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Anhydrous Ethanol/Methanol

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- Fri, 18 Nov 2016 13:57:09 EST zsw9I8fO No.78350
File: 1479495429306.jpg -(49430B / 48.27KB, 398x389) Thumbnail displayed, click image for full size. Anhydrous Ethanol/Methanol
How do I go about using something like this (pic) to make anhydrous ethanol or methanol?
9 posts and 1 images omitted. Click View Thread to read.
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Henry Cramblehall - Tue, 12 Sep 2017 18:55:54 EST M7FrGPbw No.78846 Reply
>>78845
its a pretty useful post dont ya think. plus this board is slow enuff
>>
Betsy Nugglesud - Fri, 06 Oct 2017 15:54:21 EST UoTssc8h No.78878 Reply
>>78381
magnesium sulfate won't take it all the way to 200 proof but it will get you slightly past azeotropic ethanol.

Sieves are easy to use; you don't even need to distill anything, and they can be regenerated by simply putting them in a pyrex flask (or improvised equivalent) and heating with a torch while shaking them up until no more condensation appears at the mouth of the container. They will absorb a little water while cooling but it's not much of a problem unless the humidity is super high or you need ABSOLUTELY dry ethanol. If in doubt stick a coffee filter filled with another drying agent (like mag sulf.) in the opening while it cools, so any air entering is relatively dry. Either way, the sieves will still make ethanol way drier than using MgSO4. They do take a while to work, but all you have to do is dry them out, dump them in, let it sit a few days, then filter off the sieves.

Opium Column Chromatography

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- Tue, 11 Jul 2017 21:56:30 EST QGxEeR56 No.78746
File: 1499824590034.png -(267959B / 261.68KB, 504x380) Thumbnail displayed, click image for full size. Opium Column Chromatography
Without calcium chelation, this is the best way to achieve pure morphine from a layer of puddy or otherwise concentrated poppy residue.

A mixture of 9:1:1 DCM Methanol Diethylamine will produce an elution of reticuline impurities at 0.7-0.9, codeine at 0.45, and morphine at 0.2. Other opium oils either elute at 1 and heavier, coloured oils will not elute at all (or under 0.02).

Running this column simulation once gave me morphine as light brown needles which drew in moisture and became wet after 3 hours. The second time, morphine did not completely come through as shown on TLC short wave UV light as what I expected to be high amounts of meconate salts along with insufficient methanol miscibility. This was solved by adding an additional 1 equivalent of methanol thereby moving the morphine. This gave darker brown crystals which again absorbed water after 3 hours. Full morphine elution towards 100% in a gradient column gave 2% of brown oils. This potentially allows a column to remove codeine and oils and a methanol flush to remove the morphine with a 5-10% heavy oil contamination.

Will update this thread with more conclusions and projections.
15 posts and 3 images omitted. Click View Thread to read.
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Aureolus Werrywag - Thu, 07 Sep 2017 00:47:08 EST HizIkIMY No.78839 Reply
>>78837
droopbox it up fam

>>78838
there's some paper here that requires something i can't remember
or you can go with hydrobromic acid in acetic acid solution but that's harder to find.
>>
Aureolus Werrywag - Thu, 07 Sep 2017 00:53:36 EST HizIkIMY No.78840 Reply
>>78838
https://www.researchgate.net/publication/239738471_O-Demethylation_of_Opioid_Derivatives_with_Methane_Sulfonic_Acid_Methionine_Application_to_the_Synthesis_of_Naloxone_and_Analogues

Also US patent US5071985
A mixture of 3.15 g (10-2 mole) of oxycodone, 28.3 g (3.10-1 mole) of methanesulfonic acid and 2.2 g (1.5.10-2 mole) of DL-methionine are heated to 40° and stirred at 12 hours.
Precipitate with ammonia to 9, extract with DCM. Chloroform column with a methanol gradient. 72% yield.
>>
Theophrastus Werrywag - Sun, 01 Oct 2017 01:08:19 EST m5AB1YJF No.78874 Reply
Ima just save this here

https://www.google.com/patents/US3137701

https://www.google.com/patents/US3632580

https://www.google.com/patents/US5112975

http://pubs.acs.org/doi/abs/10.1021/jo01215a002?journalCode=joceah

https://www.ncbi.nlm.nih.gov/pubmed/21630508

https://www.ncbi.nlm.nih.gov/pubmed/7511163

https://www.ncbi.nlm.nih.gov/pubmed/21630516

https://www.google.com/patents/EP2001891B1?cl=en

http://pubs.acs.org/doi/abs/10.1021/jm8011245

https://www.ncbi.nlm.nih.gov/pubmed/16563682

http://pubs.acs.org/doi/abs/10.1021/jm000119i

https://www.ncbi.nlm.nih.gov/pubmed/25059282

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053365/

http://pubs.acs.org/doi/pdfplus/10.1021/jm030311v
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Psilocetin

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- Fri, 15 Sep 2017 18:22:23 EST yzU9mG3u No.78851
File: 1505514143946.jpg -(9313B / 9.09KB, 320x320) Thumbnail displayed, click image for full size. Psilocetin
How do you properly synthesize 4-aco-dmt
Steps, glassware needed
Proper chemistry explained please
2 posts omitted. Click View Thread to read.
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Thomas Grandbanks - Wed, 20 Sep 2017 17:08:25 EST hBAZGxou No.78859 Reply
this is basically impossible because psilocin is very unstable and so doing ordinary unqualified idiot garage chemistry on psilocin will turn it into useless polymers. if you freeze-dry the mushrooms, grind them up, extract into water under nitrogen, hydrolyse with alkali for a few hours also under nitrogen, extract into chloroform under nitrogen, and treat this with acetic anhydride and pyridine under nitrogen, maybe you have a chance. but you've probably not even considered that the whole rxn has to occur "under nitrogen" or that e.g. reflux in acid as one dumbass said will tear apart that indole like a dog playing with a soccer ball. furthermore it's not even any more potent than what you started with so you're wasting mushrooms. and if you meant to do the synthesis from scratch, you have absolutely no chance so just read the tihkal entry and sob quietly about your inability to acquire 4-hydroxyindole, oxalyl chloride, dimethylamine, or LAH.
>>
Lydia Honeystock - Sat, 30 Sep 2017 06:28:55 EST H2dReURr No.78872 Reply
>>78867
This may sound retarded... but I've been dreaming of a psilocybe gut flora or equivalent. Just imagine it.. whenever you ate too much grain, you'd be tripping balls!

Ketamine

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- Wed, 20 Sep 2017 11:01:09 EST VYddMeH/ No.78854
File: 1505919669220.jpg -(136252B / 133.06KB, 640x639) Thumbnail displayed, click image for full size. Ketamine
Can you use a dehumidifier to dry 0.5-1liter of liquid ketamine or would it suck up some of the ket as well (I know of the other methods)

How do you flavour ket.Do you just simply add in some food flavouring liquid while you are drying it ? How do you workout how much to add into it ?
4 posts and 2 images omitted. Click View Thread to read.
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Archie Blittingmurk - Mon, 25 Sep 2017 17:01:57 EST +YUSEic8 No.78869 Reply
>>78862
if someone had "vanilla K" i'd refuse to buy... unless i was desperate for K for some reason.
>>
Eliza Dozzlehall - Thu, 28 Sep 2017 20:17:54 EST qV/Fy1Bz No.78870 Reply
1506644274627.jpg -(33182B / 32.40KB, 480x528) Thumbnail displayed, click image for full size.
>>78861
I can't even comprehend him writing all of this and thinking it's a good career choice unironically.
>>
Lydia Honeystock - Sat, 30 Sep 2017 06:26:05 EST H2dReURr No.78871 Reply
>>78869
What if it had sassafras extract as flavoring?

A /chem/ thread not about drugs

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- Wed, 20 Sep 2017 11:31:48 EST yU3xLtgU No.78855
File: 1505921508942.jpg -(505047B / 493.21KB, 2304x1728) Thumbnail displayed, click image for full size. A /chem/ thread not about drugs
This is a thread about pool chemistry since it's pertinent and relevant to my daily duties.

What I wanna know is if Sodium Bicarbonate has a pH of about 8 how then is it helping me keep my pH between 7.4-7.8?

Seriously, this is the hardest thing to explain to non chemistry enthusiast coworkers of mine. That and the relationship between Cyanuric Acid and Free Chlorine
4 posts and 1 images omitted. Click View Thread to read.
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Priscilla Summleworth - Fri, 22 Sep 2017 18:43:30 EST hBAZGxou No.78865 Reply
b/c it's dilute silly

didn't you ever have a chemistry set as a kid? dilution is like one of the only things you can even do with them these days

if you add 100 gallons of pH 8 to 1000 gallons of pure water you're gonna get a pH of like 7.2
>>
Phineas Blatherman - Sun, 24 Sep 2017 16:43:22 EST EmAQ3RSJ No.78868 Reply
1506285802300.jpg -(127412B / 124.43KB, 500x375) Thumbnail displayed, click image for full size.
>>78864
My level in chemistry is like 1000 level course in college plus more reading on my own. I understand how cyanuric bonds to the FC to keep it in the pool. I'm fuzzy on the carbonate buffering. pH is wacky in a few places and I'm trying to pin down a cause and also they may have me train employees and I like to know everything and assume others would as well instead of having to dig for the information like me.

Tree growing

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- Sun, 18 Jun 2017 11:26:00 EST ZPX2kpEE No.78694
File: 1497799560552.png -(771440B / 753.36KB, 639x375) Thumbnail displayed, click image for full size. Tree growing
I just read on circlejerk that some trees can reach 100ft to 300ft in a matter of a few years, if this is true why dont we just farm trees instead of cutting down rain forests?

I mean it seems possible, you might have to stick to certain types of wood but still, on top of that you could plant a shit load more trees to help with climate change.

I'm no expert though, just some thoughts.
14 posts omitted. Click View Thread to read.
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Nell Cinkinped - Thu, 07 Sep 2017 14:53:13 EST hBAZGxou No.78842 Reply
bamboo and hemp are both very strong in tension but also very flexible and therefore not very strong in compression. there are different kinds of strength required for different applications

Dutch team thinks liquid metal can help cool nuclear fusion reactor walls

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- Mon, 07 Aug 2017 07:34:27 EST X+zhyYNN No.78770
File: 1502105667272.jpg -(52291B / 51.07KB, 640x480) Thumbnail displayed, click image for full size. Dutch team thinks liquid metal can help cool nuclear fusion reactor walls
My penis is so rock hard right now.

https://www.differ.nl/news/metal-vapour-to-protect-fusion-reactor-walls
8 posts and 1 images omitted. Click View Thread to read.
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press !XIxc6BpKnU - Fri, 01 Sep 2017 15:18:42 EST PJ0/E4z+ No.78814 Reply
>>78812
ill never look you in the eye as i fuck your fat as fat ass ass. i promise balls wont touch.
shitpost quota filled.
>>
Schepperschop - Sun, 03 Sep 2017 18:47:58 EST 81NLKdBS No.78823 Reply
>>78814
You dont know what love is you are a homosexual.

Cones rods

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- Sun, 20 Aug 2017 22:54:37 EST 72cJMkb0 No.78777
File: 1503284077101.jpg -(182636B / 178.36KB, 1328x747) Thumbnail displayed, click image for full size. Cones rods
How many molecules of air can your iris pik up?
Aka. How much in a single dot of air
1 posts omitted. Click View Thread to read.
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Edwin Trotway - Wed, 30 Aug 2017 01:03:57 EST vSFc8qUQ No.78800 Reply
how many photons or something?? or are you talking about field of view. Field of view is pretty blurry lines as far as what is being fully perceived and what is peripheral.
>>
Charles Pockford - Sun, 03 Sep 2017 14:05:40 EST +YUSEic8 No.78819 Reply
>>78778
This is the funniest comment on 420chan right now

genetic diversity

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- Tue, 04 Jul 2017 23:34:57 EST BSeQaa1k No.78720
File: 1499225697763.jpg -(193016B / 188.49KB, 1500x1125) Thumbnail displayed, click image for full size. genetic diversity
How important is genetic diversity?

My mother and father are very far removed, my father being mostly Slavic/Eastern European, and my mother being mainly Celtic. My paternal grandparents are also very distant from each other, my paternal grandmother being Russian/Belarusian, and my paternal grandfather being Ukrainian and Turkish. However, it turns out that my maternal grandparents are third or fourth cousins, so I guess there is some inbreeding there. Realistically, what are the impacts of this?
15 posts and 1 images omitted. Click View Thread to read.
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press !XIxc6BpKnU - Fri, 01 Sep 2017 11:05:51 EST ak42GqP4 No.78811 Reply
1504278351531.png -(1349B / 1.32KB, 153x71) Thumbnail displayed, click image for full size.
DICKS EVERYWHERE

ethanol without methanol

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- Sat, 05 Aug 2017 11:06:50 EST Sj2brtVd No.78760
File: 1501945610321.png -(112884B / 110.24KB, 300x366) Thumbnail displayed, click image for full size. ethanol without methanol
I got some 70% denatured alcohol but now I hear it is deliberately poisoned with methanol to prevent consumption (what kind of asshole would do such a thing is beyond me). Do you know of any way to get a solution of just ethanol, without methanol, from common shops?
3 posts omitted. Click View Thread to read.
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Hedda Saffingchad - Mon, 07 Aug 2017 03:46:53 EST +YUSEic8 No.78768 Reply
>>78762
18% is probably a bit high without the turbo yeasts, the highest % i've managed was 15% with a very good yeast. But you can get up to around 30% with freeze distillation (fractional freezing)
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press !XIxc6BpKnU - Mon, 07 Aug 2017 04:02:05 EST PJ0/E4z+ No.78769 Reply
1502092925674.png -(149512B / 146.01KB, 391x391) Thumbnail displayed, click image for full size.
  1. mix water, yeast nutrients, tomato paste and citric acid
  2. make yeast starter
  3. add yeast to the sugar sludge
  4. build still while waiting for fermentation and settling to complete

or just order non denaturated hooch on the internet
homedistiller.org
>>
Bombastus Werrywag - Mon, 07 Aug 2017 09:04:18 EST RP4l/Dxt No.78771 Reply
>>78762
To my knowledge, methanol doesn't form an azeotrope with ethanol. Anhydrous samples can be distiled and collected that way. If it's 30% methanol, you can just distill out 30ml of a 100ml sample and it should be fine once the temperature reaches 75C

ALIENS!

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- Tue, 13 Jun 2017 06:18:18 EST aZjxDii8 No.78682
File: 1497349098334.jpg -(42883B / 41.88KB, 475x288) Thumbnail displayed, click image for full size. ALIENS!
in businesses there's a book that has a phone number for a place you call in case of extra terrestrials, what's their number?
someone should call them and let them know that you've found an alien who's claiming key word: Jesus Christ!
3 posts omitted. Click View Thread to read.
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Bombastus !uYErosQbLM!!Mybq1UbK - Fri, 23 Jun 2017 13:02:47 EST E1Us5n5n No.78706 Reply
>>78699
POKEMON
POKEMON MASTER
POKEMON ARE THE CHAMPIONS
>>
Bombastus Werrywag - Wed, 28 Jun 2017 02:08:03 EST 0tetFdrb No.78713 Reply
>>78709
y u ruin our perfectly good thread?
>>
John Dartville - Thu, 03 Aug 2017 18:03:31 EST ORz+tP6a No.78759 Reply
Fuck now I want a cig

Science .PDFs

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!!kWjRhGF5 - Thu, 27 Jul 2017 22:42:18 EST GBUzU4oL No.78756
File: 1501209738564.png -(123434B / 120.54KB, 1920x1080) Thumbnail displayed, click image for full size. Science .PDFs
Hi there /chem/, there is a website where you can download a lot - and I mean thousands - of science textbooks (all categories) for free. Most of them are in .pdf files, but there are a number in the .epub, .mobi, and .djvu formats as well. I uploaded a small selection of what I've gotten at Zippyshare, here:

http://www44.zippyshare.com/v/3IAuapuz/file.html

They cover the hard sciences and run at about 135 MB for the .zip file.

The website is here:

http://gen.lib.rus.ec/

and please read their "Letter of Solidarity," here:

http://custodians.online/
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Clara Fuckingcocke - Wed, 02 Aug 2017 02:39:16 EST zi8Fqzy7 No.78758 Reply
thanks m8, will definitely give it a dig

Synthesis of ghb (free acid) from gbl

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- Tue, 18 Jul 2017 22:06:27 EST 1reNg8pO No.78749
File: 1500429987701.jpg -(42696B / 41.70KB, 500x345) Thumbnail displayed, click image for full size. Synthesis of ghb (free acid) from gbl
Hey/chem/
I recently came across some lab grade gbl (gammy-butyrolactone) which is the precursor to GHB. I've got a few questions because I've never find GH and I'm having a hard time finding some info from chemists who know what they're doing.

Firstly, I wanted to make GH in its free acid firm, rather than the common sodium butyrate salt. What I want to know are whether its fine to take it in free acid form. I think the pka is about 4, so it shouldn't be too sour if diluted in water, but taking it in free acid produces the same effects right? I assume that taking the sodium salt would Judy result in it finding in the acidity of the stomach anyways, I just would prefer to not have to eat a bunch of salt on the side.
Also, did I do something wrong in my procedure?

I started with about 10g gbl weighed analytically, and calculated the moles for sodium hydroxide which was between 6-7g, but I put in some excess to try to push the reaction forward.
I then added a bit of water, roughly 20mL in a round bottom flask, added the hydroxide and then the gbl. After a few minutes, I capped the flask and put it in an oil baths at 70 celcius.
After 2-3 hours, I added a bit of hydroxide to make sure the reaction was basic and he GH would be in its salt form, then I washed the solution with ether 3x to get rid of any remaining unreacted gbl. I took the aqueous layer and added HCl from a 1M solution until the pH was about 2-3, low enough for the gh to be in its acid form. I think the problem is here, because I couldn't find concentrated acid so I ended up adding a lot of water on the side..
Then my last step was to extract the ghb from the autos later with ether. I did this about 3x, combined the etherI'm layers, and evaporated off the ether. I was left with 2g when theoretical yield should have been about 12g.

Do you think that because I ended up using so much water, my remaining gh is in the aqueous solution? I know theree acid is readily soluble in both water and ether, so I'm wondering if this is my problem.

Also, how can I test the solution to show I have ghb with no gbl? I don't want to use the NMR spectrometer just in case somebody ends up seeing the spectrum and asking questions
1 posts omitted. Click View Thread to read.
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Lydia Clannerfeck - Thu, 20 Jul 2017 17:47:14 EST UoTssc8h No.78751 Reply
ayy so GBL is a prodrug to GHB. You could just eat the GBL.

Keep extracting the aqueous layer. There's probably more in there. Also try adding some salt (NaCl) to the water to lower the solubility of the GHB in it.

You can tell if there's any GHL in it by taste. GHL supposedly tastes awful whereas GHB is tasteless.
>>
press !XIxc6BpKnU - Sat, 22 Jul 2017 18:28:22 EST PJ0/E4z+ No.78753 Reply
>>78751
ghb has a distinct taste too, it just isnt as fucking horrible as gbl
somewhere between gasoline, coconut and soap
OP have you considered to simply mix the gbl with a sodium carbonate solution to get a ready to use sodium ghb solution.
obviously youd have take in more volume but it always worked for, although getting too much sodium isnt too healthy and the sodium salt gave me just as much diarhea as gbl.
since the sodium salt is hygroscopic anyways youd have to hustle to keep it dry


https://www.erowid.org/archive/rhodium/chemistry/ghb.html
>>
Cyril Sunnertot - Mon, 24 Jul 2017 16:41:05 EST CwYciqLe No.78754 Reply
Thanks for the replies everyone. I found a paper and read that ghb is rarely found in its free acid form as it readily converts back to GBL. This back conversion happens even more easily in acidic conditions, which I used to try to protonate the free acid. I will extract as much of what is most likely gbl now from my aqueous solution using salt to push it to the organic layer, evaporate any ether and water left over and mix the gbl back with a small excess of sodium hydroxide. I'll calculate it so that once all the gbl had reacted with the sodium hydroxide in a 1:1 stoichiometric fashion, that the pH will be about 8.5 at the end in a small precculated volume so the ghb doesn't convert back to gbl

Thin Layer Chromatography

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- Mon, 19 Jun 2017 12:24:25 EST hzoMepax No.78695
File: 1497889465751.png -(861058B / 840.88KB, 726x728) Thumbnail displayed, click image for full size. Thin  Layer Chromatography
gonna make some TLC plates using some glass microscope slides, wondering what the best paper to use for cellulose is? i was thinking using a thin tissue or something but it's incredibly soft and porous which makes me think that i might not get very clearly defined results. any suggestions?
3 posts omitted. Click View Thread to read.
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Cedric Dreffinghall - Tue, 11 Jul 2017 13:49:20 EST 4tmtdVyg No.78737 Reply
>>78735

As far as destruction of the sample, when you choose a solvent for solvating the material, it must do two things:

Dissolve the sample
Be inert to the sample

As an example, sulfuric acid will probably dissolve your sample, but will typically make a poor solvent due to the likelyhood of it protonating the shit out of your sample. A solvent like octane will make a good solvent for non-polar materials because it is straight chain hydrocarbons which are non-reactive under standard conditions. Same concept with acetone, except for polar samples.

Both octane and acetone can become reactive with the right materials under the right conditions, and that's why you need to know what your sample reacts with so you can choose a solvent that will both dissolve the sample and be inert to it.
>>
Bombastus Werrywag - Tue, 11 Jul 2017 17:45:21 EST QGxEeR56 No.78745 Reply
>>78737
You can use pure water if paper is your stationary phase.

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