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420chan is Getting Overhauled - Changelog/Bug Report/Request Thread (Updated July 26)

Psychotic thought that the schizo-gene shared is trial/error adaptation

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- Sun, 15 Apr 2018 03:20:09 EST dSA4F4Wp No.55373
File: 1523776809371.jpg -(42378B / 41.38KB, 540x304) Thumbnail displayed, click image for full size. Psychotic thought that the schizo-gene shared is trial/error adaptation
Any brain scientists, Psych doctors and DNA coders lurking humor this thought?


I'm schizophrenic in midst of psychosis, I've believed to have figured out from a binge watch on schizophrenia docs i've used as white noise, that i've mapped out the cause of schizophrenia

In the part of the brain where the input/output ratio is processed. out processors send out mixed signals causing us to chain into constant misunderstood {cause} = misfired {effect} (causing a blunt affect too)
I think the gene that causes that misfire of reactions to one's perception is the trial and error program written into our DNA meant to test adaptability by making it so that one's perception and cognitive reaction to be mixed matched from each other in order to promote adaptability to unplanned reactions. it's a survival tool gone....insane
>>
A_Wizard !cMZsY.BCnU!!vVWR8L52 - Mon, 16 Apr 2018 02:48:09 EST p98oIwAn No.55375 Reply
>>55373
That's a sound theory, though I can't test the DNA aspect myself. I'm too high and tired to really aid you directly at the moment, but I will suggest reading some classic texts that give good examples of thought analysis. http://www.sacred-texts.com/cla/plato/apology.htm
Also, by tracing your thoughts back to their origin, periodically throughout the day (especially when a thought seems weird), the practice will help you understand the methods involved in the thought processes as well as make you more consciously aware of them. This in turn will help get onto a path where you will learn to script your own thought processes and turn on and off various processes or throttle sensory input, as to allow better processing.
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Fucking Nummerstork - Tue, 17 Apr 2018 05:44:17 EST seInJVW2 No.55377 Reply
>where the input/output ratio is processed

Glutaminergic signalling

>In order to support the localization hypothesis, it would be necessary to show differing cellular signaling pathways are activated by NMDA receptors based on its location within the cell membrane.[39] Experiments have been designed to stimulate either synaptic or non-synaptic NMDA receptors exclusively. These types of experiments have shown that different pathways are being activated or regulated depending on the location of the signal origin.[44] Many of these pathways use the same protein signals, but are regulated oppositely by NMDARs depending on its location. For example, synaptic NMDA excitation caused a decrease in the intracellular concentration of p38 mitogen-activated protein kinase (p38MAPK). Extrasynaptic stimulation NMDARs regulated p38MAPK in the opposite fashion, causing an increase in intracellular concentration.[45][46] Experiments of this type have since been repeated with the results indicating these differences stretch across many pathways linked to cell survival and excitotoxicity.[39]

>out processors send out mixed signals causing us to chain into constant misunderstood {cause} = misfired {effect} (causing a blunt affect too)

Breakdown of the kynurenine pathway of tryptophan's metabolism.

>A recent study shows that a genetic variation resulting in decreased expression of SNX7 is linked to increased central levels of kynurenic acid and ultimately to psychosis and cognitive dysfunction in bipolar disorder

>We conducted a genome-wide association study (GWAS) against CSF levels of KYNA in BD that revealed a genome-wide significant association with the single-nucleotide polymorphism (SNP) rs10158645 within 1p21.3, a finding that was replicated in an independent cohort of BD patients.

>I think the gene that causes that misfire of reactions to one's perception is the trial and error program written into our DNA meant to test adaptability by making it so that one's perception and cognitive reaction to be mixed matched from each other in order to promote adaptability to unplanned reactions.

>Research is done on 10–12 genes on 1q21.1 that produce DUF1220-locations. DUF1220 is an unknown protein, which is active in the neurons of the brain near the neocortex. Based on research on apes and other mammals, it is assumed that DUF1220 is related to cognitive development (man: 212 locations; chimpanzee: 37 locations; monkey: 30 locations; mouse: 1 location). It appears that the DUF1220-locations on 1q21.1 are in areas that are related to the size and the development of the brain. The aspect of the size and development of the brain is related to enthusiasm (macrocephaly) and schizophrenia (microcephaly). It has been proposed that a deletion or duplication of a gene that produces DUF1220-areas might cause growth and development disorders in the brain [12]

>Results of this research demonstrate that DUF1220 copy number is linearly associated with increased cognitive function as measured by total IQ and mathematical aptitude scores, a finding identified in two independent populations.[13][19]. This association has important implications for understanding the interplay between cognitive function and enthusiasm phenotypes.[20] These findings also provide additional support for the involvement of DUF1220 in a genomic trade-off model involving the human brain: the same key genes that have been major contributors to the evolutionary expansion of the human brain and human cognitive capacity may also, in different combinations, underlie psychiatric disorders such as enthusiasm and schizophrenia. [14]

1p21 variations leading to underactive NMDAR activity triggering a build up of toxic tryptophan byproducts that permanently inhibit the NMDA receptors affixed to dopamine neurons which leads to hyperfiring of dopamine neurons and the positive syndrome of psychosis (also implicated in affective disorders). Chronic disinhibition of glutaminergic firing leads to negative syndrome. The brain attempts to correct for this by elevating levels of kynurenic acid as kynurenic acid is neuroprotective but it cannot correct for terminal endings that have already been damaged which is why intervention during the first episode of psychosis is so conductive to good functioning. The more one stays in the psychotic state the more damage is inflicted upon the NMDA and thus the more one enters further psychosis …
Comment too long. Click here to view the full text.

Ulnar Nerve Subluxation

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- Sat, 07 Apr 2018 07:22:27 EST uuH5zaLD No.55364
File: 1523100147093.jpg -(8922B / 8.71KB, 302x225) Thumbnail displayed, click image for full size. Ulnar Nerve Subluxation
Hey people,
I have ulnar nerve subluxation on both arm (and probably on most nerves crossing joints) but i want to lift weights. Will it damage my nerve?
Basically my nerve pops out when i angle my arm, this causes it to friction with the bone.
3 posts omitted. Click View Thread to read.
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Emma Brettingville - Thu, 12 Apr 2018 05:33:17 EST uuH5zaLD No.55370 Reply
All right, i made an appointment with another doctor tomorrow. The first one diagnosed me but was focused on telling me not to do things i wouldn't do already rather than telling me useful information so i became skeptical. I think it's time to try another.

>>55369
Yeah, i'll do stretches and warmups, i didn't feel pain but stiffness when i did what you told me. I'm hoping for the best.
Thanks.
>>
Edward Honeywell - Fri, 13 Apr 2018 13:00:52 EST uuH5zaLD No.55371 Reply
The doctor it might be either the nerve or a tendon and that as of right now there is no problem and it doesn't seem there'll be; if it starts to hurt then i should come back.
That's reassuring because i wasn't very trusting of the first one as he wasn't answering my questions directly.
>>
Rebecca Bemmlewill - Sat, 14 Apr 2018 19:40:27 EST r1Y31/eq No.55372 Reply
>>55368

google the muscles that i specifically named for you and apply heat and pressure to them. if this is too hard then you deserve to suffer.

Dissection Thread

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- Wed, 11 Apr 2018 00:00:53 EST r1Y31/eq No.55367
File: 1523419253230.jpg -(36535B / 35.68KB, 500x375) Thumbnail displayed, click image for full size. Dissection Thread
Post what you have dissected!

In high school I dissected a frog. Still remember that feeling of the sternum cracking under the blade, wasn't too pleasant. In anatomy courses I dissected a sheep eyeball, brain, and heart, a pig kidney, and some parts of human cadavers - intestines, some muscles, and liver. Funny thing about human muscles is they look just like any other meat, chicken, beef, whatever.

Anyone ever entered CR?

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- Fri, 06 Apr 2018 14:52:22 EST P2ySTAQi No.55361
File: 1523040742571.jpg -(62178B / 60.72KB, 487x630) Thumbnail displayed, click image for full size. Anyone ever entered CR?
Hey /med/ I think i need some advice

Long story short, I recently entered into clinical research from a
nom-science discipline, through a combination of luck and an obsession with pharmacology.

I understand how lucky I am to have even got my foot in the door and want to ensure continued success.

I'm networking and working my ass off, but I don't want to fall behind on my personal med knowledge, amd want to gain a better understanding of the admistrative and operational aspects of research and hospital admin as a whole.

Anyone have any suggestuons for literature, best practices, tools, etc? Or transferred into a healthbscience field from a different profession?
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A_Wizard !cMZsY.BCnU!!vVWR8L52 - Fri, 06 Apr 2018 15:31:54 EST p98oIwAn No.55362 Reply
>>55361
Read the classics if you want an edge over your peers. Universities completely ignore classical works. I've found many novel constituents and uses of plants and other practices that could have real medical value, that have been entirely ignored because of the snooty attitudes produced by the modern medical community, and due to the nature of overspecialization leading to people not understanding or scoffing at classical terms. Like how everyone sees mercury in an old text and goes "THE FOOLS! Those dark age idiots!" and then fails to comprehend that MERCURY IS A SOLVENT (IE it's used to extract compounds in drug manufacturing, not the drug it's self.) and that the authors of books often put the fine details in code lurking in the drawings and margins due to the lack of copyright protections before the modern era, ensuring that only their own guild/students would understand the codes in the texts while the douchebags would just poison themselves.

Do you take the 'lttle' drugs

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- Tue, 13 Mar 2018 05:00:35 EST AzZIuaNf No.55324
File: 1520931635964.jpg -(218197B / 213.08KB, 817x880) Thumbnail displayed, click image for full size. Do you take the 'lttle' drugs
like painkillers for headaches, sleeping pills for sleeping, antihistamines for allergies etc

I wonder if all that shit will add up in the end and contribute to dementia or something.
3 posts omitted. Click View Thread to read.
>>
A_Wizard !cMZsY.BCnU!!vVWR8L52 - Wed, 04 Apr 2018 16:58:29 EST p98oIwAn No.55358 Reply
>>55325
This. ibuprofen is a bigger health hazard than taking a puff of weed or eating some akuamma seeds.
>>
A_Wizard !cMZsY.BCnU!!vVWR8L52 - Fri, 06 Apr 2018 03:33:16 EST p98oIwAn No.55360 Reply
>>55325
>ibuprofin least harmful
Despite it causing stomach, liver (it was the liver, right?), and central nervous system issues? Admittedly, this is in high quantities or with sustained issues, but ibuprofin is fucking brutal. I'm confident that it's the leading cause of many health issues had by US veterans after they get out, since the military's answer to every medical problem is "Drink a gallon of water and take a gram of ibuprofin every two hours"
>>
Reuben Fimmlefoot - Sat, 07 Apr 2018 03:06:10 EST seInJVW2 No.55363 Reply
>>55360
All NSAIDs do that and opiates as well (do not let /opi/ tell you shit about the long-term physical effects of opiates because they don't know fuck all). Acetaminophen would be preferable if not for liver damage, as it does not pose risk to cardiovascular function save a temporary increase in BP. There's really no good options here. The best in terms of side effect profile is the endocannabinoid modulator, and this might be the future direction painkiller R&D goes down since it seems to come with the least generalized risk.

Minoxidil for Beard Growth

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- Thu, 29 Mar 2018 21:47:55 EST YMKwUJrh No.55350
File: 1522374475658.jpg -(22093B / 21.58KB, 201x249) Thumbnail displayed, click image for full size. Minoxidil for Beard Growth
This isn’t a real medical or health condition, but has anyone tried Minoxidil for growing fuller facial hair? It’s the chemical in Rogaine.

I used the 2% solution regularly for a few months last year and saw some results but not much. Now I’ve decided to give 5% a go and have noticed some results within a couple weeks. I’ve never been able to grow much facial hair so kind of excited but I’m not holding my breath. I believe it only works for half of participants.

Minoxidil for Beard Growth

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- Thu, 29 Mar 2018 21:47:55 EST YMKwUJrh No.55351
File: 1522374475658.jpg -(22093B / 21.58KB, 201x249) Thumbnail displayed, click image for full size. Minoxidil for Beard Growth
This isn’t a real medical or health condition, but has anyone tried Minoxidil for growing fuller facial hair? It’s the chemical in Rogaine.

I used the 2% solution regularly for a few months last year and saw some results but not much. Now I’ve decided to give 5% a go and have noticed some results within a couple weeks. I’ve never been able to grow much facial hair so kind of excited but I’m not holding my breath. I believe it only works for half of participants.

Can too much ejaculate be a health issue?

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- Thu, 15 Mar 2018 20:24:01 EST j3a9CZT/ No.55330
File: 1521159841543.jpg -(19885B / 19.42KB, 355x342) Thumbnail displayed, click image for full size. Can too much ejaculate be a health issue?
So basically, I've been told by a lot of women that I ejaculate A LOT. However, when I'd ever masturbate, I'd observe a normal amount. Until I did it with blue balls. Essentially had to stop having fun due to go getting called into work. I had enough pain I had to do something (couldn't even walk normally). So I masturbated, and holy fuck shit. It pooled enough it was spilling onto the floor, and I had a sort of barely on faucet effect. I'm being very serious when I say it could have been close to 10-15 Tablespoons.
Now, at first it was the most amazing experience me and Handgela shared. But could this be a downside? I'm thinking of asking my doctor. But I'd rather get advice here before I have an awkward candid talk with him.
3 posts omitted. Click View Thread to read.
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George Drummlehare - Tue, 27 Mar 2018 20:07:35 EST r1Y31/eq No.55347 Reply
>>55339

OP came all the fluids in his body and died of hypovolemic shock. RIP OP.
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A_Wizard !cMZsY.BCnU!!vVWR8L52 - Thu, 29 Mar 2018 06:00:05 EST p98oIwAn No.55348 Reply
>>55347
Just don't tell /x/ or /fringe/ or even /spooky/... they'll take this as proof their succubus waifu is real.
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Edwin Battingham - Thu, 29 Mar 2018 08:14:28 EST BsYoKso+ No.55349 Reply
1522325668694.gif -(1298589B / 1.24MB, 232x255) Thumbnail displayed, click image for full size.
I dont feel like making my own thread considering my problem is also about masturbation and ejaculate.
I couldn't cum a couple times with my last girl and the only time i did was by jacking it. I guess it's
>Delayed ejaculation, also sometimes called impaired or
>retarded ejaculation,
>a condition in which a man can get an erection, but he can't ejaculate easily, so it takes an abnormally long time for him to climax and ejaculate

how long do i have to abstain from masturbation till i can cum with a girl like normal again?

Strokes

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- Wed, 07 Feb 2018 10:29:34 EST sSTCyv07 No.55276
File: 1518017374936.jpg -(3150B / 3.08KB, 343x147) Thumbnail displayed, click image for full size. Strokes
Air bubbles and dissolved air in fluids in IV bags,tubes and syringes is being injected into people.Strokes and deaths.
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Sophie Brellerfield - Thu, 15 Mar 2018 16:42:44 EST 0qXj9EJp No.55329 Reply
"dissolved air in fluids"

Skin Infection and Medical Record Concerns

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- Thu, 08 Mar 2018 07:20:28 EST 78nI8+8A No.55321
File: 1520511628540.png -(91278B / 89.14KB, 600x500) Thumbnail displayed, click image for full size. Skin Infection and Medical Record Concerns
25 year old male. 3 or 4 days ago I noticed a couple infected looking hair pores in the right of my groin where it meets the hip joint, behind the testicles off to the side and away from the anal region. Sensitive, but I washed myself down good in the shower and kept up hygiene, things seemed to be improving.

Forgot to shower last night, then when I went to a little bit ago it'd enlarged to a region about 3.5" long and 1" wide at the widest point. Skin is peeling back, but no bleeding. Washed it out gently but thoroughly with warm soapy water, but it stung like a mofo.
It's been roughly 4 months since I've had sex, so I'm pretty sure it's not that. I can include a picture if needed.

No fever, pain, or swelling of the extremities around the infected tissue at the moment.

I haven't been to a doctor in nearly 4 years though. Is it something I need to go to Urgent Care for, or is it safe to find GP and wait on an appointment from them? I'm still on my parents' health insurance which is pretty decent through WA state, but I don't want to waste the UC's time or my money if I don't have to. I'm just shocked how quickly it progressed from a relatively small reddish region to basically a full force peeling sun burn.

Other than immediate concern for my condition, I'm worried about being honest about my drug use and being labeled as a drugseeker when that's legitimately not my intention. I stopped a moderate 2 year kratom habit a week and a half ago, but goofed yesterday and took 40mg of hydrocodone. I'm really concerned about either not getting proper attention/treatment because of it, or getting something put in my record that would stop me from getting medication if I shatter my back in a car wreck etc.
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Shitting Winkinwock - Thu, 08 Mar 2018 16:37:35 EST QeaRzyVE No.55322 Reply
could be an allergic reaction. changed soaps/detergents/cleaning products/dryer sheets lately? or move/visit a new location?

also its extremely unlikely but it is possible to pick up an STI from a public restroom, can you recall using one before the onset of all this?
>>
A_Wizard !cMZsY.BCnU!!vVWR8L52 - Fri, 09 Mar 2018 03:46:03 EST p98oIwAn No.55323 Reply
>>55321
Try an anti-fungal treatment. Either something OTC or even some thyme oil. (or be a man and pour some strega on your groin.) This is a region that is likely to have more moisture regularly and as such would be more prone to fungal infection.
>washing
What type of soaps are you using? Also did you change clothes soap recently? If the PH of your skin has been messed up, it can make you more prone to fungal infection.
>worried about doc calling out being a fiend
Dude, you're seeing somebody about a skin problem on your groin. Who the hell does drugs through their groin anymore? I'm a fucking Wizard and I hardly even rub datura salve on my balls, so the odds of a doc making that connection are unlikely. You're overreacting.

Anyhow, is there swelling? Is there puss? Are there signs of ulceration? If not, odds are that this is fungal and not bacterial (fungal infections can happen immediately after bacterial ones though, if conditions are right and you broke the skin dealing with the bacterial infection, and likewise scratching fungal infections can lead to bacterial ones) so give it a cream and see if it gets better, while watching it regularly. This is a horrible spot for a bad infection as it's a sensitive area next to major arteries and your balls, so do not hesitate to go to a doctor if you see this spreading. Just get some antifungal cream though, ok?

Non Genital Skin To Skin Contact

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- Tue, 06 Mar 2018 17:45:52 EST K6zlkMOD No.55318
File: 1520376352675.jpg -(666289B / 650.67KB, 2576x1932) Thumbnail displayed, click image for full size. Non Genital Skin To Skin Contact
Hey guys,

I don't know if this a stupid question or not but I'd really appreciate a serious answer from any nurse or someone with medical knowledge. This girl was on top of me the other day and I was wearing underwear and pants and she was wearing short shorts but her thighs were rubbing on my stomach. Her genitals were completely covered. Is there any risk of STD with this kind of exposure?
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Phyllis Bipperville - Thu, 08 Mar 2018 05:47:22 EST GqRhjkaH No.55320 Reply
This website might help you out with some issues in the future.

beforeplay. org/stds/

It has a STD list, some info about them i ngeneral and is easy to use.

Hope this helps.

HOLY FUCKING SHIT MY FUCKING TOOTH HURTS LIKE FUCK

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- Mon, 26 Feb 2018 19:42:59 EST G8pwd9mR No.55314
File: 1519692179856.jpg -(62545B / 61.08KB, 813x668) Thumbnail displayed, click image for full size. HOLY FUCKING SHIT MY FUCKING TOOTH HURTS LIKE FUCK
...and I have no dental insurance nor $1k+ to throw at a dentist to fix it. The cotton ball trick doesn't work worth a shit. Warm salt water doesn't work worth a shit. OTC pain killers don't work worth a shit. Anbesol doesn't work worth a shit. Opis don't even work worth a shit. I am open to literally any suggestion here.
>>
Nell Pavingput - Mon, 26 Feb 2018 22:56:55 EST LXU7OMKO No.55315 Reply
>>55314
In the US, seek medicaid. They should allow you some sort of emergency request even after if you went to an ER.
Do it with your states medicaid. Call the medicaid line, wait wait wait. Look it up online first for emergency medicaid
so you don't your credit screwed up.

Medicaid, if you do not make enough money, freaking get it. Find a primary care DR practice that accepts medicaid.

Will save anybodys ass if something happens. Urgent care centers accept it. You would be essentialy insured, so no, I don't have insurance. It's basically right there. Go to an ER if you cannot hack it. State hospitals have 'generally' dental
days. Low income. Like tuesdays wednesdays, arrive early. Research and get it done in whatever manner.

As for opis, try with some antihistimine. Like generic benedryl, diphenhydramine 50 mgs. Sold as nightime sleep aid.
Dollar stores have these. Take like like 400 600 miligrams of ibuprophen would compliment these. As for the otc I would exceed 50 mgs of diphen and not hight that 800 mgs. Together these should work for pain safely.
>>
Walter Pockridge - Thu, 01 Mar 2018 18:09:59 EST QeaRzyVE No.55316 Reply
lol me too brother. right now i am focusing my willpower to not grimace or cringe from the waves of pain. my last wisdom tooth is making a final push up through the gum and the whole gum area is swollen and in a lot of pain as it is slowly carved out of the way. for self dental care tutorial i recommend Castaway
>>
A_Wizard !cMZsY.BCnU!!vVWR8L52 - Tue, 06 Mar 2018 01:12:15 EST p98oIwAn No.55317 Reply
>>55314
A mixture of Clove oil and Cocaine will numb that tooth right up. If you're looking to try something experimental to fix the tooth though, then I suggest cleaning it out the best you can and then taking a small sponge made of collagen that is saturated in Tideglusib and insert it into the hole of the tooth. It should repair the dentin, though you'll still have to kill the infection.

Skin Tag

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- Wed, 21 Feb 2018 18:55:14 EST VXqHEcZY No.55305
File: 1519257314387.jpg -(648957B / 633.75KB, 2576x1932) Thumbnail displayed, click image for full size. Skin Tag
Hi /med/,

I would really appreciate some sound medical advice from any nurse, med student, or doctor that happens to be scrolling these boards. Also some anxiety tips. So I'm terrified of getting an STD. Everytime I sleep with someone I'm miserable until I get my 12 week test results for everything including both types of herpes, which people usually don't even test for. I'm a 20 year old white male and was vaccinated for HPV when I was 18. Every red bump i get down there I go to my dermatologist and he tells me its nothing. Recently i discovered a white bump that looked like a wart to me where my shaft meets my scrotum and i freaked out. I went to the dermatologist the next day and he looked at it and called it a skin tag and froze it off. I asked him if it was HPV related and he said no and that they are caused by rubbing of the skin. I can't convince myself that its nothing to worry about. What do i do? Anybody else have these?
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Phyllis Buzzlock - Thu, 22 Feb 2018 00:12:17 EST IkIWMEs1 No.55306 Reply
none of that will kill you. abstinence will prevent stds. monogamy greatly reduces risk as well. if those aren't options, I recommend honest conversations with your partners and use of condoms. Other things to consider are hygene, do you shower often? after sex? do you wear clean underwear? do you keep it dry down there? are you allergic to latex in condoms?
Your pic is useless, but better than having to see your penis in the OP
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Rebecca Fundlefuck - Sat, 24 Feb 2018 09:29:43 EST 9N6CscSU No.55310 Reply
>>55305
Skin tags are a sign of insulin resistance. Simple.
Fix your blood sugar.

sharp but short, or dull non-stop

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- Thu, 15 Feb 2018 04:01:47 EST MYOnmTRH No.55287
File: 1518685307630.png -(249025B / 243.19KB, 444x307) Thumbnail displayed, click image for full size. sharp but short, or dull non-stop
Which is a sign of something worse, a sharp but short-lasting pain that only repeats rarely, or a mild pain but its always there?
>>
Alice Maddledit - Thu, 15 Feb 2018 18:38:04 EST 5pY0vFQs No.55288 Reply
this is a dumb question with no meaningful answer as every situation is completely dependent on context.
>>
Phyllis Buzzlock - Thu, 22 Feb 2018 00:15:55 EST IkIWMEs1 No.55308 Reply
That rotten tooth has to come out.

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