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... I don't know, I think they're probably comparable as far as neurotoxicity goes IF they're both dosed at comparable levels of intensity, and they're both dosed only once. The thing is, that's not how many users use - and the behavioural consequences of each drug also affects their respective neurotoxic potentials.
MDMA can leave one with a depressed mood, emotional instability(?), residual stimulation and I'm not sure what else as I've hardly ever experienced a harsh comedown or any sort of "Suicide Tuesday" effect, nor a lingering low mood. Aside from residual stimulation after a single, large dose I've yet to experience any real negative impact from MDMA use. I've also tested my product with Marquis reagent, and it is very likely MDMA/MDA and slightly less probably, an amphetamine. Judging from it's duration and qualitative effects on cognitive processes, I'd wager I'm working with the real deal.
Now, I was also very fortunate to have come across good meth - but the issue comes not from a single dose, no, damage to dopaminergic and other nerve terminals occurs when the factors of redosing, sleep deprivation, low blood sugar/poor nutrition, hyperthermia, and how sudden the withdrawal was. See, meth on it's own will cause too much dopamine to build up in the cytosol - that dopamine will essentially "go bad" and harm the surrounding neuronal cells triggering apoptosis. This process is amplified if you are redosing/taking large amounts of meth, and especially if your core body temperature rises too high during the experience. Contrary to what one might assume, most of the dopaminergic cell death doesn't occur during the rush, the peak, or the crash. It starts DAYS after the last dose was administered. I do believe tapering can help minimize this toxicity but I'm really not sure. I've also heard that once dopamine becomes scarce, good ol' Tina just starts trying to cram serotonin though the wrong transporters, or something like that.
There's a LOT of info out there on the neurotoxicity of both these substances, but most articles seem to focus on recreational doses well beyond what I would call the realm of reasonable, or even desirable, use.
This is true. Sleep deprivation and large doses of mind-altering drugs is almost always a recipe for confused/erratic behaviour and weirdness, and not just stimulants either. Want to know what really makes methamphetamine a dangerous drug?
>Dubious purity and toxic adulterants
>Presence of the criminal element
>High blood pressure can lead to cardiovascular issues over time
>Sustained periods of wakefullness in excess of X amount of hours (the science is still out on that one)
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