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P2NP reductive amination

- Mon, 20 Feb 2017 15:02:04 EST F56IS3nI No.78536
File: 1487620924101.jpg -(16458B / 16.07KB, 400x280) Thumbnail displayed, click image for full size. P2NP reductive amination
where can i find the true procedure to reduce P2NP to the amine with hgcl2/al?
Jack Blackdock - Sat, 15 Apr 2017 23:52:51 EST fXXYn8yb No.78638 Reply
1492314771660.jpg -(86932B / 84.89KB, 500x667) Thumbnail displayed, click image for full size.
funny story i tried this route many times with poor results, that amalgam is a bitch and/or not strong enough to reduce the molecule OR I fucked up something doing the amalgamation process

somebody has experience with this procedure?
press - Tue, 16 May 2017 17:59:40 EST OHYz+LTM No.78654 Reply
ime Eleusis was partly correct in hi quotation of vogels.
if you prepare the aluminium in advance it tends to get the job done much quicker and ... well quicker and thus much more dangerously. you should always care for proper safety precautions converning spillage when dealing with highly toxic bullshit.
press - Tue, 06 Jun 2017 05:18:01 EST xjn9cxbO No.78676 Reply
1496740681851.jpg -(24215B / 23.65KB, 636x319) Thumbnail displayed, click image for full size.
a strong six out of ten, id guess.

The Proper Preparation of Aluminum Amalgam
by Eleusis

This is for all of you Dr. Shulgin fans out there that might be a little miffed at poor yields when attempting mild reductive aminations (not the fruity little Disney characters, kids). The trick here is *cleaning* the damned foil before you use it. Follow closely, be careful with the mercuric solutions, they can be absorbed transdermally (in other words, use gloves, dumbass).
Preparation of Aluminum Amalgam

Aluminum Amalgam is a useful mild reducing agent which requires careful preparation in order to be effective. The following is adapted from Vogel's Practical Organic Chemistry.

Prepare 10% Sodium Hydroxide solution by dissolving 20g NaOH in 180mL of distilled water.

Prepare a ~2% Mercuric (II) Chloride solution by dissolving 1g of HgCl2 in 50mL of distilled water.

Cut 40g of aluminum foil into small squares approximately .5cm a side.

Place the aluminum into a large beaker or other suitable glass container and cover with the sodium hydroxide solution. Heat gently in a well ventilated area until hydrogen gas evolves vigorously for about 3 minutes. Strain the foil through a plastic colander and wash first with distilled water, then with denatured alcohol. Pat dry then add to a beaker with the 2% HgCl2 solution. Allow to amalgamate for 2 minutes then pour off the supernatant. It is unethical to pour mercury compounds down the drain, but you'll probably do it anyway ;-). Now wash the foil in the colander as before, with distilled water, ethanol, and then a little bit of ether. Submerge the aluminum amalgam in ether to store until use.

  • eleusis@netcom.com - Aluminum Amalgam Doc - 09/01/95 -
Nicholas Dunningbut - Wed, 14 Jun 2017 19:49:28 EST ZYvGRZ+j No.78689 Reply
tbh I prefer to use something more direct and efective to reduce chemicals
Bombastus !uYErosQbLM!!Mybq1UbK - Wed, 14 Jun 2017 23:45:52 EST Pues0B4h No.78690 Reply
LiAlH under nitrogen. But then again, that's completely different...

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