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When should I take potentiators?

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- Wed, 05 Aug 2020 19:46:37 EST aS3riTOo No.616621
File: 1596671197383.jpg -(78774B / 76.93KB, 500x460) Thumbnail displayed, click image for full size. When should I take potentiators?
I’m trying to maximize my prescription oxy but I’ve finally run into some tolerance, and am now trying to take minimum effective dose and stretch it with cough syrup or Xanax. Usually though I take the oxy, see how I feel, then take the potentiator if it isn’t enough. Sometimes this still doesn’t get me where I wanna be though. Would I have better results taking them at the same time as the oxy or can I keep doing it the other way (which keeps the amount I pop to a minimum)?
>>
Dr. Katz !KqgSR25gAQ - Wed, 05 Aug 2020 23:50:40 EST Q6HJEdas No.616622 Reply
>>616621
Xanax (alprazolam) doesn’t potentiate oxycodone. DXM has an effect on opioid tolerance and has some meager evidence for reversing tolerance.
The main means of potentiation for opioids (and benzos) are in the grapefruits. One research study had something like 8 fl. oz. 100% grapefruit juice consumed daily, which potentiated opioids. However, you MUST be careful. Potentiation can and has caused overdose/death in users.

The studies with any traction, as some posters may state as well, suggest a daily build up of CYP3A4 and CYPD2D6 inhibitors via grapefruit juice. Only a single usage does not provide the full potentiation you can receive. 100% grapefruit juice is what you’ll want. Some places still have white grapefruit juice, but it’s sparse and more so based upon region for availability.

>please, be careful and do not use my post as absolute truth or any suggestion to illegally potentiate your pain medication
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Shitting Greendale - Thu, 06 Aug 2020 18:49:39 EST OHIHxMID No.616636 Reply
>>616622
> Xanax (alprazolam) doesn’t potentiate oxycodone
I always thought it did. I guess that’s stuff like antihistamines and WGFJ. But they still synergize together right?
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Quetzalcoatl !KDjYWIiOiM - Thu, 06 Aug 2020 20:12:39 EST OIpQoQ2U No.616641 Reply
>>616636
potentiation refers to actual chemical processes

white grapefruit juice has chemicals that affect the expressions of enzymes responsible for metabolizing drugs

that's potentiating

xanax does not do that. it depresses the CNS like opiates do.

that's called synergy.

people get the two confused. it doesn't MATTER matter here on a board full of junkies. it matters in medical contexts.
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Cedric Pabberford - Thu, 06 Aug 2020 22:57:10 EST aS3riTOo No.616643 Reply
>>616641
I’m actually really glad to finally know the difference, thanks. I guess that goes for alcohol as well? Just extra CNS depression and not potentiation?
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zozyman - Sat, 08 Aug 2020 01:30:44 EST 9Mid8oW7 No.616652 Reply
>>616621
If you're going to take a potentiator ( not just something synergistic) you actually wanna take it about an hour before your other shit.
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Ernest Fondlewudging - Sat, 08 Aug 2020 20:44:46 EST OHIHxMID No.616668 Reply
>>616641
Damn never knew that. And lol true I just like to know the correct context. Thanks Quetz.
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Beatrice Clurringbere - Tue, 11 Aug 2020 14:59:28 EST 6p9GgdST No.616709 Reply
>>616652
This, I'm surprised nobody said this earlier, I use dxm and promethazine which is otc here in Oz and I'll usually dose an hour before.

Xabax as well as other benzos do potentate opiates I dunno what the other bloke is talking about, I use nitrazepam occasionally to do it when I don't take it to sleep
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Eugene Wunderhood - Tue, 11 Aug 2020 21:53:19 EST 29QbCoeq No.616717 Reply
>>616709
potentiate means makes your opaites danker. benzos just feel good to take with benzos (sometimes, imo)

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