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420chan is Getting Overhauled - Changelog/Bug Report/Request Thread (Updated July 26)

Potentiator Question

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- Sat, 17 Aug 2019 20:45:58 EST 7Teze97q No.609561
File: 1566089158857.jpg -(33241B / 32.46KB, 720x711) Thumbnail displayed, click image for full size. Potentiator Question
I've heard that hydroxyzine can potentiate opiates, but just how strong is the effect?
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Nigel Sadgemotch - Sat, 17 Aug 2019 21:04:14 EST SnO3ZRr8 No.609562 Reply
>>609561
I just got out of the ER a month ago (ish) with a perc RX and I am already prescribed hydroxyzine...

I didnt notice much of a difference...if you routinely take hydroxyzine the drowsiness isnt an issue anymore
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Martin Brecklefield - Sun, 18 Aug 2019 23:20:30 EST U8xxeth7 No.609628 Reply
>>609561
It's bullshit advice of desperate junkies and opi noobs. Antihistamines don't do shit. Mainly all they do is make you tired and dirty the high while removing energy and euphoria from it. Only reason anybody does this is trying to combat itching in desperate hopes of getting just anything for slightly longer legs on stomped on garbage. Don't even bother. If you have to mix it with anything mix it with pot. Or little bit of alcohol, if you have tolerance to both and aren't moron enough to OD.
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Dr. Katz !KqgSR25gAQ - Mon, 19 Aug 2019 00:52:14 EST 56TOD6Vq No.609634 Reply
>>609561
I think synergy is more so what you’re asking about. A typical potentiation technique for opiates involves inhibiting CYP3A4 with grapefruit or cimetidine (Tagamet), which has a rather significant reaction.

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