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Demethylation - pyridinium pathway

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!RZEwn1AX62!!xXxJO70U - Sun, 26 Jun 2016 14:02:33 EST LtWIDIP2 No.78028
File: 1466964153727.png -(3184B / 3.11KB, 120x111) Thumbnail displayed, click image for full size. Demethylation - pyridinium pathway
Trying 3-4 different demethylation strategies under mild conditions, it seems that pyridinium HX is going to the be easiest and most non-retarded way of demethylating any species.
Any other format either seems to cleave the ether bridge, require too much heat, or is simply impractically tender.

So I wonder - does anyone have any resources on a better yielding demethylation of aromatic methoxides with pyridinium salts? Can anyone find any literature that says PyHBr would be more selective and cleaner than PyHCl with a 15% yield in demethylation of "certain" compounds? Would they be more selective or would it just not matter?

Pic unrelated
10 posts and 4 images omitted. Click View Thread to read.
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 14 Jul 2016 13:50:50 EST II1FH3AD No.78091 Reply
don't retard the thread I'd just start a new one because that one has so much information to sift through its not worth rebumpin at this point (sorry fiend)

think I'm too busy to try this demeth though. I like science and shit but I also like my time more
press !QUHukXEvkY - Thu, 14 Jul 2016 23:57:40 EST fcMijPsC No.78093 Reply
it already was retarded the minute it started. but i agree with it being too flooded, hence i want to make a simple compilation

what about the potassium methoxide?
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 21 Jul 2016 19:25:38 EST vbS8CtHn No.78105 Reply
you'll never make a simple compilation because of the retardation that comes with being 420chan. that's just how life goes and i'm ready to fucking kill myself.

what ABOUT methoxide? i feel like that would be too strong of an electrophile and might just rip the ether open.

Is it possible to make shakenbake with lorantadine10mg/ psuedophedrine

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- Thu, 14 Jul 2016 13:31:03 EST sM4N11VN No.78087
File: 1468517463055.jpg -(10364B / 10.12KB, 400x300) Thumbnail displayed, click image for full size. Is it possible to make shakenbake with lorantadine10mg/ psuedophedrine
SWIM (someone who isn't me) wants to know if it is possible to make shakeNbake with psuedophedrine aulfate 240mg/loratadine(claritin D behind the counter)
If so, how would you do it, anons?
5 posts and 3 images omitted. Click View Thread to read.
Bombastus !RZEwn1AX62!!xXxJO70U - Mon, 18 Jul 2016 13:13:27 EST AoI9o4UM No.78099 Reply
Oh. That's what people are shake and baking now? Fucking weird.
Lorentadine shouldn't iinterfere. But I would also watch the dosage after the fact, though.
press !QUHukXEvkY - Mon, 18 Jul 2016 13:44:22 EST fcMijPsC No.78100 Reply
1468863862961.gif -(1182277B / 1.13MB, 500x579) Thumbnail displayed, click image for full size.
my cats friends mother thinks SWIY is missing some friends of chemicals for that reaction that isnt your friends mothers reaction of something that isnt methamphetamine. maybe you should buy her some cold packs
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 21 Jul 2016 19:17:33 EST vbS8CtHn No.78102 Reply

amphetamine related

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- Sat, 25 Jun 2016 15:37:35 EST /F1T+Pgt No.78014
File: 1466883455859.jpg -(130114B / 127.06KB, 960x960) Thumbnail displayed, click image for full size. amphetamine related
Hello guys I've been trying to reduce the P2NP (phenyl-2-nitropropene) to the amine form (amphetamine)

I tried the amalgam procedure described in erowid but this doesn't reduce the double bond (despite the rodium's archives where some people tried this and said it worked I was suspicious and tried it anyway but it doesn't give a single thing) with the "Reduction of unsubstituted P2NP by HyperLab Bee #2."

What would be a good method? LiAlH4 is expensive and difficult to handle, same with palladium or platinum compounds

I was thinking on NaBH4 to reduce the double bond and then Zn/HCl for the nitro group but I'm not sure

thanks a lot
11 posts and 3 images omitted. Click View Thread to read.
Rebecca Diddlebick - Tue, 05 Jul 2016 18:18:55 EST FgNFOc9k No.78068 Reply
thanks for your response

maybe this is a stupid question but will the aromatic ring of P2NP get reduced too if I use Pd/C? or this could only be achieved with high pressure system
Nicholas Dundleludging - Tue, 05 Jul 2016 20:07:10 EST FgNFOc9k No.78069 Reply
1467763630377.jpg -(9545B / 9.32KB, 171x200) Thumbnail displayed, click image for full size.
ok let me see if I get your idea:

In a proper flask I put my P2NP, Zn, HCl and (if I get) palladium black? which solvent can I use? any alcohol? heating? don't I need an H2 bomb? what about the proportions of each chemical?

after a couple of hours under stirring this rxn should be done, then I go for the filter (recover Pd) and extraction, right?

ALSO: I have PcCl2 but not sure if this would work the same as Pd/C, thoughs?

great thread btw
Bombastus !RZEwn1AX62!!xXxJO70U - Tue, 05 Jul 2016 23:27:34 EST LtWIDIP2 No.78070 Reply
1467775654782.jpg -(94072B / 91.87KB, 540x525) Thumbnail displayed, click image for full size.
benzene will not be hydrogenated at pressures lower than 60 degree. this is due to rapid isomerization of the products and reisomerization back to the reactants.
you'll need something like 30atm and 300C in order to fully hydrogenate benzene to cyclohexane.

This may be similar to your benzylic alkene but it does not engage in the main conjugation. 3atm of pressure may be necessary for this reaction at 0C. 0C increases hydrogen solubility in water and also prevents side reactions from happening.

My idea is to stir a mixture of pd/c, nitrox, zinc, and mild hydrochloric acid in a somewhat closed system for 24hours. water should be good eough since HCl. keep it at 0degrees and run the hydrogenation for 24 hours at the pressure needed to keep the balloon inflated - as per undergraduate reactions. that creates around 3atm and allows extra pressure to leak out through the side.

you might want to do 24hours of stirring as the double bond engages in electron sharing with the aromatic ring. you would filter through a pad of celite, sand, or sacrificial frit, neutralize with baking soda, and extract with toluene, dcm, ether, etc.
Wash the organic solvent with brine, dry with magnesim sulfate, dstill off the solvent, keep it under vaccum for 12 hours or whatever, and recrystallize from ethanol IF necessary.

Amphetamine solubility

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- Fri, 01 Jul 2016 19:20:23 EST lZft8ef9 No.78055
File: 1467415223808.jpg -(63596B / 62.11KB, 540x540) Thumbnail displayed, click image for full size. Amphetamine solubility
Okay so i dissolved 1 gram of 2 fa 2 fluroamphwtamine in 30ml of watwr. Ny question is if I let 15ml of it evaporate will i be left with some crystal 2fa?
1 posts omitted. Click View Thread to read.
Eliza Serrydock - Tue, 05 Jul 2016 03:55:57 EST Snrw7+hK No.78066 Reply
yes you will be left with 2 grams of crystal because every time you dissolve it in water and evaporate it the amount of drug doubles
press - Tue, 05 Jul 2016 16:21:58 EST fcMijPsC No.78067 Reply
maybe. i dont know the solubility.
next time use hot water and as little as possible. then just let it slowly cool down

hacking the mind

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- Wed, 22 Jun 2016 18:21:30 EST QmmUL0gM No.77992
File: 1466634090596.jpg -(1283376B / 1.22MB, 1920x1200) Thumbnail displayed, click image for full size. hacking the mind
you know how we can put those electrodes in the heads of animals ?
we put one in the head of a rat once and they made it move with a joystick

do you think the government would weaponize i mean we could do tigers?
if we wire them right we could keep them moving through death

in theory you could do it to humans it'd be almost like zombies
3 posts omitted. Click View Thread to read.

Finding Job with BSc in Biochemistry

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- Tue, 07 Jun 2016 10:45:19 EST 1hq57uuB No.77945
File: 1465310719476.png -(82305B / 80.38KB, 1941x2242) Thumbnail displayed, click image for full size. Finding Job with BSc in Biochemistry
Hello guys,

I'm 22 years old and have a BSc in Biochemistry. I was wondering if it was easy to find a Job in the U.S. only with a BSc. The reason is that I need a change in environment. I somehow have the urge to travel and live in different countries.
The industry doesn't really matter it just has to make for a living and maybe it is possible to study besides working.
I'm from switzerland if that changes anything.

SLAYER to y'all
2 posts omitted. Click View Thread to read.
Bombastus !RZEwn1AX62!!xXxJO70U - Thu, 16 Jun 2016 13:07:21 EST +CUD9CML No.77974 Reply
Some Masters can pay $20000-$25000 a year.
Find one.
Molly Pabberstane - Sat, 25 Jun 2016 00:18:13 EST MS463KCQ No.78010 Reply
If you can get accepted to a PhD. program you can usually make an annual stipend of 20-25k in exchange for teaching. Work the PhD. track towards the MSc. then leave the program with your MSc.
Bombastus !RZEwn1AX62!!xXxJO70U - Fri, 01 Jul 2016 01:43:36 EST bXUlP+sg No.78050 Reply
Both; bank loan. Or you could find a job with an undergraduate and work until you have time to return for your masters.

Alkene synthesis

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- Fri, 24 Jun 2016 13:52:08 EST WznVySGw No.78005
File: 1466790728463.png -(94053B / 91.85KB, 704x830) Thumbnail displayed, click image for full size. Alkene synthesis
anyone know how to solve this question with all the organic products ?
18 posts and 13 images omitted. Click View Thread to read.
Bombastus !RZEwn1AX62!!xXxJO70U - Sun, 26 Jun 2016 13:56:28 EST V/Ex51MS No.78027 Reply
1466963788948.png -(119507B / 116.71KB, 680x509) Thumbnail displayed, click image for full size.
Bump. It's been two hours. What now.

I also fucking hate when schools make you do that. Sorry OP.
This problem - Sun, 26 Jun 2016 15:29:16 EST YfyCDm6o No.78030 Reply
1466969356802.png -(70639B / 68.98KB, 880x922) Thumbnail displayed, click image for full size.
Wanna see some bullshit ..... stupid software I was right all along
William Clonkinman - Sun, 26 Jun 2016 15:42:25 EST IK7sy6RX No.78031 Reply
that's that pearson bullshit online hw isn't it? That's the worst shit I've ever used, the problems are all terribly made and there's typos everywhere.

Dumb scifi question

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- Fri, 24 Jun 2016 12:37:45 EST TtNn9wfR No.78004
File: 1466786265335.gif -(317533B / 310.09KB, 180x200) Thumbnail displayed, click image for full size. Dumb scifi question
So I'm dicking around with a videogame, and I had the dumb idea to make a character that's essentially a biological computer, radio controlling organic drone bodies through biological radio transmitters - basically technobabble telepathy.

Would such a thing be possible, if you had countless of hours to dick around with genes and shitloads of funding?

Also, would someone be able to jam such a biological radio signal? I mean, if you can jam real radio, or take over control of a radio signal, in real life, surely you should be able to control some biological radio controlled drone...

Also, would it be possible with only radio transmitters, or could other more exotic waves be used?

Old, novel 14-hydroxylation

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!RZEwn1AX62!!xXxJO70U - Wed, 02 Mar 2016 21:02:15 EST qWybWc+e No.77704
File: 1456970535551.jpg -(10007B / 9.77KB, 200x200) Thumbnail displayed, click image for full size. Old, novel 14-hydroxylation
Acetylate codeine. Protects the group.
Peroxyacid attacks the 14th position caused by the resonance of the double bond (absent in dihydro intermediates proposed earlier). Theoretically creates 14-hydroxy-acetyl-codeine but due to the heat, codeine and 14-hydroxycodeine are also formed.
Another acetylation can be performed and peroxyacid attack to adequately react away the byproducts (worth it IMO but needs to be recalculated).
Deacetylation with a strong acid (sulphuric) upon heating can render the hydroxide workable. Dilution and Pd/C reflux should be able to both hydrogenate and oxidise the 14-hydroxycodeine to 14-hydroxy-dihydro-codeinone.

Sounds workable but the 1916 journal mentions that it is an intermediate to create 14-hydroxycodeinone, not 14-hydroxycodeine. That's not a big issue, if that is the case. A simple borohydride reduction to 14-hydroxycodeine should make the Pd/C reflux workable and remove the need for hydrogenation - which most people cannot do.

The first step should take around 15 minutes with a workup for 30. The second step is an 8 hour reflux. The third step is a 4 hour reflux. This really means that this reaction can take just one day. A column purification step is highly recommended.

It'd be interesting to see if anyone can try it to work.
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Vehk !7HYGxe5v5c - Sat, 02 Apr 2016 22:44:41 EST aFt0bd4t No.77792 Reply

25% of an organic chemist in a month. Also, you're the one always sending me links to circlejerk threads.

Shit had me weak man

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- Thu, 03 Mar 2016 15:25:23 EST NLJmhbvz No.77707
File: 1457036723155.jpg -(10453B / 10.21KB, 218x231) Thumbnail displayed, click image for full size. Shit had me weak man
In an attempt to make some counterfeit codeine with prometh syrup (it was for a southern rap themed party), I dropped about 3 oz of pg/vg mix with some flavor, two or three shots of everclear and two shots of tito's vodka, 10 finely crushed alprazolam 2mg tablets, and to top it off, corn syrup for the texture.

Here's the real question though: Would heating up the alcohol and/or alprazolam mixture do anything to potentiate it?

I put an ounce in a big pineapple and drank that and caught a fantastic buzz and when I tried doing it with two ounces of the solution, I fell asleep before finishing it. They way I heated it up was I took two pyrex measuring cups, put very hot water in the first one and placed the second pyrex (containing the solution) on top and using a metal whisk, I mixed the ingredients until they were nice and even. There was still a little pill matter so I just took that off with a spoon since it rose to the top and ended up with a pint of some "lean".

Did the heat help or could it just be the alprazolam and alcohol working together? I put half an oz in my drink today in class because I took an adderall (it makes me nervous so I needed to chill) and ended up pretty buzzed for about an hour rather than just chilled out lol thank god the adderall kept me functional.

So what's the deal gais? I need a chemistry guy on this, help a brotha out
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Polly Mellyham - Tue, 08 Mar 2016 20:50:36 EST xxs07y/f No.77734 Reply
Your friends are gonna black out, not remember the party, and blame you.
John Brazzleshaw - Thu, 10 Mar 2016 12:44:43 EST TrPWlcRq No.77737 Reply
...Why not just get the actual syrup?
This seems unnecessary and possibly dangerous.
Ebenezer Lightville - Fri, 17 Jun 2016 18:31:54 EST RMLgtyMj No.77979 Reply
This shit sounds amazing, give in depth instructions

Phalaris Extraction Thread

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- Sat, 28 May 2016 12:28:20 EST cOHpZlwa No.77923
File: 1464452900987.jpg -(132334B / 129.23KB, 800x999) Thumbnail displayed, click image for full size. Phalaris Extraction Thread
Has anyone here done any work with extracting DMT or other trptamines from various specieis of Phalaris grass? DMT Nexus has a lot of information but a lot of it is contradictory and incomplete.
Esther Diddlemene - Sun, 29 May 2016 16:25:14 EST alUhohOf No.77931 Reply
I wouldn't bother. I'd just purchase Acacia Confuse or Mimosa Hostilis online.
Molly Honningshit - Tue, 14 Jun 2016 11:24:06 EST DXmzOHk9 No.77967 Reply
Once you have the real materials its super easy, I made some yuasca in my dorms on a freakin hot plate.
Oliver Clepperdale - Wed, 15 Jun 2016 01:23:52 EST vp89ZYzI No.77968 Reply

Stop being so afraid and jump into it. Vaporize it ideally.

liquid weed

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- Mon, 13 Jun 2016 17:05:06 EST DXmzOHk9 No.77966
File: 1465851906550.jpg -(21155B / 20.66KB, 225x225) Thumbnail displayed, click image for full size. liquid weed
So my question is, how much thc, cbd,(weed) can 1 gallon of 100% VG absorb? I'm stoned and forget the term, deal with it lol

Chlorine Biosphere?

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- Mon, 06 Jun 2016 14:04:43 EST QeFTOZ30 No.77943
File: 1465236283025.jpg -(7093B / 6.93KB, 200x200) Thumbnail displayed, click image for full size. Chlorine Biosphere?
I'm an artist that depicts space scenes. Rather than focus on scifi space battles or nebula or some shit I like to focus on making realistic-looking planets (or as realistic as I can get them to look at least). I do a lot of Earth-like planets but, as a biology nerd, I wanted to try something new. I've done a few Earth-like planets with usual colors of vegetation: red, purple, black, etc. I've been reading about alternative biochemistry and wanted to try depicting a planet with a biosphere that isn't necessarily carbon-aqueous.

Anyways, I'm not here to talk about the planet in particular. This isn't /sagan/ after all. No, I want to discussion biochemistry involving chlorides. I read a study about some scientists replacing the thymine in the DNA of E. coli with 5-Chlorouracil, so there is some precedent for chlorides being incorporated into biological systems. In my research I also came across this: 2HCl + CO2 ---> CH2O +Cl2. It looks kind of like some kind of photosynthesis that uses hydrochloric acid to form organic compounds? I'm pretty sure that's formaldehyde and chlorine gas. Do you think that the chlorine gas could be utilized in a manner similar to oxygen? Could this create any kind of sustainable biosphere? I'm honestly not sure this concept is even remotely possible but it is interesting.
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Bombastus !RZEwn1AX62!!xXxJO70U - Sat, 11 Jun 2016 11:15:13 EST 4ppVjZXo No.77962 Reply
Jupiter level gravity. The gravity would be so strong that life would not exist due to the activation energy to sustain wall membranes would be too high. It's just theoretically so implausible for it to work.
Methane would be the other best bet as it can be burned for fuel relatively easily and would be so abundant in the universe. Carbon fixation comes first; then nitrogen fixation.

On a low pressure system, it's hypothesized that silicon would be the binding site of choice due to its molecular weight. In this case, you might have gaseous bromine sticking around. However, it would be so implausible because the halogen % composition of the universe is so miniscule, the odds are just heavily stacked against your favor of a halogen- based organism.

Oxygen is the best candidate because it's heavy enough to stay on the atmosphere, be gaseous, and most importantly: is abundant enough in star death.
Bombastus !RZEwn1AX62!!xXxJO70U - Sat, 11 Jun 2016 11:16:15 EST 4ppVjZXo No.77963 Reply
Uracil is made after multiple millions of years of carbon fixation and added nitrogen fixation. No way such a complex structure would exist otherwise, unfortunately.

Edwin Fupperstodge - Sat, 11 Jun 2016 23:34:49 EST GSuYkmZT No.77964 Reply
1465702489325.jpg -(1562155B / 1.49MB, 2600x1980) Thumbnail displayed, click image for full size.
Seems like this idea is a bust. Oh well, thanks for the input anyways. It's always nice to learn something, even if it leads to disappointment.



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- Tue, 10 May 2016 23:12:56 EST V/Jmd1aC No.77888
File: 1462936376814.jpg -(516226B / 504.13KB, 1920x1080) Thumbnail displayed, click image for full size. H2SO4
I acdentely 98% pure sulefuric acid. Should I have this checked out? Could be a third degree chemicle burn? Should I just ingore it and hope it goes away. Also this happened a few days ago so this isen't a fresh wound.
1 posts omitted. Click View Thread to read.
Bombastus !RZEwn1AX62!!xXxJO70U - Wed, 25 May 2016 21:14:28 EST aXFxXtc6 No.77914 Reply
>I acdentely 98% pure sulefuric acid.

You should be fine, OP. Acid burns are normally very localised and don't cause any damage on your flesh that isn't superficial. As long as you're not using it as an inhalant, huffing it, using it as eyedrops, injecting it, plugging it, or bathing in it, this burn will just be like a tattoo.
What you have to worry about is potential infection.

How'd you let that happen to you, anyway? I've accidentally poured H2SO4 on the back of my hand before and washed it off within 20 seconds while it was already burning. How'd you let it get to that extreme?
Shit Basslesadge - Fri, 10 Jun 2016 19:11:42 EST zwhzKcaA No.77958 Reply
Keeping the sunlight(UV) off of it should also help reduce scaring. Cover lightly.

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