Bump when breakfast
My favourite is having coffee + Beer. Not mixed of course, just separately as breakfast. That's what I'm having this morning.

Of course that's something from the comfort of my own home. Out in the wild, you gotta be sneakier and put whiskey in your coffee. This is also a delicious option.

But if you have money and you're in the wild, you can buy socially acceptable mimosas and get drunk without anyone batting an eye. Shit's wild. Highly recommend.

What's your preferred morning drinks?
Augustus Mummleshit - Sun, 23 Jun 2019 19:27:07 EST 4H/9l7bZ No.281859 Reply
when i slide thru total wine for their cheap tequila way in the back i usually grab a couple little alcoholic coffee creamers, i enjoy having 1 or 2 of those with some coffee if its a day where im drinkin in the morning. when fall comes around and the gay pumpkin stuff comes back i get pumpkin alcohol coffee creamers lol

What the fuck?

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- Fri, 21 Jun 2019 05:47:57 EST Zh0nGv1T No.281838
File: 1561110477584.png -(138780B / 135.53KB, 500x500) Thumbnail displayed, click image for full size. What the fuck?
Can someone explain to me why when i have just a drink (like a pint, etc..) at night with friends i just can't manage to fall asleep afterwards? Does this happen to anyone else? It's like a part of my brain is actually stimulated and can't stop thinking, and i also get anxiety despite also taking benzos. Also, the next day i feel very unfocused and spaced out, no hangover (obviously, from such a small amount) but I used to hardly feel a pint. When i drink more i have no trouble falling asleep but i wake early and don't rest well, but that's normal.

I used to be a heavy social drinker, now i drink very rarely and almost never get shitfaced + now i take mirtazapine and benzos for insomnia if that's relevant.
Rebecca Mocklefuck - Fri, 21 Jun 2019 20:05:42 EST 4H/9l7bZ No.281841 Reply
rebound effect after depressant wears off

Alcohol testing on the job and other booze and job stories

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- Tue, 18 Jun 2019 03:33:13 EST X5k1PFRh No.281817
File: 1560843193797.jpg -(75839B / 74.06KB, 600x800) Thumbnail displayed, click image for full size. Alcohol testing on the job and other booze and job stories
So just to be clear, when people say that American companies test for booze, they mean it in the sense of "oh shit retard you came to work immediately after having two or three gin and tonics for breakfast" and not in the sense of having a weekend drinking sesh and getting tested for it monday, right?

I mean... testing to see if you're buzzed on the job is still gay as fuck, but at least it's not literally "you were drunk 48 hours ago and now we are going to fire you lol" levels of 1984. I'm so glad my job working as a dish washer doesn't give a fuck if I come in drunk. (inb4 drunk driving bad!!!! I don't drive to work. It's a 10 min walk).

Also: ITT drinking on the job thread because might as well
1 posts omitted. Click View Thread to read.
Nathaniel Baddleridge - Tue, 18 Jun 2019 19:31:14 EST 4H/9l7bZ No.281823 Reply
ive never heard of a job testing for alcohol. but there are lots if things out there ive never heard of.
Phineas Funderman - Tue, 18 Jun 2019 21:22:40 EST +mnK3pqC No.281824 Reply
the drug test that we take are the 5 panel ones that have THC/PCP/speed/opiates/cocaine

alcohol isn't included

I've drank on the job at my hotel job. It's a small hotel and after 4 pm I'm the only person there so I can have 2-3 brews in the back before I go home at 11 PM. My shift is 2nd shift (3 pm - 11 pm) so i have alot of freedom to do whatever at work
Doris Murdforth - Tue, 18 Jun 2019 22:20:48 EST CnKjqoe3 No.281825 Reply
man if you need to be drunk at your job to perform your best you should gtfo. ruins getting drunk to an extent and it's a sign your employers treat you like shit. not that there are any cushy dishwashing jobs, i've been there and also been there wasted. shit i went to the bar and grabbed a beer or two every lunch break "to survive", really it's a waste of money and booze. best of luck you fucking lush


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- Tue, 11 Jun 2019 23:51:02 EST gvvLjrv2 No.281770
File: 1560311462930.jpg -(98173B / 95.87KB, 600x900) Thumbnail displayed, click image for full size. Mouthwash?
Hey hooch so i am really desperate to get half drunk but its 3 am and where i live they have these very frustrating laws where you can't buy alcohol after 10PM or before 10AM so i can't go anywhere and buy some.

All i have in my house that has ethanol in it is mouthwash and i am really really trying not to drink some but i can't fucking get over the hump. surely the chances of dying or permanently fucking myself up drinking lets say 250ml of it once couldn't be too bad.
sodium hydroxide
sodium saccharin
cetylpyridinium chloride
sodium floride
zinc chloride)
7 posts omitted. Click View Thread to read.
Charles Clennerfuck - Sun, 16 Jun 2019 16:12:12 EST DHQrK22y No.281801 Reply
I drank a whole bottle of listerine because I was dead broke, homeless and going through bad withdrawal. I mean, it did the job but sometimes it burns when you piss afterwards. I drank hand sanitizer once too on a dare because it was the only alcohol I had that wasn't rubbing alcohol. Honestly if push came to shove I'd drink mouthwash if I was feeling as bad as I was then, but fuck drinking sanitizer even if it's just pg and ethyl alcohol.
Nathaniel Willyforth - Mon, 17 Jun 2019 00:16:24 EST zI3IcHAm No.281803 Reply
hand sanitizer is objectively healthier for you to drink than mouthwash
Augustus Fubblestire - Mon, 17 Jun 2019 19:00:17 EST RGP4fCF6 No.281812 Reply

Ah, the sweet burn of menthol pouring through your dick. It's a pleasure few but the finest of men will get to enjoy.


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- Sat, 15 Jun 2019 15:31:06 EST xsYfJtO0 No.281795
File: 1560627066108.jpg -(88586B / 86.51KB, 640x956) Thumbnail displayed, click image for full size. OUZU MIXER
I want to mix someting with this shitty liquor, any suggestions?
Phoebe Docklesidge - Sat, 15 Jun 2019 16:29:18 EST qaXDnq5c No.281796 Reply

try to mix it with cold water with a very small amount of added sugar or honey.

ouzo is very similar to absynthe, and absynthe is usually mixed with cold water poured on sugar. it is usually mixed to 10% alcohol.

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