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Benadryl vs Atarax

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- Sun, 23 Jan 2022 20:20:05 EST o6YF0MlD No.135129
File: 1642987205656.png -(1570706B / 1.50MB, 720x960) Thumbnail displayed, click image for full size. Benadryl vs Atarax
I take like 2000mg (10 of the 200 mg) Atarax at night to help me sleep and I'm wondering, since it's so closely related to Benadryl (literally just flip that molecule) if Benadryl will work for my upcoming seasonal allergies? I took 50mg the other day and felt nothing and normally it makes me a little drowsy.

Racetams

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- Thu, 20 Jan 2022 14:40:22 EST je92Fn1a No.135120
File: 1642707622309.png -(635329B / 620.44KB, 948x608) Thumbnail displayed, click image for full size. Racetams
Anyone here use a variety of racetams and what do you get out of them.
The only one that i can appreciate atm is piracetam + Alcar as the choline surce (its cheaper and works great) but citocholine may be the superior choice but albeit expensive. This one makes things interesting and can make me feel a bit like my older self when i get a good stack going on or time it right with a mushroom trip, nice gentle stimualnt and works for anxiety but does get a bit irritable when i lose focus.

Sunifiram is one i am stuggling to get a good dosage, most palces say 15mg but that doesnt seem to do much seeing as its meant to be twice the strength of piracetam. i got it because its meant to be a mood bosster and libiso enhanceher so i thought i might get add it to the fap stack.
anyways fuck it, im looking for suggestions on what to try and what dosages i do, preferably looking to try get some motivation enhancement,energy, focus , possible mood boosts or anxiety reduction etc out of the racetams, well ive read so many on circlejerk and other places saying it helps retards and brain damaged people even certain types of wd like phenibut.
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Rebecca Nenninglatch - Sun, 23 Jan 2022 07:12:22 EST 6EW+7S5N No.135128 Reply
>>135126
Yea yeah yea i already do

Gonna try 25mg of sunifram tommorow with kratom

wake up

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- Sat, 30 Oct 2021 23:37:48 EST y1qmyHin No.134971
File: 1635651468084.png -(124701B / 121.78KB, 262x231) Thumbnail displayed, click image for full size. wake up
as your mind drifts from your body in this world, you see your self drifting in another, where your consciousness is monitored by a force known as the collective.

what is a collective?

it is a group mind, a group mind that is made up of billions of minds, and it is a being, a consciousness, a soul.

the collective is made up of human beings, but you are also aware of beings that no one else can see
User is currently banned from all boards 1 posts and 1 images omitted. Click View Thread to read.

Drug Testing Kits

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- Mon, 10 Jan 2022 19:42:16 EST Izk+f3Y3 No.135099
File: 1641861736384.jpg -(7183B / 7.01KB, 190x281) Thumbnail displayed, click image for full size. Drug Testing Kits
Hey sorry if this is the wrong board, but I didn't know where else to go.

I recently may or may not have come across some "pure MDMA", but because of the recent rise of fentanyl, I am naturally a little worried. Can anyone recommend a good website to get the tests I need to be safe? I also haven't done anything outside of weed and alcohol for about 5 years, so I don't know how often someone would cut other drugs with fentanyl to make a profit. I just got really scared when I heard someone in my town OD'd on some coke cut with the shit so any advice would be greatly appreciated. Thanks!
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Ernest Gammernut - Wed, 12 Jan 2022 12:13:08 EST vhOtuPvF No.135102 Reply
>>135099
i think its more likely to be meth or dxm insteaed of fent in fake molly. But yeah do make sure it is what it is and buy a kit from dancesafe

inhaling nitrous

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- Mon, 13 Sep 2021 01:37:26 EST dGEWADAO No.134867
File: 1631511446312.jpg -(86172B / 84.15KB, 1277x1500) Thumbnail displayed, click image for full size. inhaling nitrous
Hey guys

Can anyone tell me the correct way to inhale from a balloon with nitrous in it? Inhale, hold for how long, inhale again, etc!

And what the correct technique is for using these whipped cream dispenser and if I need a balloon or not?

Thanks
2 posts omitted. Click View Thread to read.
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Sidney Bullykine - Thu, 09 Dec 2021 15:21:38 EST ZioFm7nn No.135053 Reply
1639081298387.jpg -(2016125B / 1.92MB, 3063x3024) Thumbnail displayed, click image for full size.
>>134867


Getting an iSi charger is the only way to go.
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Esther Senningpane - Wed, 15 Dec 2021 17:04:04 EST VqPq8eGP No.135063 Reply
>>134867
If you have a whipped cream dispenser instead of just a cracker you can inhale straight from the dispenser, I've done it all the time. Just be careful with the lever so you don't overfill your lungs.

Would this contain opium whence fully grown?

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- Sat, 20 Nov 2021 21:38:56 EST y1a1Ikrp No.135023
File: 1637462336330.jpg -(3055740B / 2.91MB, 4032x1908) Thumbnail displayed, click image for full size. Would this contain opium whence fully grown?
DICKS EVERYWHERE
4 posts omitted. Click View Thread to read.

Lamictal

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- Wed, 22 Dec 2021 14:42:47 EST QVBbRTv+ No.135072
File: 1640202167230.png -(405876B / 396.36KB, 1446x930) Thumbnail displayed, click image for full size. Lamictal
So i was just talking about my lifestyle(keeping it pretty normie) but i think my doctor thinks i'm batshit anyways, and wrote me a script for Lamictal.

Should I not take it? What should I expect?
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Nigel Bullynune - Sat, 25 Dec 2021 11:45:48 EST ZioFm7nn No.135076 Reply
>>135072

It's an anti-seizure med, and if it is prescribed for the crazies, if its like depakote, get ready to gain a ton of weight in a weird way.
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Martha Nickleworth - Sun, 02 Jan 2022 10:38:50 EST epL8XRbt No.135093 Reply
1641137930696.png -(741181B / 723.81KB, 735x688) Thumbnail displayed, click image for full size.
>>135076
> if its like depakote, get ready to gain a ton of weight in a weird way.
This will cover most of that need
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Doris Demmerdale - Fri, 07 Jan 2022 18:47:17 EST 7aKrfSzF No.135096 Reply
>>135075
Sounds sketchy to prescribe that for an anxiety disorder. Lamictal requires increasing the dose slowly to get to the prescribed dose or you risk some dangerous shit like Stevens-Johnson syndrome. I was prescribed it for bipolar disorder but didn't take it because fear of fucking up made my anxiety worse. My doctor told me to seek medical attention for any rash while on Lamictal. Seemed like too much of a hassle to be worthwhile. Try asking for actual anxiety meds, and better yet find a doctor who cares about your thoughts. Good psychiatrists are hard to find but make a huge difference if you can get one.

Semax and Selank

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- Sun, 02 Jan 2022 12:44:33 EST EUzqNQGm No.135094
File: 1641145473220.jpg -(11698B / 11.42KB, 220x304) Thumbnail displayed, click image for full size. Semax and Selank
https://en.m.wikipedia.org/wiki/Selank

https://en.m.wikipedia.org/wiki/Semax

Anyone experiences with these?
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Based russian - Mon, 03 Jan 2022 07:25:57 EST YJe7Unor No.135095 Reply
>>135094
Бoльшoй бвзирoвaнный русский кoт шлёпa гигoчaд сeмaкс юзeр

Kanna tea

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- Mon, 29 Nov 2021 23:11:01 EST EUzqNQGm No.135045
File: 1638245461797.jpg -(3067676B / 2.93MB, 3024x3024) Thumbnail displayed, click image for full size. Kanna tea
Kanna tea is great

I made a tea of kanna, mulungu , st Johnswort and a bit of other herbs with lemon,

It immediately lifted my bad mood

Surprisingly so

Normally I snort Kanna

But now I put a few gram in tea to spare my nose

With lemons soaked

Great stuff

https://en.m.wikipedia.org/wiki/Sceletium_tortuosum

Can highly reccon
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Barnaby Bremmlegold - Fri, 17 Dec 2021 18:20:52 EST X4NSZc0I No.135069 Reply
>>135068
ever try it whilst tripping? Do you think it would boost the visuals or feels or calm one down if they got a lil tweaky. I never felt an increase in weed buzz which was one of the main reasons i bought some extract. It seemed to work well with kratom ime.
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Walter Fipperkon - Sun, 02 Jan 2022 07:33:57 EST EUzqNQGm No.135089 Reply
>>135069
Yes with weed I find it instantly brings clarity which kinda ruins the high

Havent tried with anything else

Extracts are far better esp ET2 but its expensive
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Martha Nickleworth - Sun, 02 Jan 2022 10:35:22 EST epL8XRbt No.135092 Reply
>>135089
i was trying to find a way to expalin the kanna/cannabis connection and you did it for me, it leaves me tired but strips the funny dopey feels if that sounds right. i like kanna with psy tho, helps focus without jittertyness. certainly makes kratom more wholesome and energetic.

Nitrous Trips

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- Fri, 10 Dec 2021 19:51:18 EST NBHcV5KE No.135056
File: 1639183878775.jpg -(36348B / 35.50KB, 600x400) Thumbnail displayed, click image for full size. Nitrous Trips
When I do N2O (usually 10) I get on this "ultimate trip" of spiraling introspective 4D thought. What are your best experiences?
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Hamilton Bashham - Fri, 31 Dec 2021 01:03:48 EST M/MydH2g No.135087 Reply
>>135056
Once I huffed whip cream on a dxm come up at a mall on a rainy day face went numb and I loved watching the cars go by

tizanidine

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- Fri, 27 Dec 2019 10:20:08 EST 8byJHV2m No.133015
File: 1577460008236.jpg -(26048B / 25.44KB, 550x550) Thumbnail displayed, click image for full size. tizanidine
What do you guys think of tizanidine?
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Thomas Mopperwater - Fri, 27 Dec 2019 16:06:29 EST E2515dw0 No.133016 Reply
seems pretty pointless and non-recreational even for /other/, could be useful for an adjunct like baclofen is but on it's own probably worthless

all muscle relaxers aren't, soma or valium, a lot of the newer ones are very targeted and minimally recreational
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Clara Dundlefoot - Sun, 26 Jan 2020 17:12:48 EST fWzuoIW7 No.133062 Reply
Well, supposedly the maximum on time dose is 16 mg. I snorted something like 2-3 mg of it (MR if this matters, I had to crush the small pellets) and it made me feel really sedated (like anti-psychotics level of sedation) and got a slight relaxed feeling in my legs. Overall it was a very meh experience. I wouldn't do this again, since all that sedation and a somewhat uncomfortable overall feel isn't worth for that slightly comfortable body load if we can call it that. The other time when I took it properly (6 mg MR which works for the whole day) it just made me feel tired and dumb.

Although this stuff isn't recreational, it has its uses (besides muscle relaxation, duh). Obviously this should be very good for insomnia. Also from what I read on the side whose name we do not dare to say here and from considering the fact that it's... sedating, this must be good potentiating downers. Might be a nice combo with benzos, provided you can stay awake.
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Nigel Bullynune - Sat, 25 Dec 2021 11:59:27 EST ZioFm7nn No.135077 Reply
>>133015

It might cause hallucinations, strange dreams, and back pain.


Reset Anti-psychotic Tolerance

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- Sat, 03 Jul 2021 11:44:24 EST HH4m/UQS No.134717
File: 1625327064224.jpg -(6158B / 6.01KB, 292x380) Thumbnail displayed, click image for full size. Reset Anti-psychotic Tolerance
anyone have experience with taking antipsychotics, eg 20mg Olanzapine daily for like 6 months, and noticing the tolerance is very high and you have reduced effect compared to day one. How long did it / would it take to reset tolerance if one was to quit cold turkey for instance?
3 posts and 1 images omitted. Click View Thread to read.
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Eugene Sackleturk - Thu, 09 Dec 2021 12:07:20 EST uXJ3R71z No.135051 Reply
Would amphetamine / psychedelics upregulate those down regulated receptors caused by anti psychotics? for reducing/resetting anti psychotic tolerance
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Shitting Dundleridge - Sun, 12 Dec 2021 07:31:03 EST LrhZY5Zm No.135057 Reply
>>135051
Well, to begin with, you've got the upregulation and downregulation backwards, but that's pretty understandable considering I used to confuse them for a bit when I first started looking into pharmacology and neurobiology out of personal interest years ago. Antipsychotics usually act as antagonists or inverse agonists of a massive array of dopamine, serotonin, histamine, adrenergic, and to a lesser extent, acetylcholine receptor subtypes. Antagonists and inverse agonists typically result in upregulation of the receptor subtypes it binds to, because the brain responds to consistently lower activity by increasing the number of receptors of the subtypes in
question--the idea being that the greater number of receptors are expressed on the synaptic terminal, the more sensitive it is to the monoamine/catecholamine/neuropeptide/whatever that acts as the endogenous ligand for that type of receptor. The endogenous ligand for all dopamine receptor subtypes is dopamine, for instance (although often times there are potentially many endogenous ligands capable of binding to and stimulating a neural receptor--usually with a significantly lower binding affinity and/or it is less effective at stimulating the cell).

The brain is too insanely complicated to be able to reduce things to certain neurons upregulating or downregulating such that simply using a drug that causes the opposite response to try and counteract the effects isn't a really a viable solution, at least directly.

The brain will adjust over time on its own, provided you don't just stop taking the antipsychotic cold turkey. That can lead to very serious withdrawal effects and can cause permanent disorders like tardive dyskinesia and shit. Amphetamine would indeed cause downregulation over time, same with most psychedelics regarding the 5-HT2A and 2C receptor subtypes in particular, but if you tried to quit taking an antipsychotic after using it for over 1-3 months, especially if you've been on it for over a year, simply quitting is dangerous already. If you combined quitting cold turkey with taking a 5-HT2A agonist psychedelic like LSD, shrooms, DMT, mescaline, etc., and/or amphetamines, you wouldn't be accelerating your recovery... you'd likely be accelerating withdrawal effects and the likelihood of developing something like tardive dyskinesia.

In the case of amphetamines, you'd be overstimulating dopamine receptors in the prefrontal cortex and as well as the reward center (where dopamine receptors are most widely distributed). I'm almost positive this would result in excessive neurotoxicity--damaging or killing dopamine neurons disproportionate to what is typically observed or expected from amphetamine (ab)use. The same could be said of taking a 5-HT2A agonist psychedelic, only neurotoxicity would be harder to gauge because amphetamines simply result in reverse transport of stored dopamine, serotonin, and norepinephrine (the proportions depend on the amphetamine in question really) by potently binding to TAAR1 receptors, and to a lesser extent, VMAT2 and acts as a mild MAOI too. The psychedelics bind to
5-HT2A and 2C receptors directly and stimulate them... but to make things even more complicated, sometimes a molecule that binds to a receptor on a neuron can exhibit functional selectivity, meaning they don't produce the same response as the endogenous ligand (or even other exogenous/foreign substances, necessarily). The ramifications this functional selectivity that all classical psychedelics possess has regarding neurotoxicity is something I haven't ever looked into. Maybe I'll read up on it and get back to you on that.

Anyway, ignoring these other uncertainties, what makes it all so complex is the fact that specific types of neurons and receptor subtypes are expressed in different amounts throughout the various brain structures. Dopamine neurons show up and are distributed most in a particular area of the brain, and same goes with serotonin, norepinephrine, and indeed all neuronal subtypes. Not only that, but the neurons don't exhibit a universal consistency in behavior and the effects they have on surrounding neural activity. Dopamine in the prefrontal cortex plays more of a role in executive function (planning for the future, behaving in a socially acceptable manner that benefits you, emotional regulation, controlling impulses, etc.), whereas dopamine in the nucleus accumbens (the reward pathway) mediates the reward effect (which doesn't actually produce feelings of euphoria or pleasure, shit's a fuckin enigma honestly lol), which guides your behavior through the anticipation of reward or punishment/pain, informs your motivation, and by reinforcing behaviors that you anticipate reward for (like eating, accomplishing a task, sex, drugs, etc.). Dopamine in the prefrontal cortex also mediates motor activity in several ways. People with Parkinson's, through dopamine neurotoxicity, lose the ability to filter gross motor function (large movements) and fine motor function (small, more precise movements), so normally a bunch of internal noise you brain is always producing naturally winds up causing tremors and symptoms like "ratcheting", where somebody with Parkinson's tries to move their arm by rotating at the elbow to wave, for instance, and instead of it being a nice fluid motion, it staggers and jumps between to intermediate positions throughout the motion.

That in particular is why using amphetamine or some kind of dopamine agonist to try and accelerate recovery is a really, really dangerous and bad idea. Not only would you potentially be subjecting yourself to a significantly higher change of amphetamine/stimulant psychosis form the excessive dopamine activity, but that overstimulation will not only cause a shit ton of oxidative stress (dopamine's primarily metabolite is a free radical and it contributes signific…
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Shitting Dundleridge - Sun, 12 Dec 2021 07:41:18 EST LrhZY5Zm No.135058 Reply
I do have a more practical answer for you, though. Instead of fucking with amphetamines or psychedelics, start taking CDP-choline (also called citocoline), experiment with the racetam family of nootropics and find the one that kinda fits you best. Both CDP-choline and most racetams are known to affect the upregulation/downregulation of various receptor subtypes, such as acetylcholine, dopamine, some what minorly serotonin, GABA, and I believe some types of glutamate receptors. It's a far less intrusive, reckless, and dangerous route to go.

Also, of greatest interest to your situation, you should check out fasoracetam. It's unique among racetams because it almost exclusively acts as an agonist at all 3 family/subgroups of metabotropic glutamate receptors. Group II and III metabotropic glutamate receptors actually reduce the activity of ionotropic glutamate receptors in the brain, and it is being investigated for potential in helping treat schizophrenia. I can personally attest to its antidepressant and rather impressively strong anti-anxiety properties. But it does it in a way that feels much cleaner, doesn't cause cognitive impairment (like benzos, phenibut, kava, kratom or alcohol do). It's also being investigated to a specific type of ADHD where there is a genetic polymorphism related to the metabotropic glutamate receptors.

Like, I feel like it slows my thinking down, but in the best way possible, because usually my ability to articulate thoughts in my head is far outstripped by the speed of the underlying thought patterns and shit, so I wind up cutting off my thoughts and breaking off into other ones. Instead it's like everything has been tuned to be clocking in together in sync.

Am I germinating these poppy seeds right?

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- Sun, 28 Nov 2021 00:22:27 EST y1a1Ikrp No.135040
File: 1638076947223.jpg -(5129336B / 4.89MB, 4032x1908) Thumbnail displayed, click image for full size. Am I germinating these poppy seeds right?
This is how I germinate my marijuana seeds, only instead of taking the seeds and putting them in a glass of water for a day or 2 I just get a moist paper towel and place the seeds in it and in a container.
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driven !FTPgBqDDy. - Sun, 28 Nov 2021 17:25:15 EST m8bBVt3d No.135041 Reply
poppies are fragile and real sensitive to transplanting etc.
pretty sure they should just be germinated in place. don't treat them like a rarity, if anything you should just sow a whole bunch and let the strong survive. they sprout like crazy and most of them won't live, so take the opportunity to make a poppy sprout sammich
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Sophie Blushwell - Thu, 09 Dec 2021 23:59:15 EST lEjBEgzW No.135054 Reply
1639112355615.png -(295169B / 288.25KB, 413x406) Thumbnail displayed, click image for full size.
>>135040
From my limited knowledge. You should just take a god damned bucket of the seeds and throw them in your soil. Treat it like you would if you were growing wheat or grass.

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