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420chan is Getting Overhauled - Changelog/Bug Report/Request Thread (Updated July 26)

Drug Testing

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- Sat, 02 Mar 2019 18:28:30 EST pUb2iHzJ No.79313
File: 1551569310684.png -(127855B / 124.86KB, 1345x2392) Thumbnail displayed, click image for full size. Drug Testing
Is there a way to test whether my X is actually X without a reagent kit? Anything that could narrow down the possibilities is helpful
>>
Wesley Dugglewill - Wed, 13 Mar 2019 04:57:04 EST EgtLYZA7 No.79318 Reply
>>79313
Why are you avoiding a reagent kit in the first place?
>>
Fucking Smallforth - Thu, 14 Mar 2019 16:42:47 EST LAqsvRkE No.79320 Reply
Yes, but all are much more complicated than a reagent kit and if you can't buy or use a reagent kit you won't be able to do those. Things like melting point measurement, x-ray diffraction, GC/MS, MS/MS, HPLC/MS, IR spectroscopy, UV-VIS spectroscopy, NMR spectroscopy, conductometrics, gel-electrophoresis, etc. Just buy a fuggin reagent, or make it yourself: 4% of concentrated formaldehide, 96% of concentrated sulfuric acid. I heard in USA you can buy cc. H2SO4 as drain cleaner/declogger. Formaldehide is sold in the pharmacy. Mix it slowly while cooling, allow it to sit a few hours than drop a drop on a little piece of your X, if it turns purple it's something containing the methylenedioxy moeity, and since almost all possible drugs containing it are illegal now, why would someone bother making something like MBDB or Methylone or etc when he can make MDMA easier, cheaper and just as illegally.

Organic chemistry

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- Mon, 10 Dec 2018 01:04:36 EST xqVfPx4h No.79298
File: 1544421876364.jpg -(72004B / 70.32KB, 800x512) Thumbnail displayed, click image for full size. Organic chemistry
How the fuck do they know what's happening inside of living things? Particularly with neurochemistry. You've got, let's say, a working brain. It's full of juices. You've got a science lab. How do you go about separating which juices are which and determining how they behave in the living brain?
2 posts omitted. Click View Thread to read.
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Reuben Soshfork - Wed, 06 Mar 2019 04:31:02 EST A5rByIPr No.79316 Reply
they used of course in it
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Albert Pottingdock - Fri, 08 Mar 2019 02:24:52 EST A5rByIPr No.79317 Reply
Graphene is very interesting nanomaterial for me. I heard that grapheneis widespread and used in electronic. It has next characteristics Carbon > 99, 6%, Thickness (nm): < 3.0 , MB surface area (m2/g): ~80, Density (kg/m3): 2,2, Bulk density (kg/m3): 120, Electrical resistivity (Q.cm-1): < 0.15. I think you need to find graphene in special laboratories like it http://mstnano.com/products/graphene/
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Archie Pidgestock - Wed, 13 Mar 2019 16:35:58 EST dl9lAnzN No.79319 Reply
>>79298
>>How do you go about separating which juices are which and determining how they behave in the living brain?
It takes a really long time and a lot of work and most of the time you will be wrong or overly simplistic in your interpretation of what is going on. Serotonin for example was so named because they believed at first its primary function was modulating the consistency of blood serum.
For the specifics though, the way they tell which neurotransmitters affect what is by looking for ligand receptors at the synapse. The neurotransmitter works by being a 'key' for a specific molecular lock on the receiving cell, which initiates its action potential to propagate a shifting ion gradient through the dendrite. Then, they follow the trail of that neuron chain's axons until they get to something that's a muscle or sensory cluster (or backwards, to a specific region of the brain) and then end up saying something like 'these neurons are part of a pathway connecting this behavior/sensation to control from this brain region, modulated by this neurotransmitter.' If you noticed this is not much different than the room of blind men describing an elephant by grabbing different parts, grats, you've been paying attention.

Candyflip creation

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- Sun, 28 May 2017 22:51:16 EST eE+IWTWR No.78666
File: 1496026276961.jpg -(532507B / 520.03KB, 1507x1270) Thumbnail displayed, click image for full size. Candyflip creation
I'm looking to start small-scale creation of mdma and lsd. I've got next to no chem. knowledge, and no lab setup yet.

Got any recommendations for reading? Uncle fester and schulgin are the only ones i know of and both are above my pay grade.
What glassware is required? Recommended?
Any recommended materials sources?

Thanks
29 posts and 5 images omitted. Click View Thread to read.
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Martin Worthingshaw - Tue, 11 Dec 2018 04:20:58 EST H2dReURr No.79302 Reply
>>79292
Those books are pretty old and a lot of the ingredients lists have either been put on lists or simply become less available/more expensive due to normal market reasons, such as decreased demand and production and industry standards leading to different choices. It's quite possible that where OP is, the specified list of requirements could be 10x what he actually needs for the synth.
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Jack Blepperlure - Wed, 12 Dec 2018 18:23:16 EST X7AWx7pQ No.79303 Reply
Follow your dreams I need at least 15,000 barrels
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Polly Goodbanks - Fri, 01 Mar 2019 06:06:24 EST zrV5jqLv No.79312 Reply
OP, first place to start is to understand 'unknown unknowns'.


Why don't they just build reactors deep underground?

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- Sun, 21 Oct 2018 09:48:58 EST OuVlsNVB No.79259
File: 1540129738526.jpg -(34374B / 33.57KB, 267x345) Thumbnail displayed, click image for full size. Why don't they just build reactors deep underground?
Maybe this is a dumb question. But I'm going on my annual wikipedia dive on nuclear disasters.

If they built all of these like 500m below the surface and covered in heavy rocks or concrete/steel wouldn't most of the effects of a total melt down be contained by the ground?

It seems like the worst part of a subterainian melt down vs one on the surface is there is probably a mini earth quake in the area.
But in my mind it seems most of the fallout and radiation would be contained, you only have to worry about ejected materials and chuncks i suppose?/
And as long as your reactor isnt near any fault lines i dont see any real danger.


Also after a melt down it seems itwould be much easier to fix the problem if its in a giant hole in the ground vs sitting in the middle of a russian village.

IDK, educate me internet.
11 posts omitted. Click View Thread to read.
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Doris Chittingford - Wed, 14 Nov 2018 00:40:43 EST dl9lAnzN No.79276 Reply
>>79274
>>Why isn't it used everywhere?
It's a more advanced technology that isn't as fully developed, so everything about it costs more. And, even if it were at the same economy of scale, an individual unit of fuel costs more, since it must be transmuted from thorium to uranium first. The only savings are in safety and waste concerns, and those are long term costs which people like to ignore in favor of short term ones.
>>
James Randi - Fri, 30 Nov 2018 07:03:01 EST OuVlsNVB No.79289 Reply
>>79276
This is just my understanding, I could be wrong. It seems mainly because were stuck with the old reactors because they cost so much to build that we more or less have to use the old ones for a long time until they've paid for them selves or outlived their usefullness or economic sustainability.

Then also the whole industry is standardized around the old technology. So to switch to a new one would be like a major format shift that the entire industry would need to adapt to, and it just costs too much money.
Also you would need to train a whole new generation of nuclear power plant operators on a new type of reacor. Where I imagine that most of the work is still on old reactors, why train for the new ones?
>>
Lydia Bunfuck - Thu, 06 Dec 2018 03:29:38 EST 96grgyjN No.79294 Reply
>>79265
Power generation can't occur solely in one specific place. It's decentralized for a reason: power transmission is not an efficient process over massive amounts of distance. It's the same reason the old "why don't we just build massive solar arrays in the Sahara to power the world" trick won't work. It's not enough to generate the power, you have to wire it to the locations that consume power. Resistance, even for highly efficient conductors like copper wire, plays a big role in determining the power grid and its constituents.
>inb4 someone wanks over wireless power transmission/tesla


alternative chloral hydrate synthesis

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- Sun, 25 Nov 2018 08:07:04 EST P3Ub+nJg No.79285
File: 1543151224177.png -(19806B / 19.34KB, 1109x571) Thumbnail displayed, click image for full size. alternative chloral hydrate synthesis
so i was thinking of making some chloral hydrate but i would prefer to avoid fucking with chlorine gas then i had this idea basically use the same same method as for chobutanol but replacing the acetone with formaldehyde then either just use the tricholroethanol as is or oxidize it with probably dichromate and sulphuric acid to chloral. dose anyone know a reason why the reaction used to make chloral hydrate would not work with an aldehyde as well as it whould work with a ketone?


Your recommended method of extracting DMT?

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- Sat, 18 Aug 2018 10:13:51 EST Udk0Y39+ No.79204
File: 1534601631648.png -(365367B / 356.80KB, 602x452) Thumbnail displayed, click image for full size. Your recommended method of extracting DMT?
I was looking up how to extract DMT and apparently it's most commonly done with Mimosa Hostilis root bark. Looking at the guides it's very MacGyver tier. I'm saying I'm wondering if there is a more professional way of doing it. Essentially I'm asking, if you ever looked into extracting DMT and if you have the chemistry background, what methods of extraction do you prefer/recommend and do you have any advice regarding it? Perhaps a mistake that commonly diminishes the quality of the extraction or some deviation from the existing guides to end up with something more pure.
2 posts omitted. Click View Thread to read.
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puress - Fri, 12 Oct 2018 13:48:21 EST bibGzGaZ No.79243 Reply
>>79242
TLC is most often distribution chromatography ( with a smidgeon of absorption chromatography) , meaning its more about polarity of the substances than about their weight itself (though there often is an indirect relation between weight to affinity). you basically have a solvation hull on your substrate and the mobile phase flows above that, depending on the polarity of a substance it moves between the stationary and the mobile phase, thus seperating from other substances. ive made a nice animation for that shit but im too paranoid, ill see if i find a comparable animation

in theory you should get one band per compound of your mixture but high concentrations or an unsuitable eluent may lead to streaking and improper seperation depending on the number of theoretical seperation stages.

in the OP scenario TLC would only serve as an analytic tool, even column chromatography couldnt really yield a lot of DMT doses

youd be seperating by molecular weight if the different compounds had no intrinsic dipoles. i used to hate chromatography since its such a bitch ass compromising bullshit way of seperation... wait theyre all based on equilibrium
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purrbastus - Sat, 20 Oct 2018 04:31:22 EST L5efXmCV No.79256 Reply
>>79243
you can do TLC on a large enough plate after plating it on glass and then chisel the silica or alumina off it to extract it back out

you can do that up to like 2g of a sample depending how many silica coats you do and how patient you are. works for analytic and organic chemistry. definitely not for others. but then again, if you're operating with fucking oxymorphone or dmt or cocaine for personal usage, this may be viable.
>>
pupress - Thu, 25 Oct 2018 16:21:28 EST KFcL1XHa No.79269 Reply
>>79256
put my gold fish into the bath tub so that the aquarium is free to serve as a tlc chamber

bright star tek questions

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- Thu, 13 Sep 2018 13:45:15 EST HJwBSxjU No.79229
File: 1536860715304.gif -(1043B / 1.02KB, 512x73) Thumbnail displayed, click image for full size. bright star tek questions
One is left with impure methylamine. The stuff includes ammonia chloride.
Is this fine? Is one to assume that when using the adulterated methylamine in later reaction that the ammonia chloride wont matter?

Step 3 says to "flood the reaction contents with 1.5 L of slightly acidic water"
Mix in what container? Largest container called for is 1000ml RBF

Reducing 3,4,5-trimethoxy-beta-nitrostryrene to mescaline

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- Wed, 13 Jun 2018 11:03:55 EST rajg/xs8 No.79145
File: 1528902235968.png -(5534B / 5.40KB, 460x300) Thumbnail displayed, click image for full size. Reducing 3,4,5-trimethoxy-beta-nitrostryrene to mescaline
I want to reduce 3,4,5-trimethoxy-beta-nitrostyrene to the amine. What will do this? I've found so much worthless and bullshit information. It seems the main options are:

  1. Zn/HCl or Fe/HCl. I don't know if this goes from the nitrostyrene to the amine or if I need to use NaBH4 to first reduce the double bond. Also, some people say the yields are good and others say the yields are shit.

2. LAH. Not an option.

3. SnCl2 to reduce the nitrostyrene to an oxime and then Zn to reduce the oxime to the amine. I've never found proof of anyone doing this reaction on nitrostyrenes. SnCl2 is good for reducing nitropropenes but who knows if that applies to nitrostyrenes.

4. Al/Hg. Literally toxic. I haven't found any reports of people using the less toxic Al/Ga or Al/Cu amalgam. I also get conflicting information saying Al/Hg reduces directly to the amine, yet others are saying NaBH4 must be used to first reduce the double bond and then the Al/Hg reaction can be run to reduce the nitro group to an amine -- which is it?

Any input would be appreciated, especially from people who have actually run these reactions on this particular substrate.
3 posts omitted. Click View Thread to read.
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Samuel Turveydock - Wed, 22 Aug 2018 20:39:00 EST zbIVdkqy No.79215 Reply
>>79148
pushing it through a pad of celite or silica would help but honestly there isnt any reason to go with mg or tin
ochem portal has a page dedicated to conjugated nitro reductions...
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Martin Drablingville - Thu, 23 Aug 2018 15:55:31 EST quGHpYNb No.79217 Reply
Zn/HCl is the method of choice for terminal nitrostyrenes, but it fails for nitropropenes. Fe/HCl gives carbonyl compounds which you don't want. Make sure your zinc is good.
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Bombastus Werrywag - Sat, 20 Oct 2018 04:35:52 EST L5efXmCV No.79258 Reply
>>79217
double bond may prevent the latter but either sources of hydrogen should work. then introduce it with palladium on carbon under a little party balloon to give you the pressure required to hydrogenate that 2nd position

Naltrexone -> Oxymorphone?

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- Thu, 17 Mar 2016 18:16:02 EST GksK9UMc No.77752
File: 1458252962747.png -(55460B / 54.16KB, 992x379) Thumbnail displayed, click image for full size. Naltrexone -> Oxymorphone?
Dear /chem/,

wikipedia cites that "Naltrexone can be described as a substituted oxymorphone – here the tertiary amine methyl-substituent is replaced with methylcyclopropane. Naltrexone is the N-cyclopropylmethyl derivative of oxymorphone."

Is it possible to revert naltrexone back to oxymorphone? If so, how?

My very limited understanding of organic chemistry leads me to believe that naltrexone could, in proper solution and (probably) with the addition of heat, be broken into oxymorphone and cyclopropylmethylbromide. (pic related)

Any input regarding said (hypothetical) reaction will be greatly appreciated!
10 posts and 2 images omitted. Click View Thread to read.
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Alice Honeyhall - Mon, 09 Jul 2018 03:51:31 EST mH/x48p3 No.79163 Reply
>>79162
Cyclopropanes are very unstable but the one pictured with a stabilized alkane group is not. This group shown with an R-cyclopropane is relatively stable.
Carbon-carbon chemistry is very hard. Even harder to do selectively.

Short answer is most likely, no.
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Edwin Clarryforth - Tue, 18 Sep 2018 23:44:00 EST y5OCfqyd No.79231 Reply
>>79163

The cyclopropylmethyl can be turned into isobutyl via palladium under hydrogen. How hard would it be to remove it then?
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Pressbastus - Sat, 20 Oct 2018 04:33:55 EST L5efXmCV No.79257 Reply
>>77752
oh yeah how have we been going with this? OP did you make any significant literature readings or apply common reactions to make this even remotely practical?

ATTENTION SMART PEOPLE

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- Thu, 18 Oct 2018 16:19:01 EST +P3OcrX6 No.79249
File: 1539893941605.jpg -(141222B / 137.91KB, 640x479) Thumbnail displayed, click image for full size. ATTENTION SMART PEOPLE
I'm dumb as a brick and just want to make sure that I'm getting this right. Is the information in this link saying that L-Carnitine has a pH of 6.5 to 8 when mixed in a solution of 50 grams L-Carnitine to 1 liter of water?
https://www.sigmaaldrich.com/catalog/product/mm/840092?lang=en&region=US
3 posts omitted. Click View Thread to read.
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Thomas Honeyspear - Fri, 19 Oct 2018 09:57:48 EST WaGAkLIJ No.79253 Reply
>>79252
So if you had to make a guess would you assume that pure L-Carnitine crystals would be safe for teeth when dissolved in water? I need to take 3.5g a day and I worry about it's affect on my teeth, especially since I have a chipped tooth that I can't afford to get capped.
>>
Wesley Muttingridge - Fri, 19 Oct 2018 17:59:04 EST dl9lAnzN No.79254 Reply
>>79253
Yeah man, should be fine. If you're really concerned about it, drink it with a straw past your teeth straight down your throat, but honestly I think you should be fine.
>>
Eugene Pennersock - Fri, 19 Oct 2018 18:40:40 EST QAuHu/mb No.79255 Reply
1539988840011.jpg -(2277021B / 2.17MB, 2848x4288) Thumbnail displayed, click image for full size.
>>79254
Excellent. Thanks man, here's a picture of Jenna Fischer for your assistance.

Organic chemistry

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- Tue, 16 Jan 2018 12:06:23 EST uUZ+g3Ph No.78973
File: 1516122383293.png -(1031741B / 1007.56KB, 1334x750) Thumbnail displayed, click image for full size. Organic chemistry
What's the best way to learn organic synthesis outside of picking up a text book?
Any online courses or videos out there?
1 posts omitted. Click View Thread to read.

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