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Opiate usage worsen natural endorphins

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- Fri, 14 Aug 2020 04:21:47 EST 7h33oZRL No.616764
File: 1597393307705.png -(837268B / 817.64KB, 768x512) Thumbnail displayed, click image for full size. Opiate usage worsen natural endorphins
is it True that opioid/opiate usage reduce the quality of the natural endorphins/opioids in the brain? (mostly kratom usage not the pills) or is this just propaganda?

Also using this analogy for benzo/gaba substances, does long-term benzo usage reduce the quality of the natural "gaba signal" ... (if you Know what Im Trying to say...) or is this only the case for opioids/opiates like heroin where ones natural endorphins 'stop being used' since now the heroin is the main source for it ...

but is it just propaganda that the natural endorphins get worse with opiate addiction or is it true.. and is there a good source showing all the facts about this.

When/how long are the natural endorphins restored then when quitting those opioid drugs ?
8 posts and 2 images omitted. Click View Thread to read.
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Emma Focklechutch - Fri, 14 Aug 2020 17:01:48 EST 5W6KIQkA No.616776 Reply
1597438908809.jpg -(20357B / 19.88KB, 247x232) Thumbnail displayed, click image for full size.
>>616775
No, he absolutely stated that opiates create new endorphin receptors which is total bullshit, while only providing a lousy wiki link about abstractely related stuff.

Retard alert

Retard alert
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Reuben Cottingdale - Fri, 14 Aug 2020 22:28:10 EST 29QbCoeq No.616780 Reply
1597458490351.jpg -(75890B / 74.11KB, 863x767) Thumbnail displayed, click image for full size.
>>616776
wiki link not "ME"

Wasn't going to reply again but Dr M doesn't even know this?? tho bless him for pimping uldn
https://www.wisegeek.com/what-are-opiate-receptors.htm
Are you so dense you can't search this or are you some porky queer who needs everything delivered ?

Mind you the notion that drugs work on 'receptors' is entirely a THEORY, inb4 muh science theater 9000
>>
Priscilla Worthingwell - Sat, 15 Aug 2020 06:03:11 EST gJiH/Sd8 No.616784 Reply
receptor desensitizing in regards to Benzo/gaba substances, how does long-term use of benzo worsen the natural receptor bullshit. applying "receptor desensitizing" to benzo (instead of opiates), what receptors would get affected and how would normal receptor become worse due to external influence to the gaba receptors?

What withdrawal / addiction is worse, long-term benzo or say tramadol/subutex use?

few suboxone pill questions (absorbption + generic vs namebrand)

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- Sat, 15 Aug 2020 04:21:58 EST LGJPOwWg No.616783
File: 1597479718513.png -(37589B / 36.71KB, 229x127) Thumbnail displayed, click image for full size. few suboxone pill questions (absorbption + generic vs namebrand)
greetings all, i recently got on suboxone in Canada and have only tried these pic related generic ones, my dose has been slowly increasing to find the right amount, tried 8 to 12 to 16 now at 20mg, ive also tried 24mg total twice

1) any legit tricks for increasing absorption / trying to catch more of a buzz for the sublingual pills not strips? ive heard about the high alcohol mouthwash beforehand but not sure if thats just for strips and if it even works or not, wondering about opinions and other methods

2) how about crushing the pills up into powder and putting under tongue? does this tamper with any mechanisms like the nalaxone within? will it absorb / hit faster resulting in any more of a buzz or will it be about the same as not crushing at all

3) opinions about generic vs namebrand suboxones? ive heard of some people saying they have a better high experience with namebrands of lots of different drugs.. could be bias or in imagination sometimes but i def believe there can be a difference especially from person to person. also heard that some people feel they can take a way lower dose of namebrand to get the same feel well resulting in needing less of a script

thank you

AUS DHC

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- Sat, 15 Aug 2020 00:41:14 EST 29QbCoeq No.616781
File: 1597466474351.jpg -(56337B / 55.02KB, 468x384) Thumbnail displayed, click image for full size. AUS DHC
Hi, I am aware dihydrocodeine and other once otc opis are no longer otc, but still sold at pharmacists digression. Anyone in aus know what to say to get some? I am trying to help my young friend across the world. He needs to experience the wellness and confidence of opiates.
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Zozyman - Sat, 15 Aug 2020 01:55:50 EST ijHX005W No.616782 Reply
>>616781
I mean I just walk in and ask for the Rikodine, sometimes I just full on ask for it and be like "yeah it's for my pertussis / bronchiectasis" and that works like a charm. Same with if you find a doctor who's chill you can just ask them to give you a script "because the pharmacist reqested one, even though it's still OTC"

Just FYI DHC *IS* still OTC in AUS, some pharmasits just say it's prescription so they don't have to deal with junkies, but most will either just give you the shit or ask a couple basic questions as to why you want/need it. Maybe what you've tried before.

Just be like "I used it before, it's the only thing that helps with X. Tried, what was it, robotussin, the dxm stuff? Yeah, just made me feel funny and only helped a bit." <Actual line I used and got DPH only last week.

need help

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- Thu, 13 Aug 2020 21:02:23 EST G40t8EkM No.616760
File: 1597366943040.jpg -(2920302B / 2.79MB, 4032x2268) Thumbnail displayed, click image for full size. need help
stuck in plumas county and NEED OPIATES
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Cornelius Dogglecocke - Thu, 13 Aug 2020 23:39:50 EST qIwULXln No.616762 Reply
>>616760
Lmao what is your plan here? Assuming you even find someone on /opi/ that is in Plumas. They're not gonna serve or middle man a total strange. So here are your options if you're dopesick:
A.) Kratom
B.) Go get that shitty 70mg dose of Methadone they give you when you start at the methadone clinic
C.) Loperamide
D.) Poppy seeds maybe??
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Reuben Cottingdale - Fri, 14 Aug 2020 22:19:34 EST 29QbCoeq No.616779 Reply
LOPE or Kratom Extracts ez
seeds if youre a gambling man and like bad bets

What got you into opiates?

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- Mon, 27 Jul 2020 19:14:00 EST 3CyRQAPg No.616438
File: 1595891640431.jpg -(34373B / 33.57KB, 425x567) Thumbnail displayed, click image for full size. What got you into opiates?
Idk im fuckin bored talk to me
16 posts and 3 images omitted. Click View Thread to read.
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Angus Bipperlidge - Thu, 13 Aug 2020 01:26:52 EST iVtQ3HeV No.616754 Reply
1597296412073.jpg -(803337B / 784.51KB, 1361x2040) Thumbnail displayed, click image for full size.
My friends would get narcos and I was never into opiates. Few years later My friend introduced me to Oxys and I fell in love with opiates. He then introduced me to heroin. All this was going on while the friends that were doing narcos ended up shooting dope. Ironically I rarely used with those guys as they were balls deep in that dope game and I was more of a novice. Sadly the bod who introduced me to oxy and heroin just passed from an OD
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Cornelius Dogglecocke - Fri, 14 Aug 2020 09:15:29 EST qIwULXln No.616768 Reply
>>616742
This was my story except i got busted stealing from work
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Lydia Duckville - Fri, 14 Aug 2020 18:14:50 EST UxKGNDPm No.616777 Reply
>>616438

I currently don't take any Opiates, but, 5 years ago I heavily used Opium Poppy pods. Which contains the opiates Morphine, Codeine, and at lower concentrations Thebaine and Oripavine. I got much pleasure out if it, especially combining it with various different stimulants.

Nothing like a stimulant/opiate speedballl. I would grind up the pods and their stems in a blender until it was a fine sawdust powder. I'd then mix it with water and lemon juice, ingesting all the plant material for optimum effects. I miss it.

I first took opiates when I was 15. (50mg of Hydrocodone with Cannabis.) I'm 25 as of now. Currently using Weed and amphetamine. Opiates are pharmacologically one of the most euphoric classes of drug, I think that's what got me into it.

Low dose suboxone in a non-dependant person

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- Thu, 13 Aug 2020 22:43:49 EST eZLti/ZW No.616761
File: 1597373029536.jpg -(32109B / 31.36KB, 960x810) Thumbnail displayed, click image for full size. Low dose suboxone in a non-dependant person
if someone with a low tolerance whos currently not physically dependant on opiates doses, say, 1mg of Bupe intranasal, will the same individual be fucked if they want to do dope the next day? I know subs block most opiates, but im pretty sure thats dose dependant, right? And im not currently using enough to have been sick. Im just wondering if that will make a difference, cus im gonna be copping tomorrow and was hoping to do some maybe 12ish hours from now.

Tldr will one dose of 1mg nasal bupe block opiates the next day just like a normal dose? And does it Matter that im not dependant physically anymore (yet lol) because I feel like thats important to note
>>
Phineas Sondleman - Fri, 14 Aug 2020 14:20:00 EST 29QbCoeq No.616770 Reply
>>616761
Will probably make them less enjoyable. If you're getting good opis like real pills that will fuck you up i wouldnt take the bupe. if you have almost no tolerance 1mg might make you sick, i've seen no tolly people vomiting for hours from that, but you have probably have perma tolerance from the past

BWN Corona lock down edition

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- Thu, 26 Mar 2020 08:20:00 EST txpYQORe No.614404
File: 1585225200899.jpg -(151296B / 147.75KB, 800x540) Thumbnail displayed, click image for full size. BWN Corona lock down edition
Corona got us in self isolation but you know but I think d-boy counts as close family and friends, nah what I'm sayin? Juuuust kidding, though we know deep down we're gonna potentially risk our loved ones lives over an "unnecessary" break of iso.
That's enough negativity. Who's getting high on some opiates? Anyone have any interesting stories or antics to share?

Personally I'm bumping on some store bought Spanish seeds according to the label, I guess AUS truly ran out, these aren't half bad honestly but I'm also on a high dose of pregablin so who knows.
486 posts and 100 images omitted. Click View Thread to read.
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Phyllis Berrychog - Thu, 13 Aug 2020 18:10:04 EST WfZFyK5u No.616759 Reply
>>616738
I took 30mg methadone again today. I'm jamming to some psytrance at the moment. Wish I had some LSD so I could trip to this music.
>>
Blinkey Bill - Fri, 14 Aug 2020 01:25:36 EST tNQC2Ek5 No.616763 Reply
Any help distilling down pst / removing Actives? A pueification peocess that works ?
>>
Phineas Sondleman - Fri, 14 Aug 2020 05:09:47 EST 29QbCoeq No.616766 Reply
>>616763
yes but i dont know if I can share it in 42020chan big h era. its probably on plebbit. you need slaked lime for starters. You can pretty much get pure morphine with a lil codeine left. when mixed, it precipitates out freeze it, cut off ice with unwanted alkaloids, can refine it again. evaporate water in oven at low temp. never tried to inject it but you could seriously smoke it which was memorable.

PST to H (horrible idea?)

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- Tue, 11 Aug 2020 00:15:58 EST OHIHxMID No.616702
File: 1597119358297.gif -(4392261B / 4.19MB, 622x350) Thumbnail displayed, click image for full size. PST to H (horrible idea?)
For someone with a PST habbit how realistic is it that getting H would make things a lot easier in terms of coming off and WD. I know H will leave the body quicker and have heard people say PST WD is worse than H In terms of WD as PST has so many alkaloids and last so long but that’s just what I’ve read people say. No experience myself.

I realize a major problem would be the quality of the H and if it has fent and how much. I’m looking at the onion fields and reputable vendor has only amazing feedback w/ only comments saying it’s fent free but I’d still test it obviously.

Seeds are actually getting pretty strong again (best batches I’ve had since 2017 though not near that level this far surpassed anything since “seedpocalypse”. Absolutely able to nod off them.
5 posts omitted. Click View Thread to read.
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Sidney Soffingdale - Wed, 12 Aug 2020 11:13:06 EST OHIHxMID No.616734 Reply
>>616726
When you guys say 40+ days off this shit that’s just with a taper that leaves you able to function right? Did you guys ever try to CT the PST and how long did that take if so.
>>
m - Thu, 13 Aug 2020 07:16:42 EST jv0zZnW9 No.616757 Reply
>>616734

Back in the day when early Jan/Feb 2017 seeds went to shit (basically ~2-20% of previous potency for 3+ years), I pretty much CTed. The shipping delays back then could be 5-8 days, and 2-3 orders in a row were absolute garbage, like 10% or less of previous potency. So after so many bunk batches I basically CTed. This was back when seeds were proven to be ~1200-2788mg morphine per kg of seed, and I was probably taking like ~0.67-1.5lb/day depending on quality.

The acute stuff for me lasted a full 21 days minimum, meaning like 21 days of repeated binge vomiting, only "sleeping" 2-4hr total max during the first ~13.5 days of WD, absolutely horrible RLS that transformed into RArmS, constantly sweating myself and flu-like respiratory symptoms, etc. It's possible that symptoms didn't even peak/nearly peak until day ~4.5-6, so that 21 days might have been realistically more like ~16 or so days.

Then at around day ~21-25, I stopped vomiting every few hours and actually was sleeping at least 2-3 hours per night. There's absolutely no way on Earth I would have been presentable in a work environment until around day ~40-45, and even then I felt absolutely horrible.

That was without subs (until around day ~30-35), kratom, clonidine, ondansetron, gabapentinoids, or benzos/z-drugs though I think (just loperamide at max daily doses of ~12-18mg or so). I'd never go through that kind of bullshit ever again without most of what I just listed though.

If I had had that whole list (probably kratom > subs for PST wd since PWD still happens at day like 4.5-6 CT for me), or say benzos or gabapentinoids but not both, my WD would have probably been around ~67-85% less severe. Even without subs/kratom, those other meds would have made it well over 50% less shitty.

Omg did that experience tear me down as a person. My former spouse would always come home and find me puking in the bathroom. I basically lived in the super hot shower and just tried to meditate like the entire day lmao. Hot showers was the only way I was able to survive.

Fuck that shit. Never again. Sadly enough I still dream about PST/PPT though. It happened just a few days ago.

Trinity

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- Tue, 04 Aug 2020 13:49:19 EST YGxV6cEq No.616604
File: 1596563359864.png -(110602B / 108.01KB, 1366x768) Thumbnail displayed, click image for full size. Trinity
Trinity, 50 of oxy, two soma, 2.5 xanax bars and a dime of H plus a beer... Ain't nothin better accept Jesus of course. - BrU Not joking about Jesus!! THank God I am forgivin. tommarow suboxone and thats it!!!
12 posts and 1 images omitted. Click View Thread to read.
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Scourge of the West - Wed, 12 Aug 2020 15:19:15 EST v9rfRGO8 No.616745 Reply
1597259955447.png -(134801B / 131.64KB, 500x355) Thumbnail displayed, click image for full size.
>>616604
The origin trinity is what insurance companies drilled into the pharmacists heads to stop dispensing that combo so they didn't get a wrongful death suit. I've done it many times and it feels great but death is a possibility especially if you down a bottle as blackout is likely. Katz is also right as usual.
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Blinkey Bill - Wed, 12 Aug 2020 23:00:37 EST tNQC2Ek5 No.616752 Reply
>>616724
Huh ? Have you tried pregabalin ? Gabapentinoid are way different to benzo. Get out of town faggot

How Can i taper effectively?

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- Wed, 12 Aug 2020 18:49:22 EST qIwULXln No.616750
File: 1597272562408.png -(57507B / 56.16KB, 641x1000) Thumbnail displayed, click image for full size. How Can i taper effectively?
I'm a full blown IV Heroin addict. I've acquired 6 8mg suboxones. How can I utilize these to ease my withdrawals? Like what type of timeline should I go about dosing? I haven't shot up in about 2 days since I took a sub the yesterday and I sniffed a 30mg roxi today(which for me is a gigantic improvement considering what I typically do). How can I break these subs down effectively?
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Scourgeofthewest - Thu, 13 Aug 2020 00:03:17 EST WMgJh2mM No.616753 Reply
1597291397410.jpg -(33741B / 32.95KB, 600x400) Thumbnail displayed, click image for full size.
If you are full blown full blown you are just delaying the inevitable. I'd just wait as long as I could before it became unbearable then try taking maybe a quarter strip. Repeat until you go back to heroin.

Nobody quits until they're ready. From the way you say what your saying this isn't the end. This is a tolerance break. Which is fine. I went on lots of tolerance breaks I called quitting. I knew when I was really done.

It doesn't matter what I say. You will take all the subs in 5 or 6 days and when you can't stand it anymore the check comes and you get more dope.>>616750

opiates

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- Sat, 08 Aug 2020 03:22:29 EST iD1HI7Ht No.616654
File: 1596871349276.jpg -(39231B / 38.31KB, 1000x667) Thumbnail displayed, click image for full size. opiates
how bad is tramadol, honestly? it's all my plug can hook me up with. I've been thinking about snorting heroin again. Looking for advice.
7 posts omitted. Click View Thread to read.
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m - Wed, 12 Aug 2020 22:39:20 EST jv0zZnW9 No.616751 Reply
>>616740
Not true. Enzyme saturation is what you DO NOT want! You want as much clearance as possible, because O-DSMT is more potent, less stimmy/twichy, and much more euphoric than tramadol. You achieve a high proportion of O-DSMT by allowing as much clearance as possible.

Katz's suggestion is generally correct, and he's right in terms of those who for whatever reason can't be bothered staggering beyond 2 hours. However, if you don't mind the wait, I'd actually recommend staggered for closer to 3 hours before the ending "dump" dose.

The reason why a large dose at the end is superior is because long-term clearance is pretty good at 100mg/hr. Maybe at a 2hr time "limit" we could debate dump dosing at the beginning vs. the end, but when staggered out to ~3-3.5hr or so, "dump" dosing at the end is much, much better.
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John Dettingshit - Thu, 13 Aug 2020 13:42:33 EST 5W6KIQkA No.616758 Reply
>>616751
I pity you americans really, I just dump a 100mg ER every 3 hours until I can't resist sleep.

HELP ME I CANT SHIT!!!

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- Fri, 07 Aug 2020 19:44:06 EST UxKGNDPm No.616648
File: 1596843846775.jpg -(199575B / 194.90KB, 1200x1207) Thumbnail displayed, click image for full size. HELP ME I CANT SHIT!!!
oh my fucking goood. i took an oxy 80 with a low tolerance and now im extremely constipated and pissing blood!!! no urine is coming out.

what do i do? I CANT SHIT OUT MY ASS! I CANT SHIT OUT MY ASSSSS!!!!!!!!!!!
6 posts omitted. Click View Thread to read.
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Nicholas Fobberstone - Wed, 12 Aug 2020 15:30:54 EST sZkWkO8H No.616748 Reply
1597260654576.jpg -(63091B / 61.61KB, 568x1000) Thumbnail displayed, click image for full size.
Get an enema dumbass. One of those big super-hydrating ones.

Tilidine

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- Wed, 12 Aug 2020 15:27:37 EST iAluj6W/ No.616747
File: 1597260457449.jpg -(2196512B / 2.09MB, 4032x2268) Thumbnail displayed, click image for full size. Tilidine
Anyone of you guys get these where you live?
For the people who don't know, tilidine is basically codeine but is mostly a prodrug, it's usually combined with naloxone so it can't be injected/abused.
Just wanna know what people think of this type of pill.
I'm not a regular user so the naloxone is eliminated due to rapid first pass metabolism and the main active form nortilidine is created.

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