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Sandwich


Harm Reduction Notes for the COVID-19 Pandemic

test kits for common adulterants

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- Tue, 17 Jul 2018 08:59:13 EST FIrMW5oZ No.79182
File: 1531832353252.jpg -(62355B / 60.89KB, 670x605) Thumbnail displayed, click image for full size. test kits for common adulterants
if i wanted to start a small business where i test people's drugs for fent/pcp/meth/clam or whatever, what sort of reagents would i need to buy? I realize this is sort of an open ended question, i'm just sort of looking for general suggestions for pretty much any drug testing reagent that tests for something. there's pretty much nowhere that you can safely get your drugs tested around where i live & i really want to do what i can to help. i feel like i could save some lives with this.

especially looking for something that can detect if my jenk's been cut with dog pills
>>
pr - Thu, 19 Jul 2018 02:27:18 EST N1w1NO9M No.79185 Reply
are you sure its legal in your country to have a ton of people sending you what in fact are free drugs?

dunno, buncha tlc plates, solvents out the ass, colour reagents or their components- whichever is cheaper- a fridge

and if youre into endgame shit a GC/MS setup
>>
Caroline Dullygold - Thu, 19 Jul 2018 11:27:47 EST FIrMW5oZ No.79186 Reply
>>79185
i don't know how above board this business will be, but i'm in a pretty lenient part of america drug wise so i doubt i'd get in much trouble for people sending me small samples for chemical analysis. also is there any reagent/combination of reagents i can use to test for different benzodiazepines? from my initial googling it doesn't seem very easy but i would really like to be able to tell people if their xans were cut with clam or flam etc

Shake n Bake Meth

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- Fri, 15 Jun 2018 05:48:12 EST 3YadM9Z3 No.79147
File: 1529056092937.jpg -(15382B / 15.02KB, 604x438) Thumbnail displayed, click image for full size. Shake n Bake Meth
Is it really all that dangerous? Is there always a chance that something will go wrong even if you do everything completely right?
>>
Priscilla Dunnerfoot - Fri, 22 Jun 2018 20:38:19 EST UJwtgXMh No.79149 Reply
It's inherently dangerous. The danger is manageable although if you have the discipline and means to do that you're probably just not going to do a fucking shake and bake.
>>
Graham Greenford - Sat, 14 Jul 2018 00:18:01 EST WtJpoXSk No.79173 Reply
Meth is just really bad energy in general, bro.

Maybe get into plain amphetamine synth for fun if you really want a stimulant

General method for determing max/min within a range?

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- Thu, 28 Jun 2018 07:51:21 EST rGLueGvy No.79150
File: 1530186681836.jpg -(16201B / 15.82KB, 500x500) Thumbnail displayed, click image for full size. General method for determing max/min within a range?
Does anyone please know of a general way to determine if there's any local max and min *within a set range of X-coordinates*?

As we can see, there's a local max somwhere around -1 and a local min somwhere around 3 and none whatsoever in the range 1-2.

But how do I prove that there's no local max nor min in that range?
7 posts omitted. Click View Thread to read.
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bress - Fri, 13 Jul 2018 13:01:59 EST DbJ7MA1o No.79171 Reply
1531501319502.jpg -(129931B / 126.89KB, 800x449) Thumbnail displayed, click image for full size.
>>79164
the fact that youve posted that is further evidence of the genius of the idea to establish a /shill board. naw just kidding.

concerning the analytic component of the question, im kinda ashamed it took me this long to think of, you could take the derivative via product rule (not sure if another approach would deliver something more moldable) and then reason examine the zero points of the derivative and second derivative.

im a bit confused as to what the actual function is, should it - as mentioned before - be y= sin(x) sin(1/10), the derivative itself will be a sum of two periodic products, meaning youd have to evaluate cases where either both terms are zero or one term is the negative of the other. depending on the range the answer should be given in multiples of some fraction of pi (kirt, tex support when)

during my analytics classes giving a numeric answer was a telltale sign of misunderstanding the task

And should your task be to prove that the function has a local min/max on a given closed range you could simply show that the function is continous (as a composition of continous functions) and then a local min/max has to exist.

fighting BIG H

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- Thu, 12 Jul 2018 14:51:38 EST N1w1NO9M No.79167
File: 1531421498528.jpg -(150268B / 146.75KB, 720x720) Thumbnail displayed, click image for full size. fighting BIG H
is kirts novel way of marking big h somehow connected to the fact that i get 502 everytime i try to use my vpn on here?
because that'd kind of suck, aubrey.

IRREVERSIBLE OPOID AGONISTS - Hydrazine and azine opiate derivatives

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- Fri, 06 Jul 2018 03:58:39 EST pv6fN59z No.79161
File: 1530863919876.png -(5901B / 5.76KB, 220x159) Thumbnail displayed, click image for full size. IRREVERSIBLE OPOID AGONISTS - Hydrazine and azine opiate derivatives
Hey guys.

So recently I've been interested in irreversible opiates.

A couple decades ago some scientists were able to do this by adding a hydrazine at the 6 ketone of oxymorphone, as well as at naltrexone/naloxone, making oxymorphazone and the corresponding nalts.

When tested, these hydrazines lasted extremely long, and blocked any further effect of opiates in animals. As well, radioactive versions of the drugs cold simply not be washed away from tissue expressing opiate receptors. Meaning these drugs were staying bound to the receptor.

Originally it was thought that oxymorphazone itself was doing the irreversible binding, but it was later determined that the oxymorphazone was joining up with itself spontaneously in solution, creating a dimer of sorts, oxymorphazine.

https://en.wikipedia.org/wiki/Oxymorphazone

There's no wiki on Oxymorphazine, but here's something similar: https://en.wikipedia.org/wiki/Oxymorphone-3-methoxynaltrexonazine

It's just two oxymorphones joined by a hydrazine at the 6 position of each.

It was found that the hydrazine derivatives would spontaneously form the azine in solution, especially if it was acidic. The azines were the real irreversible agonists.

Here's a paper on it: https://pdfs.semanticscholar.org/c972/1dfeb562532929fdc9f05ad924e4276f2777.pdf

And apparently, fentanyl hydrazines can be made as well, as well as fentanyl thiocyanate (IIRC).

This has a lot of potential. The hydrazine derivatives bind once and are then bound until the receptor itself is destroyed in the lysosomes. This means it's continually agonizing for the receptors life span, and receptors generally last around 2 days, which is how long the azine derivatives last, two whole days. The agonism cannot be blocked by anything.

As well, the synthesis is exceedingly simple, hydrazine and acidic condition.

So I have two thoughts on this.

Firstly, I could see a very easy synthesis using morphine (either derived from codeine or from heroin that's been hydrolyzed in basic water), using palladium to isomerize it into hydromorphone (does raney nickel work for that too?), and then using hydrazine and acidic conditions to yield hydromorphazone, and then turn that all into hydromorphazine. This would have the incredible potency of hydromorphone (6.6x stronger than heroin), while having a duration of 48 hours, vs hydromorphones duration of 4 hours.
Comment too long. Click here to view the full text.

Anyone ever entered CR?

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- Fri, 06 Apr 2018 15:17:25 EST r6VnKCY3 No.79045
File: 1523042245920.jpg -(62178B / 60.72KB, 487x630) Thumbnail displayed, click image for full size. Anyone ever entered CR?
Posted on /med/

I think i need some advice

Long story short, I recently entered into clinical research from a
nom-science discipline.

I feel like I could be doing more to ensure future success, I'm networking and working my ass off, but I don't want to fall behind on my personal med knowledge. Really want to gain a better understanding of the admistrative and operational aspects of research and pm.

Anyone have any suggestuons for literature, best practices, tools, etc? Whats a good aim for expanded education? Anyone transferred into a health science field from a different profession?
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:52:03 EST pMrrl6aC No.79119 Reply
>>79045
Just don't come around /chem/ too often, unless /med/ is full of LVN's and you have an actual question about hard science.
>>
Jenny Pemmletine - Thu, 31 May 2018 20:43:02 EST FgLbz8nX No.79139 Reply
how'd a nitwit like you get a job in clinical research?

A Wizard

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- Wed, 14 Feb 2018 05:59:47 EST TFS5PxhL No.78997
File: 1518605987304.jpg -(155502B / 151.86KB, 900x609) Thumbnail displayed, click image for full size. A Wizard
I have to find the wizard guy. Where do I find him? I need his help on something.
2 posts omitted. Click View Thread to read.
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:01:24 EST 4Q6JexVr No.79126 Reply
>>79123
If you'd like to schedule an interview I'm available right now, in this thread.
No photographs.
>>
Katsuragi !/pe1aKvMmQ - Fri, 25 May 2018 16:38:14 EST /AXFeCtj No.79138 Reply
1527280694141.jpg -(95699B / 93.46KB, 1024x683) Thumbnail displayed, click image for full size.
>>79137
It's okay, I'm currently ingesting 600ml of diacetylmorphine and drinking 40 proof ethanol. Problem solved mr. president.

Genetics

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!hZYzX5/C3s - Thu, 24 May 2018 13:38:20 EST /AXFeCtj No.79109
File: 1527183500129.jpg -(169838B / 165.86KB, 754x392) Thumbnail displayed, click image for full size. Genetics
Here we see the cost benefit analysis of sequencing the human genome. Though already completed, it is of interest.
2 posts and 2 images omitted. Click View Thread to read.
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:43:16 EST /AXFeCtj No.79112 Reply
1527183796184.png -(272830B / 266.44KB, 724x444) Thumbnail displayed, click image for full size.
>>79111
Here are the three heterozygous DNA variants of the GAA-gene in an individual.
If anyone can explain how this applies to one of the earlier posts, I'd be happy to read that.
>>
press - Thu, 24 May 2018 16:12:49 EST xy/fS2YV No.79124 Reply
after having realized that youve made a post in every top page thread for this board im sceptical, but remain intrigued. mind elaborating on your captions for the images youve posted? especially concerning the second image since to a layyman in genetic stuff such as myself it merely looks like a chart corelating sequencing against cost. yeah, not really suprising that could sink nowadays

i hope this could turn out to be some circada ' esque scenario, but tbh i suspect youre just high as fuck and shitposting.
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:00:30 EST 4Q6JexVr No.79125 Reply
>>79124
The second image is random. The comment is about the first image. Viral carrier capacity inheritance versus viral carrier immunity sounds interesting, not sure how it relates to what was mentioned previously.

A Wizard

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- Sun, 04 Feb 2018 03:00:59 EST 9c592zYY No.78990
File: 1517731259843.gif -(93878B / 91.68KB, 576x747) Thumbnail displayed, click image for full size. A Wizard
Sup.

Oldfag /chem/ist here.

I just wanted to let you all know that I've found A Wizard. He is alive and well in a crypto discord.

He's also working on a supersoldier serum.

Good day all.
8 posts and 1 images omitted. Click View Thread to read.
>>
A_Wizard !cMZsY.BCnU!!vVWR8L52 - Fri, 09 Mar 2018 03:24:00 EST H2dReURr No.79009 Reply
>>79007
Since when is spartacus a wizard? Does he even have the syrup?
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:56:20 EST pMrrl6aC No.79121 Reply
>>78990
>supersoldier
Not my fault, not my department.

I like to post pictures of interesting molecules

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- Tue, 14 Nov 2017 23:00:42 EST k6ZWDP32 No.78906
File: 1510718442981.png -(9001B / 8.79KB, 749x297) Thumbnail displayed, click image for full size. I like to post pictures of interesting molecules
Thread premise stolen from Bluelight. Post molecules you think would make promising drugs. They can be totally novel, or known substances that, for whatever reason (synthetic difficulty, obscurity, poor effects) have never hit the recreational market. Relevant links (literature papers, PiHKAL, trip reports, syntheses, etc.) encouraged.

I’ll start with this one. This molecule is 3-methoxy-4-propoxyamphetamine (“POMA”). It’s active as a mildly psychedelic stimulant and mood elevator. Someone has already synthesized and trialed this compound; you can read the full report here (https://bitnest.netfirms.com/external.php?id=%25087%253B%250B9%2501%2509Czzy%2505)

Not terribly exciting, but interesting all the same. He starts with clove oil (containing eugenol), but an alternative route would be to start with vanillin (much cheaper than clove oil), O-propylate, condense with nitroethane, and reduce.
18 posts and 4 images omitted. Click View Thread to read.
>>
A_Wizard !cMZsY.BCnU!!vVWR8L52 - Sun, 25 Mar 2018 06:11:01 EST H2dReURr No.79024 Reply
>>78906
Can you add some deso and phenyl to that?
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:54:44 EST pMrrl6aC No.79120 Reply
1527184484841.png -(222471B / 217.26KB, 2027x2417) Thumbnail displayed, click image for full size.
>>78906
This one's kind of interesting. It keeps binding though, I'm not sure where it ends.

Doing more science

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- Sat, 02 Dec 2017 01:40:28 EST vEkGw4n0 No.78931
File: 1512196828433.gif -(767028B / 749.05KB, 400x315) Thumbnail displayed, click image for full size. Doing more science
I want to be a scientist. I want to research and be active and feel like I'm actually getting something done. What sciencey things can I do in my free time that will actually bring me closer to these goals?

I look things up on wikipedia constantly. I regularly check on a site that summarizes recent scientific papers. Isn't there something more that I can be doing while waiting for the GRE to come around that would help me reach my goals?

I work full time in a microbiology lab, but working for a company isn't the same as working for a cause. What science related things do you do? For a living or for enjoyment and fulfillment or just to kill time? What science websites do you look at? What science hobbies do you have?
9 posts and 3 images omitted. Click View Thread to read.
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Ernest Blytheville - Fri, 13 Apr 2018 11:58:01 EST qT5ivdN+ No.79062 Reply
>>79047

That's what techs are for. Scientists are for writing grant proposals and filling out 9001 GLP compliance forms to pH a solution
>>
trypto - Sat, 14 Apr 2018 14:44:08 EST a9li1sY3 No.79063 Reply
>>79040
Honestly, check out twitter. Follow some people in a field you're interested in. They'll post news/articles/trends about it.
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:50:20 EST pMrrl6aC No.79118 Reply
>>78931
Last time I wanted to do science I was accused of producing kerr black holes in the large hadron collider.
This is the most unfortunate joke. I switched to genetics.

Neurotransmitter/drug layers of the brain theory of human evolution publication

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- Sun, 08 Apr 2018 18:11:57 EST hco8bDfO No.79049
File: 1523225517087.jpg -(12168B / 11.88KB, 313x161) Thumbnail displayed, click image for full size. Neurotransmitter/drug layers of the brain theory of human evolution publication
About 8 years ago i read this article or theory or whatever, and it talked about how each substance/neurotransmitter influenced the evolution of human beings aswell as formed a new layer of their brain.

For example, it said that the base layer of the brain correlated with opiates and was like being in the womb and compared it to comfort and the very inner layer of the brain.
Then the next layer was alcohol and GABA saying that it formed the part of our brain that was used for socializing and stuff like that
Then the next layer was for dopamine and amphetamines and stuff like that used for creating and building things.
And it went on from there. I've looked everywhere to find this publication just so i could reread it because it popped into my head. I consider myself a pretty good googler but after hours of searching i couldn't find it for the life of me.

If anyone else remembers this publication, could they point me in the right direction?

Thanks
1 posts omitted. Click View Thread to read.
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Polly Tootcocke - Thu, 19 Apr 2018 15:05:31 EST 8eK2pPPB No.79077 Reply
completely fucking retarded nonsense.
>>
Cyril Tillinggold - Fri, 20 Apr 2018 01:51:54 EST zi8Fqzy7 No.79078 Reply
this shit dumbb nigga

question regarding unusual substitutions

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!57aon8jsJ2 - Fri, 27 Apr 2018 00:28:12 EST 7gSriUk/ No.79094
File: 1524803292499.jpg -(731734B / 714.58KB, 1836x3264) Thumbnail displayed, click image for full size. question regarding unusual substitutions
OK so /chem/ i purchased some drugs online but instead they sent me 98% para-hydroxy-cinnamic acid. what id like to know is can i use this despite only being 98% could i use this in the same way as people use acetic anhydride to add acetyl groups to open hydroxy positions specifically in opis at the 3,6,or 14 hydroxy positions? if not is it useful for really anything?

pic related the 25 grams of para-hydroxy-cinnamic acid
1 posts omitted. Click View Thread to read.
>>
bress - Sat, 12 May 2018 05:21:32 EST l33iXC6t No.79104 Reply
>>79101
wouldnt the carboxyl chloride then attack the phenolic functionality on the HO-cinnamic acid?
i reckon extremely low concentrations of the acylation agent compared to the substrate eg morphinnnnee would reduce the ammount of polymerizedd bullshit.
>>
Bombastus Werrywag - Mon, 14 May 2018 00:18:56 EST +BoDDLT6 No.79105 Reply
>>79104
excuse high and drunk facilitated retardation because i didn't read "para hydroxy" for some weird reason. just protect it using a benzoyl group or some sort of ether.

How much life can you create with ten bullets?

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- Mon, 14 May 2018 02:08:41 EST PQH37avw No.79106
File: 1526278121944.jpg -(48387B / 47.25KB, 324x499) Thumbnail displayed, click image for full size. How much life can you create with ten bullets?
https://www.newgrounds.com/portal/view/710921

I just realised this maddening little game is a pretty good model for the kind of self-perpetuating chemical reactions that Fritjof Capra put forward as being the origins of life in The Web Of Life...
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:03:31 EST 4Q6JexVr No.79128 Reply
>>79106
None. Unless you count natural processes governing decay.

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