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OP, rectal oxy isn't really any more efficient BA % wise than oral, so it only has the benefits of faster onset aka pseudo-rush and a tad bit higher maximum plasma level of the drug aka Cmax. Actually I suggest people do NOT plug oxy because the marginal benefits don't outweigh the risk of a bunked dose (what happens when a shadow mini turd steals the liquid goodies before you can absorb them). No matter how thoroughly you flush your guts or manually check, it's always a possibility. Only plug drugs when the benefits outweigh the potential risks. Both oxycodone and hydrocodone work just fine when taken orally, oxy especially so when taken on a light yet very high fat, low/no carb stomach (definitely wait at least 2-5hr after the fatty no carb meal) in addition to consuming a tall 8-12fl oz glass of white grapefruit juice FROM CON CENTRATE about ~90min before, or preferably drinking a glass of wgfj during the 2-3 days before the oxycodone dosing and a bigger glass about ~60-90min before the oxy, even if it's only smaller 4-6fl oz glasses.
Just know that wgfj does totally fuck with a load of other meds, usually by making them much stronger and lasting much longer, so if you take any scripted, OTC, street drugs, or other illicit meds/supplements, definitely do research or ask for our help before risking it.
Another option is an antacid type medicine (sort of anyways) called cimetidine aka generic Tagamet, which IIRC is considered a moderate enzyme inhibitor. I think wgfj is a strong enzyme inhibitor or whatever they call it (there's only three tiers labeled something like weak, moderate, and strong), but I can't remember.
The problem with cimetidine though is it doesn't work for all opioids. Basically every opioid I know of is metabolized by either the enzyme CYP2d6, CYP3a4, or possibly both. Most of the major ones are metabolized by CYP2d6, but cimetidine only inhibits CYP3a4 I believe.
If your opioid or other drug of choice is potentiated by either cimetidine or wgfj (mostly helps with most opioids except codeine, tramadol, and debatably hydrocodone but IMO they are more good than harm for hydrocodone, as well as most benzos/z class drugs aka Ambien, as well as dxm and perhaps other dissociatives as well. It's possible they may potentiate certain stimulants but I'm not aware of any), my suggestion is to only dose between 50-400mg max of cimetidine ~45-60min before your oxy, with the max dose of 400mg being okay with occasional use like 1-2x/month/max, and much smaller doses if used more regularly. Personally I would never take more than 200mg total per week, as the main problematic side effect is rare, but it can potentially make you grow man tits if you take 200mg a day, or especially if you take like 400-800mg/most days of the week. Bear in mind a regular OTC dose per tablet is 200mg, so I don't see how only taking like 100mg/half a tablet 2x/week or 50mg 4x/week can regularly cause man boobs when normal users of the medication likely take 200mg or 400mg per day.
That being said, I'm not sure if oxycodone is metabolized through CYP3A4. I know Buprenorphine is metabolized by CYP3a4 and that Methadone is metabolized by I think CYP2d6.
tl;dr don't plug oxy even in IR form as oxy is nearly equally efficient and the extra 2-8% possible BA increase and the faster pseudo rush/onset of action isn't worth having your drug solution going MIA into brown town. Check out white grapefruit juice FROM CONCENTRATE specifically the white kind or at least the 50/50 white and red blend at Walmart (drink one large 8-12fl oz cup ~90min before your opioid dose or preferably a smaller 4-6fl oz of juice daily for the 2-3 days before your opioid as well as the bigger glass before your opioid dose), or possibly cimetidine aka Tagamet (take 50-400mg ~30-45min before your opioid dose depending on dose frequency...if you don't exceed 400mg, or especially 200mg per week, then it's not notably unhealthy) in the pharmacy section (ask a pharmacy tech saying your doc suggested it for stomach problems if you can't find it), depending on if your opioid of choice happens to be metabolized aka broken down by the CYP3a4 enzyme. Both are sold OTC at every Walmart and almost every chain grocery store.