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Hydroxyl Free Radicals

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- Thu, 25 May 2017 14:43:57 EST +41/TUGa No.78663
File: 1495737837795.jpg -(549713B / 536.83KB, 1000x750) Thumbnail displayed, click image for full size. Hydroxyl Free Radicals
I'm currently using kratom to isolate its alkaloids via oxidation > extraction and am starting to get concerned of possible byproducts of my reaction. I am not using lab grade glassware for the first steps involving oxidation with H2O2.

My main concern, is it possible for free radicals to form and possible trace amounts of metals in my final product. I'm basically soaking the kratom in H2O2 and agitating on low heat with small amounts of citric acid added, then that is continued until the material is almost completely dry where I'm assuming the leftover liquid is water since the H2O2 oxidizes the mitragynine and 7-OHM into mitragynine pseudoindoxyl. Can anyone experienced in organic chemistry help me out with this?

We only use cold water for the extraction of the oxidized kratom material so that isn't much of a concern as much as using metal pots and pans during the actual oxidation process. Should I be concerned of consuming free radicals once fully evaporated? Are there any possible byproducts that can form from doing this?

Thanks a ton and excuse my ignorance in chemistry, I don't know shit besides what I learned in highschool and my current research onto this topic.

The pic attached is the final product after filtration of the initial oxidized material through cold water into 5 then 1 micron filters then finally evaporated at low heat.
1 posts omitted. Click View Thread to read.
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Hunter S. Nodson - Tue, 30 May 2017 01:32:25 EST 5wCuF3rA No.78670 Reply
>>78669
there are articles on it, it is documented my man. It takes a few minutes of google and there is plenty on the oxidation of 7-ohm into mitragynine psuedoindoxyl. I'll post it tomorrow when I get a chance though.

thanks for that reassurance, like I said I'm ignorant to this in all aspects and this is a learning experience for me so bare with me. We did though, I got the pH down to 4. As far as the difference between just soaking in water, we've tested it. It does not come out like this at all. The peroxide makes a giant difference. I do understand h2o2 wont oxidize much until the pH is lowered a decent amount.
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Graham Chunkinham - Thu, 01 Jun 2017 18:15:12 EST UoTssc8h No.78672 Reply
I still highly recommend acid base extraction so you can work with pure reactants rather than trying to oxidize the raw leaves. You have no idea how much oxidant to add because there are thousands of different compounds in the mix all with different oxidation potentials.

Also the paper you posted is an overview of a semisynthesis of mitragynine pseudoindoxyl from something other than mitragynine. I still can't find anything on chemically converting one to the other. Everything i've found so far involves bacterial or fungal metabolism to affect the rearrangement. The way I see it, it is very unlikely that you will be able to produce a sizable amount of pseudoindoxyl with household oxidants. I am kind of curious about this now though so I am still searching.

Stoichiometry a bitch

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- Fri, 26 May 2017 04:22:42 EST WkWxSK6I No.78664
File: 1495786962793.jpg -(4130979B / 3.94MB, 5312x2988) Thumbnail displayed, click image for full size. Stoichiometry a bitch
Could someone please jog the old memory bank. How in the fuck do you get 1.8×10^(-6) from 2.8x10^(-8) mol × 63.5g mol-1???
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Caroline Drennerwell - Fri, 26 May 2017 13:09:34 EST UyoEcrVg No.78665 Reply
2.8 times 63.5 is 177.8
Move the decimal over a couple places and you get 10^-6 instead of -8
It's rounded to 1.8 because of significant figures.

i'll just leave this here

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- Mon, 27 Mar 2017 03:58:41 EST 6p22FvVe No.78612
File: 1490601521191.png -(43318B / 42.30KB, 414x524) Thumbnail displayed, click image for full size. i'll just leave this here
cf piperine, phenylacetic acid, etc.
7 posts omitted. Click View Thread to read.
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Charlotte Hurringchare - Tue, 25 Apr 2017 18:52:15 EST UoTssc8h No.78643 Reply
What about forming the diol with peroxide and base then cleavage with nickel?

This paper shows 1,2-cyclohexanediol can be cleaved to adipic acid just by dumping it in with some bleach and nickel nitrate/acetate: http://pubs.acs.org/doi/abs/10.1021/jo0612574. Theoretically this should yield the aldehyde if the nickel oxidant were instead isolated and the reaction done under anhydrous conditions.
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Martin Dicklecocke - Sun, 14 May 2017 10:17:15 EST UoTssc8h No.78651 Reply
Has anyone tried the dithionite reduction of piperinic acid? The source OP cited only has info on reducing acids with aliphatic side chains and I'm thinking that conjugation with the aromatic ring might cause the beta-gamma unsaturated acid to re-arrange to the gamma-delta or otherwise muck something up

unexplored waters

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- Sat, 22 Apr 2017 17:42:58 EST UoTssc8h No.78641
File: 1492897378795.png -(23977B / 23.42KB, 567x417) Thumbnail displayed, click image for full size. unexplored waters
Pretty much any phenol without other more lablie reactive sites can be converted to an allylbenzene (like safrole) via condensation with allyl halide and subsequent aromatic Claisen rearrangement of the allyl phenol ether. From there it's known chemistry to get to an amphetamine derivative. pic related is delta-tocopherol, a form of vitamin E, and it's resulting amphetmaine derivative, which is strikingly similar to the 2C-x's and DOx's. There are literally thousands of easily obtainable phenol-derivatives out there with possibly psychoactive derivative amphetamines. Why has there not been more exploration into this chemical space?

Which Major Least hard

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- Sat, 04 Mar 2017 01:53:55 EST LObRvGV/ No.78585
File: 1488610435460.jpg -(170885B / 166.88KB, 670x901) Thumbnail displayed, click image for full size. Which Major Least hard
Which major requires less chemistry? Because to me, chem always seemed like an endless list of things to memorize: polyatomic ions, acids, bases, electron charges, drawing Lewis-dot diagrams, etc ad nauseum...

  • Neuroscience
  • Pharmacology
  • what else?
5 posts and 1 images omitted. Click View Thread to read.
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Fucking Lightham - Wed, 12 Apr 2017 00:30:04 EST roSXguau No.78634 Reply
chem is fun in the lab, did neurosci major because the psych courses were easy, now getting over more into computer science. study what you like tho, you'll have plenty to memorize anyway.
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Esther Drandlegold - Sat, 15 Apr 2017 13:01:09 EST q+gC2Vuv No.78636 Reply
Neuroscience probably has less chemistry but both of those majors are pretty heavy memorization. You will have to memorize drug/metabolic pathways. At least in chemistry there is an internal logic to it once you get the basics down, but with molecular pathways it's almost senseless memorization with having to know all the different (often randomly named) parts and how they interact with each other.

What testing could be done on RCs ordered online?

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- Mon, 09 Nov 2015 17:25:34 EST NUJLhhhW No.77357
File: 1447107934857.jpg -(221066B / 215.88KB, 1045x854) Thumbnail displayed, click image for full size. What testing could be done on RCs ordered online?
So, I found a clearnet source for both Etizolam and Clon, but then upon checkout, this shit comes up:

>We will need a detailed account of your research methodology though before shipping any order. This an include how you will be utilizing the chemicals, what equipment is used, anticipated results, etc.

What is some things I can say? Obviously they know people are just ingesting them, yet they still have the disclaimer for Not For Human Consumption. That's fine.

But I've never seen this type of bullzhit.

anyone a science student or chemistry student or actual chemist or anything? I know some people say they can test for purity of the drugs. What would be used for that? Some type of ethanol, beakers, syringes, etc?

Thanks.
6 posts omitted. Click View Thread to read.
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Fanny Nucklelune - Mon, 27 Mar 2017 11:52:55 EST NiKHAkYF No.78613 Reply
>>78583
>we cannot divulge into specifics.
Excellently worded. You'll be fine.
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Phineas Gaffingcocke - Mon, 10 Apr 2017 00:00:59 EST n/Fuk2xx No.78631 Reply
what are you trying to do?
make Oxycontin?
I really wouldn't recommend that.
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Fucking Lightham - Wed, 12 Apr 2017 00:22:40 EST roSXguau No.78633 Reply
it's for zapping labrats, read and cite some research papers.

A/B xtract. Blood interaction.

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- Thu, 06 Apr 2017 22:23:54 EST LObRvGV/ No.78627
File: 1491531834158.jpg -(15650B / 15.28KB, 320x180) Thumbnail displayed, click image for full size. A/B xtract. Blood interaction.
If you did an A/B on a bunch of used cottons with some blood in the mix as well, what would the blood do if you add base->non-polar extract->add acid to neutralize.

Or wait, now I forget... ^ that sounds like "B/A'... if you're starting with traces of heroin-hcl leftover, then you would start with the base, riiiight....

P.S. check out your
\Program Files (x86)\Steam\SteamApps\common\Counter-Strike Global Offensive\csgo\streams
folder for some cringey streamer shit.

Retrosynthesis

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- Wed, 05 Apr 2017 05:17:10 EST kVxUxljq No.78621
File: 1491383830284.png -(46084B / 45.00KB, 1445x527) Thumbnail displayed, click image for full size. Retrosynthesis
Hey guys, it's been awhile since I've studied Ochem (3 years now) and I'm pretty rusty. Thought I'd give retrosynthesis a crack but I'm seriously struggling with this kinda molecule.

I know my retrosynthesis probably looks dumb because as I said, I'm super rusty. Can anyone point me in the right direction please?
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press - Wed, 05 Apr 2017 07:15:23 EST Jirf0CGs No.78624 Reply
1491390923111.png -(140827B / 137.53KB, 389x288) Thumbnail displayed, click image for full size.
what are your criteria for starting molecules?
if you go with B i think that deprotonating acetylacetone, which can be made via the claisen condensation of ethylethanoate and acetone, and then jamming that on 4-"something"hexan-1-ol would work if you the something is a good leaving group, like a trimetyl ammonium thingy for example.
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Charles Gillerbot - Wed, 05 Apr 2017 20:55:35 EST kVxUxljq No.78626 Reply
>>78624
the only real criteria is that it should be able to be done in the least amount of steps with commercially affordable reactants (which i guess is the point of retrosynthesis)

i'll give that a go, cheers!

N2O Synthesis

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- Fri, 03 Feb 2017 08:00:40 EST fDi3lCXD No.78519
File: 1486126840649.jpg -(141394B / 138.08KB, 720x1280) Thumbnail displayed, click image for full size. N2O Synthesis
Hey guys, whippets can get expensive. Does anyone synthesize their own N2O at home/do you have a favorite method of doing so?
14 posts and 1 images omitted. Click View Thread to read.
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Bombastus !uYErosQbLM!!Mybq1UbK - Thu, 30 Mar 2017 19:31:30 EST 9aybb3lV No.78615 Reply
>>78614
why'd you delete your science madness account?
fucc i was gonna offer you a part time contracting thing there. reactivate bls.
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Augustus Blackcocke - Wed, 05 Apr 2017 14:29:58 EST 1YWXh+i8 No.78625 Reply
I'm sure the gas would get cheaper than whippets in cylinder form.

subject

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- Fri, 31 Mar 2017 00:52:19 EST 8Bqb2ojy No.78616
File: 1490935939445.jpg -(217743B / 212.64KB, 1674x670) Thumbnail displayed, click image for full size. subject
>hehe yeh bro meth is super simple to make just shake and bake my dude heh
2 posts omitted. Click View Thread to read.
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Hannah Hublingsatch - Mon, 03 Apr 2017 22:51:52 EST KtEKcIRL No.78620 Reply
i never even thought about making the nitroethane before lolwut
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press - Wed, 05 Apr 2017 06:46:51 EST Jirf0CGs No.78623 Reply
1491389211485.jpg -(88839B / 86.76KB, 640x625) Thumbnail displayed, click image for full size.
your image doesnt even include any routes using ephedrine so i dont see the point of being pissed at shake n bake.

sorry you wasted dozens of hours in ms paint.
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jet fuel paint hardner meth in a crockpot - Thu, 12 Apr 2018 13:23:45 EST 2Sv5WqAP No.79061 Reply
when i was in prison every one talkn about orange crush rc fuel an dupont acrylic paint hardner mix together in a crock pot 12 low 12 high and wala rc fuel has nitromethane andpaint hardner has well fuck i dunno but we on ta sumthin

Purity Testing GCMS HPLC etc Question

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- Tue, 28 Feb 2017 08:07:46 EST LObRvGV/ No.78584
File: 1488287266677.jpg -(11486B / 11.22KB, 439x373) Thumbnail displayed, click image for full size. Purity Testing GCMS HPLC etc Question
This is an email I sent out, but feel free to take a whack at it.

From the given information on the FAQ:
>Then we perform a qualitative analysis on each component identified where possible,
>comparing each substance with a pure reference standard.
>Our results directly provide the result of the salt of the substance, as we’re
>using a salt as a reference standard. The quantitative results are provided using
>a calibration curve from a reference standard.

as well as the techniques listed here https://energycontrol-international.org/drug-testing-service
It seems that almost all of those techniques can be used to generate a quantitative purity result, e.g. GCMS, LCMS, HPLC, UV/Vis.

So can you try to fill in the blanks here for me?

Generate pure quantitative result based on reference standard.
???
Calibration curves
???
Obtain substance % percentage.

How are these calibration curves created and how exactly are the curves used to determine the % percentage? Is it done by hand? Done via software?

The reason I ask is so I can understand and explain how people have reported widely varying purity results returned from the EC lab. In one case, someone sent to EC two samples of 4-MMC from the same batch with no obvious signs of cut, yet "the same shards came back with one 85% result and one 45% result." Why is this?

It is not the first error I've heard of, and I'd like to know, please ask your lab techs how perfect your quantitative test method is, and how much error tolerance is acceptable? Do you ever test twice to verify? For instance, testing heroin with HPLC and LCMS to compare both machine's quantitative data?
5 posts and 1 images omitted. Click View Thread to read.
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Vehk !7HYGxe5v5c - Wed, 15 Mar 2017 22:49:59 EST l5Akm3J6 No.78601 Reply
>>78591

The compound in the bottom right is incorrectly labelled. The compound pictured is methadone, while it is labelled as methedrone, which is a methcathinone and related to mephedrone.

Step up, fam.
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Walter Goodwater - Thu, 16 Mar 2017 21:31:37 EST ZUVcy1Vx No.78607 Reply
1489714297151.jpg -(4617B / 4.51KB, 259x194) Thumbnail displayed, click image for full size.
>>78584

A reference standard is a documented, authentic sample of the chemical you are looking to analyse for.

You dilute the reference standard in solvent at a range of concentrations, generally 5 different conc. are used for a good calibration curve.

You set up the instrument (GC/MS/HPLC/UV ect.) and inject each of those 5 standards you prepared.

The plot of detector response (peak area) as a function of each standard concentration should be roughly linear, fit a least squares line and use the equation of that line to calculate the amount of analyte in your test sample based on the peak area it gives.
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Walter Goodwater - Thu, 16 Mar 2017 21:34:39 EST ZUVcy1Vx No.78608 Reply
>>78607

this process is not nearly as simple as it sounds.

if you really want to test the lab's accuracy weight out a decent sized sample of a compound (~500 mg) and grind it well, then submit two samples of the same grind. They should be within 10% or so of each other

How to creat Oxygen (O2)

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- Fri, 27 Jan 2017 13:36:17 EST MuFe+5ez No.78510
File: 1485542177999.jpg -(27750B / 27.10KB, 400x300) Thumbnail displayed, click image for full size. How to creat Oxygen (O2)
Let's say you're in Syria in an ai-tight room and there's poison gas detonated. What simple household materials could you use to synthesize oxygen? Is it possible to use rust as a source for instance?
5 posts omitted. Click View Thread to read.
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Nicholas Biggleforth - Thu, 16 Feb 2017 08:48:55 EST WYa1y06F No.78535 Reply
Wouldn't that just end in you dying from oxygen poisoning?
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Hugh Trotspear - Tue, 07 Mar 2017 11:46:56 EST Lx3qHXrW No.78595 Reply
1488905216863.jpg -(449256B / 438.73KB, 780x2128) Thumbnail displayed, click image for full size.
Easy

Get some dry D cells. Take out the magnesium dioxide
Get some Hydrogen Peroxide
Mix
Capture the bubbles
O2

The most dangerous weapon in the world, hiding in plain sight.

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- Fri, 10 Mar 2017 20:09:22 EST zYI/8bOR No.78598
File: 1489194562684.jpg -(71710B / 70.03KB, 604x484) Thumbnail displayed, click image for full size. The most dangerous weapon in the world, hiding in plain sight.
==MAKE AS MUCH ORGONITE AS POSSIBLE RIGHT NOW!!!!!==
This is not a drill.
>cell phone towers are weaponized death rays ready to nuke the planet or act collectively as a super powerful HAARP-like machine.
>Orgonite converts harmful rays into healthful ones, and can be "gifted" near cellphone towers to negate the effects. The larger ones make chemtrails harmlessly dissipate.
**btw Wilhelm Reich is a notable person related to this topic.**
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Cornelius Nammerfield - Sun, 12 Mar 2017 15:23:18 EST 4tmtdVyg No.78599 Reply
1489346598186.gif -(3210878B / 3.06MB, 500x207) Thumbnail displayed, click image for full size.
Looks cool tho

I would like to know more

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- Wed, 22 Feb 2017 11:05:12 EST tYqZ8S2V No.78537
File: 1487779512722.jpg -(397458B / 388.14KB, 2244x1983) Thumbnail displayed, click image for full size. I would like to know more
Is powdering a carpet with Borax a good way to kill carpet beetles without killing the occupying human?
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William Bocklewell - Wed, 22 Feb 2017 12:29:43 EST 4tmtdVyg No.78538 Reply
I've used borax to assassinate the ant queen(s) before.

Mix it 1/3 parts borax, 1/3 part sugar, 1/3 part hot water. Let it cool then let the sugar solution sit out in a flat dish or something. I dunno if beetles are as sensitive to borax, but I'm sure they don't have a processing method for borax.
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Angus Wiblingdock - Mon, 06 Mar 2017 16:37:04 EST Ja2fAPPl No.78594 Reply
Borax will kill the bugs but any eggs they leave behind will be spared. You'll have to continuously reapply over months to get rid of all of them.
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