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420chan is Getting Overhauled - Changelog/Bug Report/Request Thread (Updated July 26)

Serotonins

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- Sun, 14 Jul 2019 00:37:42 EST 2+BQSKIL No.226988
File: 1563079062126.jpg -(41385B / 40.42KB, 426x320) Thumbnail displayed, click image for full size. Serotonins
I've read around here and other places that mdma is horrible for your brain, but other psychedelics are ok and safe? What do they mean by this? Don't shrooms/lsd do pretty much the same thing? Isn't pic related the consequence of both mdma and other psychedelics?
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Captain Misterbear - Sun, 14 Jul 2019 06:56:35 EST R9Tv5m+s No.226989 Reply
>>226988
Well I don't know anything about neuroscience, but I do know this: I've done MDMA a handful of times, and if that's what my serotonin presence (whatever that actually means) looked like two weeks later, I couldn't tell the difference.
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Simon Nunnerlerk - Sun, 14 Jul 2019 07:13:10 EST VjuI6T+y No.226990 Reply
1563102790903.gif -(1801102B / 1.72MB, 687x500) Thumbnail displayed, click image for full size.
>>226988
I think this image was debunked as a hoax, but don't have a sauce so can't tell you for sure, if I find it I will send.

Psychedelics do not cause your serotonin levels to change "directly", as far as I know they only bind to the serotonin receptors, but don't interact with the "mechanisms" that can change serotonin levels.

MDMA on the other hand does cause a release of serotonin and can cause the average levels in your brain to drop afterwards, BUT how much exactly I don't think is known and it can be a lot but only with massive dosages and even then I don't think it won't recover for 7 fucking years that just seems stupid. MDMA abuse does cause long-term effects but most people do recover and most say that after a couple of weeks they are pretty much back to baseline. And for those that don't recover for that time, I'm not sure, I haven't looked that much into it nor have I experienced severe long lasting effects.
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Matilda Bremmerken - Mon, 15 Jul 2019 01:46:56 EST lV+Bd9GH No.226995 Reply
>>226990
I dunno about the OP image either but here is a relevant study. Keep in mind though it's only one study on rats.

>For example, in the frontal cortex, specific binding of [125I]MIL was decreased by 80% at 6 hr and by 62% at 24 hr, after cessation of treatment with MDMA. Twenty-one days after administration of MDMA however, the number of binding sites for [125I]MIL was back to control levels.

https://www.sciencedirect.com/science/article/pii/002839089290126A
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Nathaniel Pockwill - Mon, 15 Jul 2019 06:32:41 EST mEFmBgXS No.226997 Reply
>>226995
>The MDMA (8 doses; 5–20 mg/kg each) was administered to rats over a period of 4 days.
Aren't these high doses?
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Edwin Suttingwater - Thu, 18 Jul 2019 15:13:25 EST r9gQldfE No.227007 Reply
>>226997
For 75kg (my weight), that would be between 375mg and 1500mg, two times per day, for 4 days !! Extremely high dose for me. Last time i did 300mg I was way too high haha.
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Hamilton Fidgefoot - Tue, 06 Aug 2019 20:54:56 EST 89cQmojl No.227052 Reply
>>226988
MDMA is a phenthylamine, meanwhile psychedelics like lsd and shrooms are triptamines. They affect the brain totally different
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Eliza Fuckingway - Thu, 15 Aug 2019 10:03:36 EST p6aNiiBb No.227070 Reply
I've only done MDMA once, but from what I'm reading in this thread, that is pretty clearly the result of MDMA abuse/misuse. Given that the rats were dosed extremely heavily, and multiple times over a period of 4 days (anyone in their right mind would dose once and then let the brain recuperate) it's safe to assume that it has very little to do with what the actual effects of MDMA are on the recreational users mind, and more to do with what happens when you overload the brain. A similar thing would happen from heavy binge use of meth, I'd imagine.
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Isabella Grandfoot - Thu, 15 Aug 2019 21:11:45 EST seksLn6z No.227072 Reply
>>227052
Mescaline is a phenylethylamine too and so are many other psychedelics as well.
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Hedda Closslebutch - Sat, 17 Aug 2019 05:41:59 EST QCF4UURB No.227075 Reply
>>226997
Very high doses. The recommended dosage for "safe" usage of MDMA is 2mg per kg. If you follow that rule you're not likely to have a hang over.

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