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- Sun, 23 Oct 2016 05:29:48 EST 9Opqdgsf No.78324
File: 1477214988518.png -(19315B / 18.86KB, 203x200) Thumbnail displayed, click image for full size. Piperadone
Any ideas how to synthesize 4-piperidone?
Eugene Dabblekat - Sun, 23 Oct 2016 22:53:02 EST 9Opqdgsf No.78326 Reply
OP here again. Tried the dickmann condensation, acrylates are too hard to make and the burnt plastic smell is not tolerable. The mannich seems to only like to make piperadones substituted on the 2&6 (benzaldehyde, acetaldehyde). Although i havn't tried it yet formaldehyde might work with acetonedicarboxylate, hydrolyse and decarboxilate to 4-piperadone. I can tell you it doesn't work with phenethylamine not in water, alchohol, or acetic acid. Not nearly as easy as most of the internet would have you believe, its quite the opposite. Unless its just me, which is possible as well.

Maybe posassium cyanide + epichlorohydrin = 3-hydroxyglutaronitrile. ***Journal of the Chemical Society, , p. 1164,1166 = 4-hydroxypiperidine**** Then oxidize the 4-hydroxypiperidine alcohol to a ketone somehow. Maybe react with phenethylbromide first then the amine is protected.

Or any other possible routes? I'd love to hear it.

Anhydrous AlCl3

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- Fri, 29 Jul 2016 15:16:32 EST ykDmWZpt No.78112
File: 1469819792455.png -(15045B / 14.69KB, 300x251) Thumbnail displayed, click image for full size. Anhydrous AlCl3
Hello, chem!
Sorry if this is a stupid question, but here it goes:
I have aluminum (III) chloride hexahydrate but I need it in the anhydrous form.
Can I oven-dry it at ~100ÂșC?
Thanks in advance!!
22 posts and 2 images omitted. Click View Thread to read.
John Merringbury - Fri, 07 Oct 2016 23:06:18 EST hBAZGxou No.78277 Reply
You can demethylate guaiacols by a radical mechanism using CuSO4 + ascorbic acid. Don't waste your time with AlCl3.
Esther Nossleway - Sun, 23 Oct 2016 22:30:30 EST NIATBazO No.78325 Reply
1477276230830.jpg -(9699B / 9.47KB, 224x287) Thumbnail displayed, click image for full size.
mind if I ask you why would you want AlCl3? just wondering

bombastus and press are fucking bosses, I've learnt a lot with this guys

love you all

Freebase vs Salt Vaporize

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- Sat, 10 Sep 2016 00:01:05 EST zsw9I8fO No.78226
File: 1473480065769.jpg -(324209B / 316.61KB, 503x376) Thumbnail displayed, click image for full size. Freebase vs Salt Vaporize
Two questions
1) What's the reason that freebase drugs are preferred for vaporizing/smoking instead of salts?

2) Will lye and baking soda both freebase a drug the same? I'm guessing it just requires more baking soda because it's a weaker base?
18 posts and 1 images omitted. Click View Thread to read.
Doris Fomblefuck - Thu, 06 Oct 2016 13:08:35 EST QFXcUDR6 No.78276 Reply
Okay great so that's what I was originally asking. You can make the pH of the solution acidic enough to convert all of it, then simply let it evaporate and you should have 1:1 mole of drug:salt. No need for a selective solvent to separate the drug:salt from excess acid and water.
Albert Wiffington - Thu, 20 Oct 2016 12:58:49 EST /9+sroAe No.78317 Reply
>What's the reason that freebase drugs are preferred for vaporizing/smoking instead of salts?

Because most people don't have vaporizers that can heat up to 3000 degrees Fahrenheit.
Clara Blythegold - Fri, 21 Oct 2016 18:17:20 EST zsw9I8fO No.78321 Reply
Then why do people vape Methamphetamine HCl all the time?

the ratman 666

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- Mon, 17 Oct 2016 00:58:05 EST 95U922wa No.78303
File: 1476680285961.jpg -(57268B / 55.93KB, 577x551) Thumbnail displayed, click image for full size. the ratman 666
>landlord comes to inspect clandestine meth lab property
>she notices the smell of benzaldehyde and asks what air freshener i'm using
>'almond breeze'

Convert Codeine Pills (Just Codeine)

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- Fri, 09 Sep 2016 23:56:07 EST zsw9I8fO No.78225
File: 1473479767769.jpg -(110887B / 108.29KB, 407x634) Thumbnail displayed, click image for full size. Convert Codeine Pills (Just Codeine)
What would be the best way to get that methyl group offa there?
Well I don't really require morphine, but just whatever opioid is easiest to convert it to while also being smokeable/snortable/get-me-high-rush?
2 posts omitted. Click View Thread to read.
press - Wed, 12 Oct 2016 04:26:18 EST KOKj6dOY No.78294 Reply
1476260778343.gif -(341552B / 333.55KB, 266x150) Thumbnail displayed, click image for full size.
make some hydrocodone. Pd/C and a mineral acid in ethanol and perhaps sone means of TLC to check conversion
Press !QUHukXEvkY - Wed, 19 Oct 2016 02:10:48 EST NyrybZOd No.78311 Reply
Was in a workplace accident, spent a week in the hospital
Was on sick leave for five weeks during which i invested my time solely into mushroom cultivation. Tfw no tyramine
Quit a job, took two new jobs. Nb

VR tech

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- Tue, 20 Sep 2016 11:59:28 EST TAs+XH9Z No.78259
File: 1474387168486.jpg -(252727B / 246.80KB, 1920x1080) Thumbnail displayed, click image for full size. VR tech
with all the VR tech coming out
i wonder what scientific applications it will have.. not only for humans but even for animals

do you think it would be possible to suit a dog with a VR tech and simulate it as another species or put other data into its eyes/mind?
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 06 Oct 2016 02:42:09 EST Req4jw5M No.78275 Reply
Not really due to the issue of their perception, senses outside of the "normal five", memory, critical thinking, sight, etc.
For that, we'll need better brain mapping technology like how we saw a blurry image of what a cat saw on a screen once.
William Bundock - Sun, 09 Oct 2016 23:58:56 EST qtUm3Qxz No.78279 Reply

It will be the only handle the amount of information when piloting a Gundam.

Nootropics Textbooks/ Papers/ Literature

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- Thu, 22 Sep 2016 08:55:08 EST XgflcvVv No.78260
File: 1474548908633.gif -(1268363B / 1.21MB, 310x314) Thumbnail displayed, click image for full size. Nootropics Textbooks/ Papers/ Literature
I'm looking for some textbooks/ literature on nootropics. My boss's brother is a surgeon, and he's heard rumblings from his pharmaceutical friends that there are compounds out there that aren't known to the public, and only given to people like special forces.

I think they're fascinating, and I'd love to better understand their chemistry. While most of my work in the industry has been with things like coatings and adhesives, I'm sure I wouldn't have any trouble with technical stuff, as I took plenty of high level organic classes in college.

C-F Bond Vaporize Harmful?

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- Sat, 17 Sep 2016 21:44:07 EST zsw9I8fO No.78254
File: 1474163047120.jpg -(9366B / 9.15KB, 297x238) Thumbnail displayed, click image for full size. C-F Bond Vaporize Harmful?
Drugs with that Flourine-Carbon bond, although scary, are supposedly actually safe because the C-F bond is one of the strongest there can be, so not likely to metabolize into free flourine.

So with drugs like 4-FA, 2F-Ketamine, what if we vaporize them? Is a lot of heat enough to break that bond?
1 posts and 1 images omitted. Click View Thread to read.
Bombastus !uYErosQbLM!!Mybq1UbK - Sun, 18 Sep 2016 03:04:54 EST Req4jw5M No.78256 Reply
Also, is that face reaction from the comic where a guy gets high, walks over to the garbage can with a ziplock bag and his bong, drops the bong in the garbage can with a shattering sound, and then proceed to make that face?

Can't find it right now since I'm on mobile.
David Fanwater - Sun, 18 Sep 2016 04:15:54 EST zsw9I8fO No.78257 Reply
Yes lol, I cropped it from that.

So cool, there is some quantitative way to figure out what it takes to break a bond.

Break a bond... break a bong... pic related.
Bombastus !uYErosQbLM!!Mybq1UbK - Sun, 18 Sep 2016 17:40:24 EST 4ppVjZXo No.78258 Reply
Bonds boil down to the electron configuration of the atoms they are bonded to (along with the neighbouring electrons) and the spatial organization of the bonds and atoms in the molecule.
To figure out the spatial organization, you just use your eyes and bond energy tables. To figure out electronical (relating to electrons) configuration, use the DFT program I told people about (http://boards.420chan.org/chem/res/77990.php) and play around with the orbital energy levels.


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- Wed, 14 Sep 2016 15:12:54 EST kO6h6vAq No.78238
File: 1473880374240.jpg -(37011B / 36.14KB, 358x335) Thumbnail displayed, click image for full size. Phosphate
I don't see much info on turning a phosphate, in my case Codeine-Phosphate (how do you even abbreviate phosphate). Perhaps because it's just like turning a salt into a freebase?

How would you go about converting Codeine-Phosphate into Codeine?
Is it even worth the effort to do it with 700mg worth of Codeine-phosphate?
2 posts omitted. Click View Thread to read.
Bombastus !uYErosQbLM!!Mybq1UbK - Sat, 17 Sep 2016 02:01:46 EST Req4jw5M No.78249 Reply
50mg of codeine is enough to change it. you'll only get 30-40mg of hydrocodone, 20mg of morphine, or 45mg of dihydrocodine. The more you make, you'll have to use almost as much solvent and other reactants in order to make the reaction work.
It costs as much to turn 50mg of codeine into hydrocodone as it does to turn 500mg. You decie what's worth it.
Bombastus !uYErosQbLM!!Mybq1UbK - Sat, 17 Sep 2016 02:02:45 EST Req4jw5M No.78250 Reply
Also, why do you even need to freebase it? If you separate the codeine phosphate from pill bulkers, you can just use the codeine phosphate to react with the other shit. Most of the time no freebase needed.

Predict Metabolism

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- Wed, 31 Aug 2016 18:40:28 EST gk9dXVsY No.78200
File: 1472683228931.png -(6779B / 6.62KB, 212x135) Thumbnail displayed, click image for full size. Predict Metabolism

Any guesses at to what this gets metabolized into?
3 posts omitted. Click View Thread to read.
Doris Sabberputch - Thu, 15 Sep 2016 19:59:47 EST 28FgXo1Q No.78243 Reply
>Why do you ask
Subject effects are opioid-like, but the molecule itself is antagonist, and I don't think we have any studies proving what it metabolizes into.
Edward Wendlegold - Thu, 15 Sep 2016 20:08:20 EST 28FgXo1Q No.78244 Reply
>since it's a pretty stressed ring.
Isn't that weird how nature makes these structures that seem so awkwardly formatted. Everything should be lines and hexagons to keep it simple.
Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 15 Sep 2016 20:20:31 EST 4ppVjZXo No.78245 Reply
Well yes and no. Nature likes to keep nitrogens tertiary and stable and will branch out to go out of the carbon comfort zone in order to satisfy the nitrogenous fetish. It also favors difficulty if it can produce a compound to help it selectively thrive better than the compounds that do not.

MXE Synthesis

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- Sat, 13 Aug 2016 11:00:34 EST xPDjzOso No.78148
File: 1471100434384.png -(16419B / 16.03KB, 220x185) Thumbnail displayed, click image for full size. MXE Synthesis
So, theoretically speaking, how hard would it be to synthesize MXE at home assuming one had no real chemistry experience or knowledge?

I'm curious because this stuff has gone the way of quaaludes and nobody is making it anymore, and after reading /dis/ for a while I've been wondering for the past few days what would making a batch imply in terms of proficiency, equipment and reagents.
11 posts and 1 images omitted. Click View Thread to read.
Schepperschop - Sat, 10 Sep 2016 19:23:26 EST xTIigKo1 No.78227 Reply
1473549806673.jpg -(836490B / 816.88KB, 2592x1944) Thumbnail displayed, click image for full size.

Zika Virus: Is it an ELE?

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- Sun, 28 Aug 2016 17:35:29 EST 5UnrR+r2 No.78188
File: 1472420129173.jpg -(72252B / 70.56KB, 1037x784) Thumbnail displayed, click image for full size. Zika Virus:  Is it an ELE?
I just had an interesting short chat with a store clerk of a quickie-mart type of place. What he said actually freaked me out. He said that Zika reached our area (Florida) and how it'll take a month before money is released to try to combat the problem. But this wasn't the interesting bit, the interesting bit was him saying: "This is bad because mothers can't have babies. Without babies, we will go extinct; an extinction level event (ELE)." It was one of those moments that it didn't strike me just how dangerous Zika is to the human race. I saw it similar to the Ebola scare we had.

I hoped to him that perhaps science will solve the issue. He replied by saying we aren't exactly Star Trek level so you never know.

It could be that as a store clerk he is searching for something exciting because life as a store clerk is anything but. It could also be a covert-Christian trying to prolysetize. So science-peeeps that may be reading this, set me straight. Why shouldn't I worry about this problem, at least not overly so?

I am sure that I am missing something that makes this problem not as major as the store Clerk made it out to be but don't know where to start. Couldn't we simply make a vaccination? Couldn't we, in the worst possible event, simply do in-vitro fertilization in which the child has a natural immunity to the virus?

What could we do? This is actually scaring me.
Nell Snodstock - Sun, 28 Aug 2016 18:55:38 EST 5UnrR+r2 No.78190 Reply
Thought you were quoting Game of Thrones for a moment there.

Are adults ok? I heard about the blood-brain barrier and how because of this barrier can't affect an adult brain. Is this true? I read an article stating that this may not be true and can cause alzheimers or other conditions.

Do you think the CDC or some organization can do a good job on this issue?
Esther Buzzcocke - Wed, 07 Sep 2016 21:54:12 EST Z4xgskMZ No.78223 Reply
It's currently gridlocked to the areas around the equator that have egypti and other tropical mosquito species in terms of mosquito transmission.

The bigger issue is that it's sexually transmitted. I think the main vector is going to be humans. As long as it's still a popular trendy scary disease and the people who have it are on lockdown then it won't spread far enough for the kind of damage you're talking about. I think a vaccine is in the works but who knows.

Molecular sandbox

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!/sly9iFJgg - Wed, 22 Jun 2016 14:54:50 EST H8Fdbu5S No.77990
File: 1466621690969.png -(291146B / 284.32KB, 1271x969) Thumbnail displayed, click image for full size. Molecular sandbox
I found a great free molecular simulator, at http://avogadro.cc/wiki/Main_Page . It's real easy to use, but the fucking thing crashes without warning or apparent reason. There's seemingly nothing I can do to make it run. The only circumstance it DOESN'T crash in is when I first load it and haven't added any atoms/loaded a save.

So unless y'all have a fix that I haven't tried, I'm looking for a program with a similar sandbox-style modeling.
10 posts and 3 images omitted. Click View Thread to read.
Bombastus !uYErosQbLM!!Mybq1UbK - Sat, 03 Sep 2016 17:34:10 EST Req4jw5M No.78217 Reply
I'm absolutely computer inept.
trypto - Tue, 06 Sep 2016 16:52:28 EST 6/EmvHqc No.78221 Reply
I'm not too familiar with molecular modelling, but I know it uses similar computations as neural networks. That is, it's mostly linear algebra, and having a good graphics card is very useful. In the NN world, an NVIDIA chipset will get you much further because it understands CUDA instructions. On the other hand, AMD chipsets use OpenCL, which is less supported. Last time I tried out modelling software (5 years ago), this was also the case. So I would look for a laptop with NVIDIA graphics... Except I've also read bad reviews about NVIDIA shit in laptops. Maybe that's old, or linux-specific, but be sure to check out reviews.

I sincerely doubt you'll be able to do any modelling on a laptop under $3k. On the other hand, you could probably build a PC with a lower midrange graphics card for $600 that could outperform the $3k laptop.
Clara Cremmerkedge - Sun, 09 Oct 2016 21:50:55 EST mC4q4Hy7 No.78278 Reply
1476064255773.jpg -(58482B / 57.11KB, 401x500) Thumbnail displayed, click image for full size.

Anti-GMO nutjobs

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- Fri, 05 Aug 2016 23:27:16 EST JmjQz8t7 No.78130
File: 1470454036382.jpg -(36320B / 35.47KB, 400x267) Thumbnail displayed, click image for full size. Anti-GMO nutjobs
Man I was having such a good day today at work.

There I was, being all kickass at my job, and SOMEHOW the topics of organics and GMOS came up. I am so for GMOs its not even funny - organics, hey, but what you want but don't try to take away my options. Also, don't tell starving kids in India what to eat while they're dying? Follow those two rules and all will be well.

Man, I had no idea. These are people who work for the government, and it was liked I whipped out a baby and started to slaughter it in front of them. I didn't state my opinion, I just appeared neutral, but I was angry inside. How can these people profess for being about knowledge and the cutting edge, but believe that pesticides don't wash off of food? And that " We don't know enough about it to eat it" while eating cheese?! In front of me?!

I'm still mad, and have to go back to work tomorrow. I hate being a pot smoking skeptic sometimes, I feel like a damn unicorn.
7 posts and 2 images omitted. Click View Thread to read.
Caroline Babblelork - Tue, 30 Aug 2016 18:05:38 EST 82e0TSBV No.78197 Reply
Roundup is less toxic than the herbicides they were using before. It's also pretty easily eliminated from the food supply during rinsing.

Good point about soil ecology.
Hugh Hellysetch - Fri, 02 Sep 2016 14:22:55 EST TtNn9wfR No.78206 Reply
Don't forget that companies like Monsanto are completely happy with the current GMO hate.

It just means that they have a monopoly position, because Monsanto can just set up an experimental farm in South-America and protect it with armed guards, while starting GMO companies have to do their experimental farms in the Western world and have fucking anti-GMO protesters (that may or may not be funded by Monsanto and other big companies) with bulldozers trashing their farms and send fucking bombs, bullet letters and mysterious powders to personnel and geneticists. Hell, people just doing research at universities without any profit gaining are getting death threats.
Shitting Messlepot - Sun, 04 Sep 2016 13:46:25 EST rybJ4K29 No.78220 Reply
1473011185994.jpg -(54663B / 53.38KB, 1170x1170) Thumbnail displayed, click image for full size.
but believe that pesticides don't wash off of food

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