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420chan is Getting Overhauled - Changelog/Bug Report/Request Thread (Updated July 26)

A Wizard

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- Sun, 04 Feb 2018 03:00:59 EST 9c592zYY No.78990
File: 1517731259843.gif -(93878B / 91.68KB, 576x747) Thumbnail displayed, click image for full size. A Wizard
Sup.

Oldfag /chem/ist here.

I just wanted to let you all know that I've found A Wizard. He is alive and well in a crypto discord.

He's also working on a supersoldier serum.

Good day all.
8 posts and 1 images omitted. Click View Thread to read.
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A_Wizard !cMZsY.BCnU!!vVWR8L52 - Fri, 09 Mar 2018 03:24:00 EST H2dReURr No.79009 Reply
>>79007
Since when is spartacus a wizard? Does he even have the syrup?
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:56:20 EST pMrrl6aC No.79121 Reply
>>78990
>supersoldier
Not my fault, not my department.

I like to post pictures of interesting molecules

View Thread Reply
- Tue, 14 Nov 2017 23:00:42 EST k6ZWDP32 No.78906
File: 1510718442981.png -(9001B / 8.79KB, 749x297) Thumbnail displayed, click image for full size. I like to post pictures of interesting molecules
Thread premise stolen from Bluelight. Post molecules you think would make promising drugs. They can be totally novel, or known substances that, for whatever reason (synthetic difficulty, obscurity, poor effects) have never hit the recreational market. Relevant links (literature papers, PiHKAL, trip reports, syntheses, etc.) encouraged.

I’ll start with this one. This molecule is 3-methoxy-4-propoxyamphetamine (“POMA”). It’s active as a mildly psychedelic stimulant and mood elevator. Someone has already synthesized and trialed this compound; you can read the full report here (https://bitnest.netfirms.com/external.php?id=%25087%253B%250B9%2501%2509Czzy%2505)

Not terribly exciting, but interesting all the same. He starts with clove oil (containing eugenol), but an alternative route would be to start with vanillin (much cheaper than clove oil), O-propylate, condense with nitroethane, and reduce.
18 posts and 4 images omitted. Click View Thread to read.
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A_Wizard !cMZsY.BCnU!!vVWR8L52 - Sun, 25 Mar 2018 06:11:01 EST H2dReURr No.79024 Reply
>>78906
Can you add some deso and phenyl to that?
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:54:44 EST pMrrl6aC No.79120 Reply
1527184484841.png -(222471B / 217.26KB, 2027x2417) Thumbnail displayed, click image for full size.
>>78906
This one's kind of interesting. It keeps binding though, I'm not sure where it ends.

Doing more science

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- Sat, 02 Dec 2017 01:40:28 EST vEkGw4n0 No.78931
File: 1512196828433.gif -(767028B / 749.05KB, 400x315) Thumbnail displayed, click image for full size. Doing more science
I want to be a scientist. I want to research and be active and feel like I'm actually getting something done. What sciencey things can I do in my free time that will actually bring me closer to these goals?

I look things up on wikipedia constantly. I regularly check on a site that summarizes recent scientific papers. Isn't there something more that I can be doing while waiting for the GRE to come around that would help me reach my goals?

I work full time in a microbiology lab, but working for a company isn't the same as working for a cause. What science related things do you do? For a living or for enjoyment and fulfillment or just to kill time? What science websites do you look at? What science hobbies do you have?
9 posts and 3 images omitted. Click View Thread to read.
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Ernest Blytheville - Fri, 13 Apr 2018 11:58:01 EST qT5ivdN+ No.79062 Reply
>>79047

That's what techs are for. Scientists are for writing grant proposals and filling out 9001 GLP compliance forms to pH a solution
>>
trypto - Sat, 14 Apr 2018 14:44:08 EST a9li1sY3 No.79063 Reply
>>79040
Honestly, check out twitter. Follow some people in a field you're interested in. They'll post news/articles/trends about it.
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:50:20 EST pMrrl6aC No.79118 Reply
>>78931
Last time I wanted to do science I was accused of producing kerr black holes in the large hadron collider.
This is the most unfortunate joke. I switched to genetics.

Neurotransmitter/drug layers of the brain theory of human evolution publication

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- Sun, 08 Apr 2018 18:11:57 EST hco8bDfO No.79049
File: 1523225517087.jpg -(12168B / 11.88KB, 313x161) Thumbnail displayed, click image for full size. Neurotransmitter/drug layers of the brain theory of human evolution publication
About 8 years ago i read this article or theory or whatever, and it talked about how each substance/neurotransmitter influenced the evolution of human beings aswell as formed a new layer of their brain.

For example, it said that the base layer of the brain correlated with opiates and was like being in the womb and compared it to comfort and the very inner layer of the brain.
Then the next layer was alcohol and GABA saying that it formed the part of our brain that was used for socializing and stuff like that
Then the next layer was for dopamine and amphetamines and stuff like that used for creating and building things.
And it went on from there. I've looked everywhere to find this publication just so i could reread it because it popped into my head. I consider myself a pretty good googler but after hours of searching i couldn't find it for the life of me.

If anyone else remembers this publication, could they point me in the right direction?

Thanks
1 posts omitted. Click View Thread to read.
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Polly Tootcocke - Thu, 19 Apr 2018 15:05:31 EST 8eK2pPPB No.79077 Reply
completely fucking retarded nonsense.
>>
Cyril Tillinggold - Fri, 20 Apr 2018 01:51:54 EST zi8Fqzy7 No.79078 Reply
this shit dumbb nigga

question regarding unusual substitutions

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!57aon8jsJ2 - Fri, 27 Apr 2018 00:28:12 EST 7gSriUk/ No.79094
File: 1524803292499.jpg -(731734B / 714.58KB, 1836x3264) Thumbnail displayed, click image for full size. question regarding unusual substitutions
OK so /chem/ i purchased some drugs online but instead they sent me 98% para-hydroxy-cinnamic acid. what id like to know is can i use this despite only being 98% could i use this in the same way as people use acetic anhydride to add acetyl groups to open hydroxy positions specifically in opis at the 3,6,or 14 hydroxy positions? if not is it useful for really anything?

pic related the 25 grams of para-hydroxy-cinnamic acid
1 posts omitted. Click View Thread to read.
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bress - Sat, 12 May 2018 05:21:32 EST l33iXC6t No.79104 Reply
>>79101
wouldnt the carboxyl chloride then attack the phenolic functionality on the HO-cinnamic acid?
i reckon extremely low concentrations of the acylation agent compared to the substrate eg morphinnnnee would reduce the ammount of polymerizedd bullshit.
>>
Bombastus Werrywag - Mon, 14 May 2018 00:18:56 EST +BoDDLT6 No.79105 Reply
>>79104
excuse high and drunk facilitated retardation because i didn't read "para hydroxy" for some weird reason. just protect it using a benzoyl group or some sort of ether.

How much life can you create with ten bullets?

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- Mon, 14 May 2018 02:08:41 EST PQH37avw No.79106
File: 1526278121944.jpg -(48387B / 47.25KB, 324x499) Thumbnail displayed, click image for full size. How much life can you create with ten bullets?
https://www.newgrounds.com/portal/view/710921

I just realised this maddening little game is a pretty good model for the kind of self-perpetuating chemical reactions that Fritjof Capra put forward as being the origins of life in The Web Of Life...
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:03:31 EST 4Q6JexVr No.79128 Reply
>>79106
None. Unless you count natural processes governing decay.

Drug neurochemistry documentaries

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- Tue, 16 Jan 2018 19:23:36 EST 7ZJCs00x No.78974
File: 1516148616630.jpg -(155468B / 151.82KB, 599x954) Thumbnail displayed, click image for full size. Drug neurochemistry documentaries
Does anyone know of any good documentaries about how different drugs effect the brain? Not scare factor "durgs r bad", I'm looking for something about the chemical reactions in an unbiased setting. Something that gets deep into, from ingestion to end of effect, how it metabolises, stores in the body, what endorphins and neurotransmitters things release and what effect that has.

It's a shot in the dark, but drug neurochemistry is an odd hobby/interest of mine and I figure this might be one of the most niche forums that I could ask.
2 posts and 2 images omitted. Click View Thread to read.
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Basil Goodbury - Tue, 06 Mar 2018 00:23:27 EST fVK4vDOO No.79005 Reply
If you want peer reviewed scientific information, then refer to the literature.

Start with some basic reviews of current neurochemistry and pharmacodynamics. These are targeted at interpreting the current state of the field.

Go Real

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- Thu, 08 Feb 2018 10:02:50 EST k7AMcD44 No.78992
File: 1518102170395.jpg -(1437987B / 1.37MB, 3264x2448) Thumbnail displayed, click image for full size. Go Real
How feasible is molecular crafting? More specifically, can we negate global warming by vacuuming up greenhouse gasses and replacing them with nitrogen/oxygen, whatever would be needed to maintain current climate conditions?
11 posts and 2 images omitted. Click View Thread to read.
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A_Wizard !cMZsY.BCnU!!vVWR8L52 - Fri, 06 Apr 2018 04:00:44 EST H2dReURr No.79042 Reply
1523001644099.png -(84074B / 82.10KB, 606x603) Thumbnail displayed, click image for full size.
>>78992
Fuck it, here's a hint. Race ya to the patent.
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:06:30 EST 4Q6JexVr No.79130 Reply
>>79042
If I patent oxygen producing algae, will you stop telling the patent office joke?

Tasters Choice

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- Thu, 29 Mar 2018 18:06:18 EST p1bUdm0a No.79030
File: 1522361178945.jpg -(39065B / 38.15KB, 380x327) Thumbnail displayed, click image for full size. Tasters Choice
Would this be the expected presentation of a patient who consumed several ounces of sulferic acid?
>>
Cornelius Siffingbanks - Thu, 29 Mar 2018 23:52:08 EST +0GOZxpM No.79031 Reply
pretty sure that's just a guy who huffed spray paint

GBL synth

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- Fri, 09 Mar 2018 12:47:56 EST UXNYhWzG No.79011
File: 1520617676505.jpg -(18221B / 17.79KB, 474x192) Thumbnail displayed, click image for full size. GBL synth
Everytime. Every fucking time I try and synthesize GBL using the Sandmeyer reaction, the temperature skyrockets up to 40c and a bunch of foam forms atop the post reaction mix. I've used many different brands of HCl, GABA, and Sodium Nitrite. I've even begun to use a mini freezer to perform the reaction. And yet everytime the temperature goes up to 40 - 50 degrees Celsius. What in the hell am I doing wrong? I am following all of the instructions, but it's impossible to keep the reaction below 2 degrees C, and to stop the foam from developing, even with a goddamn mini freezer. The rate at which I add the HCl does not seem to matter. The amount of stirring doesn't seem to make a difference either. Could anybody help a complete amateur out?
2 posts omitted. Click View Thread to read.
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press !//CEObOMBY - Thu, 15 Mar 2018 03:28:47 EST OJvL+al/ No.79017 Reply
what scale are you running it on?
got any notes?
>>
Q !57aon8jsJ2 - Fri, 27 Apr 2018 00:13:55 EST 7gSriUk/ No.79093 Reply
>>79011
heres an idea. instead of using that reaction why not do an easier synth? i just found a gbl synth thats one step and two ingredients.

Go buy some THF (tetrahydrofuran) a pretty common solvent. then use a strong oxidizer like what i read says to use aqueous sodium bromate but idk if theres anything actual special about that oxidizer or if pretty much any equally strong oxidizer would work. the THF then forms GBL in a one step one pot reaction.
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:09:22 EST 4Q6JexVr No.79131 Reply
>>79011
I prefer ethyl-alcohol, 40 proof.
Oh no, you're infrastructure is collapse.
I mean seriously, this is ridiculous.

CBN degradation synthesis from THC distillate

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- Sat, 16 Dec 2017 01:41:53 EST xJMHFoUR No.78945
File: 1513406513820.png -(212108B / 207.14KB, 2251x1508) Thumbnail displayed, click image for full size. CBN degradation synthesis from THC distillate
How would one go about a conversion synthesis of Cannabinol (CBN) from 98% pure delta9-THC distillate? Is there an economic method to do such a thing without an expensive lab or advanced chemical skills?
2 posts omitted. Click View Thread to read.
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Aureolus Werrywag - Sun, 17 Dec 2017 18:49:33 EST 9mdhBiEz No.78952 Reply
damn work IP changes.
>>
Ernest Snodway - Fri, 09 Mar 2018 03:23:47 EST GuCmmZOd No.79008 Reply
>>78950
THC synthesis from gerinol and citral is actually a relatively simple process and the weird thing about that is that I grow really dank geraniums, I've been selectively breeding them for years as a hobby. What a lucky coincidence right?
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:11:57 EST 4Q6JexVr No.79133 Reply
>>78945
cannabinoid chemistry is frustrating to think about for me, personally

Incompetent Physics Professor

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- Thu, 18 Jan 2018 18:30:51 EST MsJwbibf No.78977
File: 1516318251029.jpg -(32669B / 31.90KB, 480x328) Thumbnail displayed, click image for full size. Incompetent Physics Professor
Sup /chem/,

I'm taking general physics 2 this semester and I have the same professor I had for physics 1. Now it's just algebra-based, and I've been through calculus, so I was able to breeze through Newtonian mechanics and all that. However this semester is about electromagnetism, circuits, and optics. All topics I have zero exposure to. Now the professor is new to teaching at the college level, his experience is teaching middle-schoolers. He is very (obliviously) condescending and talks to his class of adults like they are 12. He constantly makes sexist or racist jokes (but on the fence enough to not get in trouble) and is always ranting about his personal life or past experiences. When he finally does an actual problem on the board he always struggles with basic spelling and arithmetic, and often fundamentally misunderstands the physics concept he is trying to teach. Several times last semester I had to quietly approach him after class and explain how everything he lectured that day was flawed and the next lecture he would try to fix his fuckup but he ended up just giving everyone lots of freebies on the exams.

My concern is that in this new semester of material I will not get a good exposure or foundation in these topics and might be lost in future courses. Especially electricity and circuits, I really want to learn more about that. I am worried he will teach me some fundamental concepts backward or something. Other than pre-reading the text before class what would you guys recommend to get through this course when the professor is a complete idiot and in my opinion not qualified?
2 posts omitted. Click View Thread to read.
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Augustus Fingerworth - Tue, 23 Jan 2018 09:29:09 EST MsJwbibf No.78985 Reply
>>78983

im going into PT so i wont need any more physics or math. most coursework is in biology
>>
Ian Pillernig - Thu, 25 Jan 2018 23:51:12 EST MsJwbibf No.78987 Reply
so this professor has called out of work the past 3/4 classes. not sure if he is even coming back next week. also the last lecture i had the sub was flushed, had red eyes, mumbled really quietly to himself, and when i approached him, reeked of vodka. so basically i am teaching myself about charges and electric energy and shit
>>
Polly Pottingcocke - Fri, 26 Jan 2018 22:18:48 EST a9li1sY3 No.78988 Reply
>>78987
LOL. Where is this. I'm unemployed, and could definitely be a sub there.

Is ethanol really that easy?

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- Mon, 22 Jan 2018 20:30:04 EST cTRcFZHN No.78981
File: 1516671004570.png -(68997B / 67.38KB, 1188x464) Thumbnail displayed, click image for full size. Is ethanol really that easy?
I haz a question, /chem/: can I use regular rubbing alcohol for this extraction? I am a brainlet but I would really like to try this without pucking my guts out.

Also do you prefer acids or bases?
>>
Angus Drollerchut - Mon, 22 Jan 2018 23:56:39 EST vEkGw4n0 No.78982 Reply
isopropanol is quite a bit more polar than diethyl ether. I don't think it would work. You could buy xylenes from a hardware store though.
>>
!scyTheNg3k - Tue, 23 Jan 2018 20:05:11 EST hBAZGxou No.78986 Reply
idk who tf wrote that but it's bad sorry to say. here's a real tested tek:

>(all steps to be done under a red photographic light)

>1.) 8 kg of HBWR seeds are ground to a fine powder with the assistance of dry ice or liquid nitrogen.

[note: cold makes the seeds brittle, good for grinding]

>2.) to the seeds is added a chilled (30*F) acidic methanol (80% MeOH/DH2O) solution of tartaric acid (saturated). the ammount needed is just enough to cover
the powder with 1cm of fluid and is allowed to stand cold for 24 hours in the dark. more acidic methanol may be added as the seed powder absorbes it.

>3.) after 24 hours the methanol is removed by vaccume to compleate dryness. the seeds are then made into a slurry with DMF/DCM and loaded into a large column,
the DMF/DCM is allowed to drain through and more is added until test drops evapurate with no residue. save the DMF/DCM filtate.

tartaric acid and lots of other undesirable crap dissolves in DMF/DCM, but salts, including LSA tartrate, do not. we convert the LSA to a salt and then remove excess tartaric acid and most other soluble components of the seed.

>4.) the residual DMF/DCM is then removed by vaccume and the seed powder loaded back into the column and filled with chilled MeOH and allowed to stand for 2hr before
draining. this is repeated 4 times and the methanol extracts combined, filtered and reduced under vaccume to a small volume. cold ether is added to the methanol solution
untill cloudiness does not dispell and is placed in a very cold fridge for the crystals to set overnight. save this solution. this should afford 6-10g mixed LAA's as the tartarate salt.

ok the seed powder is wet with DMF/DCM, so we want to get rid of that before extracting with methanol; when that's done, we extract the powder four times with cold methanol, combine extracts, reduce "to a small volume" and add diethyl ether to precipitate LSA crystals.

tbh i'm not sure what happens to the DMF/DCM filtrate, i can only assume he just wants to recover his solvents. DMF/DCM is probably a 1:1 mixture. note recovery is 0.1% of seed weight so if you only have 10g of seeds you're gonna get back about 10mg of LSA which is a few (active) doses but also a very very small amount of chemical, practically impossible to work with if we're being honest
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:14:30 EST 4Q6JexVr No.79134 Reply
>>78986
LSA...
Tastes like envelope sticky stuff.

Newtons law

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- Wed, 13 Dec 2017 13:10:12 EST vpcNyXDE No.78940
File: 1513188612059.jpg -(23150B / 22.61KB, 633x619) Thumbnail displayed, click image for full size. Newtons law
I'm lost on this physics question please help
>>
Caroline Druttingham - Tue, 23 Jan 2018 03:09:42 EST bd1Er6gm No.78984 Reply
>>78940
2 forces, force of gravity Fg down and air resistance Fair up combine to form Fnet. Newton's 3 Laws says Fnet = mass * acceleration which is given as a=2m/s^2. So Fnet = 1.0kg * 2.0m/s^2 = 2.0 N. Force of gravity is Fg = mass * g where g is 9.8m/s^2 so Fg = 1.0kg * 9.8m/s^2 = 9.8N. Fg - Fair = Fnet so Fair = Fg - Fnet = 9.8N - 2.0N = 7.8N.
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:24:44 EST 4Q6JexVr No.79135 Reply
>>78940
Tell your instructor that you had to go to a chemistry message board in order to even understand his question on Newtonian Mechanics. I think that's unfairly difficult.

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