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Purifying and Freebasing

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- Sun, 16 Oct 2016 02:30:25 EST zsw9I8fO No.78302
File: 1476599425480.jpg -(16063B / 15.69KB, 369x305) Thumbnail displayed, click image for full size. Purifying and Freebasing
I've gone through this process to convert salts -> freebase by:
adding some salt drug to a lye solution then using hexane to pull the freebase and evaporate.
My question is: while this process seems to have to have worked with a 2C and with U-44770, can you think of any case where the NaOH will mess up the drug somehow? Or a case where the freebase won't dissolve in the Hexane?

2) Is acetone good enough for purifying most drugs? How are you even supposed to know the solubility of a lot of these new drugs like 4-methyl-pentedrone or 3-Fluorophenmetrazine? Acetone is used for MDMA and Ketamine purificaiton, so what stuff does it NOT work on?
8 posts omitted. Click View Thread to read.
Cyril Chittingbare - Tue, 22 Nov 2016 22:17:00 EST Q2W2CR89 No.78359 Reply
Yes. CO3^2- is a better base than HCO3^- since it is able to accept 2 protons as opposed to 1. Not sure if OP should use a strong base like NaOH tho..
Bombastus !uYErosQbLM!!Mybq1UbK - Fri, 25 Nov 2016 23:22:49 EST sglEgUGb No.78370 Reply
That doesn't determine strength.

Hydrochloric Acid is around 3000x times stronger than the first proton of phosphoric acid despite it only having one proton.

Help please!!

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- Mon, 21 Nov 2016 04:54:04 EST xxe0PbAv No.78353
File: 1479722044179.jpg -(187340B / 182.95KB, 374x500) Thumbnail displayed, click image for full size. Help please!!
Hi all,

I hope I'm asking this in the best spot & really hoping someone can assist me w/this......

So I'm getting ready to try ULDN for the 1st time, that is if I can get this figured out. So I thought I added my 50mg tab of naltrexone to 1 liter or 1000mls of water however I didn't look close enough at the bottle I'm using, duh I know. Anyhow instead of 1 liter the bottle I added everything into is 1.25L.
So I'm trying to figure out how many mcg's I have per ml. The recipe I followed has the dosages based on 1 ltr not 1.25 ltr. Considering this is touchy & the dose is based on mcg's I wanted to verify what I now have w/some folks that are way better in the chemistry & mixing department.
I would be very grateful for any info you may be able to provide. Anything you also may like to add about ULDN would also be greatly appreciated.

Thank you!
2 posts omitted. Click View Thread to read.
press - Wed, 23 Nov 2016 07:56:56 EST JRoOF8iS No.78364 Reply
you might want to either get a volumetric flask, which might get expensive i dunno, or find a bottle with which you can very accurately measure a set volume. ideally it would be a bottle with a very thin neck, which would be filled to a certain level of the neck

if your solution is really mixed and the naltrexone is readily water soluble you could store it in several small containers while frozen. then youd simply have to take out a single container, thaw it and shake it before use while the others still remain frozen.

any idea how big one of your drops is? or how much one drop weighs?
LaDiDotty - Thu, 24 Nov 2016 14:24:51 EST xxe0PbAv No.78366 Reply

I don't have any fancy measuring bottles, can you suggest somewhere I could find one in expensively? The recipe I'm following is to mix 1 50mg tab into 1L but it makes a huge amount. I was thinking to see if I could cut a tab in half or even quarters, cut the water down accordingly but I'm afraid of possibly not cutting it perfectly in half or quarters each time. Your idea of storing in the freezer is great! I was afraid the solution would go bad before I'd ever get thru an entire liter. Even though the naltrexone tabs were easy enough to get I'd prefer not to waste them. I found it odd that w/each study or recipe I found nobody talked about properly storing the mixture or preserving it aside from putting the mix in an amber or cobalt glass bottle or storing in the fridge.
Do you think freezing the mixture would degrade it in any way? Do you know if the mixture is sensitive to light?
I did get a couple different syringes from the pharmacy, 1 I think is useless for dosing anyways, it's more of a child's medicine dropper, 5mls w/o small enough increments for dosing, maybe good for something else. The other syringe is 1ml, has .10 increments & even smaller. I just tried counting how many drops a full ml holds & came up w/30 almost 31 drops. One study & recipe I read said their 1ml dropper held a perfect 20 drops. Not sure what they're using but I tried several times & came to 30-31 each time.
With the recipe I'm following it says that what I should end up with is 50mcg per 1ml & .2 ml = 10mcg. Because I accidentally didn't see the bottle I'm using is a 1.25L instead of a 1 L my drops are slightly diluted. I found a couple other recipes but they're all relatively the same.
The naltrexone tabs I got dissolve very fast & completely in water. One recipe said not to shake the tab in the bottle, that made no sense to me since you want to make sure you have even doses. Another recipe said to shake it vigorously, I did the latter. When I dropped the tab in the water I just left it to dissolve while I ate dinner. When I came back it had totally dissolved on its own w/just an uber tiny amount of particulate floating around. I just shake it real well before each dose. When I draw the fluid into the syringe the water looks completely clear.
While I find it fascinating, I don't have a lot of experience w/chemistry or atleast the experience I do have involves health & beauty care items & there's rarely addition if any micro sized ingredients. Do you think I could find any of the items you suggested on EBay or Amazon? Or is there a better place to buy volumetric flasks, vials, etc?

Sorry for the long post. Thank you so much for all of your help, I really do appreciate it. I hope you have a nice Thanksgiving today!
press - Thu, 24 Nov 2016 15:41:24 EST tXprf7n7 No.78367 Reply
id try ebay or amazon for chinese volumetric flasks. doesnt matter wether its a plastic one or one made from glass aslong as the mergin of error is tight enough. real men use glass, because theyre not afraid of suffering the pain of fucking up.

a volumetric flask should be cheaper than a really accurate scale. how accurate is yours?

i dont really see how using amber or colbalt glass bottles would help, those are normally used for light sensitive stuff but im not sure about naltrexone being light insensitive. my bet would be that it shouldnt be, since ive never heard of morphine or oxymorphone are. its not going to degrade when its frozen, but be sure to really give it a good shake after dethawing it. use plastic bottles for storing it frozen. ive seen quite a few phds fucking that up once in a while.

for measuring the final dose a syringe is good
the size of a drop also depends of the diameter of the opening so its not a suprise they found some other ratio. i have no idea about ultra low naltrexone, once read that it can reap lotsa benefits but i dont remember the dosage tl;dr cant get lantrexone anyways

i guess the particulate is some gunk like magnesium stearate or some other stuff they put in to make the pill super duper
no biggie, you have a nice one too

Chemical reaction simulator

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- Tue, 15 Nov 2016 15:24:42 EST Ul4obZPS No.78349
File: 1479241482322.png -(202713B / 197.96KB, 1312x782) Thumbnail displayed, click image for full size. Chemical reaction simulator
Do you know about any program that can be used to simulate chemical reactions?
What is your opinion about it? I recently stumbled upon "Cain" but still haven't learn to work with it.

Boron tribromide demethylation of codeine

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- Mon, 10 Oct 2016 14:55:50 EST 9Opqdgsf No.78280
File: 1476125750712.png -(19996B / 19.53KB, 593x246) Thumbnail displayed, click image for full size. Boron tribromide demethylation of codeine
I am having trouble with this synthesis. I take 15ml DCM with 200mg codeine base dissolved and make sure its really dry with sieves. Then add something like 500mg of boron tribromide. Immediately the codeine drops out of the DCM solution... no doubt my homemade BBr3 contains a small amount of HBr and Br2. This stuff is unbelievably reactive with air, i've never seen anything fume like it in my life. So i waited/stirred 30mins then added ice/ammonia. No precipitate, i assume the codeine hbr simply dissolved in the aqueous. So next i tried the same thing but added 200mg DIPEA to soak up the acid. Still no morphine precipitate. I worked up both layers both times and verified there was no morphine, i thought it might be dissolved in the high PH aqueous layer but that's only possible with NaOH i believe, morphine should always be insoluble in ammonia hydroxide. I don't know what the problem is.

My boron tribromide is a bit red, i don't have enough to distill. I started from Br2 and Al to make aluminum bromide, anhydrous. Unfortunately i couldn't distill this either but i did leave it under vacuum to hopeful get the free bromine out. I melted it and poured it into another flask with potassium tetrafluoroborate and ended up with only a few ml of BBr3 distilling over. Next time i will use liquid tetrafluoroborate. All 3 of these things really fume like hell. I'm not looking forward to doing it again. I will try to use a vacuum next time, my joints weren't greased and it was pulling in more air then it was worth. I have to make sure i don't get the aluminum bromide on the ground joints as well, god damn what a mess. A propane torch wouldn't even get them apart i had to soak in WD40 then use a propane torch.
30 posts and 5 images omitted. Click View Thread to read.
Charlotte Fuckingville - Sat, 22 Oct 2016 00:48:34 EST 9Opqdgsf No.78323 Reply
I used to grow shrooms i thought about extraction but never attempted it. I was planning to use methanol only because its cheap and available at the hardware store. Evaporate with minimal heat (enough to keep condensation from making a wet goop mess) and a fan. Then try to wash with petroleum ether, maybe recrystallize from methanol in the freezer. Maybe add a little dcm to lower the solubility in the mixture.

Your way would probably be cleaner and higher yielding, but who knows. According to this somthing like that should work. https://erowid.org/archive/rhodium/chemistry/psilocin.extraction.html

I hate water in these situations though, so hard to evaporate without heat or time.
Esther Donderkare - Mon, 24 Oct 2016 19:43:12 EST 2Hc2eoG6 No.78327 Reply
Would it be easier to just buy some CYP2D6...
Albert Henkinbanks - Wed, 26 Oct 2016 15:27:19 EST 9Opqdgsf No.78328 Reply
I don't think it would be feasible to create an artificial liver, but i really don't know. I do know scientists have modified e.coli to produce thebaine. 2mg from 20grams of sugar isn't too good though, and i expect the modified bacteria would be incredibly fragile. So unfortunately we won't be growing morphine in mason jars like magic mushrooms anytime soon.

Countries like Canada are lucky just to have codeine. If you don't have an opiate to start from you are pretty much forced to grow poppies.

I've found my mercury, i'm going to shake the small amount of bbr3 i have left with it then try the reaction again.


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- Sun, 23 Oct 2016 05:29:48 EST 9Opqdgsf No.78324
File: 1477214988518.png -(19315B / 18.86KB, 203x200) Thumbnail displayed, click image for full size. Piperadone
Any ideas how to synthesize 4-piperidone?
Eugene Dabblekat - Sun, 23 Oct 2016 22:53:02 EST 9Opqdgsf No.78326 Reply
OP here again. Tried the dickmann condensation, acrylates are too hard to make and the burnt plastic smell is not tolerable. The mannich seems to only like to make piperadones substituted on the 2&6 (benzaldehyde, acetaldehyde). Although i havn't tried it yet formaldehyde might work with acetonedicarboxylate, hydrolyse and decarboxilate to 4-piperadone. I can tell you it doesn't work with phenethylamine not in water, alchohol, or acetic acid. Not nearly as easy as most of the internet would have you believe, its quite the opposite. Unless its just me, which is possible as well.

Maybe posassium cyanide + epichlorohydrin = 3-hydroxyglutaronitrile. ***Journal of the Chemical Society, , p. 1164,1166 = 4-hydroxypiperidine**** Then oxidize the 4-hydroxypiperidine alcohol to a ketone somehow. Maybe react with phenethylbromide first then the amine is protected.

Or any other possible routes? I'd love to hear it.

Anhydrous AlCl3

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- Fri, 29 Jul 2016 15:16:32 EST ykDmWZpt No.78112
File: 1469819792455.png -(15045B / 14.69KB, 300x251) Thumbnail displayed, click image for full size. Anhydrous AlCl3
Hello, chem!
Sorry if this is a stupid question, but here it goes:
I have aluminum (III) chloride hexahydrate but I need it in the anhydrous form.
Can I oven-dry it at ~100ºC?
Thanks in advance!!
22 posts and 2 images omitted. Click View Thread to read.
John Merringbury - Fri, 07 Oct 2016 23:06:18 EST hBAZGxou No.78277 Reply
You can demethylate guaiacols by a radical mechanism using CuSO4 + ascorbic acid. Don't waste your time with AlCl3.
Esther Nossleway - Sun, 23 Oct 2016 22:30:30 EST NIATBazO No.78325 Reply
1477276230830.jpg -(9699B / 9.47KB, 224x287) Thumbnail displayed, click image for full size.
mind if I ask you why would you want AlCl3? just wondering

bombastus and press are fucking bosses, I've learnt a lot with this guys

love you all

Freebase vs Salt Vaporize

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- Sat, 10 Sep 2016 00:01:05 EST zsw9I8fO No.78226
File: 1473480065769.jpg -(324209B / 316.61KB, 503x376) Thumbnail displayed, click image for full size. Freebase vs Salt Vaporize
Two questions
1) What's the reason that freebase drugs are preferred for vaporizing/smoking instead of salts?

2) Will lye and baking soda both freebase a drug the same? I'm guessing it just requires more baking soda because it's a weaker base?
18 posts and 1 images omitted. Click View Thread to read.
Doris Fomblefuck - Thu, 06 Oct 2016 13:08:35 EST QFXcUDR6 No.78276 Reply
Okay great so that's what I was originally asking. You can make the pH of the solution acidic enough to convert all of it, then simply let it evaporate and you should have 1:1 mole of drug:salt. No need for a selective solvent to separate the drug:salt from excess acid and water.
Albert Wiffington - Thu, 20 Oct 2016 12:58:49 EST /9+sroAe No.78317 Reply
>What's the reason that freebase drugs are preferred for vaporizing/smoking instead of salts?

Because most people don't have vaporizers that can heat up to 3000 degrees Fahrenheit.
Clara Blythegold - Fri, 21 Oct 2016 18:17:20 EST zsw9I8fO No.78321 Reply
Then why do people vape Methamphetamine HCl all the time?

the ratman 666

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- Mon, 17 Oct 2016 00:58:05 EST 95U922wa No.78303
File: 1476680285961.jpg -(57268B / 55.93KB, 577x551) Thumbnail displayed, click image for full size. the ratman 666
>landlord comes to inspect clandestine meth lab property
>she notices the smell of benzaldehyde and asks what air freshener i'm using
>'almond breeze'

Convert Codeine Pills (Just Codeine)

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- Fri, 09 Sep 2016 23:56:07 EST zsw9I8fO No.78225
File: 1473479767769.jpg -(110887B / 108.29KB, 407x634) Thumbnail displayed, click image for full size. Convert Codeine Pills (Just Codeine)
What would be the best way to get that methyl group offa there?
Well I don't really require morphine, but just whatever opioid is easiest to convert it to while also being smokeable/snortable/get-me-high-rush?
2 posts omitted. Click View Thread to read.
press - Wed, 12 Oct 2016 04:26:18 EST KOKj6dOY No.78294 Reply
1476260778343.gif -(341552B / 333.55KB, 266x150) Thumbnail displayed, click image for full size.
make some hydrocodone. Pd/C and a mineral acid in ethanol and perhaps sone means of TLC to check conversion
Press !QUHukXEvkY - Wed, 19 Oct 2016 02:10:48 EST NyrybZOd No.78311 Reply
Was in a workplace accident, spent a week in the hospital
Was on sick leave for five weeks during which i invested my time solely into mushroom cultivation. Tfw no tyramine
Quit a job, took two new jobs. Nb

VR tech

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- Tue, 20 Sep 2016 11:59:28 EST TAs+XH9Z No.78259
File: 1474387168486.jpg -(252727B / 246.80KB, 1920x1080) Thumbnail displayed, click image for full size. VR tech
with all the VR tech coming out
i wonder what scientific applications it will have.. not only for humans but even for animals

do you think it would be possible to suit a dog with a VR tech and simulate it as another species or put other data into its eyes/mind?
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 06 Oct 2016 02:42:09 EST Req4jw5M No.78275 Reply
Not really due to the issue of their perception, senses outside of the "normal five", memory, critical thinking, sight, etc.
For that, we'll need better brain mapping technology like how we saw a blurry image of what a cat saw on a screen once.
William Bundock - Sun, 09 Oct 2016 23:58:56 EST qtUm3Qxz No.78279 Reply

It will be the only handle the amount of information when piloting a Gundam.

Nootropics Textbooks/ Papers/ Literature

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- Thu, 22 Sep 2016 08:55:08 EST XgflcvVv No.78260
File: 1474548908633.gif -(1268363B / 1.21MB, 310x314) Thumbnail displayed, click image for full size. Nootropics Textbooks/ Papers/ Literature
I'm looking for some textbooks/ literature on nootropics. My boss's brother is a surgeon, and he's heard rumblings from his pharmaceutical friends that there are compounds out there that aren't known to the public, and only given to people like special forces.

I think they're fascinating, and I'd love to better understand their chemistry. While most of my work in the industry has been with things like coatings and adhesives, I'm sure I wouldn't have any trouble with technical stuff, as I took plenty of high level organic classes in college.

C-F Bond Vaporize Harmful?

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- Sat, 17 Sep 2016 21:44:07 EST zsw9I8fO No.78254
File: 1474163047120.jpg -(9366B / 9.15KB, 297x238) Thumbnail displayed, click image for full size. C-F Bond Vaporize Harmful?
Drugs with that Flourine-Carbon bond, although scary, are supposedly actually safe because the C-F bond is one of the strongest there can be, so not likely to metabolize into free flourine.

So with drugs like 4-FA, 2F-Ketamine, what if we vaporize them? Is a lot of heat enough to break that bond?
1 posts and 1 images omitted. Click View Thread to read.
Bombastus !uYErosQbLM!!Mybq1UbK - Sun, 18 Sep 2016 03:04:54 EST Req4jw5M No.78256 Reply
Also, is that face reaction from the comic where a guy gets high, walks over to the garbage can with a ziplock bag and his bong, drops the bong in the garbage can with a shattering sound, and then proceed to make that face?

Can't find it right now since I'm on mobile.
David Fanwater - Sun, 18 Sep 2016 04:15:54 EST zsw9I8fO No.78257 Reply
Yes lol, I cropped it from that.

So cool, there is some quantitative way to figure out what it takes to break a bond.

Break a bond... break a bong... pic related.
Bombastus !uYErosQbLM!!Mybq1UbK - Sun, 18 Sep 2016 17:40:24 EST 4ppVjZXo No.78258 Reply
Bonds boil down to the electron configuration of the atoms they are bonded to (along with the neighbouring electrons) and the spatial organization of the bonds and atoms in the molecule.
To figure out the spatial organization, you just use your eyes and bond energy tables. To figure out electronical (relating to electrons) configuration, use the DFT program I told people about (http://boards.420chan.org/chem/res/77990.php) and play around with the orbital energy levels.


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- Wed, 14 Sep 2016 15:12:54 EST kO6h6vAq No.78238
File: 1473880374240.jpg -(37011B / 36.14KB, 358x335) Thumbnail displayed, click image for full size. Phosphate
I don't see much info on turning a phosphate, in my case Codeine-Phosphate (how do you even abbreviate phosphate). Perhaps because it's just like turning a salt into a freebase?

How would you go about converting Codeine-Phosphate into Codeine?
Is it even worth the effort to do it with 700mg worth of Codeine-phosphate?
2 posts omitted. Click View Thread to read.
Bombastus !uYErosQbLM!!Mybq1UbK - Sat, 17 Sep 2016 02:01:46 EST Req4jw5M No.78249 Reply
50mg of codeine is enough to change it. you'll only get 30-40mg of hydrocodone, 20mg of morphine, or 45mg of dihydrocodine. The more you make, you'll have to use almost as much solvent and other reactants in order to make the reaction work.
It costs as much to turn 50mg of codeine into hydrocodone as it does to turn 500mg. You decie what's worth it.
Bombastus !uYErosQbLM!!Mybq1UbK - Sat, 17 Sep 2016 02:02:45 EST Req4jw5M No.78250 Reply
Also, why do you even need to freebase it? If you separate the codeine phosphate from pill bulkers, you can just use the codeine phosphate to react with the other shit. Most of the time no freebase needed.

Predict Metabolism

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- Wed, 31 Aug 2016 18:40:28 EST gk9dXVsY No.78200
File: 1472683228931.png -(6779B / 6.62KB, 212x135) Thumbnail displayed, click image for full size. Predict Metabolism

Any guesses at to what this gets metabolized into?
3 posts omitted. Click View Thread to read.
Doris Sabberputch - Thu, 15 Sep 2016 19:59:47 EST 28FgXo1Q No.78243 Reply
>Why do you ask
Subject effects are opioid-like, but the molecule itself is antagonist, and I don't think we have any studies proving what it metabolizes into.
Edward Wendlegold - Thu, 15 Sep 2016 20:08:20 EST 28FgXo1Q No.78244 Reply
>since it's a pretty stressed ring.
Isn't that weird how nature makes these structures that seem so awkwardly formatted. Everything should be lines and hexagons to keep it simple.
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 15 Sep 2016 20:20:31 EST 4ppVjZXo No.78245 Reply
Well yes and no. Nature likes to keep nitrogens tertiary and stable and will branch out to go out of the carbon comfort zone in order to satisfy the nitrogenous fetish. It also favors difficulty if it can produce a compound to help it selectively thrive better than the compounds that do not.

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