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Has smoking weed inhibited my ability to enjoy LSD?

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- Fri, 28 Aug 2020 09:28:31 EST hCc8hXoC No.904862
File: 1598621311513.jpg -(3654963B / 3.49MB, 3456x4608) Thumbnail displayed, click image for full size. Has smoking weed inhibited my ability to enjoy LSD?
Have I permanently fried my brain? These are supposedly 300ug but I've maybe 2 hours of feeling excited/joyful, then it felt like it dropped off a cliff and I felt quite sober and now I'm only feeling a slight glow.

I'm a bong smoking daily stoner.
>>
Nathaniel Muzzlelock - Fri, 28 Aug 2020 13:01:49 EST Kt+t0nzU No.904865 Reply
>>904862
The answer is no. Increase the dose. That's all. 300ug is a heavy dose. Those blotters were probably over-estimated.
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EdgesSunTattoo - Sat, 29 Aug 2020 19:36:09 EST pnFndUpJ No.904881 Reply
Personally yeah i felt like my daily use greatly diminished psychs. I was first doing them in the military and had never smoked and it was wild. Then i got out and smoked a ton and psychs just werent the same. Im 2 weeks sober now and doing a shroom hike tomorrow so hopefully the intensitys back
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Hamilton Giddledod - Sat, 29 Aug 2020 21:29:45 EST UHe1KLr2 No.904884 Reply
>>904862
Trying buying some piracetam online and taking 1600-2400mg about 30 minutes before dropping acid the next time. Piracetam is capable of potentiating psychedelics to an amazing degree, and typically makes them much more visual too. One hit of acid that I took on 1600mg piracetam + another 1600mg piracetam redosed 4 or 5 hours later was as powerful of an experience as up to 2-4 hits of the same good acid, no exaggeration.
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Edwin Himbleham - Sun, 30 Aug 2020 13:01:42 EST n5shj2K4 No.904891 Reply
no offense dude but you aren't "unable to trip" because of daily toking...you just got some shitty tabs. what youre describing cant happen.
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Edwin Himbleham - Sun, 30 Aug 2020 13:03:05 EST n5shj2K4 No.904892 Reply
ive been dabbing/smoking all day every day for like 12 years now and I'm the best, strongest trips of my life currently.
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Shitting Pegglenadge - Thu, 03 Sep 2020 13:31:24 EST hCc8hXoC No.904959 Reply
>>904891
I'm also taking anti depressants and anti psychotics so I think I really have killed my ability to "trip" because I've tried acid and shrooms and while others got super high, it didn't do much for me.
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Sidney Tillingforth - Thu, 03 Sep 2020 15:33:03 EST eDdaRyot No.904961 Reply
>>904959
>I'm also taking anti depressants and anti psychotics
mate that's you're problem??? Like fuck, this is basic.

You're not tripping because of your medication. It isn't the weed. Anti-psychotics literally stop hallucinations. Holy shit.
>>
Henry Dartspear - Thu, 03 Sep 2020 16:07:15 EST Tz1K8p+5 No.904962 Reply
>>904862
Lol at OP thinking weed fried his brain when he takes anti psychotics (which actually fry your brain)
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James Hocklehit - Thu, 03 Sep 2020 16:20:45 EST v7KU5uSC No.904963 Reply
>>904862
Smoking weed and doing 1P-LSD in combination made me hallucinate porn.
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Angus Socklefot - Fri, 04 Sep 2020 02:11:19 EST hCc8hXoC No.904972 Reply
>>904961
I've tripped fine before while taking the low dose of meds I'm on. On 125ug I was telepathically communicating with others.
I think I may have got bunk because I took 3 last night and had no effect. Sure meds can block that, but at close to 1mg I should be experiencing a bit more than that.
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BonkLorde - Thu, 24 Sep 2020 18:10:54 EST iMI7H21e No.905311 Reply
i can only have fun on acid if i have an entire weekend outside, not confined indoors whatsoever. when i first got into acid i mostly spent it inside smoking weed with friends.
Smoking an ounce a week eventually ended in a near psychotic break and shot my anxieties through the roof. I'm fine now but lose control of said anxieties when i take acid sometimes especially indoors.
In the Long Strange Trip documentary, Jerry Garcia is giving pointers to the camera crew and says itll all be better once they can see the horizon, thats the fuckin truth.
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Jenny Clettingfin - Thu, 24 Sep 2020 22:51:27 EST ifgkEFAQ No.905312 Reply
>>904972
Most of how they prevent the psychedelic effects from happening is the result of the more long-term changes to how your brain/body responds to the persistent presence of your medications in your bloodstream and brain. The structure of many of your neurons has physically changed. Functionality of the system, at least in the context of producing a hallucinogenic trip experience, has been drastically altered. These physical changes are the results of homeostatic feedback mechanism and such mechanisms fall under the purview of pharmacodynamic tolerance--tolerance that develops by the brain's direct response to overstimulation of a group of receptors in order to desensitize the response to the new stimulus through changes in genetic expression and shit that culminate in things like lower densities of receptors being present on the membranes of neurons that have been repeatedly over or underexposed to various substances.

SSRIs/SNRIs cause this response on serotonin neurons, and classical psychedelics function primarily via 5-HT2A and 5-HT2C agonism. Less of the substance floating freely in the synaptic cleft is capable of actually binding to a receptor because there are fewer, which significantly nullifies the response to them. Anti-psychotics depending on whether you're prescribed older typical psychotics or newer atypical ones, prevent at the very least the over-activity of dopamine and glutamate firing in both cases (they;re literally meant to), and acts directly as an antagonist at most 5-HT receptor subtypes in the cases of the atypical ones... further preventing any substantial amount of psychedelic activity from occurring. the overexcitation of glutamate channels is necessary for the psychedelic experience, and the reason serotonin itself doesn't cause psychedelic effects even though it's a 5-HT2A agonist is because psychedelics in particular are observed to exhibit functional selectivity at this site, which causes the stimulation of glutamate receptors that are co-localized with the 5-HT2A receptors/neurons.

So, even though it's entirely possible you tripped relatively fine before, it's most likely the case that your brain hadn't yet significantly undergone any of the physical changes resulting from the pharmacodynamic tolerance build up that your medications cause.
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Polly Gorringshaw - Fri, 25 Sep 2020 02:24:43 EST Aklz6KsZ No.905313 Reply
How do you know you're taking LSD? It could be something else, or very weak/bunk. I definitely do NOT suggest taking two or more unless you order a test kit online first and test them to make sure it's LSD.

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