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Reset drug tolerance

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- Tue, 24 Sep 2019 08:08:10 EST QJMKcKtZ No.132780
File: 1569326890265.jpg -(163650B / 159.81KB, 590x393) Thumbnail displayed, click image for full size. Reset drug tolerance
What drugs / nootropics reset drug tolerance, do they also work for anti psychotic drugs tolerance? how long you have to take those drugs for a tolerance reset / decrease ... I heard Iboga can help with that maybe
Nigel Claddlepodging - Tue, 24 Sep 2019 11:04:42 EST E+A8vRh0 No.132781 Reply
Salvia was good at helping my body renew itself. I felt less desire to consume drugs after too.

I feel salvia is worth the "troubllibg come up" just to feel those after affects.
dr. m - Fri, 27 Sep 2019 00:50:24 EST g/ej7Wui No.132796 Reply

One main one is to take ULDN/LDN (ultra low dose naltrexone or low dose naltrexone), ~10-50ug/day of ULDN if regularly using opioids, or between ~100ug-3 or 5mg/day LDN if not using opioids again any time soon and are not physically dependent on them at that time.

It works GREAT by basically doing the opposite of a pain killer/opioid in terms of effects on your mu opioid receptor. It upregulates the receptors instead of downregulating them like regular opioids. It both reduces tolerance and reduces the rate of tolerance increase when using alongside opioids. If you're going to take an opioid within 72hr of dosing though, but sure to stick to only ~10-50ug/day.

A normal naltrexone tablet contains 50mg, so that means you'd need to do volumetric dosing to get accurate doses. If you just try to eat an eyeballed quantity of a pill, you're an idiot. Assuming you only take ~50ug/day, that's 1000 days worth of daily doses from a single tablet.
Doris Cloppernork - Sat, 28 Sep 2019 02:59:51 EST 4n94r13r No.132805 Reply
I have read stroies about N-acetylcysteine (probably on /mdma/ or r€ddit) being able to reset MDMA induced brain damage and tolerance.

Enhance of taste

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- Fri, 02 Aug 2019 17:52:02 EST 39+if3d5 No.132543
File: 1564782722073.jpg -(21489B / 20.99KB, 350x381) Thumbnail displayed, click image for full size. Enhance of taste
What drugs enhance the taste / senses of food? like weed ... what is the ultimate munchie drug combination ?
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dr. m - Fri, 27 Sep 2019 00:35:28 EST g/ej7Wui No.132795 Reply

Not sure about taste specifically, but in terms of making me hungry, paxil and especially mirtrazapine were always the strongest. Either one seemed to put weed to shame in terms of munchies.
Phineas Turveystone - Fri, 27 Sep 2019 01:00:25 EST UQtfIZol No.132797 Reply
there should be a little shelf to rest your dick on too
User is currently banned from all boards
Ian Gonkinbud - Sun, 24 Nov 2019 08:57:36 EST MRzT4Kq8 No.132951 Reply
I had great munchies on 2c-b


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- Tue, 24 Sep 2019 13:36:39 EST wqt9NQxx No.132783
File: 1569346599552.jpg -(1593951B / 1.52MB, 2048x1339) Thumbnail displayed, click image for full size. Kratom
Experiences with it?

I personally use like 2g for every workday with another 2g later on if it is a long shift. I work manual labor. I also use it at night sometimes with 4-6 or more grams to sleep. I never had any bad effects from it besides small withdrawal symptoms if I go a day or more without it but it's not that bad.
Nathaniel Funnerlock - Wed, 25 Sep 2019 00:43:23 EST ZSDRQK46 No.132786 Reply
I have been using kratom since 2011. I take much much more than that on a daily basis. I have had VERY minor withdrawal symptoms when I went out of town and have not been able to access it, but it was kids shit. Very safe, good for work and for pain, very small chance for addiction, ESPECIALLY if you are only taking 4g a day.

Do not start using extracts as the reason kratom has a good safety and addiciton profile is because the leaf contains partial opiate agonists as well as opiate antagonists, creating a cieling that limits the amount of receptors it can activate at one time. Extracts sometimes do not carry these alkaloids so they can be more addictive. Stick with regular leaf and enjoy.
David Billingdale - Wed, 25 Sep 2019 06:19:33 EST vL1PWjSY No.132790 Reply
I've been taking it daily for a little over a year and I love it. Almost nothing but positive effects. The main downsides are physical withdrawal which does get worse at higher doses, but not nearly as bad as harder opiates. The other main problem is you don't always know what you're going to get. I've gotten some great stuff and some utter shit from the same companies of the supposedly same strain, so the consistency is not guaranteed, although I find it to be good far more than bad.

Ordering LSD from darkweb

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- Fri, 23 Aug 2019 05:38:57 EST GXjrDIGP No.132633
File: 1566553137834.jpg -(151246B / 147.70KB, 570x563) Thumbnail displayed, click image for full size. Ordering LSD from darkweb
I'm thinking of ordering LSD online using the darkweb, how hard would it be to have LSD go through the post system (and maybe also customs) in New Zealand (which has extensive x-rays and sniffer dogs).

  1. Can the LSD get through the x-ray scanners?
  2. Can the LSD get through the sniffer dogs?
  3. If the LSD has to go through customs (international order) how risky is it?
10 posts omitted. Click View Thread to read.
Hedda Dushnock - Fri, 20 Sep 2019 22:00:52 EST GYSe4uzh No.132769 Reply
Tangentially related, I just moved to a new town in the western US and I don't know anybody. How do I find an offline source?
Cornelius Turveyforth - Sun, 22 Sep 2019 04:52:43 EST 3SGpsltX No.132778 Reply
find something calling itself a "roots music festival" that mostly features things like folk, bluegrass, funk, and jam bands and you will have yourself the good stuff
Betsy Bunwater - Tue, 24 Sep 2019 22:57:10 EST 3SGpsltX No.132785 Reply
same shit here, I've been around 420chan since 07 and I've always

posted like this

you know

I love when the kiddos get mad about it

Me & Some Frens Found these in a Garage

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- Tue, 10 Sep 2019 15:37:59 EST aj8K69lY No.132714
File: 1568144279971.jpg -(3175112B / 3.03MB, 3264x2448) Thumbnail displayed, click image for full size. Me & Some Frens Found these in a Garage
Does anyone know if these are actually drugs? Me and some friends found them in a garage that probably hasn’t been used in a year or two. If these are drugs could you confirm their name and how much they would cost.
5 posts omitted. Click View Thread to read.
Edwin Clucklecocke - Wed, 11 Sep 2019 18:27:28 EST qIrfrJZG No.132723 Reply
that's definitely rat poison

and these days that probably wouldn't be strychnine, which you could potentially get high on
Phyllis Hubblesture - Sun, 22 Sep 2019 00:40:03 EST NHlBUo8u No.132774 Reply
Hey bros I got some dank basement gravel!

Oh shit son are those garage rocks?

Yup, the greenest sodium fluoride I've ever seen

Nootropics general

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- Sun, 28 Jan 2018 04:55:49 EST PHla0GsA No.130726
File: 1517133349649.jpg -(71534B / 69.86KB, 528x528) Thumbnail displayed, click image for full size. Nootropics general
We don't have a board for it so why not put it here. Piracetam, phenibut, modafinil, L-theanine, atomoxetine, etc...

Discuss stacks here, discuss individual use here, discuss long-term effects here. It's time to take back /other/ from the folks getting loud and boofing jenkem!
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Rebecca Furringway - Wed, 03 Jul 2019 10:12:37 EST aE2YjQh3 No.132443 Reply
I got this effect as well, however I needed to take at least 2.5g of PEA for it to do anything. It was like MDMA and yet not MDMA.
Nicholas Suvingstone - Thu, 04 Jul 2019 12:49:24 EST G37tt8It No.132446 Reply
I've noticed that effect with oxiracetam. I used to have the kind of memory that made school a joke, but a long period of DPH abuse and a weeklong fever in the hospital set me back a ways. For a few days after taking oxiracetam, I'll feel how I used to feel and be able to remember things extremely easily. That said, I think a huge part of that is my heavy reliance on mnemonic devices - once the drug wears off, the work I put in to remember information is still there.
How exactly did the Huperzine A feel? Was it very stimulating or was it more like clear-headedness you get from most racetams?

Strangely enough, I agree. Oxiracetam makes you slightly emotionally numb and it's REALLY easy to obsess over things in a harmful way on it.
Also, aniracetam gives me hella road rage. Not when I'm on it: while the drug is taking effect I feel completely emotionally numb, but in a good way. As soon as it wears off I am a complete asshole because of the emotional whiplash. Thankfully, I'm driving in Boston so absolutely nobody notices.
What's all this about noopept?
Cyril Criffingman - Sat, 21 Sep 2019 10:16:25 EST xNLfN0vB No.132770 Reply
1569075385975.png -(829153B / 809.72KB, 1274x1020) Thumbnail displayed, click image for full size.
Thoughts on DMAE?

anyone else high on nutmeg right now?

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- Wed, 11 Sep 2019 19:47:23 EST aILdVZDE No.132724
File: 1568245643593.png -(11270B / 11.01KB, 615x198) Thumbnail displayed, click image for full size. anyone else high on nutmeg right now?
it feels awesome
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Matilda Blittingshit - Wed, 18 Sep 2019 12:03:49 EST pQ3XFwLt No.132761 Reply
If you have a weak stomach it can make you pretty sick.
Fuck Busslemire - Fri, 20 Sep 2019 13:00:43 EST l8uPvjUm No.132767 Reply
Good call, imma smoke a joint and eat a piece of apple pie.

wild dagga combined+salvia divinorum

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- Thu, 12 Sep 2019 14:08:52 EST iaHx1wkX No.132728
File: 1568311732915.jpg -(216287B / 211.22KB, 921x1000) Thumbnail displayed, click image for full size. wild dagga combined+salvia divinorum
What do you think about rolling joint of wild dagga combined with salvia divinorum? Is it a dangerous combination? Have any of you tryed? If yes what were the effects?
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Doris Saddletat - Thu, 12 Sep 2019 20:06:44 EST 3SGpsltX No.132735 Reply
realistically if you are going to do anything with salvia get a torch lighter and build a gravity bong

I have discovered a terrible withdraw

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- Mon, 16 Sep 2019 02:42:35 EST qIrfrJZG No.132751
File: 1568616155787.png -(96297B / 94.04KB, 768x494) Thumbnail displayed, click image for full size. I have discovered a terrible withdraw
I had 6 Lamictal 250mg which I've taken daily as monotreatment for bipolar I for years now, with anti-psychotics PRN for bad manic episodes. Works great for the depression side of bipolar which tends to be worse for me.

Well, I lost them, and they won't give me 6 extra, even though I've been on an anticonvulsant for years now at the highest recommended dose, because something something insurance (fuck burgerland). So I figure ok it's a drug that has to build up a little bit in your system, So that was a lie. By day 2 I felt a little weird, on edge, racing thoughts, kind of figety. By day 3 I was getting terrible cramps and just a general malaise, racing thoughts, emotions all over. Day 4 my hands start to tremor and I get restless legs and toss and turn so much in my sleep I cracked my elbow hitting it on the wall. Night of day 5, I haven't slept in two, I'm constantly shivering and twitching. Took a half a bar a friend gave me and some Lunesta and I'm still wide wake (that could also be a bit of mania) but all the tremors and twitching stopped. Thank god. Got one day left. Think I'll pick up some vodka tomorrow. My mood is all over the place, one second I'm laughing hysterically at almost nothing the next I'm crying my eyes out absolutely bawling because Sing by Blur comes on the radio. Fingers crossed no seizure.

It feels like of like how people describe the infamous gabapentinoid withdraws like from pregabalin/gabapentin/phenibut only the symptoms of it hit my like a freight train, I feel like I could legitimately die if I wasn't getting more soon. These all have in common that they're sodium channel blockers, could this be a unique kind of withdrawal? It's nothing like benzo/barb/alcohol and other GABAergic withdrawals ime, and slightly different but very similar to gabapentinoid w/d, since those are also mildly GABAergic

Still love this drug though, the best psych med for my bipolar I, not psychoactive at all, keeps me from suicidal behavior and violent rages and reckless behavior, but doesn't change my rather dynamic personality at all

But god DAMN don't run out
4 posts and 1 images omitted. Click View Thread to read.
Martin Sazzleshaw - Wed, 18 Sep 2019 20:23:14 EST S4C7bXBR No.132762 Reply
Yep, can't stand any of that shit either. Hear too many scary things and I get horrific side effects from most. Seroquel leaves me feeling groggy and irritable in the morning but I still keep it around for the same reasons you do lol

Definitely seems like Lamictal is my best bet as far as treatment goes, hopefully it won't do anything bad combined with Mirtazapine and the Strattera I'm already taking. I just need to kill off my mood swings and horrible anxiety and then I'll be golden.
Molly Hurringsare - Thu, 19 Sep 2019 00:36:25 EST qIrfrJZG No.132764 Reply
It should be fine with Strattera at least, I took it with Wellbutrin until very recently
Martin Sazzleshaw - Thu, 19 Sep 2019 03:11:37 EST S4C7bXBR No.132765 Reply
That's a relief. Guess I just have to hope I don't get a skin rash now.


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- Tue, 09 Jul 2019 00:11:04 EST 3mgJ7ePw No.132453
File: 1562645464021.jpg -(128256B / 125.25KB, 1100x734) Thumbnail displayed, click image for full size. Antipsychotics
Didn't see any threads here about antipsychotics.

Curious about others experiences with them. Were you forced to take them? Were they scripts from your doctor? Do you legitimately need to take them for a condition like schizophrenia, biploar disorder?
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Cornelius Nembledale - Sat, 24 Aug 2019 07:02:49 EST xeiVx3/+ No.132640 Reply
What the fuck that sounds awful. I have the same prescription as you for the same reason as you but I've been planning to ask for anticholinergics
Polly Babberkotch - Sat, 14 Sep 2019 01:10:37 EST aILdVZDE No.132741 Reply
don't take them to get high lol you can't get high from them

seroquel. used to take it. nose gets stuffy and i get sleepy. take too much and you get restless leg syndrome.
zyprexa: makes dxm not work when you take it. take too much and you get restless leg syndrome.
Matilda Nettingspear - Sat, 14 Sep 2019 10:16:14 EST ddfNTixH No.132742 Reply
1568470574797.jpg -(32439B / 31.68KB, 636x640) Thumbnail displayed, click image for full size.
>makes dxm not work when you take it.

That's strange. When I was prescribed ziprasidonec, I did 600mg DXM and didn't feel a damn thing.

z drug experiences

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- Tue, 27 Aug 2019 04:52:57 EST qIrfrJZG No.132648
File: 1566895977901.gif -(44106B / 43.07KB, 646x512) Thumbnail displayed, click image for full size. z drug experiences
damn these things are wild, a trippy confusing blackout, all the fun of doing waaay too much of some sketchy RC benzo with an added edge.

Putting all the pieces back together is insane, apparently I snorted some at some point, wrote all sorts of shit on my door that makes NO fucking sense,

apparently I went to the VP to buy a case of beer in just jeans and a leather jacket, open

i got the feeling that every object I had in my room and bathroom were citizens of two sovereign states and that felt like it was really meaningful but then I forgot why

i put on a bunch of makeup and took a lot of pictures of myself looking like a dollar store Robert Smith, which as far as I can tell I DID NOT send to anyone, so thank fucking god for that one

came to outside when a cigarette I had been smoking burnt entirely through my jeans

couple reads on Snap that I have NO idea what the fuck I sent and one more that hasn't been opened where I spoke almost complete gibberish

even as i type this i close my eyes and see colors, there's a good chance i won't remember making this post lol

oh and also I flushed the few that were left apparently, oh well

and last but not least, I give you this gem of a trip report that I found on my computer, I don't know why the fuck I wrote like that, it is so dumb person trying to sound smart it's funny, it's like that episode of sunny Flowers for Charlie, I was medically retarded when I wrote this but I still wanted it to be shit lmao
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Reuben Docklewane - Sun, 08 Sep 2019 00:36:06 EST AwQXoj6O No.132707 Reply
1567917366809.jpg -(46993B / 45.89KB, 373x604) Thumbnail displayed, click image for full size.

I get Rx Eszopiclone (lunesta) 3 mg, love that stuff. makes you feel good and relaxed.

I once had a lot of ambien and snorted like 50gs and had a full blown psychotic episode. Never had any psychotic stuff happen before and haven't had any since. I was seeing shadow people clear as daylight and there were bugs everywhere, it was pretty scary. I thought a demon was trying to take over my body and keep me psychotic forever, I had to fight him off. And my sense of time was all off. To me it felt like I had been hallucinating shadow people for months but it was just about 2 days.

Moral of the story is I got put in the hospital and they blasted me with haldol. Ambien is a serious drug. I don't have any desire to do it again. Lunesta is awesome though.
Dextrolord - Tue, 10 Sep 2019 07:55:26 EST nTc2zKud No.132712 Reply
yuuup sounds about right for sniffing 50mgs, try 10-20 and youll have a way better time
Cedric Boffingbene - Fri, 13 Sep 2019 09:17:16 EST qIrfrJZG No.132737 Reply
Welp, I ran out of the Ambien short order so I went and told them I didnt like the side-effects, said I was sleep walking etc so they gave me eszopiclone, which is really neat, way less trippy, much more directly relaxing, took 6mg then 10mg (iirc that's based mostly on what was left lol), memory loss is about the same, idk i might try a higher dose all at once and see how that goes

ID for these pills?

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- Fri, 23 Aug 2019 22:26:35 EST NY6w/vEj No.132637
File: 1566613595867.jpg -(29833B / 29.13KB, 509x960) Thumbnail displayed, click image for full size. ID for these pills?
Got these from a friend who didn't seem to have any idea for what they contain. He said something about them begin used for people with schizophrenia, "but they can make you high".

I have checked pill ID-services but without getting any matches.

They say 50 on one side, and blank on the other side.

I live in Scandinavia, 5c coin is there for for scale.
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Graham Dosslelock - Thu, 29 Aug 2019 19:56:15 EST +5taDJsq No.132674 Reply
1567122975189.png -(172499B / 168.46KB, 448x520) Thumbnail displayed, click image for full size.
quetiapine is the actual name of the drug, seroquel is the brand name.
Doris Chosslesodge - Tue, 03 Sep 2019 18:42:22 EST 4OYEEsba No.132695 Reply
Sure, that might be the case, but the brand name for these specific pills are "Quetiapin KRKA"

Weird anti-depressant side effects

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- Mon, 19 Aug 2019 14:12:14 EST WnoKTsVE No.132619
File: 8.jpg -(80085B / 78.21KB, 666x69) Thumbnail displayed, click image for full size. Weird anti-depressant side effects
So there was this girl at the psychiatry and she was given an anti-depressant she has never taken before (I forgot the name of drug, I know it wasn't). The thing is she started hallucinating like seeing things flow together and away. The effects only persisted for an evening. I'm really intriqued by this. Did this happen to anyone else? What anti-depressants have a larger chance of causing this?
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John Morringdag - Mon, 02 Sep 2019 03:56:23 EST UzDAggtB No.132688 Reply
wellbutrin made me feel weird and foggy the entire time i was on it. i would regularly do it for about 5 days and then stop for 2 days, because the 2 days i would stop taking it i would feel like i was fuckin zooming and super euphoric and happy. idk, i had a weird reaction to it
Lydia Blatherwell - Mon, 02 Sep 2019 06:36:09 EST qIrfrJZG No.132689 Reply
Yeah I've been on it plus Lamictal for BD after getting put on Lexapro brought out said BD and then I had a brief period of time where I could reliably abuse Sertraline to get manic if I took enough, which went about how you'd expect.

Wellbutrin was really great for me from the get go with motivation, appetite, and anhedonia and even the tougher symptoms like suicidal ideation but after a month or two I plateaued and they raised it from 150 to 300 and I started getting all these terrible side-effects. After doing any amount of physical effort at all I get beet red, feel like running a 105 degree fever, and start pouring sweat. When it happens I also get this really hard to describe sensation that I get on stimulants sometime if I take too much where I get really itchy and when I move my arms it gets worse and I feel pins and needles. I wonder what that is? Oh, also I haven't slept more than a few hours every other night for the past couple weeks now and it's really starting to take its toll. Took my last dose yesterday, going to call them when they open today.

They gave me Ambien but it did nothing to help me sleep and I got very trippy side-effects even on 20mg. I think this all points to me coming up on a manic episode but I'm just gonna be honest I'm not going on an antipsychotic and I'm not going on an SSRI/SNRI again. I don't know what my options would be at that point though.
Ebenezer Gazzlefield - Tue, 03 Sep 2019 14:06:54 EST UzDAggtB No.132694 Reply
Normally stimulants (wellbutrin is a substituted cathinone, making it one) cause vasoconstriction, but if you are turning beet red and feel like you're running a fever, chances are that's from vasodilation. The vasodilation, if in part it's caused at least in part by histamine release, can cause itching.

The pins and needles, if I had to guess, given the vasodilation and the fact this happens in your arms, is actually a result of your enlarged veins exerting more pressure on the carpal tunnel nerve that runs between the wrist bone(s) and maybe the median nerve that it connects to and runs up the length of the arm. These are sandwiched between veins and bones, making the carpal tunnel nerve in particular easy to pinch because of inflammation or and vasodilation. Pinched nerves, of course, cause a feeling of pins and needles.


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- Thu, 29 Aug 2019 00:13:00 EST G2VzOFbi No.132664
File: 1567051980762.jpg -(14924B / 14.57KB, 320x320) Thumbnail displayed, click image for full size. Sertraline
Been prescribed zoloft 50mg and have never done any other drugs before except for ket a couple times.

Kinda scared tbh, what should I expect? I've had a bit of schizophrenia and hallucinations and paranoia a few years ago that was untreated but didn't think to mention it to the doctor. The doc said that my seratonin levels and dopamine levels are so ridiculously low from a decade of suicidal depression that the first couple weeks are going to be utter hell. What are the possible long term side effects and withdrawals like? I'm a bit of a pussy when it comes to physical pain and I'm afraid of being fucked up long term over this shit. The whole ordeal kinda weirded me out a bit since I was there all of 5 minutes and was given drugs without even really saying much other than some general anxiety and long term depression.

The doc guy kept saying how rough the first few weeks were going to be but to power through unless I'm about to kill myself. ngl, kinda freaked out a bit at all of it.

Don't even know if this is the right board or not. Thought about posting it on /benz//spoiler]
4 posts omitted. Click View Thread to read.
Caroline Hegglestit - Thu, 29 Aug 2019 03:07:16 EST qIrfrJZG No.132670 Reply
Well like I mean sertraline fucking sucks in general for me, but apparently it must work for people otherwise they wouldn't still prescribe it. IDK why they don't at least give you Lexapro or a newer SSRI with fewer side-effects

It makes no fucking sense to me at all that sertraline is still used, it's ridiculous to me
Ernest Dazzlewere - Tue, 03 Sep 2019 02:42:31 EST G2VzOFbi No.132692 Reply
Week in, me bird don't rise and shine no more and it's making me sleep like 30 minutes then wake up, then sleep 30 minutes and wake up over and over. Aside from that no effects whatsoever.
Ebenezer Gazzlefield - Tue, 03 Sep 2019 13:57:36 EST UzDAggtB No.132693 Reply
I'm not opposed to using SSRIs and SNRIs, they do at the very least seem to help treat Generalized Anxiety Disorder and are potentially capable of helping some people at least get suicidal depression under control, giving them a chance to work on improve things in their life, attitudes, and outlooks, but they do virtually nothing in the way of actually treating depression outright.

Side-effects are typically limited to having trouble concentrating at first, yawning a lot (and it feels weird to yawn), paradoxically having trouble sleeping sometimes, having trouble waking up after getting to sleep, have sexual dysfunction. Withdrawal can make getting off of them a bit of a challenge because it starts to cause rebound depression, anhedonia, bouts of vertigo, brain zaps, etc.

Really, I wouldn't start taking them unless it's as a last resort or unless you have a significant anxiety problem coupled with your depression. Clinical depression is hypothesized to be the result of an imbalance of key neurotransmitters (what your doctor was referring to by saying you have low dopamine and serotonin levels), but there is virtually no evidence suggesting this to actually be the case and there's actually quite a bit that suggests the hypothesis is without basis and possibly totally bunk. It's what's taught, so it's understandable your doctor mentioned it to you, but I'm a bit irked at them specifically telling you that you have low dopamine and serotonin levels. The only way to test for that is to check your piss for levels of certain metabolites that indicate a possible lower or higher level of dopamine and serotonin. It's not actually a given/a fact that you have lower serotonin and dopamine levels--the doctor is literally talking out of their ass when they say that.

That said, Cognitive Behavioral Therapy will likely have better results for you, even if in combination with an SSRI, at treating your depression than the SSRI will. The SSRI just seems unnecessary unless you've got your back to the wall and need to just try anything as a last resort. Most studies on clinical depression now suggest a causal link to elevated stress levels and the patient's brain's poor ability to cope with stress in relation to depression. Substances that improve the brain's ability to deal with stress (both physical and mental) seem to have higher success treating depression, even ones that act, in contrast to the chemical imbalance hypothesis (and that it's low serotonin in particular), as Selective Serotonin Reuptake Enhancers rather than inhibitors, reducing levels of brain serotonin. Developing mental resiliency, developing stress coping techniques and skills, and being prescribed medications that improve the brain's ability to mitigate stress and anxiety seem to have a much greater chance of success than simply prescribing and SSRI because that's the only real treatment we have at the moment.

You see, the reasoning behind the chemical imbalance hypothesis is totally fallacious. You can look it up on google if you want, but it's hunches and assumptions based on more hunches and assumptions. Improvement or deterioration in mental state was observed under certain circumstances and it was just assumed that it was for greater levels of serotonin and norepinephrine (dopamine too, but less so) or lower levels respectively, but it was never investigated further. There were no further experiments with controls designed to actually determine what was actually leading to the improvements or deteriorations, they just ran with something and pharmaceutical companies wound up making enough profit from it that it's gotten a good foothold on the market and consensus in the medical community.

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