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IRREVERSIBLE OPOID AGONISTS - Hydrazine and azine opiate derivatives

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- Fri, 06 Jul 2018 03:58:39 EST pv6fN59z No.79161
File: 1530863919876.png -(5901B / 5.76KB, 220x159) Thumbnail displayed, click image for full size. IRREVERSIBLE OPOID AGONISTS - Hydrazine and azine opiate derivatives
Hey guys.

So recently I've been interested in irreversible opiates.

A couple decades ago some scientists were able to do this by adding a hydrazine at the 6 ketone of oxymorphone, as well as at naltrexone/naloxone, making oxymorphazone and the corresponding nalts.

When tested, these hydrazines lasted extremely long, and blocked any further effect of opiates in animals. As well, radioactive versions of the drugs cold simply not be washed away from tissue expressing opiate receptors. Meaning these drugs were staying bound to the receptor.

Originally it was thought that oxymorphazone itself was doing the irreversible binding, but it was later determined that the oxymorphazone was joining up with itself spontaneously in solution, creating a dimer of sorts, oxymorphazine.

https://en.wikipedia.org/wiki/Oxymorphazone

There's no wiki on Oxymorphazine, but here's something similar: https://en.wikipedia.org/wiki/Oxymorphone-3-methoxynaltrexonazine

It's just two oxymorphones joined by a hydrazine at the 6 position of each.

It was found that the hydrazine derivatives would spontaneously form the azine in solution, especially if it was acidic. The azines were the real irreversible agonists.

Here's a paper on it: https://pdfs.semanticscholar.org/c972/1dfeb562532929fdc9f05ad924e4276f2777.pdf

And apparently, fentanyl hydrazines can be made as well, as well as fentanyl thiocyanate (IIRC).

This has a lot of potential. The hydrazine derivatives bind once and are then bound until the receptor itself is destroyed in the lysosomes. This means it's continually agonizing for the receptors life span, and receptors generally last around 2 days, which is how long the azine derivatives last, two whole days. The agonism cannot be blocked by anything.

As well, the synthesis is exceedingly simple, hydrazine and acidic condition.

So I have two thoughts on this.

Firstly, I could see a very easy synthesis using morphine (either derived from codeine or from heroin that's been hydrolyzed in basic water), using palladium to isomerize it into hydromorphone (does raney nickel work for that too?), and then using hydrazine and acidic conditions to yield hydromorphazone, and then turn that all into hydromorphazine. This would have the incredible potency of hydromorphone (6.6x stronger than heroin), while having a duration of 48 hours, vs hydromorphones duration of 4 hours.
Comment too long. Click here to view the full text.

Anyone ever entered CR?

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- Fri, 06 Apr 2018 15:17:25 EST r6VnKCY3 No.79045
File: 1523042245920.jpg -(62178B / 60.72KB, 487x630) Thumbnail displayed, click image for full size. Anyone ever entered CR?
Posted on /med/

I think i need some advice

Long story short, I recently entered into clinical research from a
nom-science discipline.

I feel like I could be doing more to ensure future success, I'm networking and working my ass off, but I don't want to fall behind on my personal med knowledge. Really want to gain a better understanding of the admistrative and operational aspects of research and pm.

Anyone have any suggestuons for literature, best practices, tools, etc? Whats a good aim for expanded education? Anyone transferred into a health science field from a different profession?
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:52:03 EST pMrrl6aC No.79119 Reply
>>79045
Just don't come around /chem/ too often, unless /med/ is full of LVN's and you have an actual question about hard science.
>>
Jenny Pemmletine - Thu, 31 May 2018 20:43:02 EST FgLbz8nX No.79139 Reply
how'd a nitwit like you get a job in clinical research?

A Wizard

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- Wed, 14 Feb 2018 05:59:47 EST TFS5PxhL No.78997
File: 1518605987304.jpg -(155502B / 151.86KB, 900x609) Thumbnail displayed, click image for full size. A Wizard
I have to find the wizard guy. Where do I find him? I need his help on something.
2 posts omitted. Click View Thread to read.
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Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:01:24 EST 4Q6JexVr No.79126 Reply
>>79123
If you'd like to schedule an interview I'm available right now, in this thread.
No photographs.
>>
Katsuragi !/pe1aKvMmQ - Fri, 25 May 2018 16:38:14 EST /AXFeCtj No.79138 Reply
1527280694141.jpg -(95699B / 93.46KB, 1024x683) Thumbnail displayed, click image for full size.
>>79137
It's okay, I'm currently ingesting 600ml of diacetylmorphine and drinking 40 proof ethanol. Problem solved mr. president.

Genetics

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!hZYzX5/C3s - Thu, 24 May 2018 13:38:20 EST /AXFeCtj No.79109
File: 1527183500129.jpg -(169838B / 165.86KB, 754x392) Thumbnail displayed, click image for full size. Genetics
Here we see the cost benefit analysis of sequencing the human genome. Though already completed, it is of interest.
2 posts and 2 images omitted. Click View Thread to read.
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Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:43:16 EST /AXFeCtj No.79112 Reply
1527183796184.png -(272830B / 266.44KB, 724x444) Thumbnail displayed, click image for full size.
>>79111
Here are the three heterozygous DNA variants of the GAA-gene in an individual.
If anyone can explain how this applies to one of the earlier posts, I'd be happy to read that.
>>
press - Thu, 24 May 2018 16:12:49 EST xy/fS2YV No.79124 Reply
after having realized that youve made a post in every top page thread for this board im sceptical, but remain intrigued. mind elaborating on your captions for the images youve posted? especially concerning the second image since to a layyman in genetic stuff such as myself it merely looks like a chart corelating sequencing against cost. yeah, not really suprising that could sink nowadays

i hope this could turn out to be some circada ' esque scenario, but tbh i suspect youre just high as fuck and shitposting.
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:00:30 EST 4Q6JexVr No.79125 Reply
>>79124
The second image is random. The comment is about the first image. Viral carrier capacity inheritance versus viral carrier immunity sounds interesting, not sure how it relates to what was mentioned previously.

A Wizard

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- Sun, 04 Feb 2018 03:00:59 EST 9c592zYY No.78990
File: 1517731259843.gif -(93878B / 91.68KB, 576x747) Thumbnail displayed, click image for full size. A Wizard
Sup.

Oldfag /chem/ist here.

I just wanted to let you all know that I've found A Wizard. He is alive and well in a crypto discord.

He's also working on a supersoldier serum.

Good day all.
8 posts and 1 images omitted. Click View Thread to read.
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A_Wizard !cMZsY.BCnU!!vVWR8L52 - Fri, 09 Mar 2018 03:24:00 EST H2dReURr No.79009 Reply
>>79007
Since when is spartacus a wizard? Does he even have the syrup?
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:56:20 EST pMrrl6aC No.79121 Reply
>>78990
>supersoldier
Not my fault, not my department.

I like to post pictures of interesting molecules

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- Tue, 14 Nov 2017 23:00:42 EST k6ZWDP32 No.78906
File: 1510718442981.png -(9001B / 8.79KB, 749x297) Thumbnail displayed, click image for full size. I like to post pictures of interesting molecules
Thread premise stolen from Bluelight. Post molecules you think would make promising drugs. They can be totally novel, or known substances that, for whatever reason (synthetic difficulty, obscurity, poor effects) have never hit the recreational market. Relevant links (literature papers, PiHKAL, trip reports, syntheses, etc.) encouraged.

I’ll start with this one. This molecule is 3-methoxy-4-propoxyamphetamine (“POMA”). It’s active as a mildly psychedelic stimulant and mood elevator. Someone has already synthesized and trialed this compound; you can read the full report here (https://bitnest.netfirms.com/external.php?id=%25087%253B%250B9%2501%2509Czzy%2505)

Not terribly exciting, but interesting all the same. He starts with clove oil (containing eugenol), but an alternative route would be to start with vanillin (much cheaper than clove oil), O-propylate, condense with nitroethane, and reduce.
18 posts and 4 images omitted. Click View Thread to read.
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A_Wizard !cMZsY.BCnU!!vVWR8L52 - Sun, 25 Mar 2018 06:11:01 EST H2dReURr No.79024 Reply
>>78906
Can you add some deso and phenyl to that?
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:54:44 EST pMrrl6aC No.79120 Reply
1527184484841.png -(222471B / 217.26KB, 2027x2417) Thumbnail displayed, click image for full size.
>>78906
This one's kind of interesting. It keeps binding though, I'm not sure where it ends.

Doing more science

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- Sat, 02 Dec 2017 01:40:28 EST vEkGw4n0 No.78931
File: 1512196828433.gif -(767028B / 749.05KB, 400x315) Thumbnail displayed, click image for full size. Doing more science
I want to be a scientist. I want to research and be active and feel like I'm actually getting something done. What sciencey things can I do in my free time that will actually bring me closer to these goals?

I look things up on wikipedia constantly. I regularly check on a site that summarizes recent scientific papers. Isn't there something more that I can be doing while waiting for the GRE to come around that would help me reach my goals?

I work full time in a microbiology lab, but working for a company isn't the same as working for a cause. What science related things do you do? For a living or for enjoyment and fulfillment or just to kill time? What science websites do you look at? What science hobbies do you have?
9 posts and 3 images omitted. Click View Thread to read.
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Ernest Blytheville - Fri, 13 Apr 2018 11:58:01 EST qT5ivdN+ No.79062 Reply
>>79047

That's what techs are for. Scientists are for writing grant proposals and filling out 9001 GLP compliance forms to pH a solution
>>
trypto - Sat, 14 Apr 2018 14:44:08 EST a9li1sY3 No.79063 Reply
>>79040
Honestly, check out twitter. Follow some people in a field you're interested in. They'll post news/articles/trends about it.
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:50:20 EST pMrrl6aC No.79118 Reply
>>78931
Last time I wanted to do science I was accused of producing kerr black holes in the large hadron collider.
This is the most unfortunate joke. I switched to genetics.

Neurotransmitter/drug layers of the brain theory of human evolution publication

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- Sun, 08 Apr 2018 18:11:57 EST hco8bDfO No.79049
File: 1523225517087.jpg -(12168B / 11.88KB, 313x161) Thumbnail displayed, click image for full size. Neurotransmitter/drug layers of the brain theory of human evolution publication
About 8 years ago i read this article or theory or whatever, and it talked about how each substance/neurotransmitter influenced the evolution of human beings aswell as formed a new layer of their brain.

For example, it said that the base layer of the brain correlated with opiates and was like being in the womb and compared it to comfort and the very inner layer of the brain.
Then the next layer was alcohol and GABA saying that it formed the part of our brain that was used for socializing and stuff like that
Then the next layer was for dopamine and amphetamines and stuff like that used for creating and building things.
And it went on from there. I've looked everywhere to find this publication just so i could reread it because it popped into my head. I consider myself a pretty good googler but after hours of searching i couldn't find it for the life of me.

If anyone else remembers this publication, could they point me in the right direction?

Thanks
1 posts omitted. Click View Thread to read.
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Polly Tootcocke - Thu, 19 Apr 2018 15:05:31 EST 8eK2pPPB No.79077 Reply
completely fucking retarded nonsense.
>>
Cyril Tillinggold - Fri, 20 Apr 2018 01:51:54 EST zi8Fqzy7 No.79078 Reply
this shit dumbb nigga

question regarding unusual substitutions

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!57aon8jsJ2 - Fri, 27 Apr 2018 00:28:12 EST 7gSriUk/ No.79094
File: 1524803292499.jpg -(731734B / 714.58KB, 1836x3264) Thumbnail displayed, click image for full size. question regarding unusual substitutions
OK so /chem/ i purchased some drugs online but instead they sent me 98% para-hydroxy-cinnamic acid. what id like to know is can i use this despite only being 98% could i use this in the same way as people use acetic anhydride to add acetyl groups to open hydroxy positions specifically in opis at the 3,6,or 14 hydroxy positions? if not is it useful for really anything?

pic related the 25 grams of para-hydroxy-cinnamic acid
1 posts omitted. Click View Thread to read.
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bress - Sat, 12 May 2018 05:21:32 EST l33iXC6t No.79104 Reply
>>79101
wouldnt the carboxyl chloride then attack the phenolic functionality on the HO-cinnamic acid?
i reckon extremely low concentrations of the acylation agent compared to the substrate eg morphinnnnee would reduce the ammount of polymerizedd bullshit.
>>
Bombastus Werrywag - Mon, 14 May 2018 00:18:56 EST +BoDDLT6 No.79105 Reply
>>79104
excuse high and drunk facilitated retardation because i didn't read "para hydroxy" for some weird reason. just protect it using a benzoyl group or some sort of ether.

How much life can you create with ten bullets?

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- Mon, 14 May 2018 02:08:41 EST PQH37avw No.79106
File: 1526278121944.jpg -(48387B / 47.25KB, 324x499) Thumbnail displayed, click image for full size. How much life can you create with ten bullets?
https://www.newgrounds.com/portal/view/710921

I just realised this maddening little game is a pretty good model for the kind of self-perpetuating chemical reactions that Fritjof Capra put forward as being the origins of life in The Web Of Life...
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:03:31 EST 4Q6JexVr No.79128 Reply
>>79106
None. Unless you count natural processes governing decay.

Drug neurochemistry documentaries

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- Tue, 16 Jan 2018 19:23:36 EST 7ZJCs00x No.78974
File: 1516148616630.jpg -(155468B / 151.82KB, 599x954) Thumbnail displayed, click image for full size. Drug neurochemistry documentaries
Does anyone know of any good documentaries about how different drugs effect the brain? Not scare factor "durgs r bad", I'm looking for something about the chemical reactions in an unbiased setting. Something that gets deep into, from ingestion to end of effect, how it metabolises, stores in the body, what endorphins and neurotransmitters things release and what effect that has.

It's a shot in the dark, but drug neurochemistry is an odd hobby/interest of mine and I figure this might be one of the most niche forums that I could ask.
2 posts and 2 images omitted. Click View Thread to read.
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Basil Goodbury - Tue, 06 Mar 2018 00:23:27 EST fVK4vDOO No.79005 Reply
If you want peer reviewed scientific information, then refer to the literature.

Start with some basic reviews of current neurochemistry and pharmacodynamics. These are targeted at interpreting the current state of the field.

Go Real

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- Thu, 08 Feb 2018 10:02:50 EST k7AMcD44 No.78992
File: 1518102170395.jpg -(1437987B / 1.37MB, 3264x2448) Thumbnail displayed, click image for full size. Go Real
How feasible is molecular crafting? More specifically, can we negate global warming by vacuuming up greenhouse gasses and replacing them with nitrogen/oxygen, whatever would be needed to maintain current climate conditions?
11 posts and 2 images omitted. Click View Thread to read.
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A_Wizard !cMZsY.BCnU!!vVWR8L52 - Fri, 06 Apr 2018 04:00:44 EST H2dReURr No.79042 Reply
1523001644099.png -(84074B / 82.10KB, 606x603) Thumbnail displayed, click image for full size.
>>78992
Fuck it, here's a hint. Race ya to the patent.
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:06:30 EST 4Q6JexVr No.79130 Reply
>>79042
If I patent oxygen producing algae, will you stop telling the patent office joke?

Tasters Choice

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- Thu, 29 Mar 2018 18:06:18 EST p1bUdm0a No.79030
File: 1522361178945.jpg -(39065B / 38.15KB, 380x327) Thumbnail displayed, click image for full size. Tasters Choice
Would this be the expected presentation of a patient who consumed several ounces of sulferic acid?
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Cornelius Siffingbanks - Thu, 29 Mar 2018 23:52:08 EST +0GOZxpM No.79031 Reply
pretty sure that's just a guy who huffed spray paint

GBL synth

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- Fri, 09 Mar 2018 12:47:56 EST UXNYhWzG No.79011
File: 1520617676505.jpg -(18221B / 17.79KB, 474x192) Thumbnail displayed, click image for full size. GBL synth
Everytime. Every fucking time I try and synthesize GBL using the Sandmeyer reaction, the temperature skyrockets up to 40c and a bunch of foam forms atop the post reaction mix. I've used many different brands of HCl, GABA, and Sodium Nitrite. I've even begun to use a mini freezer to perform the reaction. And yet everytime the temperature goes up to 40 - 50 degrees Celsius. What in the hell am I doing wrong? I am following all of the instructions, but it's impossible to keep the reaction below 2 degrees C, and to stop the foam from developing, even with a goddamn mini freezer. The rate at which I add the HCl does not seem to matter. The amount of stirring doesn't seem to make a difference either. Could anybody help a complete amateur out?
2 posts omitted. Click View Thread to read.
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press !//CEObOMBY - Thu, 15 Mar 2018 03:28:47 EST OJvL+al/ No.79017 Reply
what scale are you running it on?
got any notes?
>>
Q !57aon8jsJ2 - Fri, 27 Apr 2018 00:13:55 EST 7gSriUk/ No.79093 Reply
>>79011
heres an idea. instead of using that reaction why not do an easier synth? i just found a gbl synth thats one step and two ingredients.

Go buy some THF (tetrahydrofuran) a pretty common solvent. then use a strong oxidizer like what i read says to use aqueous sodium bromate but idk if theres anything actual special about that oxidizer or if pretty much any equally strong oxidizer would work. the THF then forms GBL in a one step one pot reaction.
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:09:22 EST 4Q6JexVr No.79131 Reply
>>79011
I prefer ethyl-alcohol, 40 proof.
Oh no, you're infrastructure is collapse.
I mean seriously, this is ridiculous.

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