| >> | >>611022
If they're instant release, especially with APAP, don't bother plugging/boofing them. It's not worth the chance your bowels aren't empty. Depending on your dose, you can either choose to CWE, choose not to CWE, or choose to CWE/not CWE and simply consume NAC alongside your oxy dose. It's N acetyl cystine and only costs like ~$7-12 for a decently sized jar of it on amazon etc. It's what's used in the hospital for APAP overdose.
There might be debate on oxy's rectal BA, but I can tell you that oral oxy IR has a bioavailability of between roughly ~60-90%. Rectal is supposedly 67% give or take, but I don't assume all patients in those studies had empty bowels. Anyways, even if it's like ~75% oral BA on average and say for sake of argument rectal BA is ~80-90%, that's only a maximum of ~20% increased rectal BA relative to the average oral BA. Unless you're willing to go on a fisting...I mean fishing expedition into your anal cavity for the sake of a maximum ~10-20% strength increase over oral, that's not worth the risk of one of your turds soaking up all of the solution.
As long as you don't have liver problems, and don't regularly drink and don't drink within ~12-24hr before or after the oxy, you can arguably consume as much as ~2-3g APAP maximum at any one time, or ~4-5g within 24hr. It's better to not consume more than ~2g APAP if you can avoid it. CWEing your pills will lose roughly ~5-15% of your oxy depending on who you ask about it. I've never CWE'd anything except tylenol 3s, so I wouldn't really know. Personally, as long as it's less than like ~2.5-3g APAP, I usually just eat 500-750mg NAC (or more depending on APAP dose) about 15min before the oxy, and another 500-750mg NAC roughly 3 hours since the first NAC dose.
Bear in mind that I've only consumed an opioid with APAP in it once this entire calender year, so that's why I don't really bother to CWE. If you don't have NAC and your APAP dose is higher than 7-9 percocet 5s/7.5/10s with 325mg APAP each (or 2275-2925mg APAP total), then yeah, definitely CWE your shit using MINIMAL water they're nearly freezing temperature.
You'll have to decide if said liver "damage" from ~2-3g APAP is worth the extra ~5-15% oxy you won't lose from the extraction process, assuming you don't have micron filters available. If you had NAC, a small dose of just ~1000-2000mg spread out over 2-3 doses depending on APAP quantity would reduce APAP-related liver damage substantially, likely somewhere between ~50-80%+. I'm not saying abandon doing CWEs just because you might have NAC, but it's infinitely better to combine it with oral NAC without a CWE, instead of not doing either a CWE or consuming NAC.
This is something any and every opioid user should have in their stash, or arguably any "medium" or "hard" drug user for that matter. Just $10-20 worth could last you a minimum of years, or as long as a lifetime. Even when you do a CWE, some degree of APAP still ends up in the final solution, both via water-soluble APAP (minimal if small amount of water is used) and via insoluble APAP that isn't successfully stopped via a non-micron filter. As a result, everyone who regularly or semi-regularly consumes CWEable opioids (especially otc codeine, perhaps otc dhc not sure, maybe even Rx ultram aka tramadol+APAP, etc.) should combine their dose with a minimum of 500mg NAC, preferably within 15 mins before the APAP dose, but surely within 15-30min after said APAP dose.
If someone is doing a CWE on something very opioid impure, such as UK tylenol 1 or 2 tablets (something like 325-500mg APAP per 8mg codeine), medium or higher tolerance users might have to consume as much as ~20-50 tablets worth. Even if a user does a CWE, that's still a starting dose of like 12.5-25g of APAP before being filtered. All such users should be consuming like 500-1000mg NAC a bit before the APAP dose, another 500-100mg roughly 3 hours later, and a final 500-1000mg dose 6 hours after the initial NAC dose.
tl;dr buy some n-acetylcysteine for just $7-20 for a multi-year supply, stick to oral use, consider crushing them up even if you don't do a CWE for a marginally faster absorption rate, and decide for yourself if the APAP damage of your specific dosage range is worth the "cost" of ~5-15 or 20% loss of your oxy. … Comment too long. Click here to view the full text. |
