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- Wed, 05 Apr 2017 05:17:10 EST kVxUxljq No.78621
File: 1491383830284.png -(46084B / 45.00KB, 1445x527) Thumbnail displayed, click image for full size. Retrosynthesis
Hey guys, it's been awhile since I've studied Ochem (3 years now) and I'm pretty rusty. Thought I'd give retrosynthesis a crack but I'm seriously struggling with this kinda molecule.

I know my retrosynthesis probably looks dumb because as I said, I'm super rusty. Can anyone point me in the right direction please?
press - Wed, 05 Apr 2017 07:15:23 EST Jirf0CGs No.78624 Reply
1491390923111.png -(140827B / 137.53KB, 389x288) Thumbnail displayed, click image for full size.
what are your criteria for starting molecules?
if you go with B i think that deprotonating acetylacetone, which can be made via the claisen condensation of ethylethanoate and acetone, and then jamming that on 4-"something"hexan-1-ol would work if you the something is a good leaving group, like a trimetyl ammonium thingy for example.
Charles Gillerbot - Wed, 05 Apr 2017 20:55:35 EST kVxUxljq No.78626 Reply
the only real criteria is that it should be able to be done in the least amount of steps with commercially affordable reactants (which i guess is the point of retrosynthesis)

i'll give that a go, cheers!

N2O Synthesis

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- Fri, 03 Feb 2017 08:00:40 EST fDi3lCXD No.78519
File: 1486126840649.jpg -(141394B / 138.08KB, 720x1280) Thumbnail displayed, click image for full size. N2O Synthesis
Hey guys, whippets can get expensive. Does anyone synthesize their own N2O at home/do you have a favorite method of doing so?
14 posts and 1 images omitted. Click View Thread to read.
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 30 Mar 2017 19:31:30 EST 9aybb3lV No.78615 Reply
why'd you delete your science madness account?
fucc i was gonna offer you a part time contracting thing there. reactivate bls.
Augustus Blackcocke - Wed, 05 Apr 2017 14:29:58 EST 1YWXh+i8 No.78625 Reply
I'm sure the gas would get cheaper than whippets in cylinder form.

Purity Testing GCMS HPLC etc Question

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- Tue, 28 Feb 2017 08:07:46 EST LObRvGV/ No.78584
File: 1488287266677.jpg -(11486B / 11.22KB, 439x373) Thumbnail displayed, click image for full size. Purity Testing GCMS HPLC etc Question
This is an email I sent out, but feel free to take a whack at it.

From the given information on the FAQ:
>Then we perform a qualitative analysis on each component identified where possible,
>comparing each substance with a pure reference standard.
>Our results directly provide the result of the salt of the substance, as we’re
>using a salt as a reference standard. The quantitative results are provided using
>a calibration curve from a reference standard.

as well as the techniques listed here https://energycontrol-international.org/drug-testing-service
It seems that almost all of those techniques can be used to generate a quantitative purity result, e.g. GCMS, LCMS, HPLC, UV/Vis.

So can you try to fill in the blanks here for me?

Generate pure quantitative result based on reference standard.
Calibration curves
Obtain substance % percentage.

How are these calibration curves created and how exactly are the curves used to determine the % percentage? Is it done by hand? Done via software?

The reason I ask is so I can understand and explain how people have reported widely varying purity results returned from the EC lab. In one case, someone sent to EC two samples of 4-MMC from the same batch with no obvious signs of cut, yet "the same shards came back with one 85% result and one 45% result." Why is this?

It is not the first error I've heard of, and I'd like to know, please ask your lab techs how perfect your quantitative test method is, and how much error tolerance is acceptable? Do you ever test twice to verify? For instance, testing heroin with HPLC and LCMS to compare both machine's quantitative data?
5 posts and 1 images omitted. Click View Thread to read.
Vehk !7HYGxe5v5c - Wed, 15 Mar 2017 22:49:59 EST l5Akm3J6 No.78601 Reply

The compound in the bottom right is incorrectly labelled. The compound pictured is methadone, while it is labelled as methedrone, which is a methcathinone and related to mephedrone.

Step up, fam.
Walter Goodwater - Thu, 16 Mar 2017 21:31:37 EST ZUVcy1Vx No.78607 Reply
1489714297151.jpg -(4617B / 4.51KB, 259x194) Thumbnail displayed, click image for full size.

A reference standard is a documented, authentic sample of the chemical you are looking to analyse for.

You dilute the reference standard in solvent at a range of concentrations, generally 5 different conc. are used for a good calibration curve.

You set up the instrument (GC/MS/HPLC/UV ect.) and inject each of those 5 standards you prepared.

The plot of detector response (peak area) as a function of each standard concentration should be roughly linear, fit a least squares line and use the equation of that line to calculate the amount of analyte in your test sample based on the peak area it gives.
Walter Goodwater - Thu, 16 Mar 2017 21:34:39 EST ZUVcy1Vx No.78608 Reply

this process is not nearly as simple as it sounds.

if you really want to test the lab's accuracy weight out a decent sized sample of a compound (~500 mg) and grind it well, then submit two samples of the same grind. They should be within 10% or so of each other

How to creat Oxygen (O2)

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- Fri, 27 Jan 2017 13:36:17 EST MuFe+5ez No.78510
File: 1485542177999.jpg -(27750B / 27.10KB, 400x300) Thumbnail displayed, click image for full size. How to creat Oxygen (O2)
Let's say you're in Syria in an ai-tight room and there's poison gas detonated. What simple household materials could you use to synthesize oxygen? Is it possible to use rust as a source for instance?
5 posts omitted. Click View Thread to read.
Nicholas Biggleforth - Thu, 16 Feb 2017 08:48:55 EST WYa1y06F No.78535 Reply
Wouldn't that just end in you dying from oxygen poisoning?
Hugh Trotspear - Tue, 07 Mar 2017 11:46:56 EST Lx3qHXrW No.78595 Reply
1488905216863.jpg -(449256B / 438.73KB, 780x2128) Thumbnail displayed, click image for full size.

Get some dry D cells. Take out the magnesium dioxide
Get some Hydrogen Peroxide
Capture the bubbles

The most dangerous weapon in the world, hiding in plain sight.

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- Fri, 10 Mar 2017 20:09:22 EST zYI/8bOR No.78598
File: 1489194562684.jpg -(71710B / 70.03KB, 604x484) Thumbnail displayed, click image for full size. The most dangerous weapon in the world, hiding in plain sight.
This is not a drill.
>cell phone towers are weaponized death rays ready to nuke the planet or act collectively as a super powerful HAARP-like machine.
>Orgonite converts harmful rays into healthful ones, and can be "gifted" near cellphone towers to negate the effects. The larger ones make chemtrails harmlessly dissipate.
**btw Wilhelm Reich is a notable person related to this topic.**
Cornelius Nammerfield - Sun, 12 Mar 2017 15:23:18 EST 4tmtdVyg No.78599 Reply
1489346598186.gif -(3210878B / 3.06MB, 500x207) Thumbnail displayed, click image for full size.
Looks cool tho

I would like to know more

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- Wed, 22 Feb 2017 11:05:12 EST tYqZ8S2V No.78537
File: 1487779512722.jpg -(397458B / 388.14KB, 2244x1983) Thumbnail displayed, click image for full size. I would like to know more
Is powdering a carpet with Borax a good way to kill carpet beetles without killing the occupying human?
William Bocklewell - Wed, 22 Feb 2017 12:29:43 EST 4tmtdVyg No.78538 Reply
I've used borax to assassinate the ant queen(s) before.

Mix it 1/3 parts borax, 1/3 part sugar, 1/3 part hot water. Let it cool then let the sugar solution sit out in a flat dish or something. I dunno if beetles are as sensitive to borax, but I'm sure they don't have a processing method for borax.
Angus Wiblingdock - Mon, 06 Mar 2017 16:37:04 EST Ja2fAPPl No.78594 Reply
Borax will kill the bugs but any eggs they leave behind will be spared. You'll have to continuously reapply over months to get rid of all of them.

Vaping Safety Questions

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- Tue, 07 Feb 2017 04:15:28 EST LObRvGV/ No.78523
File: 1486458928741.jpg -(59137B / 57.75KB, 1200x630) Thumbnail displayed, click image for full size. Vaping Safety Questions
I'm going to describe a process and ask some questions at the end (though any helpful feedback is good)

  1. heroin dissolved in isopropyl alcohol
  2. baking soda added
  3. caffeine about 1:1 to lower MP
  4. iso evaporated onto foil

The end result way too baking soda and some went into my throat in scalding liquid form. Good thing heroin kills pain.

  • what's that called when two substances are mixed to create a lower boiling point?
  • Is it safe to vape that baking soda?
  • If I used soda ash, would it be safe to vape that too?
  • any recommendations?
breakabond - Tue, 07 Feb 2017 04:20:53 EST LObRvGV/ No.78524 Reply
1486459253103.jpg -(32054B / 31.30KB, 549x383) Thumbnail displayed, click image for full size.
  • would acetone be better?
  • is caffeine soluble in acetone?
  • what about heroin?
  • what about baking soda?
Press - Tue, 07 Feb 2017 17:17:30 EST vUcWj3D5 No.78525 Reply
Its called freezing point depression. Pretty cool shit, back inna days people determined purity and molecular weight with that effect.

Vaping either baking powder or any inorganic nontoxic base wont be a problem unless you inhale too hard.

Concerning the solvent, just look for the swg drugs heroin dossier( guess thats what your chart is based on?) or someother tables to check which solvent is useable for both the HCl and the freebase. You dont have to add the caffeine while thd h is still is in solution as long as you mix it thoroughly

Id recommend using as little solvent as possible while not slowing the dissolution of the base down too much and installing gentoo just to be safe
You have an error in your SQL syntax; check the manual that corresponds to your MySQL server version for the right syntax to use near '' at line 1
breakabond - Wed, 08 Feb 2017 00:27:51 EST LObRvGV/ No.78526 Reply
That chart is from the swdrug. We dont have acetone solubiltiy info afaik then. ill stick with IPA

How much Sodium Carbonate -> basify

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!!D0XjIgKF - Sat, 21 Jan 2017 01:17:05 EST zsw9I8fO No.78484
File: 1484979425963.jpg -(34039B / 33.24KB, 513x392) Thumbnail displayed, click image for full size. How much Sodium Carbonate -> basify
How much sodium carbonate would convert 1 molecule of Heroin HCl, or wait, would it be Acetate, yeah.
How much sodium carbonate 1 molecule Heroin acetate -> Heroin base.
9 posts and 2 images omitted. Click View Thread to read.
Oliver Fanforth - Tue, 24 Jan 2017 01:24:46 EST LObRvGV/ No.78497 Reply
Okay so the solution to avoiding the accidental morphine production then is to perhaps use a weaker base (is ammonia weaker? maybe just baking soda) and quickly extract it afterwards?
Bombastus !uYErosQbLM!!Mybq1UbK - Tue, 24 Jan 2017 01:34:48 EST Req4jw5M No.78498 Reply
Deprotection. Sorry, I was /benz/ed as shit when I decided to legitpost on a few boards. I mean, the information is still good.
Fuck I should teach more when I'm benzed no i really shouldn't

No. You use as little water as possible with an ice bath and then do a vacuum filtration when the freebase precipitates. I don't see why an extraction after freebasing wouldn't work. However, I don't really work with that stuff as much and have no idea if it acts like morphine chemically (it shouldn't due to no active OH groups). Alternatively, You could do the boil down and then acetylate the morphine back into diamorphine.

I'm too chemical, though. I would look up conversion between #3 and #4 or whatever on the internet. Homebaking is much easier than what I would do.
breakabond - Tue, 07 Feb 2017 01:18:50 EST LObRvGV/ No.78522 Reply
So I used sodium carbonate super-saturated (pH was ~10-11) then added some heroin salt -> tried using hexane to extract it -> evaporated.
Evaporating is always the worst step for me, because unless you're doing a massive batch, you end up with such a small amount of freebase residue, so for max efficiency I try to evaporate directly onto foil, which means I try to make a wide dish out of foil, which often ends up breaking and leaking all over my desk, BUT when it does work Im able to vape right off that foil. The alternative would be to put it solid container, but there's ALWAYS some waste when you try to scrape it all up.

So did it get me high? barely. Not enough. Wasteful.

Changing Carbon to Silicon for new life

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- Tue, 24 Jan 2017 17:41:29 EST B2LKOBQC No.78499
File: 1485297689266.png -(20193B / 19.72KB, 1008x630) Thumbnail displayed, click image for full size. Changing Carbon to Silicon for new life
So me and this girl on one of my classes had come up with substituting Carbon for Silicon that we could get a new form of life, but one of our teachers said it was unbalanced. What does she mean?
5 posts and 2 images omitted. Click View Thread to read.
Frigate - Wed, 25 Jan 2017 17:44:20 EST B2LKOBQC No.78505 Reply
But why tho? I never stated anything about their bonds. I meant they are similar. My main question was why it was unbalanced.
Charlotte Drablingspear - Fri, 27 Jan 2017 21:49:13 EST klMiQ9iI No.78511 Reply
I remember reading somewhere that scientists were able to genetically engineer a bacteria that was able to create silicon bonds, to demonstrate that silicon-based lifeforms are possible and could maybe be found somewhere else in the universe. However I do not believe that they got so far as to create a glucose molecule with silicon instead of carbons. That kind of science is probably decades or centuries away. The reaction you have there is "balanced" in the sense that there are equal numbers of each atom on both sides of the equation. I think your teacher was just trying to tell you that you are full of shit.
Esther Bublingstick - Tue, 31 Jan 2017 21:59:07 EST FMRNgMnb No.78518 Reply
1485917947505.jpg -(69479B / 67.85KB, 800x351) Thumbnail displayed, click image for full size.

The electronegativity. Si forms sissy bonds compared to carbon. It's a harsh universe out there... lots of O2 and water. Without the strength and versitility of the carbon bond, silicon based lifeforms would get wrecked by the simplest forces of nature.

Anorganic Chem Q

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- Wed, 18 Jan 2017 06:14:04 EST +xNTZBER No.78473
File: 1484738044507.png -(1001768B / 978.29KB, 734x1088) Thumbnail displayed, click image for full size. Anorganic Chem Q
So me and my colleague are arguing about whether KOH or NaOH is stronger base. While in practice it is not important, I'd argue that theoretically it must be KOH, as the enthalpy of K+ is lower, therefore KOH will be more likely to dissociate. However, the colleague is buzzing around with a dubious Pkbn from chembuddy which states that pKbn values for NaOH and KOH are 0.2 and 0.5 respectively, indicating that NaOH would in fact be a stronger base (and LiOH the strongest). Why would that be? Pls explain. pic unrel
2 posts omitted. Click View Thread to read.
Bombastus !uYErosQbLM!!Mybq1UbK - Sat, 28 Jan 2017 01:26:18 EST ViNIYyYK No.78513 Reply
You are right but that's a product, not a reason. The question is WHY it is more electronegative than potassium and the answer is ironic radius trends.

Where my electrons @@@@@@@@@?
Eliza Grandwill - Sat, 28 Jan 2017 02:36:32 EST vukMbHQH No.78515 Reply

That logic makes no sense to me; I would expect Potassium to be more likely to give up the ghost due it its relatively large electron cloud. The distance of the periphery of the electron cloud to the center of the atoms nucleus should allow easier access to its valence electrons, no?

Which is why pure cesium reacts so violently in water in comparison to lithium, sodium, and potassium.

I guess what I'm saying is NaOH being stronger than KOH goes against my intuition.
Eliza Grandwill - Sat, 28 Jan 2017 02:41:50 EST vukMbHQH No.78516 Reply
Nvm, I gets it.

The ionic association of potassium is stronger than sodium with anions, so you would expect less dissociation as the alkali metals get heavier.

Introduction to /chem/

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- Wed, 17 Aug 2016 05:46:46 EST rX48mQ3L No.78159
File: 1471427206573.jpg -(551642B / 538.71KB, 2101x2560) Thumbnail displayed, click image for full size. Introduction to /chem/
Hello, I am a newcomer to this board but it seems cozy enough for me to stay here. It is a dream for me to make a home-lab one day, because univeristy labs (studying medicine) have restrictions and objections against experiments that I'm interested at.

It would be nice if you could tell more about your setups/projects/goals.

>also general current project thread
5 posts and 2 images omitted. Click View Thread to read.
breakabond - Sun, 05 Mar 2017 10:37:18 EST LObRvGV/ No.78588 Reply
just a test:
>fuckin tolerance

E=MC^2 question

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- Thu, 22 Dec 2016 12:08:21 EST E5ztys4h No.78408
File: 1482426501194.jpg -(953131B / 930.79KB, 1600x780) Thumbnail displayed, click image for full size. E=MC^2 question
So I was randomly thinking about Einsteins most popular contribution to physics, and I have a problem with it:

If E=MC^2, then how is it possible that a mass-less photon can carry any energy?

I expect there's probably a well established answer to this, but in trying to track it down I'm realizing a lot of this stuff is well above my reading level.
14 posts and 1 images omitted. Click View Thread to read.
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 12 Jan 2017 02:03:23 EST 8NEuSnNe No.78465 Reply
Thanks! Those threads have more or less died at this point. My experiences with psychedelics is on hiatus since I my consecutive ego deaths on like 750 LSD, 35mg 2-CE, 125mg 4-AcO-DMT, and other doses similar.

That shit actually scares me to the point where weed gives me intense spiritual flashbacks and really need to take a break. Times a changed, I guess. I'll be back soon, though.

Keep grooving in the meantime and ask any question whatsoever.
Bombastus !uYErosQbLM!!Mybq1UbK - Sun, 22 Jan 2017 23:00:43 EST iygy/n6D No.78494 Reply
damn where'd that response go to this post. i was gonna response to it too

Guy who wanted to mix two solids for X-Ray analysis

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!uYErosQbLM!!Mybq1UbK - Fri, 20 Jan 2017 14:52:25 EST jTCURNhV No.78483
File: 1484941945945.jpg -(137980B / 134.75KB, 809x656) Thumbnail displayed, click image for full size. Guy who wanted to mix two solids for X-Ray analysis
I guess because of a certain news article, we can't discuss specific molecules like that here............ I suppose the molecule in question is attracting too much media attention so even on a small board such as this, it is unwise to do so?

Sorry anon for killing your thread for asking for specifics.

Where are the fucking units

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!!D0XjIgKF - Fri, 13 Jan 2017 10:55:34 EST zsw9I8fO No.78467
File: 1484322934943.jpg -(11152B / 10.89KB, 257x136) Thumbnail displayed, click image for full size. Where are the fucking units
Can someone tell me what the units here are?
(<-- image)

source: http://www.pharmpress.com/files/docs/Excipients7e_samplemonos(1).pdf
1 posts omitted. Click View Thread to read.
trypto - Fri, 13 Jan 2017 11:20:10 EST ltcKYWSL No.78469 Reply
Whoops. Actually, not mass percent since it's not multiplied by 100. Mass ratio?

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