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420chan is Getting Overhauled - Changelog/Bug Report/Request Thread (Updated July 26)

4fmph

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- Thu, 20 Sep 2018 17:02:33 EST JsuSKLxG No.79232
File: 1537477353525.png -(109613B / 107.04KB, 680x448) Thumbnail displayed, click image for full size. 4fmph
Can I turn all this 4F-MPH, this 4fluoro-methylphenidate, into plain old methylphenidate (Ritalin) ? For studying? Assume ive dabbled extensively in kitchen chemistry (assume I'm not as feeble in the lab as I am in the psychiatrist offices)
i know its a long shot and im pretty much asking for my work to be done for me but what the hell. the man is on a mission to go back to school
1 posts omitted. Click View Thread to read.
>>
Lillian Cogglehack - Thu, 27 Sep 2018 19:46:25 EST xsneeAgl No.79236 Reply
>>79235
Op here

Im willing to be a good chemist with unlimited resources could do it....
>>
William Brinkinwick - Thu, 27 Sep 2018 22:42:23 EST oKyR6MUr No.79238 Reply
1538102543388.jpg -(7299B / 7.13KB, 201x200) Thumbnail displayed, click image for full size.
Fluorine is the most electronegative element. It grabs on to shit and doesn't let go. It's almost certainly possible to do what you're asking, but not necessarily in a one step reaction, and certainly not easily

OTC Nonpolar Solvent

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- Thu, 07 Jun 2018 01:15:44 EST 3wTRifUB No.79140
File: 1528348544368.png -(9674B / 9.45KB, 83x80) Thumbnail displayed, click image for full size. OTC Nonpolar Solvent
What's something pure and reliable I can use a nonpolar solvent that I can quickly buy?
4 posts omitted. Click View Thread to read.
>>
Martin Drablingville - Thu, 23 Aug 2018 15:57:14 EST quGHpYNb No.79218 Reply
I don't know what the fuck you can buy but the standard answers are "acetone", "methyl ethyl ketone", "dichloromethane", "toluene" and "petroleum ether", in decreasing order of polarity. Some distillation may be required.
>>
Martin Drablingville - Thu, 23 Aug 2018 15:58:06 EST quGHpYNb No.79219 Reply
>>79218
based on your other reply, DCM is the best choice here, or MEK or toluene. pet ether is too weakly solvating and acetone is too polar.

What makes atoms do what they do?

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- Sat, 10 Mar 2018 11:49:56 EST PTghO7Nx No.79012
File: 1520700596496.jpg -(161331B / 157.55KB, 639x999) Thumbnail displayed, click image for full size. What makes atoms do what they do?
Sup /chem/,

There is a fundamental gap in my understanding of the universe. When we look out into the sky and see the sun and stars, measure the Earth orbiting the sun, or see a volcano, it is commonly accepted that eventually, all of these processes will run out of energy and cease to do their thing. However every atom in the universe has positive and negative charges, with the negatively charged particles constantly in motion (and i guess the positive ones too if we count vibration or whatever). How do subatomic particles get a charge in the first place? Will it ever wear off? What makes electrons move? Will an electron ever stop moving and become neutrally charged? Can we apply this seemingly infinite source of subatomic energy to the macro scale to prevent a big freeze or one day generate limitless energy?
36 posts and 4 images omitted. Click View Thread to read.
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trypto - Sun, 19 Aug 2018 13:29:31 EST OdR7meD+ No.79210 Reply
>>79209
To recap: At this point, the long-held theory that light is a wave was being challenged by a bunch of experiments/models.

And then, while trying to figure that shit out, a bunch of experiments/models suddenly showed that MATTER is a wave.

This is still really only the preamble to quantum mechanics, and it's where the math starts to get more intense. Until this point, the math involved was pretty much calculus and differential equations

The next big experiment would be the one that hippies and armchair philosophers love, which is the variation of the double-slit experiment where observation changes the expected outcome. People try to extrapolate so much metaphysical bullshit with this experiment, and I hate it. Yes, it's an amazing result. yes, the math is deep and profoundly alters how we view reality or truth itself. But at the same time, it's simply a mathematical model that's describing what we see. And then we call it reality. It's boring.

IF I do another post, I'll try to explain this experiment, the math it spawned, and the (legit) philisophical interpretations. This is where linear algebra comes into play, infinite arrays, the schrodinger equation, imaginary numbers, wave equations, and more. IMO, it's the point where "quantum weirdness" becomes solved for the most part. There's some philisophical differences of opinion, but they're not too important.
>>
trypto - Sun, 19 Aug 2018 13:35:45 EST OdR7meD+ No.79211 Reply
>>79207
>A positive charge interacts with a positive charge differently than a negative charge interacts with a negative charge.
Also, fuck. This should be "A positive charge interacts with a positive charge diferferently than a POSTIVE charge interacts with a negative charge".

Of course, P-P interactions are identical to N-N interactions.
>>
trypto - Sun, 19 Aug 2018 13:48:46 EST OdR7meD+ No.79212 Reply
>>79210
> IMO, it's the point where "quantum weirdness" becomes solved for the most part. There's some philisophical differences of opinion, but they're not too important.
Oh yeah, and of course special relativity/gravity is still an open question in regards to quantum-scale. Blefht. I'm done. These rambling posts brought to you by Bush. Breakfast of champions.

Molecule

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- Fri, 13 Jul 2018 12:51:01 EST 1xukUjeD No.79170
File: 1531500661281.png -(11786B / 11.51KB, 505x503) Thumbnail displayed, click image for full size. Molecule
Hey guys, so I am helping someone out with there organic chem class.
They have to write a syntesis for this molecule.

my question is,what is the IUPAC name for this molecule?
I can't find it online when I try the molecular formula or draw it.
>>
trypto - Sat, 14 Jul 2018 16:27:22 EST OdR7meD+ No.79174 Reply
>>79170
Is that shit real? I could see it with cyclohexane, but with a benzene ring? Looks like way too much strain. If it's real, I bet it's extremely fragile.

3,5-somethingoxysomething-aniline
>>
p - Mon, 16 Jul 2018 13:40:49 EST N1w1NO9M No.79177 Reply
concerning the synthesis
this is some pretty whack shit. you can even synth superphane but this would be way too much strain on the sp2 carbons of the benzene.

theoretically speaking its an 5-amino anhydride derivative of isophthalic acid, my best guess is that its an exercise aimed at the nomenclature or bicyclocompounds or rather heterocycles.

could you double check if you got that structure right?
>>
Nell Binnerman - Mon, 23 Jul 2018 22:46:55 EST hBAZGxou No.79189 Reply
  • you can't put an anhydride and an unsubstituted amine in the same molecule
  • you can't link meta-separated benzene substituents unless you make an 8-or-more membered ring, because otherwise you're violating bredt's rule

that said, the compound you've drawn could be called 3-amino-6,8-dioxo-7-oxabicyclo[3.3.1]nona-1,3,9-triene. but it is impossible.

Secret unwatched meth precursor cartels are using tha nobody knows about!

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- Thu, 12 Jul 2018 11:36:25 EST AEosv4I7 No.79165
File: 1531409785030.jpg -(26144B / 25.53KB, 630x333) Thumbnail displayed, click image for full size. Secret unwatched meth precursor cartels are using tha nobody knows about!
They use a ketone nobody knows about called "ADDS"

It's not on any list so you can order a million gallons from China easily
1 posts omitted. Click View Thread to read.
>>
Charlotte Blembleshaw - Thu, 12 Jul 2018 22:09:24 EST IsgjdvUw No.79169 Reply
I'm having a hard time picturing cartels sweating chemical watchlists. Let's say it's true. It would realistically have to come from one source and have one consumer for it to remain a secret and it would be easily traceable in a way that diverted chemicals would not. Also unless it was an in-house operation I don't think there would be much of a price advantage. No, I think you're full of shit.
>>
trypto - Mon, 23 Jul 2018 20:01:21 EST OdR7meD+ No.79188 Reply
If nobody knows about it, then how do you know about it?

little Water CWE

View Thread Reply
- Sat, 21 Jul 2018 08:35:39 EST CE1aGD0g No.79187
File: 1532176539983.jpg -(38759B / 37.85KB, 530x530) Thumbnail displayed, click image for full size. little Water CWE
Hi

it's been a milltion years since i've done a CWE and there's one question i have in regards to the amoung of water to be used.

i understand that there is always going to be a little Acetaminophen in the final solution. however, codeine phosphate being as soluble in cold water, or just plain water, as it is i was wondering wether you could skip the whole freezing part of the procedure and instead use a small amount of water. where would potential problems be? i can imagine it would take a really long time as the water would have problems penetrating through the sludge of filter and Paracetamol. but apart from that why could this be a bad idea?

thanks for reading,
love Anon

picture unrelated

test kits for common adulterants

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- Tue, 17 Jul 2018 08:59:13 EST FIrMW5oZ No.79182
File: 1531832353252.jpg -(62355B / 60.89KB, 670x605) Thumbnail displayed, click image for full size. test kits for common adulterants
if i wanted to start a small business where i test people's drugs for fent/pcp/meth/clam or whatever, what sort of reagents would i need to buy? I realize this is sort of an open ended question, i'm just sort of looking for general suggestions for pretty much any drug testing reagent that tests for something. there's pretty much nowhere that you can safely get your drugs tested around where i live & i really want to do what i can to help. i feel like i could save some lives with this.

especially looking for something that can detect if my jenk's been cut with dog pills
>>
pr - Thu, 19 Jul 2018 02:27:18 EST N1w1NO9M No.79185 Reply
are you sure its legal in your country to have a ton of people sending you what in fact are free drugs?

dunno, buncha tlc plates, solvents out the ass, colour reagents or their components- whichever is cheaper- a fridge

and if youre into endgame shit a GC/MS setup
>>
Caroline Dullygold - Thu, 19 Jul 2018 11:27:47 EST FIrMW5oZ No.79186 Reply
>>79185
i don't know how above board this business will be, but i'm in a pretty lenient part of america drug wise so i doubt i'd get in much trouble for people sending me small samples for chemical analysis. also is there any reagent/combination of reagents i can use to test for different benzodiazepines? from my initial googling it doesn't seem very easy but i would really like to be able to tell people if their xans were cut with clam or flam etc

Shake n Bake Meth

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- Fri, 15 Jun 2018 05:48:12 EST 3YadM9Z3 No.79147
File: 1529056092937.jpg -(15382B / 15.02KB, 604x438) Thumbnail displayed, click image for full size. Shake n Bake Meth
Is it really all that dangerous? Is there always a chance that something will go wrong even if you do everything completely right?
>>
Priscilla Dunnerfoot - Fri, 22 Jun 2018 20:38:19 EST UJwtgXMh No.79149 Reply
It's inherently dangerous. The danger is manageable although if you have the discipline and means to do that you're probably just not going to do a fucking shake and bake.
>>
Graham Greenford - Sat, 14 Jul 2018 00:18:01 EST WtJpoXSk No.79173 Reply
Meth is just really bad energy in general, bro.

Maybe get into plain amphetamine synth for fun if you really want a stimulant

General method for determing max/min within a range?

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- Thu, 28 Jun 2018 07:51:21 EST rGLueGvy No.79150
File: 1530186681836.jpg -(16201B / 15.82KB, 500x500) Thumbnail displayed, click image for full size. General method for determing max/min within a range?
Does anyone please know of a general way to determine if there's any local max and min *within a set range of X-coordinates*?

As we can see, there's a local max somwhere around -1 and a local min somwhere around 3 and none whatsoever in the range 1-2.

But how do I prove that there's no local max nor min in that range?
7 posts omitted. Click View Thread to read.
>>
bress - Fri, 13 Jul 2018 13:01:59 EST DbJ7MA1o No.79171 Reply
1531501319502.jpg -(129931B / 126.89KB, 800x449) Thumbnail displayed, click image for full size.
>>79164
the fact that youve posted that is further evidence of the genius of the idea to establish a /shill board. naw just kidding.

concerning the analytic component of the question, im kinda ashamed it took me this long to think of, you could take the derivative via product rule (not sure if another approach would deliver something more moldable) and then reason examine the zero points of the derivative and second derivative.

im a bit confused as to what the actual function is, should it - as mentioned before - be y= sin(x) sin(1/10), the derivative itself will be a sum of two periodic products, meaning youd have to evaluate cases where either both terms are zero or one term is the negative of the other. depending on the range the answer should be given in multiples of some fraction of pi (kirt, tex support when)

during my analytics classes giving a numeric answer was a telltale sign of misunderstanding the task

And should your task be to prove that the function has a local min/max on a given closed range you could simply show that the function is continous (as a composition of continous functions) and then a local min/max has to exist.

fighting BIG H

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- Thu, 12 Jul 2018 14:51:38 EST N1w1NO9M No.79167
File: 1531421498528.jpg -(150268B / 146.75KB, 720x720) Thumbnail displayed, click image for full size. fighting BIG H
is kirts novel way of marking big h somehow connected to the fact that i get 502 everytime i try to use my vpn on here?
because that'd kind of suck, aubrey.

IRREVERSIBLE OPOID AGONISTS - Hydrazine and azine opiate derivatives

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- Fri, 06 Jul 2018 03:58:39 EST pv6fN59z No.79161
File: 1530863919876.png -(5901B / 5.76KB, 220x159) Thumbnail displayed, click image for full size. IRREVERSIBLE OPOID AGONISTS - Hydrazine and azine opiate derivatives
Hey guys.

So recently I've been interested in irreversible opiates.

A couple decades ago some scientists were able to do this by adding a hydrazine at the 6 ketone of oxymorphone, as well as at naltrexone/naloxone, making oxymorphazone and the corresponding nalts.

When tested, these hydrazines lasted extremely long, and blocked any further effect of opiates in animals. As well, radioactive versions of the drugs cold simply not be washed away from tissue expressing opiate receptors. Meaning these drugs were staying bound to the receptor.

Originally it was thought that oxymorphazone itself was doing the irreversible binding, but it was later determined that the oxymorphazone was joining up with itself spontaneously in solution, creating a dimer of sorts, oxymorphazine.

https://en.wikipedia.org/wiki/Oxymorphazone

There's no wiki on Oxymorphazine, but here's something similar: https://en.wikipedia.org/wiki/Oxymorphone-3-methoxynaltrexonazine

It's just two oxymorphones joined by a hydrazine at the 6 position of each.

It was found that the hydrazine derivatives would spontaneously form the azine in solution, especially if it was acidic. The azines were the real irreversible agonists.

Here's a paper on it: https://pdfs.semanticscholar.org/c972/1dfeb562532929fdc9f05ad924e4276f2777.pdf

And apparently, fentanyl hydrazines can be made as well, as well as fentanyl thiocyanate (IIRC).

This has a lot of potential. The hydrazine derivatives bind once and are then bound until the receptor itself is destroyed in the lysosomes. This means it's continually agonizing for the receptors life span, and receptors generally last around 2 days, which is how long the azine derivatives last, two whole days. The agonism cannot be blocked by anything.

As well, the synthesis is exceedingly simple, hydrazine and acidic condition.

So I have two thoughts on this.

Firstly, I could see a very easy synthesis using morphine (either derived from codeine or from heroin that's been hydrolyzed in basic water), using palladium to isomerize it into hydromorphone (does raney nickel work for that too?), and then using hydrazine and acidic conditions to yield hydromorphazone, and then turn that all into hydromorphazine. This would have the incredible potency of hydromorphone (6.6x stronger than heroin), while having a duration of 48 hours, vs hydromorphones duration of 4 hours.
Comment too long. Click here to view the full text.

Anyone ever entered CR?

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- Fri, 06 Apr 2018 15:17:25 EST r6VnKCY3 No.79045
File: 1523042245920.jpg -(62178B / 60.72KB, 487x630) Thumbnail displayed, click image for full size. Anyone ever entered CR?
Posted on /med/

I think i need some advice

Long story short, I recently entered into clinical research from a
nom-science discipline.

I feel like I could be doing more to ensure future success, I'm networking and working my ass off, but I don't want to fall behind on my personal med knowledge. Really want to gain a better understanding of the admistrative and operational aspects of research and pm.

Anyone have any suggestuons for literature, best practices, tools, etc? Whats a good aim for expanded education? Anyone transferred into a health science field from a different profession?
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:52:03 EST pMrrl6aC No.79119 Reply
>>79045
Just don't come around /chem/ too often, unless /med/ is full of LVN's and you have an actual question about hard science.
>>
Jenny Pemmletine - Thu, 31 May 2018 20:43:02 EST FgLbz8nX No.79139 Reply
how'd a nitwit like you get a job in clinical research?

A Wizard

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- Wed, 14 Feb 2018 05:59:47 EST TFS5PxhL No.78997
File: 1518605987304.jpg -(155502B / 151.86KB, 900x609) Thumbnail displayed, click image for full size. A Wizard
I have to find the wizard guy. Where do I find him? I need his help on something.
2 posts omitted. Click View Thread to read.
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:01:24 EST 4Q6JexVr No.79126 Reply
>>79123
If you'd like to schedule an interview I'm available right now, in this thread.
No photographs.
>>
Katsuragi !/pe1aKvMmQ - Fri, 25 May 2018 16:38:14 EST /AXFeCtj No.79138 Reply
1527280694141.jpg -(95699B / 93.46KB, 1024x683) Thumbnail displayed, click image for full size.
>>79137
It's okay, I'm currently ingesting 600ml of diacetylmorphine and drinking 40 proof ethanol. Problem solved mr. president.

Genetics

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!hZYzX5/C3s - Thu, 24 May 2018 13:38:20 EST /AXFeCtj No.79109
File: 1527183500129.jpg -(169838B / 165.86KB, 754x392) Thumbnail displayed, click image for full size. Genetics
Here we see the cost benefit analysis of sequencing the human genome. Though already completed, it is of interest.
2 posts and 2 images omitted. Click View Thread to read.
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Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:43:16 EST /AXFeCtj No.79112 Reply
1527183796184.png -(272830B / 266.44KB, 724x444) Thumbnail displayed, click image for full size.
>>79111
Here are the three heterozygous DNA variants of the GAA-gene in an individual.
If anyone can explain how this applies to one of the earlier posts, I'd be happy to read that.
>>
press - Thu, 24 May 2018 16:12:49 EST xy/fS2YV No.79124 Reply
after having realized that youve made a post in every top page thread for this board im sceptical, but remain intrigued. mind elaborating on your captions for the images youve posted? especially concerning the second image since to a layyman in genetic stuff such as myself it merely looks like a chart corelating sequencing against cost. yeah, not really suprising that could sink nowadays

i hope this could turn out to be some circada ' esque scenario, but tbh i suspect youre just high as fuck and shitposting.
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:00:30 EST 4Q6JexVr No.79125 Reply
>>79124
The second image is random. The comment is about the first image. Viral carrier capacity inheritance versus viral carrier immunity sounds interesting, not sure how it relates to what was mentioned previously.

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