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Synthesis of ghb (free acid) from gbl

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- Tue, 18 Jul 2017 22:06:27 EST 1reNg8pO No.78749
File: 1500429987701.jpg -(42696B / 41.70KB, 500x345) Thumbnail displayed, click image for full size. Synthesis of ghb (free acid) from gbl
I recently came across some lab grade gbl (gammy-butyrolactone) which is the precursor to GHB. I've got a few questions because I've never find GH and I'm having a hard time finding some info from chemists who know what they're doing.

Firstly, I wanted to make GH in its free acid firm, rather than the common sodium butyrate salt. What I want to know are whether its fine to take it in free acid form. I think the pka is about 4, so it shouldn't be too sour if diluted in water, but taking it in free acid produces the same effects right? I assume that taking the sodium salt would Judy result in it finding in the acidity of the stomach anyways, I just would prefer to not have to eat a bunch of salt on the side.
Also, did I do something wrong in my procedure?

I started with about 10g gbl weighed analytically, and calculated the moles for sodium hydroxide which was between 6-7g, but I put in some excess to try to push the reaction forward.
I then added a bit of water, roughly 20mL in a round bottom flask, added the hydroxide and then the gbl. After a few minutes, I capped the flask and put it in an oil baths at 70 celcius.
After 2-3 hours, I added a bit of hydroxide to make sure the reaction was basic and he GH would be in its salt form, then I washed the solution with ether 3x to get rid of any remaining unreacted gbl. I took the aqueous layer and added HCl from a 1M solution until the pH was about 2-3, low enough for the gh to be in its acid form. I think the problem is here, because I couldn't find concentrated acid so I ended up adding a lot of water on the side..
Then my last step was to extract the ghb from the autos later with ether. I did this about 3x, combined the etherI'm layers, and evaporated off the ether. I was left with 2g when theoretical yield should have been about 12g.

Do you think that because I ended up using so much water, my remaining gh is in the aqueous solution? I know theree acid is readily soluble in both water and ether, so I'm wondering if this is my problem.

Also, how can I test the solution to show I have ghb with no gbl? I don't want to use the NMR spectrometer just in case somebody ends up seeing the spectrum and asking questions
1 posts omitted. Click View Thread to read.
Lydia Clannerfeck - Thu, 20 Jul 2017 17:47:14 EST UoTssc8h No.78751 Reply
ayy so GBL is a prodrug to GHB. You could just eat the GBL.

Keep extracting the aqueous layer. There's probably more in there. Also try adding some salt (NaCl) to the water to lower the solubility of the GHB in it.

You can tell if there's any GHL in it by taste. GHL supposedly tastes awful whereas GHB is tasteless.
press !XIxc6BpKnU - Sat, 22 Jul 2017 18:28:22 EST PJ0/E4z+ No.78753 Reply
ghb has a distinct taste too, it just isnt as fucking horrible as gbl
somewhere between gasoline, coconut and soap
OP have you considered to simply mix the gbl with a sodium carbonate solution to get a ready to use sodium ghb solution.
obviously youd have take in more volume but it always worked for, although getting too much sodium isnt too healthy and the sodium salt gave me just as much diarhea as gbl.
since the sodium salt is hygroscopic anyways youd have to hustle to keep it dry

Cyril Sunnertot - Mon, 24 Jul 2017 16:41:05 EST CwYciqLe No.78754 Reply
Thanks for the replies everyone. I found a paper and read that ghb is rarely found in its free acid form as it readily converts back to GBL. This back conversion happens even more easily in acidic conditions, which I used to try to protonate the free acid. I will extract as much of what is most likely gbl now from my aqueous solution using salt to push it to the organic layer, evaporate any ether and water left over and mix the gbl back with a small excess of sodium hydroxide. I'll calculate it so that once all the gbl had reacted with the sodium hydroxide in a 1:1 stoichiometric fashion, that the pH will be about 8.5 at the end in a small precculated volume so the ghb doesn't convert back to gbl

Thin Layer Chromatography

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- Mon, 19 Jun 2017 12:24:25 EST hzoMepax No.78695
File: 1497889465751.png -(861058B / 840.88KB, 726x728) Thumbnail displayed, click image for full size. Thin  Layer Chromatography
gonna make some TLC plates using some glass microscope slides, wondering what the best paper to use for cellulose is? i was thinking using a thin tissue or something but it's incredibly soft and porous which makes me think that i might not get very clearly defined results. any suggestions?
3 posts omitted. Click View Thread to read.
Cedric Dreffinghall - Tue, 11 Jul 2017 13:49:20 EST 4tmtdVyg No.78737 Reply

As far as destruction of the sample, when you choose a solvent for solvating the material, it must do two things:

Dissolve the sample
Be inert to the sample

As an example, sulfuric acid will probably dissolve your sample, but will typically make a poor solvent due to the likelyhood of it protonating the shit out of your sample. A solvent like octane will make a good solvent for non-polar materials because it is straight chain hydrocarbons which are non-reactive under standard conditions. Same concept with acetone, except for polar samples.

Both octane and acetone can become reactive with the right materials under the right conditions, and that's why you need to know what your sample reacts with so you can choose a solvent that will both dissolve the sample and be inert to it.
Bombastus Werrywag - Tue, 11 Jul 2017 17:45:21 EST QGxEeR56 No.78745 Reply
You can use pure water if paper is your stationary phase.

BK-2-CB > Injectable 2-CB solution?

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- Thu, 06 Jul 2017 06:02:36 EST A0Fffnyd No.78722
File: 1499335356854.jpg -(407511B / 397.96KB, 1024x768) Thumbnail displayed, click image for full size. BK-2-CB > Injectable 2-CB solution?
Have tried this three (3) times with repeatable results:

2ml sterile water

(x) amount of Ascorbic Acid to sufficiently acidify the water (No precise measuring equipment available)

(x) amount of B-K-2-CB (As above)

Add enough Ascorbic Acid (it is believed Citric as supplied in UK would work as well) to the water to dissolve *Without Heating*

Add (x) amount of B-K to dissolve with *a very little heating* or you're going to be injecting recrystallised 2-CB - exciting as that sounds, it is fucking painful and could possibly end very quickly in sudden cardiac arrest, depending on which vein is used... *BE VERY CAUTIOUS*

Enjoy your instant stimmy effects followed by typical 2-CB effects


PS enjoy one and all any potential profits made from this discovery
8 posts and 3 images omitted. Click View Thread to read.
Samuel Davingdidge - Fri, 07 Jul 2017 12:44:17 EST UoTssc8h No.78733 Reply
The standard procedure for reducing ketones to alkanes in one step is the wolff-kishner reduction, which requires complexation of the ketone with hydrazine (used in rocket fuel) and heating the mixture to 200 C for a few days to a week. ascorbic acid is a MILD reducing agent, and there is pretty much zero chance of this method producing even fractions of a percent of yield of 2CB from bk-2CB. The placebo effect is a much better reducing agent, but still not as good as hydrazine.
Hannah Susslebury - Fri, 07 Jul 2017 16:36:34 EST rANt8sEP No.78734 Reply
Awesome guys, thanks for all the info... Back to the drawing board then, or a very expensive lab...
Bombastus Werrywag - Tue, 11 Jul 2017 17:43:46 EST QGxEeR56 No.78744 Reply
1499809426609.jpg -(60156B / 58.75KB, 514x569) Thumbnail displayed, click image for full size.
You don't need need Hydrazine. LiAH could work because of the conjugation from the pi ring. If LiAH does work, then you can just do it using the pop bottle test and overkill it with LiAH. No water allowed, of course.

A simpler, cheaper, but much harder method is clemmenson that is an in-situ reducing agent (hydrogen gas) by mixing a zinc or mercury amalgum and with HCl or HBr

keine chemische ist legal im deutschland... danke, praesident der E-U.

From what my basic knowledge of receptors tells me (from around one and a half pharmaceutical chemistry courses i took a while ago) is that that ketonic group would be much less active than 2c-b for dopamine / serotonin effects. it could possibly give you the side effects of the compund but none of the mental, spiritual, or stimulating properties.

Extract Heroin from Garlic Paste

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- Mon, 01 May 2017 08:23:55 EST GJqJPZ5S No.78644
File: 1493641435717.jpg -(5774B / 5.64KB, 259x194) Thumbnail displayed, click image for full size. Extract Heroin from Garlic Paste
This is urgent as my life literally depends on it. My suppliers showed up with what was seemingly my regular kg pickup but actually was 10kg of garlic paste with the heroin suspended within it somehow. Am told that I have to extract the materials from the paste for them or I will exist no more.

Will a simple Acid Base extraction do the trick IE:

Mix Paste into Water + Lye Solution and Agitate for hour

Add solvent of choice (Cold Distilled Water + Methanol Mixture?)

Let contents settle

Siphon Solvent and Evaporate to retrieve powder

Purify powder using known methods via HCL / Diethyl Ether

Can anyone tell me if this is adequate enough? Im essentially going to go in blind and hope this process works and that I don't get killed in the process.

Hope you guys read this and realize where opis may lead you as it has lead me....hopefully not to my death.
4 posts omitted. Click View Thread to read.
Cyril Hasslespear - Fri, 30 Jun 2017 08:46:34 EST BIUvdYqW No.78716 Reply
bro, no one is gonna send valuable tar in garlic powder, I hope you die for being tar dealer
George Depperfit - Sat, 01 Jul 2017 11:12:11 EST 4tmtdVyg No.78717 Reply
Holy lol,

I wouldn't try acid base, I'd start with an aromatic solvent like xylene. Diamorphine is highly aromatic and you're more likely to get a hit on a non polar aromatic solvent. Plus acid base is typically used to free chemicals from plant matter. Since garlic doesn't naturally contain morphine, or any forms of it, I would think that the morphine is mixed in rather than bonded with the garlic in any way.

I would try soaking the material in xylene for an hour, placing the mixture in a cheese cloth, and squeezing the liquid into a separate container, preferably glass since some plastics are soluble in aromatic/non-polar solvents. Then chill the strained liquid in a freezer and scrape up the solids that come out. Use the liquid left over to soak the garlic again for a second and third extraction.

More than likely, the solids that appear after freezing will be dirty with garlic compounds as well, but it's the first step in the right direction. after that, just purify it.
George Depperfit - Sat, 01 Jul 2017 11:20:59 EST 4tmtdVyg No.78718 Reply
Oh wow, this thread is old as fuck

OP, you dead?

Work thoughts

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- Sun, 21 May 2017 07:51:22 EST ZPX2kpEE No.78655
File: 1495367482443.png -(245976B / 240.21KB, 398x297) Thumbnail displayed, click image for full size. Work thoughts
Does anyone else think of dumb shit while they're at work? Yesterday I was thinking about bubble theory, what if this entire universe repeats itself exactly when it ends.

So everything happens again and again in one big circle, like how your pulse keep pulsing and your lungs keep breathing, what if the solar system is an element like those in the periodic table, I mean if you look at one then you see the electrons orbiting around a neutron or something right?

I realise all this is very retarded but this kind of thinking does help the hours go by.
5 posts omitted. Click View Thread to read.
Betsy Dapperwater - Mon, 12 Jun 2017 18:56:07 EST 4tmtdVyg No.78680 Reply
1497308167717.gif -(921544B / 899.95KB, 171x141) Thumbnail displayed, click image for full size.

>which states that electrons form clouds

I always thought that the 'cloud' was a conceptual method to help us visualize what is happening at the subatomic level, as in the cloud is the average position of the electron while the electron is still a minuscule fraction of the cloud as a whole.

Does the electron take up the entire space of the cloud? Or is located at a single point in the cloud which we average to be spatially accurate? Or is it both? Or is it neither? Am I here now or am I an average of my current position? Am I real?
Ernest Bubberbanks - Wed, 14 Jun 2017 00:00:06 EST GaLvZHtU No.78684 Reply
Read the other anon's post. The cloud isn't a "cloud", it's a probability field where the electrons are about 90% of the time.
When you get down to such small particles they don't behave like matter, so it's hard to visualize. Basically these electrons pop in and out of existence and preferably along this cloud, albeit sometimes outside.

Volatile stuff

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- Sun, 21 May 2017 20:21:38 EST hNxjAHrm No.78658
File: 1495412498451.jpg -(134104B / 130.96KB, 720x960) Thumbnail displayed, click image for full size. Volatile stuff
At my job in a corn refinery I check solutions of 3% NH3, 2&5%NaOH, 7%HCl w/v using a graduated cylinder, specific gravity bobber, a pH meter temperature probe, and a reference calculation.

Is there a better way? It seems to me we should be able to incorporate some kind of probe out in the plant to check these constantly and automatically adjust instead of taking everyone's time to do them be hand every few hours, look at the results elsewhere, call them reasonably accurate, and adjust, all the while exposing the sample collectors and lab personnel to hazards.

Pic is from my research plot at uni, Boris came from a stray pollen grain in this otherwise introgressed population and had to be castrated.
Hamilton Bockledock - Fri, 02 Jun 2017 03:20:48 EST zsw9I8fO No.78674 Reply
I wish I could tell you but I don't know about fractional distillation nor column chromatography. Sorry sir.
press - Wed, 14 Jun 2017 13:39:45 EST 3upPNRT1 No.78686 Reply
1497461985771.png -(360691B / 352.24KB, 600x800) Thumbnail displayed, click image for full size.
im not familiar with the setup of a sugar factory and i dont know what exactly youre asking but in some cases an icorporated EC or pH sensor -or a series thereof- is good enough to adjust to the correct levels.

but if all youre checking is the stated solutions which are then added in a whole batch as opposed to continous flow, id reckon that a graduated zylinder and a single EC or pH probe that is calibrated for the given range would be enough. you could then just mix them in bulk and store the fitting amounts in containers? ive got no fucking idea.

as i now begin rambling id like you to take everything with a 58g of salt.
for automation of pH and EC and density you could use an arduino based sensor system if youre just getting into automation. there are quite reliable prebuilt shields and chips for pH and EC. depending on the general setup of the system you could either use a microcontroller, arduino based or a clone, and fucking labview, or run a microcontroller via python to log data and readjust the solutions. but in my experience the pumps and valves(which would normally fare fine at the concentrations youve listed) are still fucking expensive or not that easy to build from scrap.

and no offense, eventhough ive been both a security supervisor and a union representative, there bettter be a huge lot of 3% ammonia or 7% HCl before its more of a danger to personnel than to equipment.

was that 2,5% sodium hurensohnoxide or 2,5? and just keep volatile shit out of direct sunlight and in airtight bottles that arent placed above a fire.

Hydroxyl Free Radicals

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- Thu, 25 May 2017 14:43:57 EST +41/TUGa No.78663
File: 1495737837795.jpg -(549713B / 536.83KB, 1000x750) Thumbnail displayed, click image for full size. Hydroxyl Free Radicals
I'm currently using kratom to isolate its alkaloids via oxidation > extraction and am starting to get concerned of possible byproducts of my reaction. I am not using lab grade glassware for the first steps involving oxidation with H2O2.

My main concern, is it possible for free radicals to form and possible trace amounts of metals in my final product. I'm basically soaking the kratom in H2O2 and agitating on low heat with small amounts of citric acid added, then that is continued until the material is almost completely dry where I'm assuming the leftover liquid is water since the H2O2 oxidizes the mitragynine and 7-OHM into mitragynine pseudoindoxyl. Can anyone experienced in organic chemistry help me out with this?

We only use cold water for the extraction of the oxidized kratom material so that isn't much of a concern as much as using metal pots and pans during the actual oxidation process. Should I be concerned of consuming free radicals once fully evaporated? Are there any possible byproducts that can form from doing this?

Thanks a ton and excuse my ignorance in chemistry, I don't know shit besides what I learned in highschool and my current research onto this topic.

The pic attached is the final product after filtration of the initial oxidized material through cold water into 5 then 1 micron filters then finally evaporated at low heat.
1 posts omitted. Click View Thread to read.
Hunter S. Nodson - Tue, 30 May 2017 01:32:25 EST 5wCuF3rA No.78670 Reply
there are articles on it, it is documented my man. It takes a few minutes of google and there is plenty on the oxidation of 7-ohm into mitragynine psuedoindoxyl. I'll post it tomorrow when I get a chance though.

thanks for that reassurance, like I said I'm ignorant to this in all aspects and this is a learning experience for me so bare with me. We did though, I got the pH down to 4. As far as the difference between just soaking in water, we've tested it. It does not come out like this at all. The peroxide makes a giant difference. I do understand h2o2 wont oxidize much until the pH is lowered a decent amount.
Graham Chunkinham - Thu, 01 Jun 2017 18:15:12 EST UoTssc8h No.78672 Reply
I still highly recommend acid base extraction so you can work with pure reactants rather than trying to oxidize the raw leaves. You have no idea how much oxidant to add because there are thousands of different compounds in the mix all with different oxidation potentials.

Also the paper you posted is an overview of a semisynthesis of mitragynine pseudoindoxyl from something other than mitragynine. I still can't find anything on chemically converting one to the other. Everything i've found so far involves bacterial or fungal metabolism to affect the rearrangement. The way I see it, it is very unlikely that you will be able to produce a sizable amount of pseudoindoxyl with household oxidants. I am kind of curious about this now though so I am still searching.

Stoichiometry a bitch

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- Fri, 26 May 2017 04:22:42 EST WkWxSK6I No.78664
File: 1495786962793.jpg -(4130979B / 3.94MB, 5312x2988) Thumbnail displayed, click image for full size. Stoichiometry a bitch
Could someone please jog the old memory bank. How in the fuck do you get 1.8×10^(-6) from 2.8x10^(-8) mol × 63.5g mol-1???
Caroline Drennerwell - Fri, 26 May 2017 13:09:34 EST UyoEcrVg No.78665 Reply
2.8 times 63.5 is 177.8
Move the decimal over a couple places and you get 10^-6 instead of -8
It's rounded to 1.8 because of significant figures.

i'll just leave this here

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- Mon, 27 Mar 2017 03:58:41 EST 6p22FvVe No.78612
File: 1490601521191.png -(43318B / 42.30KB, 414x524) Thumbnail displayed, click image for full size. i'll just leave this here
cf piperine, phenylacetic acid, etc.
7 posts omitted. Click View Thread to read.
Charlotte Hurringchare - Tue, 25 Apr 2017 18:52:15 EST UoTssc8h No.78643 Reply
What about forming the diol with peroxide and base then cleavage with nickel?

This paper shows 1,2-cyclohexanediol can be cleaved to adipic acid just by dumping it in with some bleach and nickel nitrate/acetate: http://pubs.acs.org/doi/abs/10.1021/jo0612574. Theoretically this should yield the aldehyde if the nickel oxidant were instead isolated and the reaction done under anhydrous conditions.
Martin Dicklecocke - Sun, 14 May 2017 10:17:15 EST UoTssc8h No.78651 Reply
Has anyone tried the dithionite reduction of piperinic acid? The source OP cited only has info on reducing acids with aliphatic side chains and I'm thinking that conjugation with the aromatic ring might cause the beta-gamma unsaturated acid to re-arrange to the gamma-delta or otherwise muck something up

unexplored waters

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- Sat, 22 Apr 2017 17:42:58 EST UoTssc8h No.78641
File: 1492897378795.png -(23977B / 23.42KB, 567x417) Thumbnail displayed, click image for full size. unexplored waters
Pretty much any phenol without other more lablie reactive sites can be converted to an allylbenzene (like safrole) via condensation with allyl halide and subsequent aromatic Claisen rearrangement of the allyl phenol ether. From there it's known chemistry to get to an amphetamine derivative. pic related is delta-tocopherol, a form of vitamin E, and it's resulting amphetmaine derivative, which is strikingly similar to the 2C-x's and DOx's. There are literally thousands of easily obtainable phenol-derivatives out there with possibly psychoactive derivative amphetamines. Why has there not been more exploration into this chemical space?

Which Major Least hard

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- Sat, 04 Mar 2017 01:53:55 EST LObRvGV/ No.78585
File: 1488610435460.jpg -(170885B / 166.88KB, 670x901) Thumbnail displayed, click image for full size. Which Major Least hard
Which major requires less chemistry? Because to me, chem always seemed like an endless list of things to memorize: polyatomic ions, acids, bases, electron charges, drawing Lewis-dot diagrams, etc ad nauseum...

  • Neuroscience
  • Pharmacology
  • what else?
5 posts and 1 images omitted. Click View Thread to read.
Fucking Lightham - Wed, 12 Apr 2017 00:30:04 EST roSXguau No.78634 Reply
chem is fun in the lab, did neurosci major because the psych courses were easy, now getting over more into computer science. study what you like tho, you'll have plenty to memorize anyway.
Esther Drandlegold - Sat, 15 Apr 2017 13:01:09 EST q+gC2Vuv No.78636 Reply
Neuroscience probably has less chemistry but both of those majors are pretty heavy memorization. You will have to memorize drug/metabolic pathways. At least in chemistry there is an internal logic to it once you get the basics down, but with molecular pathways it's almost senseless memorization with having to know all the different (often randomly named) parts and how they interact with each other.

What testing could be done on RCs ordered online?

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- Mon, 09 Nov 2015 17:25:34 EST NUJLhhhW No.77357
File: 1447107934857.jpg -(221066B / 215.88KB, 1045x854) Thumbnail displayed, click image for full size. What testing could be done on RCs ordered online?
So, I found a clearnet source for both Etizolam and Clon, but then upon checkout, this shit comes up:

>We will need a detailed account of your research methodology though before shipping any order. This an include how you will be utilizing the chemicals, what equipment is used, anticipated results, etc.

What is some things I can say? Obviously they know people are just ingesting them, yet they still have the disclaimer for Not For Human Consumption. That's fine.

But I've never seen this type of bullzhit.

anyone a science student or chemistry student or actual chemist or anything? I know some people say they can test for purity of the drugs. What would be used for that? Some type of ethanol, beakers, syringes, etc?

6 posts omitted. Click View Thread to read.
Fanny Nucklelune - Mon, 27 Mar 2017 11:52:55 EST NiKHAkYF No.78613 Reply
>we cannot divulge into specifics.
Excellently worded. You'll be fine.
Phineas Gaffingcocke - Mon, 10 Apr 2017 00:00:59 EST n/Fuk2xx No.78631 Reply
what are you trying to do?
make Oxycontin?
I really wouldn't recommend that.
Fucking Lightham - Wed, 12 Apr 2017 00:22:40 EST roSXguau No.78633 Reply
it's for zapping labrats, read and cite some research papers.

A/B xtract. Blood interaction.

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- Thu, 06 Apr 2017 22:23:54 EST LObRvGV/ No.78627
File: 1491531834158.jpg -(15650B / 15.28KB, 320x180) Thumbnail displayed, click image for full size. A/B xtract. Blood interaction.
If you did an A/B on a bunch of used cottons with some blood in the mix as well, what would the blood do if you add base->non-polar extract->add acid to neutralize.

Or wait, now I forget... ^ that sounds like "B/A'... if you're starting with traces of heroin-hcl leftover, then you would start with the base, riiiight....

P.S. check out your
\Program Files (x86)\Steam\SteamApps\common\Counter-Strike Global Offensive\csgo\streams
folder for some cringey streamer shit.

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