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Harm Reduction Notes for the COVID-19 Pandemic

New, Novel, Potent Opioids

Reply
!lnkYxlAbaw!!7zlcjO/U - Thu, 04 Feb 2016 17:39:55 EST ElYFdcKO No.77619
File: 1454625595580.png -(9820B / 9.59KB, 372x408) Thumbnail displayed, click image for full size. New, Novel, Potent Opioids
Thants (our br/opi/ in Canada) has recently nodded off W-18, which is a totally novel opioids that hasn't seen street time. So /chem/ might as well talk about it.

The current method of synthesis is outlined in patent no. US4468403
>A mixture of 1-phenylethylpiperdylidene-2-(4-chlorophenyl)sulfonamide (1.17 g, 3.11 mmol) W-15, 90% fuming nitric acid (3.0 ml) and concentrated nitric acid (2.0 ml) were stirred vigorously for 4 hours at 25° C.
Preparation of 1-phenylethylpiperdylidene-2-(4-chlorophenyl)sulfonamide is not outlined, unfortunately. But it's pretty easy to figure it out as it's a straight chained molecule.

So uhh ya. W-18. Talk about it. It's legal everywhere except in Sweden right now. I guess that is a thing. It was discovered by Knaus back in the 80s who was a pretty sick guy who liked opioids. He's had a lot of work doing shit like that. Here's some condensed reading:
http://chemistry.mdma.ch/synthforum/about635.html

W-18 is the 18th item on his patent list: http://www.google.com/patents/US4468403
It includes up to 35 different, unscheduled, and very potent, novel opioids that do not rely on the morphinan group. Check em.
>>
Bombastus !lnkYxlAbaw!!7zlcjO/U - Thu, 04 Feb 2016 17:42:36 EST ElYFdcKO No.77620 Reply
>>77619
>Preparation of 1-phenylethylpiperdylidene-2-(4-chlorophenyl)sulfonamide is not outlined, unfortunately
Nope. I'm fucking wrong.
It's just simple chemistry related to the first page of the general outline with R1-5s of the different groups. If one had all the simple yet rare precursors, it'd be incredibly easy to make the molecule itself.

W-18 is more interesting as it is (to my knowledge) the first opioid of any kind to have a nitro group.
>>
Polly Debberham - Sun, 07 Feb 2016 15:13:54 EST CabrmvWb No.77630 Reply
>>77619
They are so potent dosing would be impossible without some advanced equipment.
>>
Phineas Hirringfan - Sun, 07 Feb 2016 15:37:29 EST ffLJfJPb No.77631 Reply
>>77630
Get ready for more deaths after fucking vendors start stocking these.
>>
Vehk !7HYGxe5v5c - Sun, 07 Feb 2016 17:31:10 EST lSqMn6+G No.77632 Reply
1454884270045.jpg -(100029B / 97.68KB, 504x470) Thumbnail displayed, click image for full size.
>>77631
and who
are you
the volumetric dosing
said
>>
Bombastus !lnkYxlAbaw!!7zlcjO/U - Sun, 07 Feb 2016 18:12:37 EST vbS8CtHn No.77633 Reply
>>77631
>>77630
That's why everyone is having trouble with 1P-LSD, right?
Volumetric dosing is a thing. A very plausible thing.

The main worry when it comes to deaths would be people confusing this with heroin, oxycodone, or even fentanyl.
>>
Reuben Lightworth - Tue, 09 Feb 2016 09:07:28 EST IYdLFEtN No.77639 Reply
>>77633
What is volumetric dosing? Dissolve compound in a large amount of suitable solvent and inject only a fraction?
>>
press !QUHukXEvkY - Tue, 09 Feb 2016 12:36:33 EST MD/oThse No.77641 Reply
>>77639
basically that sans the injecting part

you dissolve say a gram in lets say 100mL, then take 10mL from that, dilute those down to 100mL and so on and so forth until youre at a concentration that isnt going to fucking kill a village

but id recommend using proper equipment such as volumetric flasks, good pipettes and a good scale. that way you can even calculate the error margin, to evaluate the possible deviation from the intended concentration

http://www.chemistryland.com/CHM151Lab/Pipette/PipetteInstructions.html
goddamn that asian is pissing me off
>>
Reuben Lightworth - Wed, 10 Feb 2016 08:01:53 EST p48/torv No.77646 Reply
>>77641
OK, that's a regular "serial dilution" then. But isn't the suitably diluted solution ingested eventually (IV or otherwise)?
>>
press !QUHukXEvkY - Wed, 10 Feb 2016 09:45:10 EST MD/oThse No.77647 Reply
>>77646
yeah, youre right.
but id guess that youd want to work in an isotonic sodiumchloride solution for that
and since sterility wont be a given, a wheel filter would be a wise investment
>>
Fanny Bardham - Wed, 10 Feb 2016 18:20:53 EST DIZp74tV No.77648 Reply
>>77641
Thanks for the info on pipette tolerances. Someone doing careful weighing and serial dilution might be interested in a microliter syringe also.
>>
Bombastus !lnkYxlAbaw!!7zlcjO/U - Sun, 14 Feb 2016 17:21:18 EST vbS8CtHn No.77660 Reply
>>77646
Ingested, yes. I would not recommend IVing anything that requires volumetric dosing (serial dilution). From what I hear on /opi/, fentanyl and all their analogues as well as other super potent opioids do not have an appreciable nod.
Their oral BAs are all high enough as they don't have metabolizable groups like the conventional morphinan opioids do.

I mean, if you really want to IV, you could just put the 100ml of final solution into a pressure cooker and sterilize it that way for injection every time. But the reality is that you still should not be injecting any random ass powder off the internet.
>>
Emma Turveyford - Sat, 20 Feb 2016 12:52:53 EST p0QLwGpF No.77669 Reply
Hi bombastus sorry to bother but did your oxycodone synthesis tek work?
>>
Bombastus !lnkYxlAbaw!!7zlcjO/U - Sat, 20 Feb 2016 15:03:46 EST 4ppVjZXo No.77672 Reply
>>77669
a few friends of mine and me got together a few years ago and made something like 5g and split it evenly. That was a sweet adventure.
That binge and subsequent withdrawals made them almost all give up opioids after that. Which tk did you talk about?
>>
Lydia Picklock - Thu, 07 Apr 2016 17:59:34 EST IsDQAl0D No.77814 Reply
>>77619


okay well i have experience with butyrfent. all i have to say is be prepared to poke yourself full of holes if IVing. the highs are so cracky that they will have you compulsively redosing every few hours, effectively turning you into a pin cushion until you flush the sheet.
>>

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