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420chan is Getting Overhauled - Changelog/Bug Report/Request Thread (Updated July 26)

Mescaline Creation

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!!HToBa9dh - Fri, 21 Aug 2015 17:13:58 EST 4ppVjZXo No.76958
File: 1440191638629.jpg -(42448B / 41.45KB, 460x422) Thumbnail displayed, click image for full size. Mescaline Creation
I just proposed this on /psy/ so let's see what you people think.
>>>/psy/839044

I do have an add-on, though. L-Tyrosine can be decarboxylated to Tyramine so you don't have to get a shitload of cheese to extract. From there, you can just brominate it selectively in basic conditions to brominate the carbons meta to the hydroxide. A simple LG > Hydroxide reaction later, you'll have 2,3,4 tri-hydroxyl(aminoethyl)benzene.

One simple reflux with 4eq of Methyliodide should yield mescaline in 95%+ yields. What do you think, /chem/?
78 posts and 16 images omitted. Click View Thread to read.
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Nell Gecklecocke - Fri, 23 Dec 2016 23:17:17 EST DPjhXpIm No.78415 Reply
>>76973
A good old methylamination with benzaldehyde then a reduction for some trimethoxyamphetamine, a 1000 percent increse in potentcy.
>>
Schepperschop - Sat, 24 Dec 2016 13:33:31 EST xTIigKo1 No.78417 Reply
Find the cactus>>Eat the cactus
>>
press - Sun, 25 Dec 2016 11:24:27 EST Hzvahzwj No.78419 Reply
>>78415
i think you mean a henry condensation with a following reduction?

tfw calmus oil is expenis as fuck and you cant just go via reductive amination for tma2

Solubility question

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- Sat, 24 Dec 2016 18:26:32 EST 750GEpVs No.78418
File: 1482621992333.png -(491474B / 479.96KB, 500x484) Thumbnail displayed, click image for full size. Solubility question
Is α-Methylfentanyl alcohol soluble, or is there something else you'd recommend?

TiCl4

View Thread Reply
- Fri, 15 Jul 2016 00:06:30 EST 2+q0LcOC No.78094
File: 1468555590148.jpg -(24503B / 23.93KB, 530x297) Thumbnail displayed, click image for full size. TiCl4
If Ti has the follow electron config as a base config: (where ^ represents an e-)

^^ ^ ^
4s 3d 3d 3d 3d 3d

would it hybridise to the following (to accommodate (Cl-)4)?
^ ^ ^ ^
sp3d sp3d sp3d sp3d sp3d

leaving it with a final config of (with bonded (Cl-)4):
^ ^ ^ ^ ^ ^ ^ ^
sp3d sp3d sp3d sp3d sp3d

thereby classifying it as a lewis acid because it can accept a lone pair?
i hope this makes sense
cheers

pic unrelated
2 posts omitted. Click View Thread to read.
>>
Isabella Sullyshaw - Sun, 24 Jul 2016 13:14:18 EST R8K15vkj No.78110 Reply
use pre tags for
m o n o s p a c e
>>
levi - Mon, 19 Dec 2016 08:54:13 EST 2kHGLnfS No.78406 Reply
hey man not sure im following you exactly, but it would be much easier to think of this in terms of CFT/ligand field model, as in 4 M-L bonding interactions lying lower in energy than the metal based d-orbitals (e and t2 sets) which have an occupancy of 4. Electronically speaking TiCl4 has low-lying MO's, of primarly Ti character, so yeah it is fairly electrophilic and a decent lewis acid. evidenced in that it happily forms adducts with donor solvents such as THF

Salt

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- Wed, 07 Dec 2016 16:09:37 EST mswwHH6I No.78386
File: 1481144977392.jpg -(169265B / 165.30KB, 1000x744) Thumbnail displayed, click image for full size. Salt
in a context of conducting a synthesis, does it matter whether a reagent is in a form of a salt or not? can you even make such a general statement?

i'm asking because im interested in the chemistry behind converting codeine phosphate to morphine. does it matter whether someone uses codeine phosphate or codeine freebase?

pic unrelated
5 posts omitted. Click View Thread to read.
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James Lightspear - Sun, 11 Dec 2016 23:56:05 EST 9Opqdgsf No.78397 Reply
Depends on the solvent your going to carry out your reaction in. In most cases i can think of the freebase is required. Careful, codeine is easily destroyed by strong acids and bases. Hell, even heat and a little too much ammonia will do it. Also too much water and it will stay in the aqueous layer. Work as small as you can because 9 times of of 10 you will have failures.

codeine 300g/mol
codeine phos 397g/mol
ammonia 17g/mol
sodium carbonate 106g/mol

0.001mol 1mmol codeine phosphate = 397mg
add 1mmol ammonia = 17mg or 170mg 10% ammonia
or add 0.5mmol carbonate because there are 2 sodiums = 53mg
and you should be left with 300mg codeine

In reality you will likely need a little more base in many cases, but it gives you a general idea how much to start with.
>>
Schepperschop - Wed, 14 Dec 2016 18:16:13 EST xTIigKo1 No.78404 Reply
Want morphine?
Ask Papaver!
That difficult?
Not really.

Query for good entry point into chemistry

View Thread Reply
- Fri, 28 Oct 2016 13:21:20 EST g4yJTuN/ No.78329
File: 1477675280844.jpg -(42607B / 41.61KB, 480x391) Thumbnail displayed, click image for full size. Query for good entry point into chemistry
I've always wanted to stick my nose into chemistry and now I have some spare time to do it, so I wanted to ask,
does anyone have a recommendation on good material/literature to start out with?
6 posts and 1 images omitted. Click View Thread to read.
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Doris Hellyfuck - Wed, 07 Dec 2016 23:54:51 EST g4yJTuN/ No.78387 Reply
1481172891901.png -(2208367B / 2.11MB, 1436x938) Thumbnail displayed, click image for full size.
>>78330
Thanks for the pointers!

>>78332
>>78363
This is not really serious enough to warrant that. This is more something productive to do for fun instead of blunting my brain with those animoos and games. Checked out Zumdahl though, seems just right for my way of learning.

>>78384
Actually found that one while browsing chemistry torrents, I love how far away it is from modern learning literature.
>>
Jack Pankinstod - Mon, 12 Dec 2016 12:22:14 EST klMiQ9iI No.78399 Reply
>>78387
I suppose you could go online and find an old chemistry text book and purchase that? That would be a good entry point anyway, instead of jumping right in and mixing a bunch of shit together in your kitchen
>>
Schepperschop - Wed, 14 Dec 2016 17:50:14 EST xTIigKo1 No.78403 Reply
>>78329
Heat food>>>does this taste better>>>why>>>chemistry

DXM Purification

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- Thu, 03 Nov 2016 21:26:09 EST HfyaiY9o No.78336
File: 1478222769896.jpg -(35595B / 34.76KB, 500x750) Thumbnail displayed, click image for full size. DXM Purification
Hello all,

I am interested if knowing the method for purifying DXM from over the counter medication. I have read that such a method exists and would like to learn more about it. I have some basic experience with chemistry and access to laboratory equipment. Could anyone please share the methodology and the background information? Thanks.
>>
press - Fri, 04 Nov 2016 17:11:58 EST aoZYWjFW No.78337 Reply
what kind of preparation of DXM will you be using?
>>
Bombastus !uYErosQbLM!!Mybq1UbK - Wed, 07 Dec 2016 00:26:09 EST MzxQ4oNO No.78385 Reply
>>78336
Buy DXM from research chemical sites?

Anti-Radiation WIFI Antennas

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- Tue, 23 Aug 2016 16:39:24 EST zsw9I8fO No.78166
File: 1471984764869.jpg -(38747B / 37.84KB, 600x600) Thumbnail displayed, click image for full size. Anti-Radiation WIFI Antennas
Is this legit? What evidence do we have to backup that there's dangerous radiation coming from wifi antennas?

http://www.banggood.com/Anti-Radiation-WIFI-Modem-Router-Antennas-p-1078327.html
15 posts and 3 images omitted. Click View Thread to read.
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Cyril Chaffingman - Thu, 24 Nov 2016 17:21:28 EST g4yJTuN/ No.78368 Reply
1480026088801.jpg -(156833B / 153.16KB, 400x581) Thumbnail displayed, click image for full size.
>>78341
Just in passing...
Would covering a room in tin foil block out the cosmic rays?
Or would one need sturdier means?
>>
Eugene Hezzlenure - Tue, 29 Nov 2016 13:57:03 EST K4ted3sw No.78375 Reply
Transmitting antennas are designed to be radiators. An anti-radiation "antenna" is a dummy load which is useful when you want to test a transmitter without radiating a signal.
>>
Bombastus !uYErosQbLM!!Mybq1UbK - Fri, 02 Dec 2016 23:42:33 EST ZEo1qUmp No.78378 Reply
>>78368
I actually don't know if this is a troll post or not. I mean, we literally have /tinfoil/ as a board.

Actually. I love this post

Transform dry vaped herb into bricks

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- Mon, 28 Nov 2016 10:34:32 EST nZCjXMk3 No.78373
File: 1480347272043.jpg -(1015945B / 992.13KB, 3264x2448) Thumbnail displayed, click image for full size. Transform dry vaped herb into bricks
...Walrus
Transform Dry vaped herb into (...)
11/28/16(Mon)19:25:41 No.8502283
992 KB
992 KB JPG
Hello !
I am playing the sorcerer's
Apprentice.

> have ABV ( already been vaped weed ) . It can be grinded as a powder if necessary.
> want to put it together and make it a brick, or something else like solid

Problem, the herb is no longer sticky.

I tried to make it solid by adding a bit of water, let the sun evaporate it , and put this shit in tue fridge for like 10 minutes .... FAILURE, it gave me a muddy mixture ...( pic related )

Any advices ?

Filter Papers

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- Sun, 13 Nov 2016 15:32:34 EST zsw9I8fO No.78345
File: 1479069154587.jpg -(381434B / 372.49KB, 2048x1365) Thumbnail displayed, click image for full size. Filter Papers
As you can, there are a lot of types:
https://en.wikipedia.org/wiki/Filter_paper#Laboratory_filters

Which type should I get for basic gravity filtration of drugs?
>>
Bombastus !uYErosQbLM!!Mybq1UbK - Tue, 15 Nov 2016 01:10:58 EST HCt0W/hp No.78348 Reply
>>78345
do you have a vacuum filtration set?

if yes, 1-2 works best. if no, coffee filters work best. when dealing with pills, it's still best to use coffee filters
>>
Vehk !7HYGxe5v5c - Sun, 27 Nov 2016 22:18:13 EST l5Akm3J6 No.78372 Reply
>>78345

Coffee Filters are best, fine scientific filters tend to filter rather slowly. If you are working with Ibuprofen, you're better off decanting - it is heavy and highly insoluble even at room temperature, so it will form an adhesive block at the bottom of the container that won't fall out even when tilted at a strong angle. Paracetamol is a bit more awkward.

Purifying and Freebasing

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- Sun, 16 Oct 2016 02:30:25 EST zsw9I8fO No.78302
File: 1476599425480.jpg -(16063B / 15.69KB, 369x305) Thumbnail displayed, click image for full size. Purifying and Freebasing
1)
I've gone through this process to convert salts -> freebase by:
adding some salt drug to a lye solution then using hexane to pull the freebase and evaporate.
My question is: while this process seems to have to have worked with a 2C and with U-44770, can you think of any case where the NaOH will mess up the drug somehow? Or a case where the freebase won't dissolve in the Hexane?

2) Is acetone good enough for purifying most drugs? How are you even supposed to know the solubility of a lot of these new drugs like 4-methyl-pentedrone or 3-Fluorophenmetrazine? Acetone is used for MDMA and Ketamine purificaiton, so what stuff does it NOT work on?
8 posts omitted. Click View Thread to read.
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Cyril Chittingbare - Tue, 22 Nov 2016 22:17:00 EST Q2W2CR89 No.78359 Reply
>>78358
Yes. CO3^2- is a better base than HCO3^- since it is able to accept 2 protons as opposed to 1. Not sure if OP should use a strong base like NaOH tho..
>>
Bombastus !uYErosQbLM!!Mybq1UbK - Fri, 25 Nov 2016 23:22:49 EST sglEgUGb No.78370 Reply
>>78359
That doesn't determine strength.

Hydrochloric Acid is around 3000x times stronger than the first proton of phosphoric acid despite it only having one proton.

Help please!!

View Thread Reply
- Mon, 21 Nov 2016 04:54:04 EST xxe0PbAv No.78353
File: 1479722044179.jpg -(187340B / 182.95KB, 374x500) Thumbnail displayed, click image for full size. Help please!!
Hi all,

I hope I'm asking this in the best spot & really hoping someone can assist me w/this......

So I'm getting ready to try ULDN for the 1st time, that is if I can get this figured out. So I thought I added my 50mg tab of naltrexone to 1 liter or 1000mls of water however I didn't look close enough at the bottle I'm using, duh I know. Anyhow instead of 1 liter the bottle I added everything into is 1.25L.
So I'm trying to figure out how many mcg's I have per ml. The recipe I followed has the dosages based on 1 ltr not 1.25 ltr. Considering this is touchy & the dose is based on mcg's I wanted to verify what I now have w/some folks that are way better in the chemistry & mixing department.
I would be very grateful for any info you may be able to provide. Anything you also may like to add about ULDN would also be greatly appreciated.

Thank you!
2 posts omitted. Click View Thread to read.
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press - Wed, 23 Nov 2016 07:56:56 EST JRoOF8iS No.78364 Reply
>>78360
you might want to either get a volumetric flask, which might get expensive i dunno, or find a bottle with which you can very accurately measure a set volume. ideally it would be a bottle with a very thin neck, which would be filled to a certain level of the neck

if your solution is really mixed and the naltrexone is readily water soluble you could store it in several small containers while frozen. then youd simply have to take out a single container, thaw it and shake it before use while the others still remain frozen.

any idea how big one of your drops is? or how much one drop weighs?
>>
LaDiDotty - Thu, 24 Nov 2016 14:24:51 EST xxe0PbAv No.78366 Reply
>>78364
Hi!

I don't have any fancy measuring bottles, can you suggest somewhere I could find one in expensively? The recipe I'm following is to mix 1 50mg tab into 1L but it makes a huge amount. I was thinking to see if I could cut a tab in half or even quarters, cut the water down accordingly but I'm afraid of possibly not cutting it perfectly in half or quarters each time. Your idea of storing in the freezer is great! I was afraid the solution would go bad before I'd ever get thru an entire liter. Even though the naltrexone tabs were easy enough to get I'd prefer not to waste them. I found it odd that w/each study or recipe I found nobody talked about properly storing the mixture or preserving it aside from putting the mix in an amber or cobalt glass bottle or storing in the fridge.
Do you think freezing the mixture would degrade it in any way? Do you know if the mixture is sensitive to light?
I did get a couple different syringes from the pharmacy, 1 I think is useless for dosing anyways, it's more of a child's medicine dropper, 5mls w/o small enough increments for dosing, maybe good for something else. The other syringe is 1ml, has .10 increments & even smaller. I just tried counting how many drops a full ml holds & came up w/30 almost 31 drops. One study & recipe I read said their 1ml dropper held a perfect 20 drops. Not sure what they're using but I tried several times & came to 30-31 each time.
With the recipe I'm following it says that what I should end up with is 50mcg per 1ml & .2 ml = 10mcg. Because I accidentally didn't see the bottle I'm using is a 1.25L instead of a 1 L my drops are slightly diluted. I found a couple other recipes but they're all relatively the same.
The naltrexone tabs I got dissolve very fast & completely in water. One recipe said not to shake the tab in the bottle, that made no sense to me since you want to make sure you have even doses. Another recipe said to shake it vigorously, I did the latter. When I dropped the tab in the water I just left it to dissolve while I ate dinner. When I came back it had totally dissolved on its own w/just an uber tiny amount of particulate floating around. I just shake it real well before each dose. When I draw the fluid into the syringe the water looks completely clear.
While I find it fascinating, I don't have a lot of experience w/chemistry or atleast the experience I do have involves health & beauty care items & there's rarely addition if any micro sized ingredients. Do you think I could find any of the items you suggested on EBay or Amazon? Or is there a better place to buy volumetric flasks, vials, etc?

Sorry for the long post. Thank you so much for all of your help, I really do appreciate it. I hope you have a nice Thanksgiving today!
>>
press - Thu, 24 Nov 2016 15:41:24 EST tXprf7n7 No.78367 Reply
>>78366
id try ebay or amazon for chinese volumetric flasks. doesnt matter wether its a plastic one or one made from glass aslong as the mergin of error is tight enough. real men use glass, because theyre not afraid of suffering the pain of fucking up.

a volumetric flask should be cheaper than a really accurate scale. how accurate is yours?

i dont really see how using amber or colbalt glass bottles would help, those are normally used for light sensitive stuff but im not sure about naltrexone being light insensitive. my bet would be that it shouldnt be, since ive never heard of morphine or oxymorphone are. its not going to degrade when its frozen, but be sure to really give it a good shake after dethawing it. use plastic bottles for storing it frozen. ive seen quite a few phds fucking that up once in a while.

for measuring the final dose a syringe is good
the size of a drop also depends of the diameter of the opening so its not a suprise they found some other ratio. i have no idea about ultra low naltrexone, once read that it can reap lotsa benefits but i dont remember the dosage tl;dr cant get lantrexone anyways

i guess the particulate is some gunk like magnesium stearate or some other stuff they put in to make the pill super duper
no biggie, you have a nice one too

Chemical reaction simulator

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- Tue, 15 Nov 2016 15:24:42 EST Ul4obZPS No.78349
File: 1479241482322.png -(202713B / 197.96KB, 1312x782) Thumbnail displayed, click image for full size. Chemical reaction simulator
Do you know about any program that can be used to simulate chemical reactions?
What is your opinion about it? I recently stumbled upon "Cain" but still haven't learn to work with it.

Boron tribromide demethylation of codeine

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- Mon, 10 Oct 2016 14:55:50 EST 9Opqdgsf No.78280
File: 1476125750712.png -(19996B / 19.53KB, 593x246) Thumbnail displayed, click image for full size. Boron tribromide demethylation of codeine
I am having trouble with this synthesis. I take 15ml DCM with 200mg codeine base dissolved and make sure its really dry with sieves. Then add something like 500mg of boron tribromide. Immediately the codeine drops out of the DCM solution... no doubt my homemade BBr3 contains a small amount of HBr and Br2. This stuff is unbelievably reactive with air, i've never seen anything fume like it in my life. So i waited/stirred 30mins then added ice/ammonia. No precipitate, i assume the codeine hbr simply dissolved in the aqueous. So next i tried the same thing but added 200mg DIPEA to soak up the acid. Still no morphine precipitate. I worked up both layers both times and verified there was no morphine, i thought it might be dissolved in the high PH aqueous layer but that's only possible with NaOH i believe, morphine should always be insoluble in ammonia hydroxide. I don't know what the problem is.

My boron tribromide is a bit red, i don't have enough to distill. I started from Br2 and Al to make aluminum bromide, anhydrous. Unfortunately i couldn't distill this either but i did leave it under vacuum to hopeful get the free bromine out. I melted it and poured it into another flask with potassium tetrafluoroborate and ended up with only a few ml of BBr3 distilling over. Next time i will use liquid tetrafluoroborate. All 3 of these things really fume like hell. I'm not looking forward to doing it again. I will try to use a vacuum next time, my joints weren't greased and it was pulling in more air then it was worth. I have to make sure i don't get the aluminum bromide on the ground joints as well, god damn what a mess. A propane torch wouldn't even get them apart i had to soak in WD40 then use a propane torch.
30 posts and 5 images omitted. Click View Thread to read.
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Charlotte Fuckingville - Sat, 22 Oct 2016 00:48:34 EST 9Opqdgsf No.78323 Reply
>>78320
I used to grow shrooms i thought about extraction but never attempted it. I was planning to use methanol only because its cheap and available at the hardware store. Evaporate with minimal heat (enough to keep condensation from making a wet goop mess) and a fan. Then try to wash with petroleum ether, maybe recrystallize from methanol in the freezer. Maybe add a little dcm to lower the solubility in the mixture.

Your way would probably be cleaner and higher yielding, but who knows. According to this somthing like that should work. https://erowid.org/archive/rhodium/chemistry/psilocin.extraction.html

I hate water in these situations though, so hard to evaporate without heat or time.
>>
Esther Donderkare - Mon, 24 Oct 2016 19:43:12 EST 2Hc2eoG6 No.78327 Reply
Would it be easier to just buy some CYP2D6...
>>
Albert Henkinbanks - Wed, 26 Oct 2016 15:27:19 EST 9Opqdgsf No.78328 Reply
>>78327
I don't think it would be feasible to create an artificial liver, but i really don't know. I do know scientists have modified e.coli to produce thebaine. 2mg from 20grams of sugar isn't too good though, and i expect the modified bacteria would be incredibly fragile. So unfortunately we won't be growing morphine in mason jars like magic mushrooms anytime soon.

Countries like Canada are lucky just to have codeine. If you don't have an opiate to start from you are pretty much forced to grow poppies.

I've found my mercury, i'm going to shake the small amount of bbr3 i have left with it then try the reaction again.

Piperadone

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- Sun, 23 Oct 2016 05:29:48 EST 9Opqdgsf No.78324
File: 1477214988518.png -(19315B / 18.86KB, 203x200) Thumbnail displayed, click image for full size. Piperadone
Any ideas how to synthesize 4-piperidone?
>>
Eugene Dabblekat - Sun, 23 Oct 2016 22:53:02 EST 9Opqdgsf No.78326 Reply
OP here again. Tried the dickmann condensation, acrylates are too hard to make and the burnt plastic smell is not tolerable. The mannich seems to only like to make piperadones substituted on the 2&6 (benzaldehyde, acetaldehyde). Although i havn't tried it yet formaldehyde might work with acetonedicarboxylate, hydrolyse and decarboxilate to 4-piperadone. I can tell you it doesn't work with phenethylamine not in water, alchohol, or acetic acid. Not nearly as easy as most of the internet would have you believe, its quite the opposite. Unless its just me, which is possible as well.

Maybe posassium cyanide + epichlorohydrin = 3-hydroxyglutaronitrile. ***Journal of the Chemical Society, , p. 1164,1166 = 4-hydroxypiperidine**** Then oxidize the 4-hydroxypiperidine alcohol to a ketone somehow. Maybe react with phenethylbromide first then the amine is protected.

Or any other possible routes? I'd love to hear it.

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