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420chan is Getting Overhauled - Changelog/Bug Report/Request Thread (Updated July 26)

Finding Job with BSc in Biochemistry

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- Tue, 07 Jun 2016 10:45:19 EST 1hq57uuB No.77945
File: 1465310719476.png -(82305B / 80.38KB, 1941x2242) Thumbnail displayed, click image for full size. Finding Job with BSc in Biochemistry
Hello guys,

I'm 22 years old and have a BSc in Biochemistry. I was wondering if it was easy to find a Job in the U.S. only with a BSc. The reason is that I need a change in environment. I somehow have the urge to travel and live in different countries.
The industry doesn't really matter it just has to make for a living and maybe it is possible to study besides working.
I'm from switzerland if that changes anything.

SLAYER to y'all
2 posts omitted. Click View Thread to read.
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Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 16 Jun 2016 13:07:21 EST +CUD9CML No.77974 Reply
>>77973
Some Masters can pay $20000-$25000 a year.
Find one.
>>
Molly Pabberstane - Sat, 25 Jun 2016 00:18:13 EST MS463KCQ No.78010 Reply
If you can get accepted to a PhD. program you can usually make an annual stipend of 20-25k in exchange for teaching. Work the PhD. track towards the MSc. then leave the program with your MSc.
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Bombastus !RZEwn1AX62!!xXxJO70U - Fri, 01 Jul 2016 01:43:36 EST bXUlP+sg No.78050 Reply
>>78049
Both; bank loan. Or you could find a job with an undergraduate and work until you have time to return for your masters.

Alkene synthesis

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- Fri, 24 Jun 2016 13:52:08 EST WznVySGw No.78005
File: 1466790728463.png -(94053B / 91.85KB, 704x830) Thumbnail displayed, click image for full size. Alkene synthesis
anyone know how to solve this question with all the organic products ?
http://imgur.com/cZwGsyt
18 posts and 13 images omitted. Click View Thread to read.
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Bombastus !RZEwn1AX62!!xXxJO70U - Sun, 26 Jun 2016 13:56:28 EST V/Ex51MS No.78027 Reply
1466963788948.png -(119507B / 116.71KB, 680x509) Thumbnail displayed, click image for full size.
Bump. It's been two hours. What now.

I also fucking hate when schools make you do that. Sorry OP.
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This problem - Sun, 26 Jun 2016 15:29:16 EST YfyCDm6o No.78030 Reply
1466969356802.png -(70639B / 68.98KB, 880x922) Thumbnail displayed, click image for full size.
>>78027
Wanna see some bullshit ..... stupid software I was right all along
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William Clonkinman - Sun, 26 Jun 2016 15:42:25 EST IK7sy6RX No.78031 Reply
>>78030
that's that pearson bullshit online hw isn't it? That's the worst shit I've ever used, the problems are all terribly made and there's typos everywhere.

Dumb scifi question

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- Fri, 24 Jun 2016 12:37:45 EST TtNn9wfR No.78004
File: 1466786265335.gif -(317533B / 310.09KB, 180x200) Thumbnail displayed, click image for full size. Dumb scifi question
So I'm dicking around with a videogame, and I had the dumb idea to make a character that's essentially a biological computer, radio controlling organic drone bodies through biological radio transmitters - basically technobabble telepathy.

Would such a thing be possible, if you had countless of hours to dick around with genes and shitloads of funding?

Also, would someone be able to jam such a biological radio signal? I mean, if you can jam real radio, or take over control of a radio signal, in real life, surely you should be able to control some biological radio controlled drone...

Also, would it be possible with only radio transmitters, or could other more exotic waves be used?

Old, novel 14-hydroxylation

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!RZEwn1AX62!!xXxJO70U - Wed, 02 Mar 2016 21:02:15 EST qWybWc+e No.77704
File: 1456970535551.jpg -(10007B / 9.77KB, 200x200) Thumbnail displayed, click image for full size. Old, novel 14-hydroxylation
Acetylate codeine. Protects the group.
Peroxyacid attacks the 14th position caused by the resonance of the double bond (absent in dihydro intermediates proposed earlier). Theoretically creates 14-hydroxy-acetyl-codeine but due to the heat, codeine and 14-hydroxycodeine are also formed.
Another acetylation can be performed and peroxyacid attack to adequately react away the byproducts (worth it IMO but needs to be recalculated).
Deacetylation with a strong acid (sulphuric) upon heating can render the hydroxide workable. Dilution and Pd/C reflux should be able to both hydrogenate and oxidise the 14-hydroxycodeine to 14-hydroxy-dihydro-codeinone.

Sounds workable but the 1916 journal mentions that it is an intermediate to create 14-hydroxycodeinone, not 14-hydroxycodeine. That's not a big issue, if that is the case. A simple borohydride reduction to 14-hydroxycodeine should make the Pd/C reflux workable and remove the need for hydrogenation - which most people cannot do.

The first step should take around 15 minutes with a workup for 30. The second step is an 8 hour reflux. The third step is a 4 hour reflux. This really means that this reaction can take just one day. A column purification step is highly recommended.

It'd be interesting to see if anyone can try it to work.
4 posts and 1 images omitted. Click View Thread to read.
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Vehk !7HYGxe5v5c - Sat, 02 Apr 2016 22:44:41 EST aFt0bd4t No.77792 Reply
>>77790

25% of an organic chemist in a month. Also, you're the one always sending me links to circlejerk threads.

Shit had me weak man

View Thread Reply
- Thu, 03 Mar 2016 15:25:23 EST NLJmhbvz No.77707
File: 1457036723155.jpg -(10453B / 10.21KB, 218x231) Thumbnail displayed, click image for full size. Shit had me weak man
In an attempt to make some counterfeit codeine with prometh syrup (it was for a southern rap themed party), I dropped about 3 oz of pg/vg mix with some flavor, two or three shots of everclear and two shots of tito's vodka, 10 finely crushed alprazolam 2mg tablets, and to top it off, corn syrup for the texture.

Here's the real question though: Would heating up the alcohol and/or alprazolam mixture do anything to potentiate it?

I put an ounce in a big pineapple and drank that and caught a fantastic buzz and when I tried doing it with two ounces of the solution, I fell asleep before finishing it. They way I heated it up was I took two pyrex measuring cups, put very hot water in the first one and placed the second pyrex (containing the solution) on top and using a metal whisk, I mixed the ingredients until they were nice and even. There was still a little pill matter so I just took that off with a spoon since it rose to the top and ended up with a pint of some "lean".

Did the heat help or could it just be the alprazolam and alcohol working together? I put half an oz in my drink today in class because I took an adderall (it makes me nervous so I needed to chill) and ended up pretty buzzed for about an hour rather than just chilled out lol thank god the adderall kept me functional.

So what's the deal gais? I need a chemistry guy on this, help a brotha out
2 posts and 1 images omitted. Click View Thread to read.
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Polly Mellyham - Tue, 08 Mar 2016 20:50:36 EST xxs07y/f No.77734 Reply
Your friends are gonna black out, not remember the party, and blame you.
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John Brazzleshaw - Thu, 10 Mar 2016 12:44:43 EST TrPWlcRq No.77737 Reply
...Why not just get the actual syrup?
This seems unnecessary and possibly dangerous.
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Ebenezer Lightville - Fri, 17 Jun 2016 18:31:54 EST RMLgtyMj No.77979 Reply
>>77707
This shit sounds amazing, give in depth instructions

Phalaris Extraction Thread

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- Sat, 28 May 2016 12:28:20 EST cOHpZlwa No.77923
File: 1464452900987.jpg -(132334B / 129.23KB, 800x999) Thumbnail displayed, click image for full size. Phalaris Extraction Thread
Has anyone here done any work with extracting DMT or other trptamines from various specieis of Phalaris grass? DMT Nexus has a lot of information but a lot of it is contradictory and incomplete.
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Esther Diddlemene - Sun, 29 May 2016 16:25:14 EST alUhohOf No.77931 Reply
I wouldn't bother. I'd just purchase Acacia Confuse or Mimosa Hostilis online.
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Molly Honningshit - Tue, 14 Jun 2016 11:24:06 EST DXmzOHk9 No.77967 Reply
>>77923
Once you have the real materials its super easy, I made some yuasca in my dorms on a freakin hot plate.
>>
Oliver Clepperdale - Wed, 15 Jun 2016 01:23:52 EST vp89ZYzI No.77968 Reply
>>77923

Stop being so afraid and jump into it. Vaporize it ideally.

liquid weed

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- Mon, 13 Jun 2016 17:05:06 EST DXmzOHk9 No.77966
File: 1465851906550.jpg -(21155B / 20.66KB, 225x225) Thumbnail displayed, click image for full size. liquid weed
So my question is, how much thc, cbd,(weed) can 1 gallon of 100% VG absorb? I'm stoned and forget the term, deal with it lol

Chlorine Biosphere?

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- Mon, 06 Jun 2016 14:04:43 EST QeFTOZ30 No.77943
File: 1465236283025.jpg -(7093B / 6.93KB, 200x200) Thumbnail displayed, click image for full size. Chlorine Biosphere?
I'm an artist that depicts space scenes. Rather than focus on scifi space battles or nebula or some shit I like to focus on making realistic-looking planets (or as realistic as I can get them to look at least). I do a lot of Earth-like planets but, as a biology nerd, I wanted to try something new. I've done a few Earth-like planets with usual colors of vegetation: red, purple, black, etc. I've been reading about alternative biochemistry and wanted to try depicting a planet with a biosphere that isn't necessarily carbon-aqueous.

Anyways, I'm not here to talk about the planet in particular. This isn't /sagan/ after all. No, I want to discussion biochemistry involving chlorides. I read a study about some scientists replacing the thymine in the DNA of E. coli with 5-Chlorouracil, so there is some precedent for chlorides being incorporated into biological systems. In my research I also came across this: 2HCl + CO2 ---> CH2O +Cl2. It looks kind of like some kind of photosynthesis that uses hydrochloric acid to form organic compounds? I'm pretty sure that's formaldehyde and chlorine gas. Do you think that the chlorine gas could be utilized in a manner similar to oxygen? Could this create any kind of sustainable biosphere? I'm honestly not sure this concept is even remotely possible but it is interesting.
3 posts and 1 images omitted. Click View Thread to read.
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Bombastus !RZEwn1AX62!!xXxJO70U - Sat, 11 Jun 2016 11:15:13 EST 4ppVjZXo No.77962 Reply
>>77961
Jupiter level gravity. The gravity would be so strong that life would not exist due to the activation energy to sustain wall membranes would be too high. It's just theoretically so implausible for it to work.
Methane would be the other best bet as it can be burned for fuel relatively easily and would be so abundant in the universe. Carbon fixation comes first; then nitrogen fixation.

On a low pressure system, it's hypothesized that silicon would be the binding site of choice due to its molecular weight. In this case, you might have gaseous bromine sticking around. However, it would be so implausible because the halogen % composition of the universe is so miniscule, the odds are just heavily stacked against your favor of a halogen- based organism.

Oxygen is the best candidate because it's heavy enough to stay on the atmosphere, be gaseous, and most importantly: is abundant enough in star death.
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Bombastus !RZEwn1AX62!!xXxJO70U - Sat, 11 Jun 2016 11:16:15 EST 4ppVjZXo No.77963 Reply
>>77961
Uracil is made after multiple millions of years of carbon fixation and added nitrogen fixation. No way such a complex structure would exist otherwise, unfortunately.

nb
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Edwin Fupperstodge - Sat, 11 Jun 2016 23:34:49 EST GSuYkmZT No.77964 Reply
1465702489325.jpg -(1562155B / 1.49MB, 2600x1980) Thumbnail displayed, click image for full size.
Seems like this idea is a bust. Oh well, thanks for the input anyways. It's always nice to learn something, even if it leads to disappointment.

nb

H2SO4

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- Tue, 10 May 2016 23:12:56 EST V/Jmd1aC No.77888
File: 1462936376814.jpg -(516226B / 504.13KB, 1920x1080) Thumbnail displayed, click image for full size. H2SO4
I acdentely 98% pure sulefuric acid. Should I have this checked out? Could be a third degree chemicle burn? Should I just ingore it and hope it goes away. Also this happened a few days ago so this isen't a fresh wound.
1 posts omitted. Click View Thread to read.
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Bombastus !RZEwn1AX62!!xXxJO70U - Wed, 25 May 2016 21:14:28 EST aXFxXtc6 No.77914 Reply
>>77888
>I acdentely 98% pure sulefuric acid.
10/10

You should be fine, OP. Acid burns are normally very localised and don't cause any damage on your flesh that isn't superficial. As long as you're not using it as an inhalant, huffing it, using it as eyedrops, injecting it, plugging it, or bathing in it, this burn will just be like a tattoo.
What you have to worry about is potential infection.

How'd you let that happen to you, anyway? I've accidentally poured H2SO4 on the back of my hand before and washed it off within 20 seconds while it was already burning. How'd you let it get to that extreme?
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Shit Basslesadge - Fri, 10 Jun 2016 19:11:42 EST zwhzKcaA No.77958 Reply
Keeping the sunlight(UV) off of it should also help reduce scaring. Cover lightly.

I'm a dumb ass.

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- Fri, 10 Jun 2016 19:04:12 EST zwhzKcaA No.77956
File: 1465599852698.jpg -(106264B / 103.77KB, 720x719) Thumbnail displayed, click image for full size. I'm a dumb ass.
Why won't my shitty bottle crank fully dry out: It's kind of waxy. Seems acidic. Also burns toward the end of evaporation.
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Shit Basslesadge - Fri, 10 Jun 2016 19:27:34 EST zwhzKcaA No.77959 Reply
This is the only time this has occurred; Generally I get a nice fluffy white substance that evaporates cleanly, so I'm a bit confused as to what I changed. Under-reduced?

Future LSD Analogs?

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!jmUcEJD43k!!E9WUPA0s - Fri, 29 Apr 2016 05:18:06 EST 7x9SM9m4 No.77870
File: 1461921486846.jpg -(871740B / 851.31KB, 3354x1758) Thumbnail displayed, click image for full size. Future LSD Analogs?
Hey guys, I had an idea for new possible LSD analogs. All important details are in the attached image, I am curious to see what all your thoughts will be on this!
2 posts omitted. Click View Thread to read.
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Charlotte Shakeham - Sun, 15 May 2016 19:41:26 EST +5AM2MwN No.77891 Reply
>>77870
Does anyone know how these break down in the body? Probably the one that is most risky is the bromine one. LSD is in microgram doses so this probably isn't a risk but the bromide ion does have a long half-life in the body. As a rough estimate, if someone does 800 000 100 ug blots a day for 12 days straight they might run into problems but maybe I'm missing something.
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Bombastus !RZEwn1AX62!!xXxJO70U - Wed, 25 May 2016 21:10:53 EST G8mu3scS No.77913 Reply
>>77870
Hey Press. Get over here and check out these N-X bonds (where X-Cl,F,Br,I).

I don't think these would be stable at all. Google the stability of chloramine and their reactions. I know mono-chloro-amine hydrolyses into ammonium and chlorine gas. I don't see how these compounds would be stable given the first chance at a proton source and create the R2N-H bond.

If you want to make it a relatively good leaving group and available for adaptation in the body, I would highly recommend an Acetyl or a Tosyl group on that nitrogen. Tosylic acid is toxic to your kidneys but maybe at light concentrations like 1mg in the blood stream, it could be fine.
I wonder if you could make di-tosylic-morphine as a better alternative to heroin................ hmmmmmmmm.............................................

>>77891
Organobromides are toxic to your liver and endocrine system. However, aromatic bromides are either excreted in your urine, safely or made into HBr and then NaBr which are safe enough in low concentrations. Not of a concern.
Examples: Bromovanilin, Bromazepam
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TheDiggityDank !jmUcEJD43k!!E9WUPA0s - Fri, 10 Jun 2016 00:48:00 EST aNLlWMG5 No.77953 Reply
>>77913

Thank you for the thorough explanation! I suspected that might be an issue, but I was just not sure if having the nitrogen of the amine group bonded into a more complex structure, as it is in LSD, would alleviate the issue. I have been looking into other potential LSD analogs, and I have come up with a few interesting hypothetical structures. However, I really do not know enough about lysergamide structural activity relationships to know if they would be active or not.

CWE and saturation

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- Wed, 18 May 2016 13:54:30 EST 9YAuxRQ8 No.77896
File: 1463594070164.jpg -(61049B / 59.62KB, 400x400) Thumbnail displayed, click image for full size. CWE and saturation
I've been wondering about some thing regarding CWE. The main point of CWE with products containing APAP seems to be to reduce the amount of APAP in the final product since it seems to be more water soluble than I thought it was. Which means the less water you use and the colder it is, less APAP will be in the final product. Which led me to some questions:

  1. Assuming that you have a drug containing Codeine Phosphate and APAP. Could you, in theory, dissolve the pills in say 10ml of water ("One gram [of Codeine Phosphate ]dissolves in 2.3 ml water,", O'Neil M. J. (ed.), Smith A. (ed.), Heckelman P. E. (ed.)-The Merck Index_ An Encyclopedia of Chemicals, Drugs, and Biologicals (1996)) and have some kind of "super concentrated", crystal clear solute of Codeine Phosphate with a ridiculous low amount of APAP? Or would the filter clog up? Or the solution get over-saturated? Which leads me to my next question

2. Both APAP and Codeine Phosphate are soluble in water. I don't understand the mechanics of dissolution completely but would it be possible to not have any 'space' left to dissolve the Codeine Phosphate? Or does it get dissolved first because it's so much more soluble? Or does it work completely different?

Recrystallizing APAP is a bother to me so by exploiting the great solubility of Codeine Phosphate I could in theory use cold water from the fridge or something. Maybe dissolving the pills in 50ml? Even at 20C this would leave me with 639mg of APAP which is a joke. (https://en.wikipedia.org/wiki/Paracetamol)
15 posts and 4 images omitted. Click View Thread to read.
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press !QUHukXEvkY - Wed, 08 Jun 2016 16:11:39 EST fcMijPsC No.77946 Reply
1465416699151.jpg -(38045B / 37.15KB, 500x375) Thumbnail displayed, click image for full size.
>>77944
well shit. apparently my version of claydens is too big for 420chan even compressed. a tiny low res pic thats 30mb big is mighty suspicious anyways.

but it shouldnt be too hard to come by
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Edward Fanningdodge - Thu, 09 Jun 2016 11:43:00 EST D9t26pna No.77948 Reply
>>77940
>jpg
>3.38MB
>195x225
what the fuck is wrong with you

Ant level of consciousness

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- Sun, 05 Jun 2016 20:11:52 EST 92gUf0sA No.77942
File: 1465171912338.gif -(1001210B / 977.74KB, 350x197) Thumbnail displayed, click image for full size. Ant level of consciousness
What would it be like to be an ant? Would you "feel" anything? Would you be able to think? Would you know that you're an individual or would you have no free will and just be a little organic robot that does whatever the colony needs?

Theory against science: gravity

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- Tue, 02 Feb 2016 01:26:43 EST vzB5izFF No.77606
File: 1454394403433.jpg -(72701B / 71.00KB, 516x418) Thumbnail displayed, click image for full size. Theory against science: gravity
I have a theory on what could cause gravity that may go against popular science and I was wondering what people may think about it.

Gravity is caused by the sun. It is a condensed ball of molecules that has a reaction happening that need to be fed. It does not burn like a fire because it is an intense chemical reaction, but like a fire it needs to be fed to continue "burning". It pulls matter, including planets, towards it, and as these planets are pulled towards it it is spiraled around the sun, sort of like a toilet flushing. The sun pulls these planets towards it and as they travel towards the sun in a spiral they have a gravity created on them, much like an increase of gravity when you are spun around at a high speed on a park ride or on a astronaut g-force training machine. The gravity of the earth that is created by the sun can also spiral objects towards it, which results in the moon that spirals around the earth (but will eventually will be caught in an orbit and will stay at all times in one part of the earth. Look it up). Perhaps what will happen to the moon will happen to the planets as well, who knows. But this is just a theory that came to my head and that I was wondering what other people thought about.
1 posts and 1 images omitted. Click View Thread to read.
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Cyril Brookstone - Fri, 06 May 2016 10:27:12 EST 46/eGtv8 No.77881 Reply
1462544832688.png -(214122B / 209.10KB, 600x469) Thumbnail displayed, click image for full size.
>>77606
The increase in gravity caused by movement is in fact inertia, and aside from that, their are free agent planets that aren't orbiting any sun and indeed still have gravity.
Nb young einstein do more research before you come up with a theory.
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Albert Tillinglock - Mon, 30 May 2016 08:45:50 EST PYwdfvCt No.77933 Reply
>>77606
This isn't how scientific theories work, theories are based on evidence. This is just some stuff you made up.

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