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Sandwich


Secret unwatched meth precursor cartels are using tha nobody knows about!

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- Thu, 12 Jul 2018 11:36:25 EST AEosv4I7 No.79165
File: 1531409785030.jpg -(26144B / 25.53KB, 630x333) Thumbnail displayed, click image for full size. Secret unwatched meth precursor cartels are using tha nobody knows about!
They use a ketone nobody knows about called "ADDS"

It's not on any list so you can order a million gallons from China easily
1 posts omitted. Click View Thread to read.
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Charlotte Blembleshaw - Thu, 12 Jul 2018 22:09:24 EST IsgjdvUw No.79169 Reply
I'm having a hard time picturing cartels sweating chemical watchlists. Let's say it's true. It would realistically have to come from one source and have one consumer for it to remain a secret and it would be easily traceable in a way that diverted chemicals would not. Also unless it was an in-house operation I don't think there would be much of a price advantage. No, I think you're full of shit.
>>
trypto - Mon, 23 Jul 2018 20:01:21 EST OdR7meD+ No.79188 Reply
If nobody knows about it, then how do you know about it?

little Water CWE

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- Sat, 21 Jul 2018 08:35:39 EST CE1aGD0g No.79187
File: 1532176539983.jpg -(38759B / 37.85KB, 530x530) Thumbnail displayed, click image for full size. little Water CWE
Hi

it's been a milltion years since i've done a CWE and there's one question i have in regards to the amoung of water to be used.

i understand that there is always going to be a little Acetaminophen in the final solution. however, codeine phosphate being as soluble in cold water, or just plain water, as it is i was wondering wether you could skip the whole freezing part of the procedure and instead use a small amount of water. where would potential problems be? i can imagine it would take a really long time as the water would have problems penetrating through the sludge of filter and Paracetamol. but apart from that why could this be a bad idea?

thanks for reading,
love Anon

picture unrelated

test kits for common adulterants

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- Tue, 17 Jul 2018 08:59:13 EST FIrMW5oZ No.79182
File: 1531832353252.jpg -(62355B / 60.89KB, 670x605) Thumbnail displayed, click image for full size. test kits for common adulterants
if i wanted to start a small business where i test people's drugs for fent/pcp/meth/clam or whatever, what sort of reagents would i need to buy? I realize this is sort of an open ended question, i'm just sort of looking for general suggestions for pretty much any drug testing reagent that tests for something. there's pretty much nowhere that you can safely get your drugs tested around where i live & i really want to do what i can to help. i feel like i could save some lives with this.

especially looking for something that can detect if my jenk's been cut with dog pills
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pr - Thu, 19 Jul 2018 02:27:18 EST N1w1NO9M No.79185 Reply
are you sure its legal in your country to have a ton of people sending you what in fact are free drugs?

dunno, buncha tlc plates, solvents out the ass, colour reagents or their components- whichever is cheaper- a fridge

and if youre into endgame shit a GC/MS setup
>>
Caroline Dullygold - Thu, 19 Jul 2018 11:27:47 EST FIrMW5oZ No.79186 Reply
>>79185
i don't know how above board this business will be, but i'm in a pretty lenient part of america drug wise so i doubt i'd get in much trouble for people sending me small samples for chemical analysis. also is there any reagent/combination of reagents i can use to test for different benzodiazepines? from my initial googling it doesn't seem very easy but i would really like to be able to tell people if their xans were cut with clam or flam etc

Shake n Bake Meth

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- Fri, 15 Jun 2018 05:48:12 EST 3YadM9Z3 No.79147
File: 1529056092937.jpg -(15382B / 15.02KB, 604x438) Thumbnail displayed, click image for full size. Shake n Bake Meth
Is it really all that dangerous? Is there always a chance that something will go wrong even if you do everything completely right?
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Priscilla Dunnerfoot - Fri, 22 Jun 2018 20:38:19 EST UJwtgXMh No.79149 Reply
It's inherently dangerous. The danger is manageable although if you have the discipline and means to do that you're probably just not going to do a fucking shake and bake.
>>
Graham Greenford - Sat, 14 Jul 2018 00:18:01 EST WtJpoXSk No.79173 Reply
Meth is just really bad energy in general, bro.

Maybe get into plain amphetamine synth for fun if you really want a stimulant

General method for determing max/min within a range?

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- Thu, 28 Jun 2018 07:51:21 EST rGLueGvy No.79150
File: 1530186681836.jpg -(16201B / 15.82KB, 500x500) Thumbnail displayed, click image for full size. General method for determing max/min within a range?
Does anyone please know of a general way to determine if there's any local max and min *within a set range of X-coordinates*?

As we can see, there's a local max somwhere around -1 and a local min somwhere around 3 and none whatsoever in the range 1-2.

But how do I prove that there's no local max nor min in that range?
7 posts omitted. Click View Thread to read.
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bress - Fri, 13 Jul 2018 13:01:59 EST DbJ7MA1o No.79171 Reply
1531501319502.jpg -(129931B / 126.89KB, 800x449) Thumbnail displayed, click image for full size.
>>79164
the fact that youve posted that is further evidence of the genius of the idea to establish a /shill board. naw just kidding.

concerning the analytic component of the question, im kinda ashamed it took me this long to think of, you could take the derivative via product rule (not sure if another approach would deliver something more moldable) and then reason examine the zero points of the derivative and second derivative.

im a bit confused as to what the actual function is, should it - as mentioned before - be y= sin(x) sin(1/10), the derivative itself will be a sum of two periodic products, meaning youd have to evaluate cases where either both terms are zero or one term is the negative of the other. depending on the range the answer should be given in multiples of some fraction of pi (kirt, tex support when)

during my analytics classes giving a numeric answer was a telltale sign of misunderstanding the task

And should your task be to prove that the function has a local min/max on a given closed range you could simply show that the function is continous (as a composition of continous functions) and then a local min/max has to exist.

fighting BIG H

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- Thu, 12 Jul 2018 14:51:38 EST N1w1NO9M No.79167
File: 1531421498528.jpg -(150268B / 146.75KB, 720x720) Thumbnail displayed, click image for full size. fighting BIG H
is kirts novel way of marking big h somehow connected to the fact that i get 502 everytime i try to use my vpn on here?
because that'd kind of suck, aubrey.

IRREVERSIBLE OPOID AGONISTS - Hydrazine and azine opiate derivatives

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- Fri, 06 Jul 2018 03:58:39 EST pv6fN59z No.79161
File: 1530863919876.png -(5901B / 5.76KB, 220x159) Thumbnail displayed, click image for full size. IRREVERSIBLE OPOID AGONISTS - Hydrazine and azine opiate derivatives
Hey guys.

So recently I've been interested in irreversible opiates.

A couple decades ago some scientists were able to do this by adding a hydrazine at the 6 ketone of oxymorphone, as well as at naltrexone/naloxone, making oxymorphazone and the corresponding nalts.

When tested, these hydrazines lasted extremely long, and blocked any further effect of opiates in animals. As well, radioactive versions of the drugs cold simply not be washed away from tissue expressing opiate receptors. Meaning these drugs were staying bound to the receptor.

Originally it was thought that oxymorphazone itself was doing the irreversible binding, but it was later determined that the oxymorphazone was joining up with itself spontaneously in solution, creating a dimer of sorts, oxymorphazine.

https://en.wikipedia.org/wiki/Oxymorphazone

There's no wiki on Oxymorphazine, but here's something similar: https://en.wikipedia.org/wiki/Oxymorphone-3-methoxynaltrexonazine

It's just two oxymorphones joined by a hydrazine at the 6 position of each.

It was found that the hydrazine derivatives would spontaneously form the azine in solution, especially if it was acidic. The azines were the real irreversible agonists.

Here's a paper on it: https://pdfs.semanticscholar.org/c972/1dfeb562532929fdc9f05ad924e4276f2777.pdf

And apparently, fentanyl hydrazines can be made as well, as well as fentanyl thiocyanate (IIRC).

This has a lot of potential. The hydrazine derivatives bind once and are then bound until the receptor itself is destroyed in the lysosomes. This means it's continually agonizing for the receptors life span, and receptors generally last around 2 days, which is how long the azine derivatives last, two whole days. The agonism cannot be blocked by anything.

As well, the synthesis is exceedingly simple, hydrazine and acidic condition.

So I have two thoughts on this.

Firstly, I could see a very easy synthesis using morphine (either derived from codeine or from heroin that's been hydrolyzed in basic water), using palladium to isomerize it into hydromorphone (does raney nickel work for that too?), and then using hydrazine and acidic conditions to yield hydromorphazone, and then turn that all into hydromorphazine. This would have the incredible potency of hydromorphone (6.6x stronger than heroin), while having a duration of 48 hours, vs hydromorphones duration of 4 hours.

Sadly morphine hydrazine (morphazone/morphazine) cannot be made directly, because morphine has a hydroxy at the 6 position, while it seems necessary to have a carbonyl, because that's what hydrazine is reactive to. If this is not the case please let me know, it'd be a lot easier to just use morphine and attach a hydrazine at the 6 position somehow.

What's also an interesting idea is the injection of a azine derivative into the carotid artery. I know, I know, bare with me. Think about it like this: morphine administered ICV (directly into the brain, basically) is 100x stronger than IV morphine, meaning 1mg ICV is 100mg IV, the potency of IV fentanyl.

Now, DIY trepanning is impossible for us, but we could do something similar by administering the drug into the artery that feeds the brain with blood. Now, the problem with just using morphine via the carotid artery is that within a couple more heartbeats the morphine would be redistributed. But if you used the azine, all the morphazine has to do is bind once, which is easy for 1mg to do, once it's bound it's staying in the brain. Meaning, morphazine or hydromorphazine administered by injection into the carotid artery would be 100x the strength of morphine IV, and would last 48 hours. Isn't that just fucking amazing?

Now about carotid infusion. Carotid injections are done in animals without problems, and I saw an article about carotid infusions for certain patients. So it seems possible. I know it's bad when people inject into the femoral artery, but is that true for all arteries or just the femoral? Would it be possible to use a very needle? As well, the amount of liquid needed to contain all the morphazine/hydromorphazine would be small, a drop or two of water would be more than enough to dissolve the 1-5mg needed to get really really high. So it'd be barely any liquid at all. Possible?

Last thing. What if you made loperazine? Loperamide with a hydrazine at the carbonyl. Do you think that'd be possible, and would it be irreversible? Loperamide seems like it'd bind to the opioid receptor just like fentanyl, but it's held back by the chlorine. If you made it irreversible though, and administered it as mentioned before, you could get enough in the brain once, and that's all you need, all it has to do is bind once and you'd be high. Only downside I can think of, is that because loperamide's central efficacy is controlled primarily by P-glycoprotein, this could lead to major inconsistencies. For instance maybe one day PGP isn't working as well as before but you use the same amount of loperazine, boom too much bound and you can't be revived. This PGP inconsistency could be a problem. That said, loperazine could be a fentanyl like opiate that can be bought OTC.
Comment too long. Click here to view the full text.

Anyone ever entered CR?

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- Fri, 06 Apr 2018 15:17:25 EST r6VnKCY3 No.79045
File: 1523042245920.jpg -(62178B / 60.72KB, 487x630) Thumbnail displayed, click image for full size. Anyone ever entered CR?
Posted on /med/

I think i need some advice

Long story short, I recently entered into clinical research from a
nom-science discipline.

I feel like I could be doing more to ensure future success, I'm networking and working my ass off, but I don't want to fall behind on my personal med knowledge. Really want to gain a better understanding of the admistrative and operational aspects of research and pm.

Anyone have any suggestuons for literature, best practices, tools, etc? Whats a good aim for expanded education? Anyone transferred into a health science field from a different profession?
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:52:03 EST pMrrl6aC No.79119 Reply
>>79045
Just don't come around /chem/ too often, unless /med/ is full of LVN's and you have an actual question about hard science.
>>
Jenny Pemmletine - Thu, 31 May 2018 20:43:02 EST FgLbz8nX No.79139 Reply
how'd a nitwit like you get a job in clinical research?

A Wizard

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- Wed, 14 Feb 2018 05:59:47 EST TFS5PxhL No.78997
File: 1518605987304.jpg -(155502B / 151.86KB, 900x609) Thumbnail displayed, click image for full size. A Wizard
I have to find the wizard guy. Where do I find him? I need his help on something.
2 posts omitted. Click View Thread to read.
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Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:01:24 EST 4Q6JexVr No.79126 Reply
>>79123
If you'd like to schedule an interview I'm available right now, in this thread.
No photographs.
>>
Katsuragi !/pe1aKvMmQ - Fri, 25 May 2018 16:38:14 EST /AXFeCtj No.79138 Reply
1527280694141.jpg -(95699B / 93.46KB, 1024x683) Thumbnail displayed, click image for full size.
>>79137
It's okay, I'm currently ingesting 600ml of diacetylmorphine and drinking 40 proof ethanol. Problem solved mr. president.

Genetics

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!hZYzX5/C3s - Thu, 24 May 2018 13:38:20 EST /AXFeCtj No.79109
File: 1527183500129.jpg -(169838B / 165.86KB, 754x392) Thumbnail displayed, click image for full size. Genetics
Here we see the cost benefit analysis of sequencing the human genome. Though already completed, it is of interest.
2 posts and 2 images omitted. Click View Thread to read.
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Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:43:16 EST /AXFeCtj No.79112 Reply
1527183796184.png -(272830B / 266.44KB, 724x444) Thumbnail displayed, click image for full size.
>>79111
Here are the three heterozygous DNA variants of the GAA-gene in an individual.
If anyone can explain how this applies to one of the earlier posts, I'd be happy to read that.
>>
press - Thu, 24 May 2018 16:12:49 EST xy/fS2YV No.79124 Reply
after having realized that youve made a post in every top page thread for this board im sceptical, but remain intrigued. mind elaborating on your captions for the images youve posted? especially concerning the second image since to a layyman in genetic stuff such as myself it merely looks like a chart corelating sequencing against cost. yeah, not really suprising that could sink nowadays

i hope this could turn out to be some circada ' esque scenario, but tbh i suspect youre just high as fuck and shitposting.
>>
Katsuragi !/pe1aKvMmQ - Thu, 24 May 2018 22:00:30 EST 4Q6JexVr No.79125 Reply
>>79124
The second image is random. The comment is about the first image. Viral carrier capacity inheritance versus viral carrier immunity sounds interesting, not sure how it relates to what was mentioned previously.

A Wizard

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- Sun, 04 Feb 2018 03:00:59 EST 9c592zYY No.78990
File: 1517731259843.gif -(93878B / 91.68KB, 576x747) Thumbnail displayed, click image for full size. A Wizard
Sup.

Oldfag /chem/ist here.

I just wanted to let you all know that I've found A Wizard. He is alive and well in a crypto discord.

He's also working on a supersoldier serum.

Good day all.
8 posts and 1 images omitted. Click View Thread to read.
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A_Wizard !cMZsY.BCnU!!vVWR8L52 - Fri, 09 Mar 2018 03:24:00 EST H2dReURr No.79009 Reply
>>79007
Since when is spartacus a wizard? Does he even have the syrup?
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:56:20 EST pMrrl6aC No.79121 Reply
>>78990
>supersoldier
Not my fault, not my department.

I like to post pictures of interesting molecules

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- Tue, 14 Nov 2017 23:00:42 EST k6ZWDP32 No.78906
File: 1510718442981.png -(9001B / 8.79KB, 749x297) Thumbnail displayed, click image for full size. I like to post pictures of interesting molecules
Thread premise stolen from Bluelight. Post molecules you think would make promising drugs. They can be totally novel, or known substances that, for whatever reason (synthetic difficulty, obscurity, poor effects) have never hit the recreational market. Relevant links (literature papers, PiHKAL, trip reports, syntheses, etc.) encouraged.

I’ll start with this one. This molecule is 3-methoxy-4-propoxyamphetamine (“POMA”). It’s active as a mildly psychedelic stimulant and mood elevator. Someone has already synthesized and trialed this compound; you can read the full report here (https://bitnest.netfirms.com/external.php?id=%25087%253B%250B9%2501%2509Czzy%2505)

Not terribly exciting, but interesting all the same. He starts with clove oil (containing eugenol), but an alternative route would be to start with vanillin (much cheaper than clove oil), O-propylate, condense with nitroethane, and reduce.
18 posts and 4 images omitted. Click View Thread to read.
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A_Wizard !cMZsY.BCnU!!vVWR8L52 - Sun, 25 Mar 2018 06:11:01 EST H2dReURr No.79024 Reply
>>78906
Can you add some deso and phenyl to that?
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:54:44 EST pMrrl6aC No.79120 Reply
1527184484841.png -(222471B / 217.26KB, 2027x2417) Thumbnail displayed, click image for full size.
>>78906
This one's kind of interesting. It keeps binding though, I'm not sure where it ends.

Doing more science

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- Sat, 02 Dec 2017 01:40:28 EST vEkGw4n0 No.78931
File: 1512196828433.gif -(767028B / 749.05KB, 400x315) Thumbnail displayed, click image for full size. Doing more science
I want to be a scientist. I want to research and be active and feel like I'm actually getting something done. What sciencey things can I do in my free time that will actually bring me closer to these goals?

I look things up on wikipedia constantly. I regularly check on a site that summarizes recent scientific papers. Isn't there something more that I can be doing while waiting for the GRE to come around that would help me reach my goals?

I work full time in a microbiology lab, but working for a company isn't the same as working for a cause. What science related things do you do? For a living or for enjoyment and fulfillment or just to kill time? What science websites do you look at? What science hobbies do you have?
9 posts and 3 images omitted. Click View Thread to read.
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Ernest Blytheville - Fri, 13 Apr 2018 11:58:01 EST qT5ivdN+ No.79062 Reply
>>79047

That's what techs are for. Scientists are for writing grant proposals and filling out 9001 GLP compliance forms to pH a solution
>>
trypto - Sat, 14 Apr 2018 14:44:08 EST a9li1sY3 No.79063 Reply
>>79040
Honestly, check out twitter. Follow some people in a field you're interested in. They'll post news/articles/trends about it.
>>
Katsuragi !hZYzX5/C3s - Thu, 24 May 2018 13:50:20 EST pMrrl6aC No.79118 Reply
>>78931
Last time I wanted to do science I was accused of producing kerr black holes in the large hadron collider.
This is the most unfortunate joke. I switched to genetics.

Neurotransmitter/drug layers of the brain theory of human evolution publication

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- Sun, 08 Apr 2018 18:11:57 EST hco8bDfO No.79049
File: 1523225517087.jpg -(12168B / 11.88KB, 313x161) Thumbnail displayed, click image for full size. Neurotransmitter/drug layers of the brain theory of human evolution publication
About 8 years ago i read this article or theory or whatever, and it talked about how each substance/neurotransmitter influenced the evolution of human beings aswell as formed a new layer of their brain.

For example, it said that the base layer of the brain correlated with opiates and was like being in the womb and compared it to comfort and the very inner layer of the brain.
Then the next layer was alcohol and GABA saying that it formed the part of our brain that was used for socializing and stuff like that
Then the next layer was for dopamine and amphetamines and stuff like that used for creating and building things.
And it went on from there. I've looked everywhere to find this publication just so i could reread it because it popped into my head. I consider myself a pretty good googler but after hours of searching i couldn't find it for the life of me.

If anyone else remembers this publication, could they point me in the right direction?

Thanks
1 posts omitted. Click View Thread to read.
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Polly Tootcocke - Thu, 19 Apr 2018 15:05:31 EST 8eK2pPPB No.79077 Reply
completely fucking retarded nonsense.
>>
Cyril Tillinggold - Fri, 20 Apr 2018 01:51:54 EST zi8Fqzy7 No.79078 Reply
this shit dumbb nigga

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