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Opium Column Chromatography

- Tue, 11 Jul 2017 21:56:30 EST QGxEeR56 No.78746
File: 1499824590034.png -(267959B / 261.68KB, 504x380) Thumbnail displayed, click image for full size. Opium Column Chromatography
Without calcium chelation, this is the best way to achieve pure morphine from a layer of puddy or otherwise concentrated poppy residue.

A mixture of 9:1:1 DCM Methanol Diethylamine will produce an elution of reticuline impurities at 0.7-0.9, codeine at 0.45, and morphine at 0.2. Other opium oils either elute at 1 and heavier, coloured oils will not elute at all (or under 0.02).

Running this column simulation once gave me morphine as light brown needles which drew in moisture and became wet after 3 hours. The second time, morphine did not completely come through as shown on TLC short wave UV light as what I expected to be high amounts of meconate salts along with insufficient methanol miscibility. This was solved by adding an additional 1 equivalent of methanol thereby moving the morphine. This gave darker brown crystals which again absorbed water after 3 hours. Full morphine elution towards 100% in a gradient column gave 2% of brown oils. This potentially allows a column to remove codeine and oils and a methanol flush to remove the morphine with a 5-10% heavy oil contamination.

Will update this thread with more conclusions and projections.
William Checklehall - Fri, 14 Jul 2017 11:44:37 EST 4tmtdVyg No.78747 Reply
Cool stuff brah. You gonna test it outside the vacuum?
press !XIxc6BpKnU - Fri, 01 Sep 2017 10:55:37 EST ak42GqP4 No.78810 Reply
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does anybody have experience with using an acidic ion exchange resin? ive found multiple patents and papers which make it sound very promising and tbh much too easy to be true, since i recently aqquired several different resins at a garage sale.

havent tested anything yet as i only have a pound of poop straw left and the publications arent too conclusive about the crude extract
Schepperschop - Sun, 03 Sep 2017 18:49:56 EST 81NLKdBS No.78824 Reply
Morphine ?
Rather have codeine.
Schepperschop - Sun, 03 Sep 2017 23:45:17 EST 81NLKdBS No.78825 Reply
Stupid USA junkie junk lusting after fake looks like your brain whould not handle opiates.
Theophrastus Werrywag - Mon, 04 Sep 2017 05:36:43 EST npebQgFy No.78827 Reply
Hey Press. Someone's dissing your fly girl. Give me some oxymorphone through a mesylate mediated demethylation of oxycodone through column chromatography of oxycontins or acetaminophen preparations.

Anyway, I'm high enough to finally look through this (and woke up way too early). Is there a reason you posted the ion exchange resin in this thread? Something interesting with the separation of the solutions that OP faggot was trying to do?

Ion exchange resin normally has some sort of magical property like electrochemistry. So patents and papers are normally trustworthy with this kind of chemistry. Same goes with polymer mediated organic and inorganic chemistry.
press !XIxc6BpKnU - Mon, 04 Sep 2017 11:56:06 EST bm6Bfbck No.78831 Reply
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never had oxymorphone, so my motivation is somewhat limited, sooooorry
might get some oxy later next month but im not sure ill be doing anything special with them besides shoving them up my ass.

oh, no particular reason i just thought that you might be interested in ion exchange as a method too since it should be less expensive than column chromatography, but i guess you dont have to pay for solvents anyways. lately ive been looking into clandestine electrochemistry and ion exchange resins since a lot of reductions would be really easy and purification of more complex mixtures would be easy.
i recently found a chemical vendor that sells trimethoxybenzaldehyde for 40europoors /100g, but im a big faggot that doesnt like LAH reductions.

sorry, didnt mean to derail your thread, but might as well only have one opium "x" chromatography thread. and thanks for having trust in publications, the only thing i ever learned from university was that you cant trust any scientist
Theophrastus Werrywag - Tue, 05 Sep 2017 00:43:27 EST npebQgFy No.78832 Reply
Demethylation requires mesylic acid and some amino acid. You can extract your ass juice to get protein strands and do a different kind of chromatography to get that. Search up the procedure for OC > OM with mesylic acid. It's pretty easy and if you're going to shove oxy up your ass, at least make it oxymorphone.

Also, it's not derailment. Don't you ever say that word again. It's add on. Ion exchange is quite meticulous in how people carry out the reaction. I've done it thrice in my life with no success. Much like cross coupling reactions, there's an art to it somehow which is quite odd. Where's the specific information? It'll be worth looking into it since I can probably swipe some beads from work one day.

Anyway, I found a vendor that sold the already reduced version of it somewhere on ebay (NC-CHH-CHH-Ph-(MeO)3) for quite cheap as well. It was something stupid like 10g for $60 but it's one reduction away from the pure compound. It was apparently a one time deal and one of my friends in Quebec ended up getting the product. LAH is easy if you have a blast shield. Shake. And. Bake.

Anyway, I hope you trust me bress. Gief trust nao. even tho i don't fucking trust myself
Schepperschop - Tue, 05 Sep 2017 15:46:08 EST 1tcgFn9N No.78833 Reply
How about you leave the mescaline making to the cactus.
press !XIxc6BpKnU - Wed, 06 Sep 2017 10:17:54 EST cWIAjghj No.78837 Reply
1504707474213.png -(349926B / 341.72KB, 650x995) Thumbnail displayed, click image for full size.
its not hate. i think the kids nowadays call it tsundere. thats basically chinese for trying hard to get.
ill compile the few papers ive got so far soon, damn shame 420chan doesnt support pdfs.
David Buzzwell - Wed, 06 Sep 2017 14:48:20 EST hBAZGxou No.78838 Reply
Mesylic acid? I'm pretty sure methanesulfonate isn't nucleophilic enough to attack an ether. Most demethylations I'm used to hearing about use hydrobromic acid or pyridine hydrochloride. Hydrogen iodide is very effective but also expensive.

you can use Zn powder / hydrochloric acid to reduce terminal nitrostyrenes like for mescaline; it's really just nitropropenes that are "hard" to reduce (although Al/Hg licks it)

Aureolus Werrywag - Thu, 07 Sep 2017 00:47:08 EST HizIkIMY No.78839 Reply
droopbox it up fam

there's some paper here that requires something i can't remember
or you can go with hydrobromic acid in acetic acid solution but that's harder to find.
Aureolus Werrywag - Thu, 07 Sep 2017 00:53:36 EST HizIkIMY No.78840 Reply

Also US patent US5071985
A mixture of 3.15 g (10-2 mole) of oxycodone, 28.3 g (3.10-1 mole) of methanesulfonic acid and 2.2 g (1.5.10-2 mole) of DL-methionine are heated to 40° and stirred at 12 hours.
Precipitate with ammonia to 9, extract with DCM. Chloroform column with a methanol gradient. 72% yield.
Theophrastus Werrywag - Sun, 01 Oct 2017 01:08:19 EST m5AB1YJF No.78874 Reply
Ima just save this here


































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