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Any way to extract mitragynine from kratom?

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- Tue, 13 Nov 2018 17:24:30 EST pv6fN59z No.79275
File: 1542147870232.png -(3583B / 3.50KB, 269x187) Thumbnail displayed, click image for full size. Any way to extract mitragynine from kratom?
First off I'm not a complete noob asking if adding hydrogen peroxide to kratom leaf makes 7-hydroxymitragynine.

I'm basically just wondering if it's even possible to extract 90%+ pure mitragynine from kratom. Would such a thing be possible without chromatography? Simple A/B then chloroform and then maybe specific solvents/PH?
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poopresstitution - Wed, 14 Nov 2018 04:17:45 EST ExXXwvaB No.79277 Reply
hello nodson


you already read a few papers on this matter? i remember the procedure being roughly what you outlined. i suspect the main problem at first would be to set up a test series in suitable sizes since it would take a lot of plant material

i reckon you wont be able to get around TLC to check for qualitative purity but it shouldnt be considered a hassle since otherwise youd be flying blind more or less. any other non instrumental analysis either qualitative or quantitative is going to require much more material and a lot of references and i doubt people bother to post melting points.
nvm the first result on my search engine is a nice paper by the malaysian journal of analytics. the second result is somebody telling me how get and stay hard. journals from less developed nations are awesome, not only for the subtle grammatical errors but also since they tend to use less complex methods
http://www.ukm.my/mjas/v15_n1/Goh.pdf
the swg drugs monograph is fucking useless unless you can get access to a GCMS
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Emma Brookfield - Mon, 19 Nov 2018 21:21:53 EST pv6fN59z No.79278 Reply
>>79277

After some research I've discovered DIY coloumn chromatography is fairly easy. Just a column (cheap on ebay), silica, sand, cotton, and solvent/buffer medium. Pretty easy and has pretty much identical results of flash chromatography except it's much slower, which I'm fine with.

An easy tek would be to soak powdered dry kratom with ammonia to basify and then let it evaporate. Then add chloroform and extract. Evap to get dry powder. Use coloumn chromatography. Recrystalize in hot methanol with picric acid. Filter. Add to chloroform and basify with ammonia. Add citrate and filter. Evap and you got 95-98% pure mitragynine citrate.
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Emma Brookfield - Tue, 20 Nov 2018 14:40:56 EST pv6fN59z No.79279 Reply
>>79278

To simply it, it's as simple as soaking kratom in a small amount of ammonia, passively evaporating it, adding hexane and heating, filter, add to coloumn and seperate fractions, evaporate mitragynine fraction and weigh, add mitragynine freebase to acidic methanol (equal mol of HCL or citric acid), mix, and evap. Boom, 95% pure mitragynine HCL/citrate.
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press - Wed, 21 Nov 2018 04:37:00 EST bibGzGaZ No.79282 Reply
>>79279
having a really hard time believing that.

and why would you recrystallize with picric acid?
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trypto - Thu, 22 Nov 2018 08:46:00 EST OdR7meD+ No.79283 Reply
>>79282
> why would you recrystallize with picric acid?
hahahahaha
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press - Thu, 22 Nov 2018 10:21:11 EST KFcL1XHa No.79284 Reply
>>79283

would make sense to me if it was to measure the melting point but i see no mention of that and its not even at the last step
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Henry Pommermine - Sun, 02 Dec 2018 21:30:57 EST pv6fN59z No.79291 Reply
>>79282

I was gonna reply a week ago but it got deleted so I never did.

Picric acid is unnecessary, it's just for recrystalization which isn't necessary for my purposes.

I'd just evap the mitragynine hexane fraction to get freebase mitragynine or salt it with citric acid.
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Sophie Grandman - Sun, 03 Mar 2019 20:11:33 EST LEIFpGAY No.79314 Reply
>>79283
LOL, yeah the active compounds are way more bioavailable as their picrate salts!
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press !YxHJQHLaEk - Fri, 29 Mar 2019 15:42:36 EST XqaGYEnB No.79335 Reply
>>79314

somebody else - pre supposed snows torm disaster- pointed out that many alkaloids form picrate salts which are poorly soluble in organic solvents, thus precipitating.

but youre right, id rather not risk exposure to carcinogens, he said while opening his second pack of the day.
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Henry Hocklested - Mon, 01 Apr 2019 12:53:26 EST RsiLyIYo No.79342 Reply
>>79335

I would rather not risk exposure to concentrated picric acid.
Even in a well equipped lab, that is one that will give your EHS people heart attacks.

Or the friction sensitive explosive compounds that result from it's reaction with organics.

HCL will crash out your alkaloids just as well.
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hsn - Thu, 25 Apr 2019 10:57:06 EST DRDiF8PI No.79391 Reply
>>79335
I feel like im having a stroke, I posted here to tell you this thread isn't mine and some other shit about methanol but the post is gone.
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press - Fri, 26 Apr 2019 16:22:33 EST kphkeya5 No.79400 Reply
>>79391
according to kirt the servers were fucked up by a snow storm and the backup wasnt up to date. but tbh i cant be arsed to reconstruct the time line.
>>79342
i was just repeating what somebody else posted. i see your point but i suppose employing picrate to precipitate alcaloids comes from the same time where you had to spend multiple years to describe the structure of a molecule. not to shit on indian or indonesian publications

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