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420chan is Getting Overhauled - Changelog/Bug Report/Request Thread (Updated July 26)

Classification

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- Fri, 02 Sep 2016 15:26:59 EST CfiuryLA No.78207
File: 1472844419342.webm [mp4] -(3594835B / 3.43MB, 540x360) Thumbnail displayed, click image for full size. Classification
So this might be more semantic than scientific but I wanted your guys thoughts on the matter,

So hypothetically, if we did find life from another world, life evolved from a completely independent source than ours, and even if it was animate, easily recognizable life, maybe even humanoid...

It still couldn't technically be an animal or any of our kingdoms/domains of life, right? Like, when we're talking about the various domains and kingdoms of life, it's kind of implied those can only be terrestrial in origin since we're talking about a tree of life with a common ancestry right? Like if we got an Earth fungus to grow on another planet and it evolved into a new species of fungus to better live on that world, it would still be a fungus because it's ancestors were Earth fungi. But if a life form from somewhere in space from a completely different line of evolution were to travel to earth, even if it coincidentally shared a lot of similar traits to Earth fungi due to functional convergent evolution, it still could never be considered kingdom: fungi right?

tlIf do we sort alien life forms by phenotype traits or genotype ones?
>>
Henry Brobberbitch - Fri, 02 Sep 2016 19:36:46 EST bvtI5MJW No.78210 Reply
i suspect that if and when we discover extraterrestrial life, biologists and zoologists will agree to classify every evolutionary ancestral lineage independently. maybe add a celestial identity marker, e.g. Terra Homo Sapiens Sapiens

iNaturalist

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!/sly9iFJgg - Thu, 01 Sep 2016 08:07:03 EST H8Fdbu5S No.78201
File: 1472731623063.png -(165760B / 161.88KB, 640x1136) Thumbnail displayed, click image for full size. iNaturalist
It has some design flaws, like an inability to delete your own ID's, but it's hella fun and a great way to support the scientific community!

Estimating the relative potency of a fentanyl analogue

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- Mon, 15 Aug 2016 12:02:06 EST Y1ptdQKh No.78154
File: 1471276926041.png -(13693B / 13.37KB, 554x376) Thumbnail displayed, click image for full size. Estimating the relative potency of a fentanyl analogue
Dearest /chem/,

I wish I were one of you, but I'm not. My knowledge of chemistry trivia might impress at some parties but when actual questions arise, assistance is necessary. I was hoping you could help me estimate the relative potency of cyclopentyl-fentanyl, a novel fentanyl analogue. You will find It's structure displayed in the picture.

My thoughts: Cyclopentyl-F seems to be structurally related to Acryl-F. The latter is said to be active at doses <10 mcg. But on the other hand, cyclopentyl-F also seems related to Acetyl-F which is said to only be 1/20th the potency of regular fentanyl.

Thank you for your time.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 25 Aug 2016 19:54:09 EST Req4jw5M No.78177 Reply
>>78154
With most of this shit, you simply can't look at the molecule and guess its relative potency, unfortunately. This is just the reality of biological assays and why they are necessary.

Organic chemistry is simple to estimate but biochemistry requires in depth knowledge of all the enzyme sites around your receptors which can lead to potency changes. This is near impossible to do without high computational machines or more accurately: petri dish bio assays.

Sorry to burst your bubble, Sarringberk.
>>
David Mondlelotch - Sun, 28 Aug 2016 11:12:00 EST wAPrdwU9 No.78185 Reply
>>78177
Hi, a solution with 120-140mg / 10ml dest. water.
I recieved the powder in oxalate form, it needed alot of heating to solve. This solution was then added to a nasal spray. Akryl recipe, is 20mg/10ml dest water, for nasal sprays.

hydrogen

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- Tue, 23 Aug 2016 04:15:50 EST Ano5zrbo No.78164
File: 1471940150381.png -(1814256B / 1.73MB, 1920x1080) Thumbnail displayed, click image for full size. hydrogen
ik we are carbon based lifeforms but really, arent we hydrogen based life forms?
wouldnt all life be based off hydrogen in some fashion?
I mean look at it
H20 man.
8 posts and 2 images omitted. Click View Thread to read.
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Caroline Crungermore - Sat, 27 Aug 2016 21:31:05 EST zsw9I8fO No.78182 Reply
>>78167
I wasn't intending for this post to be taken seriously.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Sun, 28 Aug 2016 02:14:08 EST Req4jw5M No.78183 Reply
1472364848352.jpg -(74184B / 72.45KB, 640x480) Thumbnail displayed, click image for full size.
>>78182
Well you clearly underestimated my enthusiasm powers.

Books, books, more books

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!7HYGxe5v5c - Sun, 12 Jun 2016 22:36:55 EST zn1t5pEx No.77965
File: 1465785415158.png -(40799B / 39.84KB, 1189x269) Thumbnail displayed, click image for full size. Books, books, more books
Recently in the CWE thread someone was asking for book recommendations on chemistry textbooks, and the rest, and Press uploaded a couple of image-rars. I've been thinking we could benefit from our own central thread where we can discuss our collections, what we're reading, with an organic chemistry/synthesis theme. I know they have a good recommendation list at the /sci/ wiki over on the future, but fuck the future. This is /chem/ and we are a proud people. Also, we have a smaller community centered more around org-chem and synthesis, so it's a niche this thread should fill with more in-depth recommendations on the subject, and the provision of papers and other supplemental material.

To anyone looking for books, I'd recommend libgen. I only recently discovered it and I'm quite frankly relieved at not having to scour torrent sites and the awkward interface of #bookz for hours on end only to discover a rare book I'm looking for isn't being seeded.

I recently got Alan F Casy's Opioid Analgesics: Chemistry and Receptors off it, which I'd actually considering buying for about 50 euro used half a year ago. What a travesty that would have been. So far I've only checked out the chapter on 4-phenylpiperidines, but so far it's an interesting read. I used to have a better collection on my old computer but it crapped out, and here's what I'm working with at the moment while I rebuild it. I'm an undergrad, so I assume some of the more seasoned veterans here will have comprehensive collections.
14 posts and 4 images omitted. Click View Thread to read.
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press !QUHukXEvkY - Mon, 27 Jun 2016 13:39:12 EST fcMijPsC No.78034 Reply
>>77998

id guess that growing yeast or bacteria is a bit simpler and less dependant on sociopolitical bullshit than poppies.
>>
Hamilton Honeylock - Wed, 03 Aug 2016 15:45:47 EST V/qMoGDW No.78127 Reply
Right, so what can you people tell me about them fume hoods? What do you have to consider when setting up a basement lab? I think I can't just go right ahead and pump all the fumes out the fucking window, right? Do I need some kind of filter? Are there any laws for this shit? It's really unfortunate for me because I can only do this in my basement with a window that's facing the backyard. Occasionally there are some fucking brats running around too. I beg for your help! It's the only thing seperating me from doing lab work

Why am I so fucking shit at kitchen chemistry

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!1CreRGKd/6!!TfPvomrn - Thu, 07 Jul 2016 21:22:03 EST 5Pw/LIPu No.78073
File: 1467940923077.jpg -(40715B / 39.76KB, 575x383) Thumbnail displayed, click image for full size. Why am I so fucking shit at kitchen chemistry
I fucking hate my life. Bombastus, can I please come live with you since you're actually good at chemistry? I promise I will be a faithful lab assistant, am totally willing to get a Canadian visa, and would love to learn all about how to not suck dick at kitchen chemistry.

I really need general tips on how to actually manage to perform kitchen chemistry and not fail at things as simple as fucking morphine extractions. Nothing I attempt ever seems to work. I'm just quite unhappy right now. Pls gib advice.

Sorry for the super low-res photo
6 posts omitted. Click View Thread to read.
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Bombastus !RZEwn1AX62!!xXxJO70U - Mon, 08 Aug 2016 14:46:39 EST HCt0W/hp No.78140 Reply
>>78139
Good watch glasses and lab covers.
Liquid liquid extract everything else. Then filter extract morphine. That sounds easier than other options.

HCN my shit up fam.
>>
Press - Tue, 09 Aug 2016 03:06:51 EST MKujOXWI No.78143 Reply
>>78140
Meh, shits gonna get stuck at the rims.

Just methylmercury my fam, fuck
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Tue, 09 Aug 2016 19:42:54 EST HCt0W/hp No.78144 Reply
>>78143
Methylmercury is probably a great way to suicide. It's like condensed cancer and the doctors would probably give you all the opiates you want. Maybe even some benzos.

pic related of my script
nb

How water goes up straws

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- Sun, 07 Aug 2016 22:02:44 EST MVUX73Om No.78135
File: 1470621764791.gif -(1571571B / 1.50MB, 370x288) Thumbnail displayed, click image for full size. How water goes up straws
The reason that liquids go up straws is not because you're sucking it in but because you're displacing the oxygen inside the straw allowing the liquid to shape without the pressure of oxygen.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Sun, 07 Aug 2016 23:32:27 EST HCt0W/hp No.78136 Reply
>displacing the oxygen
You mean the air? Specify. We're on /chem/ afteral
>allowing the liquid to shape
The definition of a liquid is that it has no shape nor does it retain on. what do you mean "the pressure of oxygen"?

Also, why did you start this thread even.
>>
James Dinningbanks - Sun, 07 Aug 2016 23:59:23 EST MVUX73Om No.78137 Reply
>>78136
I don't know, I like pretending like I know science
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Mon, 08 Aug 2016 14:47:21 EST HCt0W/hp No.78141 Reply
>>78137
Good for you for admitting it, at least.

nb

Oxymorphinol and Hydromorphinol

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!RZEwn1AX62!!xXxJO70U - Mon, 27 Jun 2016 02:29:51 EST G8mu3scS No.78032
File: 1467008991222.jpg -(92318B / 90.15KB, 790x753) Thumbnail displayed, click image for full size. Oxymorphinol and Hydromorphinol
Hey faggotqueers. Are these the same fucking thing?
https://en.wikipedia.org/wiki/Oxymorphol
https://en.wikipedia.org/wiki/Hydromorphinol

Possible synthesis discussion below.
11 posts and 2 images omitted. Click View Thread to read.
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Bombastus !RZEwn1AX62!!xXxJO70U - Fri, 22 Jul 2016 21:26:14 EST ycAJxrEI No.78108 Reply
>>78047
I swear these shits are the same fucking thing.
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Sun, 24 Jul 2016 14:17:21 EST HCt0W/hp No.78111 Reply
>>78109
No in the molecule. I still can't see the difference and it's NOT in chirality.

microscopic telescope

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- Fri, 22 Jul 2016 13:12:29 EST 6cilZam8 No.78106
File: 1469207549120.png -(11018B / 10.76KB, 798x294) Thumbnail displayed, click image for full size. microscopic telescope
I just wondered, I have never heard of a microscopic telescope. By this I mean a device along the lines of a large nature-style camera lens or traditional telecope that is able to zoom in to the target area of a physical item and produce a 3d environment of that area through the lens? Surely theres an infinite amount of detail from a physical item We have all this advanced astronomical technology these days to look at things that lie in the distance. What would happen if technology was put into microscopic telecopes thanks everyone

TLDR: a lens of intricately layered magnifying glasses that self multiply
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Fri, 22 Jul 2016 15:51:09 EST ElYFdcKO No.78107 Reply
>>78106
the width of photons and their wave functions still have a measurement and you need to capture a lot of them to concentrate them. this is why a microscopic telescope isn't worth producing because they'd be so damn sensitive, there'd be no point. the curvature of the glass is also then limited due to the angles possible when the radius is limited.

Demethylation - pyridinium pathway

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!RZEwn1AX62!!xXxJO70U - Sun, 26 Jun 2016 14:02:33 EST LtWIDIP2 No.78028
File: 1466964153727.png -(3184B / 3.11KB, 120x111) Thumbnail displayed, click image for full size. Demethylation - pyridinium pathway
Trying 3-4 different demethylation strategies under mild conditions, it seems that pyridinium HX is going to the be easiest and most non-retarded way of demethylating any species.
Any other format either seems to cleave the ether bridge, require too much heat, or is simply impractically tender.

So I wonder - does anyone have any resources on a better yielding demethylation of aromatic methoxides with pyridinium salts? Can anyone find any literature that says PyHBr would be more selective and cleaner than PyHCl with a 15% yield in demethylation of "certain" compounds? Would they be more selective or would it just not matter?

Pic unrelated
10 posts and 4 images omitted. Click View Thread to read.
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Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 14 Jul 2016 13:50:50 EST II1FH3AD No.78091 Reply
>>78086
don't retard the thread I'd just start a new one because that one has so much information to sift through its not worth rebumpin at this point (sorry fiend)

think I'm too busy to try this demeth though. I like science and shit but I also like my time more
>>
press !QUHukXEvkY - Thu, 14 Jul 2016 23:57:40 EST fcMijPsC No.78093 Reply
>>78091
it already was retarded the minute it started. but i agree with it being too flooded, hence i want to make a simple compilation


what about the potassium methoxide?
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 21 Jul 2016 19:25:38 EST vbS8CtHn No.78105 Reply
>>78093
you'll never make a simple compilation because of the retardation that comes with being 420chan. that's just how life goes and i'm ready to fucking kill myself.

what ABOUT methoxide? i feel like that would be too strong of an electrophile and might just rip the ether open.

Is it possible to make shakenbake with lorantadine10mg/ psuedophedrine

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- Thu, 14 Jul 2016 13:31:03 EST sM4N11VN No.78087
File: 1468517463055.jpg -(10364B / 10.12KB, 400x300) Thumbnail displayed, click image for full size. Is it possible to make shakenbake with lorantadine10mg/ psuedophedrine
SWIM (someone who isn't me) wants to know if it is possible to make shakeNbake with psuedophedrine aulfate 240mg/loratadine(claritin D behind the counter)
If so, how would you do it, anons?
5 posts and 3 images omitted. Click View Thread to read.
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Bombastus !RZEwn1AX62!!xXxJO70U - Mon, 18 Jul 2016 13:13:27 EST AoI9o4UM No.78099 Reply
>>78092
Oh. That's what people are shake and baking now? Fucking weird.
Lorentadine shouldn't iinterfere. But I would also watch the dosage after the fact, though.
>>
press !QUHukXEvkY - Mon, 18 Jul 2016 13:44:22 EST fcMijPsC No.78100 Reply
1468863862961.gif -(1182277B / 1.13MB, 500x579) Thumbnail displayed, click image for full size.
my cats friends mother thinks SWIY is missing some friends of chemicals for that reaction that isnt your friends mothers reaction of something that isnt methamphetamine. maybe you should buy her some cold packs
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Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 21 Jul 2016 19:17:33 EST vbS8CtHn No.78102 Reply
R A C K S

amphetamine related

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- Sat, 25 Jun 2016 15:37:35 EST /F1T+Pgt No.78014
File: 1466883455859.jpg -(130114B / 127.06KB, 960x960) Thumbnail displayed, click image for full size. amphetamine related
Hello guys I've been trying to reduce the P2NP (phenyl-2-nitropropene) to the amine form (amphetamine)

I tried the amalgam procedure described in erowid but this doesn't reduce the double bond (despite the rodium's archives where some people tried this and said it worked I was suspicious and tried it anyway but it doesn't give a single thing) with the "Reduction of unsubstituted P2NP by HyperLab Bee #2."

What would be a good method? LiAlH4 is expensive and difficult to handle, same with palladium or platinum compounds

I was thinking on NaBH4 to reduce the double bond and then Zn/HCl for the nitro group but I'm not sure

thanks a lot
11 posts and 3 images omitted. Click View Thread to read.
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Rebecca Diddlebick - Tue, 05 Jul 2016 18:18:55 EST FgNFOc9k No.78068 Reply
>>78065
thanks for your response

maybe this is a stupid question but will the aromatic ring of P2NP get reduced too if I use Pd/C? or this could only be achieved with high pressure system
>>
Nicholas Dundleludging - Tue, 05 Jul 2016 20:07:10 EST FgNFOc9k No.78069 Reply
1467763630377.jpg -(9545B / 9.32KB, 171x200) Thumbnail displayed, click image for full size.
>>78065
ok let me see if I get your idea:

In a proper flask I put my P2NP, Zn, HCl and (if I get) palladium black? which solvent can I use? any alcohol? heating? don't I need an H2 bomb? what about the proportions of each chemical?

after a couple of hours under stirring this rxn should be done, then I go for the filter (recover Pd) and extraction, right?

ALSO: I have PcCl2 but not sure if this would work the same as Pd/C, thoughs?

great thread btw
>>
Bombastus !RZEwn1AX62!!xXxJO70U - Tue, 05 Jul 2016 23:27:34 EST LtWIDIP2 No.78070 Reply
1467775654782.jpg -(94072B / 91.87KB, 540x525) Thumbnail displayed, click image for full size.
>>78068
benzene will not be hydrogenated at pressures lower than 60 degree. this is due to rapid isomerization of the products and reisomerization back to the reactants.
you'll need something like 30atm and 300C in order to fully hydrogenate benzene to cyclohexane.

This may be similar to your benzylic alkene but it does not engage in the main conjugation. 3atm of pressure may be necessary for this reaction at 0C. 0C increases hydrogen solubility in water and also prevents side reactions from happening.

>>78069
My idea is to stir a mixture of pd/c, nitrox, zinc, and mild hydrochloric acid in a somewhat closed system for 24hours. water should be good eough since HCl. keep it at 0degrees and run the hydrogenation for 24 hours at the pressure needed to keep the balloon inflated - as per undergraduate reactions. that creates around 3atm and allows extra pressure to leak out through the side.

you might want to do 24hours of stirring as the double bond engages in electron sharing with the aromatic ring. you would filter through a pad of celite, sand, or sacrificial frit, neutralize with baking soda, and extract with toluene, dcm, ether, etc.
Wash the organic solvent with brine, dry with magnesim sulfate, dstill off the solvent, keep it under vaccum for 12 hours or whatever, and recrystallize from ethanol IF necessary.

Amphetamine solubility

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- Fri, 01 Jul 2016 19:20:23 EST lZft8ef9 No.78055
File: 1467415223808.jpg -(63596B / 62.11KB, 540x540) Thumbnail displayed, click image for full size. Amphetamine solubility
Okay so i dissolved 1 gram of 2 fa 2 fluroamphwtamine in 30ml of watwr. Ny question is if I let 15ml of it evaporate will i be left with some crystal 2fa?
1 posts omitted. Click View Thread to read.
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Eliza Serrydock - Tue, 05 Jul 2016 03:55:57 EST Snrw7+hK No.78066 Reply
yes you will be left with 2 grams of crystal because every time you dissolve it in water and evaporate it the amount of drug doubles
>>
press - Tue, 05 Jul 2016 16:21:58 EST fcMijPsC No.78067 Reply
maybe. i dont know the solubility.
next time use hot water and as little as possible. then just let it slowly cool down

hacking the mind

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- Wed, 22 Jun 2016 18:21:30 EST QmmUL0gM No.77992
File: 1466634090596.jpg -(1283376B / 1.22MB, 1920x1200) Thumbnail displayed, click image for full size. hacking the mind
you know how we can put those electrodes in the heads of animals ?
we put one in the head of a rat once and they made it move with a joystick

do you think the government would weaponize i mean we could do tigers?
if we wire them right we could keep them moving through death

in theory you could do it to humans it'd be almost like zombies
3 posts omitted. Click View Thread to read.

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